Faculty Profiles - TANAKA Akihito

Papers - TANAKA Akihito

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Clinical Impacts of Urinary Neutrophil Gelatinase-Associated Lipocalin in Patients With Chronic Kidney Disease Undergoing Percutaneous Coronary Intervention Reviewed International journal

Ozaki Yuta, Uemura Yusuke, Tanaka Akihito, Yamaguchi Shogo, Okajima Takashi, Mitsuda Takayuki, Ishikawa Shinji, Takemoto Kenji, Murohara Toyoaki, Watarai Masato

Circulation Journal Vol. 88 ( 6 ) page： 944 - 950 2024.5

Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Circulation Society

Background: Chronic kidney disease (CKD) is associated with poor prognosis in patients undergoing percutaneous coronary intervention (PCI). Urinary neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker for renal injury. However, the association between urinary NGAL concentrations and renal and cardiovascular events in patients with CKD undergoing PCI has not been elucidated. This study investigated the clinical impact of urinary NGAL concentrations on renal and cardiovascular outcomes in patients with non-dialysis CKD undergoing PCI.Methods and Results: We enrolled 124 patients with non-dialysis CKD (estimated glomerular filtration rate <60 mL/min/1.73 m2) undergoing elective PCI. Patients were divided into low and high NGAL groups based on the median urinary NGAL concentration measured the day before PCI. Patients were monitored for renal and cardiovascular events during the 2-year follow-up period. Kaplan-Meier analyses showed that the incidence of renal and cardiovascular events was higher in the high than low NGAL group (log-rank P<0.001 and P=0.032, respectively). Multivariate Cox proportional hazards analyses revealed that urinary NGAL was an independent risk factor for renal (hazard ratio [HR] 4.790; 95% confidence interval [CI] 1.537–14.924; P=0.007) and cardiovascular (HR 2.938; 95% CI 1.034–8.347; P=0.043) events.Conclusions: Urinary NGAL could be a novel and informative biomarker for predicting subsequent renal and cardiovascular events in patients with CKD undergoing elective PCI.

DOI： 10.1253/circj.cj-24-0060

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PubMed

CiNii Research

Refractory atrial tachycardia after transcatheter closure of an atrial septal defect, successfully treated by catheter ablation with transseptal approach via the side of the device Reviewed International journal

Hiramatsu K., Tanaka A., Furusawa K., Inden Y., Murohara T.

Journal of Cardiology Cases 2024

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Cardiology Cases

Atrial tachyarrhythmias occurring after transcatheter atrial septal defect closure are not uncommon; however, those related to device stimulation are rare. Herein, a case involving a 24-year-old female, who developed drug-refractory atrial tachycardia during the early postoperative period, is reported. The results of electroanatomical mapping could eventually be obtained from both atria. They revealed a focal pattern, and the earliest site was located on the left atrial side of the superior atrial septum, between the left and right atrial discs of the device. An ablation catheter was inserted through the side of the device into the left atrial septum, and cauterization successfully achieved recovery of the sinus rhythm without device dislodgement. Learning objective: Atrial tachyarrhythmia related to mechanical stimulation with an atrial septal defect closure device in the early perioperative period is a rare complication. Catheter ablation with transseptal approach through the side of the device might be an option, although careful attention should be paid to the risk for device dislodgement.

DOI： 10.1016/j.jccase.2024.02.007

Scopus

Clinical features, future cardiac events, and prognostic factors following percutaneous coronary intervention in young female patients Reviewed International journal

Tatami Y., Tanaka A., Ohashi T., Kubota R., Kaneko S., Shinoda M., Uemura Y., Takagi K., Tanaka M., Umemoto N., Tashiro H., Shibata N., Yoshioka N., Watarai M., Morishima I., Takada Y., Shimizu K., Ishii H., Murohara T.

