研究者詳細 - 武市　拓也

Psoriasis is a common skin disorder that is characterized by hyperkeratosis, epidermal hyperplasia, T-cell and neutrophil recruitment, and changes in the vascular endothelial system. The several upregulated variable lipid mediators, including the eicosanoids, in psoriatic keratinocytes were described previously, although some results were contradictory. Since hepoxilin is less stable than other eicosanoids such as hydroxyeicosatetraenoic acid (HETE), the measurement of hepoxilin is difficult. In this study, to clarify the relationship between hepoxilin/hepoxilin-related fatty acid derivatives and psoriasis vulgaris, we evaluated the amount of production of lipid mediators including hepoxilins in skin tissues of patients with psoriasis vulgaris in comparison with normal controls by high-performance liquid chromatography/mass spectrometry. Most of the hepoxilins and related lipids evaluated in this study tended to be more abundant in the lesional skin from the psoriasis patient group (PPG) than in the skin from controls. Interestingly, 12R-HETE was markedly higher in the skin samples from the PPG. In addition, the lipids produced in the lipoxygenase pathway, including hepoxilin, were elevated in the skin lesions of the PPG compared with those of normal controls, whereas the lipids produced in the cyclooxygenase pathway were decreased in the skin lesions from the PPG. Our results suggest that an imbalance between the lipoxygenase and cyclooxygenase pathways may contribute to psoriatic pathomechanisms.

DOI： 10.1002/cia2.12039

Web of Science

Scopus

A novel missense mutation in the ABCA12 gene in Japanese siblings with congenital ichthyosis erythroderma 査読有り

Kobashi H., Ishimoto T., Yamamoto M., Nakajima K., Takeichi T., Akiyama S., Sano S.

Nishinihon Journal of Dermatology 81 巻 ( 5 ) 頁： 382 - 386 2019年

[Successful treatment of pre-engraftment disseminated fusariosis with high-dose liposomal amphotericin B in a cord blood transplant recipient]. 査読有り

Harada Y, Murata M, Matsumoto A, Kato D, Yagi T, Yaguchi T, Yoshikawa T, Takeichi T, Akiyama M, Yamaguchi Y, Koyama D, Terakura S, Nishida T, Kiyoi H

[Rinsho ketsueki] The Japanese journal of clinical hematology 60 巻 ( 12 ) 頁： 1641 - 1646 2019年

Reduction of stratum corneum ceramides in Neu-Laxova syndrome caused by phosphoglycerate dehydrogenase deficiency 査読有り国際誌

Takeichi, T; Okuno, Y; Kawamoto, A; Inoue, T; Nagamoto, E; Murase, C; Shimizu, E; Tanaka, K; Kageshita, Y; Fukushima, S; Kono, M; Ishikawa, J; Ihn, H; Takahashi, Y; Akiyama, M

JOURNAL OF LIPID RESEARCH 59 巻 ( 12 ) 頁： 2413 - 2420 2018年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Lipid Research

Neu-Laxova syndrome (NLS) is a very rare autosomal recessive congenital disorder characterized by disturbed development of the central nervous system and the skin and caused by mutations in any of the three genes involved in de novo l-serine biosynthesis: PHGDH, PSAT1, and PSPH. l-Serine is essential for the biosynthesis of phosphatidylserine and sphingolipids. The extracellular lipid of the stratum corneum, of which sphingolipid constitutes a significant part, plays a primary role in skin barrier function. Here, we describe a Japanese NLS pedigree with a previously unreported nonsense mutation in PHGDH and a unique inversion of chromosome 1. In addition, the levels of 11 major ceramide classes in the tape-stripped stratum corneum of the NLS patient’s skin were assessed by LC/MS. Notably, lower amounts of ceramides of all classes were found in the patient’s stratum corneum than in those of controls. This is the first report to demonstrate the reduction of ceramides in the stratum corneum of an NLS patient due to PHGDH mutations. The clinical findings and a detailed analysis of ceramides from the stratum corneum in the family extend the spectrum of clinical anomalies and give us a clue to the pathomechanisms of ichthyosis in NLS patients with phosphoglycerate dehydrogenase deficiency.—Takeichi, T., Y. Okuno, A. Kawamoto, T. Inoue, E. Nagamoto, C. Murase, E. Shimizu, K. Tanaka, Y. Kageshita, S. Fukushima, M. Kono, J. Ishikawa, H. Ihn, Y. Takahashi, and M. Akiyama. Reduction of stratum corneum ceramides in Neu-Laxova syndrome caused by phosphoglycerate dehydrogenase deficiency.

