研究者詳細 - 武市　拓也

論文 - 武市　拓也

分割表示 227 件中 21 - 40 件目／全件表示 >>

Comparing the severity of epidermolysis bullosa simplex harboring KRT5 variants with the AlphaMissense score 査読有り国際誌

Omi, M; Takeichi, T; Yoshikawa, T; Inoue, Y; Fukaura, R; Hattori, I; Nakazawa, Y; Noda, T; Muro, Y; Akiyama, M

JOURNAL OF DERMATOLOGY 2024年10月

Generalized pustular psoriasis patient with a heterozygous hypomorphic MPO variant refractory to intravenous spesolimab 査読有り国際誌

Ogawa, Y; Maejima, E; Takeichi, T; Okamoto, T; Mitsui, H; Shimada, S; Akiyama, M; Kawamura, T

JOURNAL OF DERMATOLOGY 52 巻 ( 1 ) 頁： 167 - 170 2024年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Dermatology

Generalized pustular psoriasis (GPP) is a recurrent and sometimes life-threatening sterile pustular disease. Because interleukin (IL)-36 is the central cytokine in disease formation, spesolimab, which interferes with IL-36 receptor signaling, is highly effective. Here, we report a patient with GPP with a heterozygous hypomorphic MPO variant refractory to intravenous spesolimab. Although spesolimab showed excellent clinical efficacy in resolving pre-existing pustules and erythema, it did not suppress the emergence of new pustules and erythema, which did not decrease the peripheral blood neutrophil count, therefore bimekizumab, an anti-IL-17A/IL-17F antibody, was administered after the second spesolimab infusion, which resolved the pustules and erythema. We discuss the possible reasons for the resistance mechanism to spesolimab.

DOI： 10.1111/1346-8138.17464

Web of Science

Scopus

PubMed

Correlation of serum allergen-specific IgE with total serum IgE and IgE specific to other allergens in Atopic dermatitis patients 査読有り国際誌

Akashi, N; Ogawa-Momohara, M; Taki, T; Fukaura, R; Wakahara, K; Kamiya, S; Yamashita, Y; Koizumi, H; Takeichi, T; Muro, Y; Akiyama, M

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY 38 巻 ( 9 ) 頁： e761 - e763 2024年9月

Multiple subcutaneous reactive angioendotheliomatosis in a patient with antiphospholipid syndrome 査読有り国際誌

Yokoyama, T; Nakaguro, M; Ogawa-Momohara, M; Nakano, Y; Fukaura, R; Takeichi, T; Muro, Y; Akiyama, M

CLINICAL AND EXPERIMENTAL DERMATOLOGY 49 巻 ( 11 ) 頁： 1452 - 1455 2024年8月

Comment on: Longitudinal study of patients with anti-SAE antibody-positive dermatomyositis: a multicenter cohort study in China 査読有り国際誌

Yamashita, Y; Muro, Y; Koizumi, H; Kamiya, S; Akashi, N; Ogawa-Momohara, M; Takeichi, T; Akiyama, M

RHEUMATOLOGY 2024年8月

A novel splicing CYLD variant associated with trichoepithelioma papulosum multiplex demonstrating intrafamilial severity variability 査読有り国際誌

Fukaura, R; Takeichi, T; Noda, T; Seishima, M; Muro, Y; Akiyama, M

JOURNAL OF DERMATOLOGY 51 巻 ( 8 ) 頁： e274 - e276 2024年8月

Localized epidermolysis bullosa simplex caused by a previously unreported substitution in the linker 12 domain of keratin 14 査読有り国際誌

Misaki, M; Takeichi, T; Omi, M; Ito, Y; Ogi, T; Muro, Y; Akiyama, M

JOURNAL OF DERMATOLOGY 51 巻 ( 8 ) 頁： e264 - e265 2024年8月

Cross-sectional nationwide epidemiologic survey on quality of life and treatment efficacy in Japanese patients with congenital ichthyoses 査読有り国際誌

Suzuki, Y; Tanahashi, K; Terashima-Murase, C; Takeichi, T; Kobayashi, Y; Kinoshita, F; Akiyama, M

JOURNAL OF INVESTIGATIVE DERMATOLOGY 144 巻 ( 8 ) 頁： S37 - S37 2024年8月

A case of pachyonychia congenita with a hotspot variant at Arg127 in KRT16: Disease severity assessment using AlphaMissense technology 査読有り国際誌

Noda, T; Takeichi, T; Tanahashi, K; Muro, Y; Akiyama, M

JOURNAL OF DERMATOLOGY 51 巻 ( 8 ) 頁： 1134 - 1136 2024年8月

A Netherton syndrome infant complicated with infective endocarditis 査読有り国際誌

Tago, M; Takeichi, T; Suzuki, Y; Yoshikawa, T; Sato, Y; Kato, T; Go, K; Sakaida, T; Muro, Y; Akiyama, M

JOURNAL OF DERMATOLOGY 52 巻 ( 1 ) 頁： e12 - e13 2024年7月

Panniculitis on the trunk as a possible characteristic feature of anti-SAE1/2 antibody-positive dermatomyositis: A possible cutaneous manifestation of treatment resistance 査読有り国際誌

Tago, M; Koizumi, H; Kamiya, S; Akashi, N; Miyazaki, A; Yamashita, Y; Ogawa-Momohara, M; Takeichi, T; Muro, Y; Akiyama, M