Heart and Vessels 2024

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Heart and Vessels

Background: The proportion of young females among the patients who undergo percutaneous coronary intervention (PCI) is relatively small, and information on their clinical characteristics is limited. This study investigated the clinical characteristics and prognostic factors for future cardiac events in young females who underwent PCI. Methods: This multicenter observational study included 187 consecutive female patients aged < 60 years who underwent PCI in seven hospitals. The primary composite endpoint was the incidence of cardiac death, nonfatal myocardial infarction, and target vessel revascularization. Results: The mean patient age was 52.1 ± 6.1 years and 89 (47.6%) had diabetes, and renal dysfunction (an estimated glomerular filtration rate < 60 mL/min/1.73 m2) was observed in 38 (20.3%). During a median follow-up of 3.3 years, the primary endpoint occurred in 28 patients. The Cox proportional hazards models showed that renal dysfunction was an independent predictor for the primary endpoint (hazard ratio 3.04, 95% confidence interval 1.25–7.40, p = 0.01), as well as multivessel disease (hazard ratio 2.79, 95% confidence interval 1.12–6.93, p = 0.03). Patients with renal dysfunction had a significantly higher risk for the primary endpoint than those without renal dysfunction. Conclusions: Renal dysfunction was strongly associated with future cardiac events in young females who underwent PCI.

DOI： 10.1007/s00380-024-02369-7

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PubMed

Long-term clinical outcomes following percutaneous coronary intervention in patients aged 90 years and older Reviewed International journal

Tokuda K., Tanaka A., Uemura Y., Shibata N., Iwama M., Sakaguchi T., Yoshida R., Negishi Y., Tashiro H., Tanaka M., Tatami Y., Yamaguchi S., Yoshioka N., Umemoto N., Ohashi T., Takada Y., Asano H., Yoshida Y., Tanaka T., Noda T., Morishima I., Ishii H., Murohara T.

Journal of Cardiology 2024

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Cardiology

Background: In an aging society, percutaneous coronary intervention (PCI) for super-elderly patients is commonly performed in clinical practice. However, data are scarce regarding the clinical features and outcomes of this population. Methods: This multicenter observational study enrolled patients aged over 90 years who underwent PCI across 10 hospitals between 2011 and 2020. The study included patients presenting with acute coronary syndrome (ACS) and chronic coronary syndrome (CCS). The occurrence of all-cause and cardiac deaths during hospitalization and after discharge was investigated. Results: In total, 402 patients (91.9 ± 2.0 years, 48.3 % male) participated in the study, of whom 77.9 % presented with ACS. The rate of in-hospital death was significantly higher in patients with ACS compared to patients with CCS (15.3 % vs. 2.2 %, p < 0.001). The estimated cumulative incidence rates of all-cause death were 24.3 %, 39.5 %, and 60.4 % at 1, 3, and 5 years, respectively. No significant difference was observed in the occurrence of all-cause death between patients with ACS and CCS. Regarding causes of death after discharge, non-cardiac deaths accounted for just over half of the cases. Conclusion: This study highlights the clinical features and long-term clinical course of patients aged over 90 years who underwent PCI in a real-world setting. Patients presenting with ACS exhibited a higher rate of in-hospital mortality compared to those with CCS. Following discharge, both ACS and CCS patients experienced comparable and substantial increases in the incidence rates of both cardiac and non-cardiac mortality over time, and a more holistic management approach is warranted.

DOI： 10.1016/j.jjcc.2024.07.004

Scopus

The incidence and influencing factors of in-hospital frailty progression following transcatheter aortic valve implantation Reviewed

Miyazaki Tatsuya, Tanaka Akihito, Tokuda Yoshiyuki, Shirai Yoshinori, Mizutani Koji, Furusawa Kenji, Akita Sho, Ozeki Takahiro, Kobayashi Kiyonori, Ishii Hideki, Mutsuga Masato, Murohara Toyoaki

Internal Medicine Vol. advpub ( 0 ) 2024

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Internal Medicine

Objective Patients undergoing transcatheter aortic valve implantation (TAVI) are generally older and frailty is therefore an important clinical issue. The baseline degree of frailty is associated with the prognosis in patients undergoing TAVI; however, the incidence of in-hospital frailty progression and its influencing factors have not yet been elucidated. Methods This observational, single-center study retrospectively evaluated 281 patients who underwent TAVI. The degree of frailty at baseline and discharge was evaluated using the Clinical Frailty Scale (CFS). In-hospital frailty progression was defined as an increase of at least one level in the CFS score at discharge from baseline, and predictors of frailty progression were assessed. Results The median baseline CFS score was 4.0 (interquartile range: 3.0-4.0). In-hospital frailty progression was observed in 49 patients (17.4%). No significant differences were observed in age, sex, comorbidities, or surgical risk scores between patients with and without frailty progression. Patients with frailty progression experienced stroke more frequently during hospitalization than those without (12.2% vs. 1.3%, p = 0.001). A multivariable logistic analysis showed that in-hospital stroke was a significant predictor of frailty progression (odds ratio, 10.7; 95% confidence interval: 2.34-49.2, p = 0.002). Patients with frailty progression had a longer hospital stay than those without frailty progression [7.0 (4.0-17.0) vs. 4.0 (4.0-8.0) days, p = 0.001]. Conclusions In-hospital frailty progression was not uncommon in patients undergoing TAVI. Stroke incidence was a significant influencing factor in frailty progression, whereas baseline comorbidities and surgical risks were not.

