研究者詳細 - 武市　拓也

論文 - 武市　拓也

分割表示 227 件中 121 - 140 件目／全件表示 >>

ANCA-associated neuropathy in systemic sclerosis: A case report and review of literature 査読有り

Takenaka, K; Takeichi, T; Nishi, R; Suzuki, M; Koike, H; Katsuno, M; Ogawa-Momohara, M; Muro, Y; Akiyama, M

JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY 4 巻 ( 2 ) 頁： 34 - 36 2021年4月

記述言語：英語出版者・発行元：Journal of Cutaneous Immunology and Allergy

Systemic sclerosis (SSc) is a multi-system autoimmune disease. Anti-neutrophil cytoplasmic antibodies (ANCA) are autoantibodies directed against enzymes found within primary granules of neutrophils and lysosomes in monocytes. Although up to 12% of SSc patients have ANCA, only a minority of these patients develop an overlap syndrome with ANCA-associated vasculitis. We summarize previous reports on SSc patients with ANCA-associated neuropathy. In all the reported cases, the SSc diagnosis preceded the ANCA-associated neuropathy diagnosis. Seven of the eight patients with limited cutaneous SSc had interstitial lung disease (ILD). Thus, patients with ANCA-associated neuropathy in lSSc may be prone to complication with ILD.

DOI： 10.1002/cia2.12153

Web of Science

Scopus

Acute generalized exanthematous pustulosis triggered by acetaminophen in an IL36RN variant heterozygote 査読有り国際誌

Murase, C; Takeichi, T; Sugiura, K; Akiyama, M

JOURNAL OF DERMATOLOGY 48 巻 ( 4 ) 頁： E186 - E187 2021年4月

Identification of a novel causative mutation in KRT1 in diffuse palmoplantar keratoderma, facilitated by whole-exome sequencing 査読有り国際誌

Takeuchi, S; Takeichi, T; Ito, Y; Tanahashi, K; Muro, Y; Ogi, T; Akiyama, M

EUROPEAN JOURNAL OF DERMATOLOGY 31 巻 ( 2 ) 頁： 264 - 265 2021年3月

Two Cases of Porokeratosis with MVD Mutations, in Association with Bullous Pemphigoid 査読有り国際誌

Arisawa, Y; Ito, Y; Tanahashi, K; Muro, Y; Ogi, T; Takeichi, T; Akiyama, M

ACTA DERMATO-VENEREOLOGICA 101 巻 ( 3 ) 頁： adv00423 2021年3月

A case with overlapping features of IgG4-related autoimmune pancreatitis, Sjogren's syndrome and anti-aminoacyl-tRNA synthetase syndrome 査読有り国際誌

Yoshikawa, M; Muro, Y; Ogawa-Momohara, M; Ito, S; Takeichi, T; Akiyama, M

MODERN RHEUMATOLOGY CASE REPORTS 5 巻 ( 1 ) 頁： 82 - 86 2021年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Modern Rheumatology Case Reports

A 55-year-old man who had been diagnosed with autoimmune pancreatitis five years earlier was referred to our department because of finger swelling, finger stiffness and the presence of interstitial lung disease (ILD). The patient was diagnosed with Sjögren’s syndrome according to the pathological findings of minor salivary glands and positive anti-SS-A antibodies. Later, at age 58, he was hospitalised due to the exacerbation of the ILD. Serum IgG4 level was checked and was found to be elevated (417 mg/dL). After the introduction of cyclosporine in addition to the prednisolone, at age 60, the ILD disease activity stabilised. However, at age 62, fever, myalgia and mechanic’s hands appeared. His serum creatine kinase level was high, and magnetic resonance imaging showed inflammatory findings of muscle. In-house ELISA clarified that his serum carried anti-PL-7 antibody among anti-aminoacyl-tRNA synthetase antibodies. This is a unique case who had overlapping features of IgG4-related autoimmune pancreatitis, Sjögren’s syndrome and anti-synthetase syndrome. Although the aetiology of the complications in this patient is obscure, autoimmunity might have played a significant role in the disease conditions and prognosis of the present case with IgG4-related disease.

DOI： 10.1080/24725625.2020.1816675

Web of Science

Scopus

PubMed

A patient with CARD14-associated papulosquamous eruptions showing atopic dermatitis-like features 査読有り国際誌

Takeichi, T; Terawaki, S; Kubota, Y; Ito, Y; Tanahashi, K; Muro, Y; Akiyama, M

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY 35 巻 ( 1 ) 頁： E58 - E59 2021年1月

Generalized pustular psoriasis associated with systemic lupus erythematosus successfully treated with secukinumab 査読有り国際誌

Akaji, K; Nakagawa, Y; Kakuda, K; Takafuji, M; Kiyohara, E; Murase, C; Takeichi, T; Akiyama, M; Fujimoto, M