DOI： 10.1194/jlr.P087536

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Scopus

PubMed

Sterol profiles are valuable biomarkers for phenotype expression of Conradi-Hunermann-Happle syndrome with EBP mutations 査読有り

Takeichi, T; Honda, A; Okuno, Y; Kojima, D; Kono, M; Nakamura, Y; Tohyama, M; Tanaka, T; Aoyama, Y; Akiyama, M

BRITISH JOURNAL OF DERMATOLOGY 179 巻 ( 5 ) 頁： 1186 - 1188 2018年11月

Mild Hailey-Hailey disease cases with aberrant splicing variants of ATP2C1 successfully controlled with excimer light 査読有り

Kono, M; Niizawa, M; Takeichi, T; Muro, Y; Akiyama, M

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY 32 巻 ( 11 ) 頁： E413 - E416 2018年11月

Hearing impairment: A secondary symptom in a congenital ichthyosiform erythroderma patient with ABCA12 mutations 査読有り国際誌

Murase, C; Takeichi, T; Sugiura, K; Kobayashi, M; Shiomi, K; Ikebuchi, K; Tsutsumi, Y; Akiyama, M

JOURNAL OF DERMATOLOGY 45 巻 ( 11 ) 頁： E303 - E304 2018年11月

Dyschromatosis symmetrica hereditaria may be successfully controlled by topical sunscreen 査読有り国際誌

Kono, M; Okamoto, T; Takeichi, T; Muro, Y; Akiyama, M

EUROPEAN JOURNAL OF DERMATOLOGY 28 巻 ( 6 ) 頁： 840 - 841 2018年11月

Cross-sectional survey on disease severity in Japanese patients with harlequin ichthyosis/ichthyosis: Syndromic forms and quality-of-life analysis in a subgroup 査読有り国際誌

Murase, C; Takeichi, T; Shibata, A; Nakatochi, M; Kinoshita, F; Kubo, A; Nakajima, K; Ishii, N; Amano, H; Masuda, K; Kawakami, H; Kanekura, T; Washio, K; Asano, M; Teramura, K; Akasaka, E; Tohyama, M; Hatano, Y; Ochiai, T; Moriwaki, S; Sato, T; Ishida-Yamamoto, A; Seishima, M; Kurosawa, M; Ikeda, S; Akiyama, M

JOURNAL OF DERMATOLOGICAL SCIENCE 92 巻 ( 2 ) 頁： 127 - 133 2018年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Dermatological Science

Background: Congenital ichthyoses (CIs) adversely affect quality of life (QOL) in patients. However, the effects of CIs on patient QOL have not been studied sufficiently. Objective: To investigate the association between disease severity and QOL in patients with harlequin ichthyosis (HI) and ichthyosis: syndromic forms (ISFs) Methods: Clinical information of patients with HI and ISFs from 2010 to 2015 were obtained from 100 dermatology departments/divisions of principal institutes/hospitals throughout Japan. We examined the relationship between disease severity and QOL in patients with HI and ISFs. Patients who were aged 8 years or older and participated in a multicenter retrospective questionnaire survey in Japan were assessed by dermatology life quality index (DLQI, range of 0–30) and clinical ichthyosis score (range of 0–100). Results: Netherton syndrome patients had a significantly higher risk of allergy to food or environmental allergens than patients with other phenotypes. Keratitis-ichthyosis-deafness (KID) syndrome patients showed a significantly higher risk of skin infections than patients with other phenotypes. Complete data on DLQI were obtained from 13 patients, whose median age was 21 (8–71) years. Nine patients were male, and 4 were female. Systemic retinoids were administrated to 2 of the 3 HI patients. The Spearman's correlation coefficient between the clinical ichthyosis score and DLQI was 0.611 (P < 0.05). Conclusion: We confirmed that Netherton syndrome and KID syndrome patients have a higher risk of allergy to food or environmental allergens and of skin infections, respectively. QOL impairment correlates with disease severity in HI and ISFs patients.

DOI： 10.1016/j.jdermsci.2018.08.008

Web of Science

Scopus

PubMed

Autosomal dominant progressive hyperpigmentation and lentigines in a Japanese pedigree due to a missense mutation near the C-terminus of KIT 査読有り国際誌

Takeichi, T; Sugiura, K; Tanahashi, K; Noda, K; Kono, M; Akiyama, M

BRITISH JOURNAL OF DERMATOLOGY 179 巻 ( 5 ) 頁： 1210 - 1211 2018年11月

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