DOI： 10.2169/internalmedicine.3146-23

PubMed

CiNii Research

Reply to the Editor —Additional value of venous flow pattern for ultrasound-guided venous closure with suture-mediated vascular closure device Invited Reviewed International journal

Tachi M., Tanaka A., Teraoka T., Furuta T., Matsushita E., Hayashi K., Shimojo M., Yanagisawa S., Inden Y., Murohara T.

Heart Rhythm 2024

Can a new biomarker complement the current diagnostic gap in the management of patients with suspected acute coronary syndrome? Invited Reviewed International journal

Tanaka A., Ishii H.

International Journal of Cardiology Vol. 393 page： 131390 2023.12

Impact of proteinuria on long-term prognosis in patients with coronary artery disease Reviewed International journal

Funakubo H., Tanaka A., Tobe A., Kunieda T., Kubota Y., Yoshioka N., Otsuka S., Kudo N., Shirai Y., Furusawa K., Ishii H., Murohara T.

Journal of Cardiovascular Medicine Vol. 24 ( 12 ) page： 900 - 905 2023.12

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Cardiovascular Medicine

BackgroundThis study aimed to investigate the association between proteinuria and long-term prognosis in patients with coronary artery disease.MethodsThis was a single-center observational study. A total of 1351 patients were identified who underwent percutaneous coronary intervention, and whose urine data were available. Patients were divided into two groups according to the presence (n = 245) or absence (n = 1106) of proteinuria. All-cause and cardiovascular deaths were primarily evaluated.ResultsThe prevalence rates of hypertension and diabetes were significantly higher, and the baseline estimated glomerular filtration rate (eGFR) was lower in patients with proteinuria than in those without proteinuria. During the median follow-up of 4.1 years (interquartile range, 1.7-6.8 years), the occurrences of all-cause and cardiovascular deaths were significantly higher in patients with proteinuria. Multivariable Cox regression analysis indicated that the presence of proteinuria was a significant predictor of cardiovascular death as well as age, BMI, reduced eGFR, and left ventricular ejection fraction. When stratified into four groups based on eGFR category (eGFR <60 or ≥60 ml/min/1.73 m2) and absence or presence of proteinuria, the incidence rates of all-cause and cardiovascular deaths were highest in patients with proteinuria and eGFR less than 60 ml/min/1.73 m2. Furthermore, the incidence rates of all-cause and cardiovascular deaths were significantly higher in patients with proteinuria among both diabetic and nondiabetic patients.ConclusionProteinuria is associated with the long-term prognosis, and all-cause and cardiovascular deaths in patients with coronary artery disease, regardless of eGFR and the presence or absence of diabetes mellitus.

DOI： 10.2459/JCM.0000000000001573

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PubMed

Lethal ventricular arrhythmia due to entrectinib-induced Brugada syndrome: a case report and literature review Reviewed Open Access

Futamura Keisuke, Hase Tetsunari, Tanaka Akihito, Sakai Yoshinori, Okachi Shotaro, Shibata Hirofumi, Ushijima Futoshi, Hashimoto Takahiko, Nakashima Kuniya, Ito Katsuki, Yamamoto Takanori, Numaguchi Atsushi, Inden Yasuya, Ishii Makoto

INTERNATIONAL CANCER CONFERENCE JOURNAL Vol. 12 ( 4 ) page： 299 - 304 2023.10

Author's reply.