JOURNAL OF DERMATOLOGY 48 巻 ( 1 ) 頁： E43 - E44 2021年1月

Systemic inflammatory diseases due to germ line EGFR mutations, with features suggestive of autoinflammatory keratinization diseases 査読有り国際誌

Takeichi, T; Akiyama, M

JOURNAL OF DERMATOLOGY 48 巻 ( 1 ) 頁： E24 - E25 2021年1月

Morphea in a Crohn's disease patient undergoing ustekinumab treatment 査読有り国際誌

Makihara-Inukai, M; Takeichi, T; Ogawa-Momohara, M; Muro, Y; Akiyama, M

EUROPEAN JOURNAL OF DERMATOLOGY 31 巻 ( 1 ) 頁： 96 - 97 2021年1月

A heterozygous SERPINB7 mutation is a possible modifying factor for epidermolytic palmoplantar keratoderma 査読有り国際誌

Yoshikawa, T; Takeichi, T; Ogi, T; Suga, Y; Muro, Y; Akiyama, M

JOURNAL OF DERMATOLOGICAL SCIENCE 100 巻 ( 2 ) 頁： 148 - 151 2020年11月

Anti-Zo antibodies in Japanese myositis patients detected by a newly developed ELISA. 査読有り国際誌

Yoshinao Muro, Takako Hashimoto, Shinyu Izumi, Mariko Ogawa-Momohara, Takuya Takeichi, Hiroyuki Yamashita, Hidekata Yasuoka, Masashi Akiyama

Clinical and experimental rheumatology 40 巻 ( 2 ) 頁： 219 - 223 2020年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: The myositis-specific autoantibodies that characterise certain forms of idiopathic inflammatory myopathy (IIM) are useful for diagnosing dermatomyositis (DM) / polymyositis (PM) and predicting its prognosis. The autoantibody to phenylalanyl-tRNA synthetase (anti-Zo) has been identified as a disease marker antibody for anti-synthetase syndrome only in a UK cohort. Here we aim to establish an ELISA for the measurement of anti-Zo and to characterise the clinical features of Japanese patients who have this autoantibody. METHODS: Anti-Zo was investigated by immunoprecipitation with recombinant phenylalanyl-tRNA synthetase α/β proteins. The results were confirmed by immunoprecipitation-Western blotting with cell extract. Sera from patients with DM/PM (n=224) were screened by an ELISA with the recombinant proteins. Medical records were retrospectively reviewed to obtain detailed information on the clinical phenotypes of the anti-Zo-positive patients. RESULTS: Only two male patients were confirmed to have anti-Zo. Both patients had fever, myopathy, interstitial lung disease, and mechanic's hands, and these clinical features are consistent with those of anti-synthetase syndrome. Another patient's serum showed a higher level than the cut-off value for anti-phenylalanyl-tRNA synthetase α by our in-house ELISA, but was judged to be negative for anti-Zo by immunoprecipitation-Western blotting. CONCLUSIONS: This is the first report of anti-Zo-positive IIM patients from Asia. Although Japanese patients with anti-Zo have a clinical phenotype similar to that of Caucasian patients, further large cohort studies are necessary to confirm the frequency of anti-Zo in Japanese IIM patients. Our newly developed ELISA should be validated for sensitivity and specificity in large cohorts.

DOI： 10.55563/clinexprheumatol/q70vmh

PubMed

Acquired reactive perforating collagenosis with chondrodermatitis nodularis chronica helicis 国際誌

Murase, Y; Takeichi, T; Tanahashi, K; Takama, H; Akiyama, M

JOURNAL OF DERMATOLOGY 47 巻 ( 10 ) 頁： E362 - E364 2020年10月

Clinical and serological features of dermatomyositis and systemic lupus erythematosus patients with autoantibodies to ADAR1 国際誌

Muro, Y; Ogawa-Momohara, M; Takeichi, T; Fukaya, S; Yasuoka, H; Kono, M; Akiyama, M

JOURNAL OF DERMATOLOGICAL SCIENCE 100 巻 ( 1 ) 頁： 82 - 84 2020年10月

Classical Vohwinkel syndrome with heterozygous p.Asp66His mutation in GJB2 gene: Second Asian case 国際誌

Ikeda, K; Takeichi, T; Ito, Y; Kawakami, Y; Nakagawa, Y; Naito, S; Yamasaki, O; Akiyama, M; Morizane, S

JOURNAL OF DERMATOLOGY 47 巻 ( 10 ) 頁： E352 - E354 2020年10月

Association of Topical Minoxidil With Autosomal Recessive Woolly Hair/Hypotrichosis Caused by LIPH Pathogenic Variants 査読有り国際誌

Taki, T; Tanahashi, K; Takeichi, T; Yoshikawa, T; Murase, Y; Sugiura, K; Akiyama, M