JOURNAL OF DERMATOLOGY 51 巻 ( 7 ) 頁： e227 - e228 2024年7月

病変部毛包内に毛包虫を認めたMorbihan病の1例査読有り

竹内想, 武市拓也, 中黒匡人, 秋山真志

皮膚科の臨床 2024年7月

角化症の研究から学ぶこと

武市拓也

角化症研究会記録集 2024年7月

悪性黒色腫が多発したKRT10変異によるichthyosis with confettiの1例

勅使河原眞子, 武市拓也, 棚橋華奈, 室慶直, 秋山真志, 伊藤靖敏, 中川浩一, 萩朋男

角化症研究会記録集 2024年7月

Treating epidermolytic ichthyosis and ichthyosis with confetti with epidermal autografts cultured from revertant skin 査読有り国際誌

Tanahashi, K; Kono, M; Yoshikawa, T; Suzuki, Y; Inoie, M; Kuwatsuka, Y; Kinoshita, F; Takeichi, T; Akiyama, M

BRITISH JOURNAL OF DERMATOLOGY 191 巻 ( 3 ) 頁： 397 - 404 2024年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：British Journal of Dermatology

Background: No efficient treatment has yet been established for epidermolytic ichthyosis (EI), which is caused by pathogenic variants of KRT1 or KRT10. Patients with ichthyosis with confetti (IWC) have multiple normal-appearing spots, caused by the revertant somatic recombination of pathogenic variants that occurs at each spot independently. Additionally, some patients with EI have large areas of normal skin due to revertant postzygotic mosaicism. Objectives: To assess the feasibility of transplanting cultured epidermal autografts (CEAs) produced from revertant epidermal keratinocytes in patients with EI and IWC. Methods: We performed a clinical trial of treatment with CEAs produced from each patient's own revertant epidermal keratinocytes as a proof-of-concept study. This was a single-arm, open, unmasked, uncontrolled, single-assignment, treatment-purpose study. The primary outcome was the percentage area that lacked recurrence of ichthyosis lesions 4 weeks after the final transplant. The secondary outcome was the percentage area lacking recurrence of ichthyosis lesions 24 weeks after the initial transplantation. The trial was registered with the Japan Registry of Clinical Trials (jRCTb041190097). Results: We successfully produced CEAs from genetically confirmed revertant skin from two patients with mosaic EI and from one patient with IWC and confirmed by amplicon sequencing and droplet digital polymerase chain reaction analysis that the CEAs mainly consisted of revertant wild-type cells. Single-cell RNA sequencing analysis confirmed the normal proliferation and safety profiling of CEAs. CEAs were transplanted onto desquamated lesional sites in the patients. Four weeks post-transplantation, the percentage area lacking recurrence of ichthyosis lesions in the three patients was 40%, 100% and 100% respectively, although recurrence of ichthyosis lesions was seen at the site of CEA transplantation in all three patients at 24 weeks post-transplantation. Conclusions: CEAs from normal skin have the potential to be a safe and local treatment option for EI and IWC.

DOI： 10.1093/bjd/ljae193

Web of Science

Scopus

PubMed

Two patients with Hailey-Hailey disease with novel pathogenic ATP2C1 variants suggesting possible genotype/phenotype correlations 査読有り国際誌

Omi, M; Takeichi, T; Ito, Y; Yoshikawa, T; Mizutani, Y; Nagai, M; Seishima, M; Ogi, T; Muro, Y; Akiyama, M

JOURNAL OF DERMATOLOGY 51 巻 ( 6 ) 頁： e185 - e187 2024年6月

Combined oral lichen planus and oral lichenoid contact hypersensitivity reaction in a patient with Hashimoto's thyroiditis

Suzuki S., Yamashita Y., Fujio M., Hanai Y., Koizumi H., Ogawa-Momohara M., Takeichi T., Muro Y., Akiyama M.

Oral Oncology Reports 10 巻 2024年6月

ELISA detection of anti-eIF2B antibodies in Japanese patients with systemic sclerosis 査読有り国際誌

Koizumi, H; Yamano, Y; Muro, Y; Fukaura, R; Yamashita, Y; Kamiya, S; Akashi, N; Ogawa-Momohara, M; Takeichi, T; Kondoh, Y; Akiyama, M

RHEUMATOLOGY 63 巻 ( 6 ) 頁： e164 - e165 2024年5月

Natal teeth, hypoplasia of the first toe, and growth retardation in a patient with severe epidermolysis bullosa simplex 査読有り国際誌

Shimomura-Ishihara, M; Takeichi, T; Noda, T; Koizumi, H; Mitsuma, T; Ogi, T; Muro, Y; Akiyama, M

JOURNAL OF DERMATOLOGY 51 巻 ( 5 ) 頁： e175 - e177 2024年5月

Pneumocystis pneumonia in a patient with severe generalized pustular psoriasis treated with biologics 査読有り国際誌

Noguchi, H; Takeichi, T; Hayai, S; Yoshikawa, M; Muro, Y; Akiyama, M

JOURNAL OF DERMATOLOGY 51 巻 ( 4 ) 頁： e112 - e114 2024年4月

　前のページ - 次のページ　

<武市 拓也>

論文 - 武市 拓也

<武市　拓也>

論文 - 武市　拓也