Iwama M, Noda T, Takagi K, Tanaka A, Murohara T

Journal of cardiology 2023.9

特集血行再建の適応を見直そう診る4b 血行再建適応を考えるb.急性冠症候群

田中哲人

Heart View Vol. 27 ( 7 ) page： 640 - 644 2023.7

Executive Summary　― Acute Coronary Syndrome in the Japan Resuscitation Council Guidelines for Resuscitation 2020 ― Reviewed Open Access

Kikuchi Migaku, Tahara Yoshio, Yamaguchi Junichi, Nakashima Takahiro, Nomura Osamu, Tanaka Akihito, Kojima Sunao, Hashiba Katsutaka, Nakayama Naoki, Hanada Hiroyuki, Mano Toshiaki, Yamamoto Takeshi, Matsuo Kunihiro, Takeuchi Ichiro, Matoba Tetsuya, Nonogi Hiroshi, for the Japan Resuscitation Council (JRC) Acute Coronary Syndrome (ACS) Task Force and the Guideline Editorial Committee on behalf of the Japanese Circulation Society (JCS) Emergency and Critical Care Committee

Circulation Journal Vol. 87 ( 6 ) page： 866 - 878 2023.5

Ischemic and Bleeding Outcomes in Patients Who Underwent Percutaneous Coronary Intervention With Chronic Kidney Disease or Dialysis (from a Japanese Nationwide Registry) Reviewed International journal

Tobe A., Sawano M., Kohsaka S., Ishii H., Tanaka A., Numasawa Y., Amano T., Nakamura M., Ikari Y., Murohara T.

American Journal of Cardiology Vol. 195 page： 37 - 44 2023.5

Language：English Publishing type：Research paper (scientific journal) Publisher：American Journal of Cardiology

The relation between chronic kidney disease (CKD) and outcomes in patients receiving percutaneous coronary intervention (PCI) is thought to be bidirectional; these patients are at a higher risk of ischemic and bleeding events. From a Japanese nationwide PCI registry, ischemic (cardiovascular death, nonfatal myocardial infarction, or nonfatal ischemic stroke) and bleeding events (fatal or nonfatal major bleeding) 1 year after discharge among patients who had second- or newer-generation drug-eluting stent implantation were analyzed. Patients on oral anticoagulants were excluded. Patients were stratified according to their preprocedural renal function: CKD stages 1 to 2 (estimated glomerular filtration rate [eGFR] ≥60 ml/min/1.73 m2), 3 (eGFR 30 to 59), or 4 to 5 (eGFR <30), or those receiving dialysis. Overall, 23,349 patients, including 2,798 patients with CKD 3 to 5 (12.0%) and 1,464 patients on dialysis (6.3%), were investigated. One-year ischemic events were observed in 1.5%, 5.2%, 9.7%, and 5.3% in the CKD stages 1-to-2, 3, 4-to-5, and dialysis groups, respectively; patients with CKD stages 3 or 4 to 5 and those receiving dialysis were associated with higher risks of ischemic events after adjustment of covariates than were patients without CKD. Compared with ischemic events, 1-year bleeding events were low, with incidence rates of 1.5%, 2.0%, 3.4%, and 2.3%, respectively. Furthermore, the presence of CKD or dialysis was not associated with a higher risk of bleeding events after adjustment of covariates. In conclusion, in the contemporary nationwide PCI registry, the presence of CKD and dialysis was independently associated with a higher risk of ischemic events but not with bleeding events, and this suggests a need to alter the models of care delivery in these patients.

DOI： 10.1016/j.amjcard.2023.02.027

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PubMed

Clinical implications of the cardio-ankle vascular index before and after transcatheter aortic valve implantation. Reviewed

Miki Y, Tanaka A, Tokuda Y, Tobe A, Shirai Y, Yuhara S, Akita S, Furusawa K, Ishii H, Mutsuga M, Murohara T

Journal of cardiovascular medicine (Hagerstown, Md.) Vol. 24 ( 5 ) page： 302 - 307 2023.5

Relationship between the volume of cases and in-hospital mortality in patients with cardiogenic shock receiving short-term mechanical circulatory support. Reviewed International journal Open Access

Araki T, Kondo T, Imaizumi T, Sumita Y, Nakai M, Tanaka A, Okumura T, Yang M, Butt JH, Petrie MC, Murohara T

American heart journal 2023.4

Impact of right coronary artery dominance on the long-term mortality in the patients with acute Total/ subtotal occlusion of unprotected left Main coronary artery. Reviewed