JAMA DERMATOLOGY 156 巻 ( 10 ) 頁： 1030 - 1032 2020年10月

Reducing immunosuppressant use in patients with chronic inflammation during the COVID-19 pandemic: Risks versus benefits

Ogawa-Momohara, M; Muro, Y; Takeichi, T; Akiyama, M

JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY 3 巻 ( 5 ) 頁： 120 - 121 2020年10月

Exploration of biomarkers to predict clinical improvement of atopic dermatitis in patients treated with dupilumab A study protocol 査読有り国際誌

Nakahara, T; Izuhara, K; Onozuka, D; Nunomura, S; Tamagawa-Mineoka, R; Masuda, K; Ichiyama, S; Saeki, H; Kabata, Y; Abe, R; Ohtsuki, M; Kamiya, K; Okano, T; Miyagaki, T; Ishiuji, Y; Asahina, A; Kawasaki, H; Tanese, K; Mitsui, H; Kawamura, T; Takeichi, T; Akiyama, M; Nishida, E; Morita, A; Tonomura, K; Nakagawa, Y; Sugawara, K; Tateishi, C; Kataoka, Y; Fujimoto, R; Kaneko, S; Morita, E; Tanaka, A; Hide, M; Aoki, N; Sano, S; Matsuda-Hirose, H; Hatano, Y; Takenaka, M; Murota, H; Katoh, N; Furue, M

MEDICINE 99 巻 ( 38 ) 頁： e22043 2020年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Medicine (United States)

Background:Atopic dermatitis (AD) is a common eczematous skin disorder that profoundly reduces the quality of life due to intractable pruritus. Excellent therapeutic success of the anti-interleukin 4 receptor-α antibody dupilumab in clinical trials and a real-world clinical context indicates the crucial roles of interleukin (IL)-4 and IL-13 in the pathogenesis of AD. Along with the clinical improvement in skin scores and pruritus, dupilumab significantly and progressively reduces and normalizes the upregulated expression of T helper type 2 signatures such as Chemokine (C-C motif) ligand (CCL)17, CCL18, CCL22, and CCL26 in the lesional skin of AD. However, no blood/serum biomarkers are known to predict good or poor outcome in patients with AD treated with dupilumab.Methods:Patients are at least 18 years of age and have moderate-to-severe AD with Eczema Area and Severity Index (EASI) ≥16, Investigator's Global Assessment ≥3, and body surface area ≥10%. We are going to enroll more than 130 subjects from 18 medical facilities. Clinical objective findings will be evaluated by EASI. Subjective symptoms will be assessed by Patient-Oriented Eczema Measure, Numerical Rating Scale for Pruritus (Pruritus-NRS), Skin Comfort-NRS, and Treatment Satisfaction-NRS. We will measure 18blood/serum biomarkers including % eosinophils in blood cell count, lactate dehydrogenase, total IgE, soluble interleukin 2 receptor, CCL17, CCL18, CCL22, CCL26, CCL27, IL-13, IL-22, IL-24, IL-25, IL-31, IL-33, thymic stromal lymphopoietin, periostin, and squamous cell carcinoma antigen-2. The clinical evaluation and biomarker sampling will be performed at 0, 2, 4, 8, and 16 weeks of dupilumab treatment. We will also perform proteomic analysis (of roughly 300 proteins) of the patients' sera obtained at 0 and 2 weeks of treatment. The primary endpoint is the association between "baseline levels of 18 biomarkers" and "% change from baseline of EASI at 16 weeks of dupilumab treatment."Discussion:This is the first clinical trial to explore the biomarkers, including potential proteomic markers, most strongly associated with improvement in EASI in patients with moderate-to-severe AD treated with dupilumab for 16 weeks (B-PAD study). A limitation is that we will only enroll Japanese patients.

DOI： 10.1097/MD.0000000000022043

Web of Science

Scopus

PubMed

A case of systemic lupus erythematosus/systemic sclerosis overlap syndrome successfully treated with belimumab 国際誌

Hara, M; Ogawa-Momohara, M; Muro, Y; Takeichi, T; Akiyama, M

EUROPEAN JOURNAL OF DERMATOLOGY 30 巻 ( 5 ) 頁： 615 - 617 2020年9月

Mild epidermolytic ichthyosis with palmoplantar keratoderma due to the KRT1 mutation p.lle479Thr 査読有り国際誌

Murase, Y; Tanahashi, K; Takeichi, T; Sugiura, K; Aiyama, A; Nishida, K; Mitsuma, T; Akiyama, M

JOURNAL OF DERMATOLOGY 47 巻 ( 9 ) 頁： E336 - E339 2020年9月

Late-onset Langerhans cell histiocytosis without extracutaneous involvement 査読有り国際誌

Iwata, M; Takeichi, T; Muro, Y; Akiyama, M

JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY 3 巻 ( 4 ) 頁： 94 - 95 2020年8月

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論文 - 武市　拓也