Iwama M, Noda T, Takagi K, Tanaka A, Uemura Y, Umemoto N, Shibata N, Negishi Y, Ohashi T, Tanaka M, Yoshida R, Shimizu K, Tashiro H, Yoshioka N, Morishima I, Watarai M, Tanaka T, Tatami Y, Takada Y, Ishii H, Murohara T, N-registry investigators

Journal of cardiology 2023.4

JCS/CVIT/JCC 2023 Guideline Focused Update on Diagnosis and Treatment of Vasospastic Angina (Coronary Spastic Angina) and Coronary Microvascular Dysfunction Open Access

Hokimoto Seiji, Kaikita Koichi, Yasuda Satoshi, Tsujita Kenichi, Ishihara Masaharu, Matoba Tetsuya, Matsuzawa Yasushi, Mitsutake Yoshiaki, Mitani Yoshihide, Murohara Toyoaki, Noda Takashi, Node Koichi, Noguchi Teruo, Suzuki Hiroshi, Takahashi Jun, Tanabe Yasuhiko, Tanaka Atsushi, Tanaka Nobuhiro, Teragawa Hiroki, Yasu Takanori, Yoshimura Michihiro, Asaumi Yasuhide, Godo Shigeo, Ikenaga Hiroki, Imanaka Takahiro, Ishibashi Kohei, Ishii Masanobu, Ishihara Takayuki, Matsuura Yunosuke, Miura Hiroyuki, Nakano Yasuhiro, Ogawa Takayuki, Shiroto Takashi, Soejima Hirofumi, Takagi Ryu, Tanaka Akihito, Taruya Akira, Tsuda Etsuko, Wakabayashi Kohei, Yokoi Kensuke, Minamino Toru, Nakagawa Yoshihisa, Sueda Shozo, Shimokawa Hiroaki, Ogawa Hisao, on behalf of the Japanese Circulation Society and Japanese Association of Cardiovascular Intervention and Therapeutics and Japanese College of Cardiology Joint Working Group

Circulation Journal Vol. advpub ( 0 ) 2023.3

Prognosis in Patients With Cardiogenic Shock Who Received Temporary Mechanical Circulatory Support. International journal Open Access

Toru Kondo, Takashi Araki, Takahiro Imaizumi, Yoko Sumita, Michikazu Nakai, Akihito Tanaka, Takahiro Okumura, Jawad H Butt, Mark C Petrie, John J V McMurray, Toyoaki Murohara

JACC. Asia Vol. 3 ( 1 ) page： 122 - 134 2023.2

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Temporary mechanical circulatory support (MCS) is often used in patients with cardiogenic shock (CS), and the type of MCS may vary by cause of CS. OBJECTIVES: This study sought to describe the causes of CS in patients receiving temporary MCS, the types of MCS used, and associated mortality. METHODS: This study used a nationwide Japanese database to identify patients receiving temporary MCS for CS between April 1, 2012, and March 31, 2020. RESULTS: Of 65,837 patients, the cause of CS was acute myocardial infarction (AMI) in 77.4%, heart failure (HF) in 10.9%, valvular disease in 2.7%, fulminant myocarditis (FM) in 2.5%, arrhythmia in 4.5%, and pulmonary embolism (PE) in 2.0% of cases. The most commonly used MCS was an intra-aortic balloon pump alone in AMI (79.2%) and in HF (79.0%) and in valvular disease (66.0%), extracorporeal membrane oxygenation with intra-aortic balloon pump in FM (56.2%) and arrhythmia (43.3%), and extracorporeal membrane oxygenation alone in PE (71.5%). Overall in-hospital mortality was 32.4%; 30.0% in AMI, 32.6% in HF, 33.1% in valvular disease, 34.2% in FM, 60.9% in arrhythmia, and 59.2% in PE. Overall in-hospital mortality increased from 30.4% in 2012 to 34.1% in 2019. After adjustment, valvular disease, FM, and PE had lower in-hospital mortality than AMI: valvular disease, OR: 0.56 (95% CI: 0.50-0.64); FM: OR: 0.58 (95% CI: 0.52-0.66); PE: OR: 0.49 (95% CI: 0.43-0.56); whereas HF had similar in-hospital mortality (OR: 0.99; 95% CI: 0.92-1.05) and arrhythmia had higher in-hospital mortality (OR: 1.14; 95% CI: 1.04-1.26). CONCLUSIONS: In a Japanese national registry of patients with CS, different causes of CS were associated with different types of MCS and differences in survival.

DOI： 10.1016/j.jacasi.2022.10.004

Impact of Albuminuria on the Prognosis After Transcatheter Aortic Valve Implantation Reviewed International journal

Tobe A., Tanaka A., Tokuda Y., Shirai Y., Miyazaki T., Yuhara S., Akita S., Furusawa K., Ishii H., Mutsuga M., Murohara T.

American Journal of Cardiology Vol. 186 page： 156 - 162 2023.1

Language：English Publishing type：Research paper (scientific journal) Publisher：American Journal of Cardiology

The impact of preoperative albuminuria on the prognosis after transcatheter aortic valve implantation (TAVI) has not been studied. A total of 228 patients who underwent TAVI for severe aortic stenosis (AS) and for whom preoperative urinary data was available were retrospectively investigated. Patients were divided into two groups according to the urinary albumin-to-creatinine ratio (ACR): high (ACR≥ 30 mg/g) and low (ACR<30 mg/g). The urinary total protein-to-creatinine ratio (PCR) and dipstick proteinuria were also evaluated. The primary outcome was the composite outcome of all-cause death and readmission for heart failure. In total, 117 patients had a high ACR and 111 patients had a low ACR. During the median follow-up period of 467 days, patients with a high ACR had a higher incidence of the primary outcome than those with a low ACR (p<0.001). Patients with a high PCR or positive dipstick proteinuria were also at a higher risk for the primary outcome (p<0.001 and p=0.008, respectively). Multivariable Cox proportional hazards analysis showed a high ACR was independently associated with a primary outcome (hazard ratio, 4.98; 95% confidence interval, 1.84–13.49; p=0.002). In conclusion, preoperative albuminuria is an independent predictor of cardiac events in patients with severe AS undergoing TAVI.

DOI： 10.1016/j.amjcard.2022.09.020

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PubMed

Impact of C-Reactive Protein on Long-Term Cardiac Events in Stable Coronary Artery Disease Patients with Chronic Kidney Disease Reviewed Open Access

Tokuda Kotaro, Tanaka Akihito, Tobe Akihiro, Shirai Yoshinori, Kurobe Masanari, Kubota Yoshiaki, Kunieda Takeshige, Miyazaki Tatsuya, Mizutani Koji, Furusawa Kenji, Ishii Hideki, Murohara Toyoaki

Journal of Atherosclerosis and Thrombosis Vol. advpub ( 0 ) 2023

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Atherosclerosis Society

Aim: Chronic inflammation is associated with atherosclerosis development. Chronic kidney disease (CKD) is an independent risk factor for cardiovascular events and is associated with chronic inflammation. We aimed to investigate the influence of C-reactive protein (CRP), an important marker of inflammation, on the clinical outcomes of patients with CKD and stable coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI). Methods: Among patients with stable CAD and CKD who underwent PCI, 516 patients whose CRP levels were available before the PCI procedure were identified. The patients were divided into two groups according to the CRP levels: those with CRP ≥ 2.0 mg/L (high-CRP group) and those with CRP ＜2.0 mg/L (low-CRP group). The primary endpoint of this study was the occurrence of major adverse cardiac events (MACE), defined as a composite of cardiac death, myocardial infarction, and unplanned revascularization. Results: Overall, the mean age of the patients was 72.5±9.7 years, and 20.7% were female. The median CRP level was 1.43 mg/L (0.6–4.9 mg/L). The median follow-up period was 3.6 years. The occurrence of MACE was significantly higher in the high-CRP group than in the low-CRP group (log-rank p＜0.001). Notably, the incidence rate of cardiac death was significantly higher in the high-CRP group (log-rank p＜0.001). According to the multivariable analysis, CRP level ≥ 2.0 mg/L was found to be a significant predictor of MACE (hazard ratio [HR]: 1.54, 95% confidence interval [CI]: 1.04–2.28, p=0.003), as well as estimated glomerular filtration rate (HR: 0.98, 95% CI: 0.97–0.99, p＜0.01). Conclusion: High-CRP levels adversely affect long-term cardiac events in patients with stable CAD and CKD.

DOI： 10.5551/jat.64047

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