研究者詳細 - 武市　拓也

論文 - 武市　拓也

分割表示 227 件中 61 - 80 件目／全件表示 >>

Ichthyotic skin phenotype induced by the chronic activation of Toll-like receptor 2, and autoinflammation 査読有り国際誌

Takeichi, T; Muro, Y; Akiyama, M

BRITISH JOURNAL OF DERMATOLOGY 189 巻 ( 2 ) 頁： 252 - 252 2023年7月

KLK11 ichthyosis: large truncal hyperkeratotic pigmented plaques underscore a distinct autosomal dominant disorder of cornification 査読有り国際共著国際誌

Takeichi, T; Ito, Y; Lee, JYW; Murase, C; Okuno, Y; Muro, Y; McGrath, JA; Akiyama, M

BRITISH JOURNAL OF DERMATOLOGY 189 巻 ( 1 ) 頁： 134 - 136 2023年7月

Cutaneous manifestations of microscopic polyangiitis successfully controlled with avacopan alone 査読有り国際誌

Kamiya, S; Koizumi, H; Suzuki, Y; Imai, S; Yamashita, Y; Ogawa-Momohara, M; Takeichi, T; Muro, Y; Yasuda, K; Akiyama, M

JOURNAL OF DERMATOLOGY 50 巻 ( 7 ) 頁： E206 - E207 2023年7月

Recent Advances in Clinical Research on Rare Intractable Hereditary Skin Diseases in Japan. 査読有り

Akiyama M, Takeichi T, Ikeda S, Ishiko A, Kurosawa M, Murota H, Shimomura Y, Suzuki T, Tamai K, Tanaka A, Terui T, Amagai M

The Keio journal of medicine 2023年6月

COVID-19 infection- and vaccination-related exacerbation of Darier's disease in a single patient 査読有り国際誌

Fukaura, R; Takeichi, T; Ebata, A; Muro, Y; Akiyama, M

JOURNAL OF DERMATOLOGY 50 巻 ( 6 ) 頁： 833 - 836 2023年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Dermatology

Darier's disease (DD) is a rare autosomal dominantly inherited disorder. DD patients usually present with widespread keratotic eruptions with itching in the seborrheic regions that are exacerbated by various factors, including heat, sweat, and physical trauma. The SARS-CoV-2 (COVID-19) pandemic has stirred confusion among the medical community, including dermatologists, as this infection has been implicated in various skin conditions. Only a handful of reports have documented DD associated with COVID-19. Here, we report a 30-year-old male with Darier's disease whose symptoms were exacerbated following both COVID-19 vaccination and COVID-19 infection. The patient had noticed slight eruptions 7 years prior, but was not particularly concerned. After COVID-19 vaccination and infection, he had erythematous maculopapular lesions in large areas of the trunk and extremities. The previously reported pathogenic variant c.2255_2257del (p.(Ile752_Tyr753delinsAsn)) in ATP2A2 was detected in the present patient. Oral etretinate greatly improved his DD manifestations. As far as we know, the present patient is the first genetically confirmed DD case who showed both COVID-19 infection- and vaccination-related DD exacerbations independently. We think that the further accumulation of DD cases exacerbated by COVID-19 infection/vaccination is needed to clarify the mechanisms of DD aggravation.

DOI： 10.1111/1346-8138.16725

Web of Science

Scopus

PubMed

Ichthyotic skin lesions of Conradi-Hunermann-Happle syndrome successfully treated with dupilumab 査読有り国際誌

Fukaura, R; Takeichi, T; Ebata, A; Murase, C; Muro, Y; Akiyama, M

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY 37 巻 ( 6 ) 頁： E732 - E734 2023年6月

The use of certolizumab pegol to successfully treat generalized pustular psoriasis combined with psoriatic uveitis 査読有り国際誌

Yatsuzuka, K; Matsumoto, T; Sakane, Y; Fukaura, R; Takeichi, T; Akiyama, M; Murakami, M

JOURNAL OF DERMATOLOGY 50 巻 ( 6 ) 頁： E175 - E176 2023年6月

Successful combination therapy of bimekizumab and granulocyte monocyte adsorption apheresis for generalized pustular psoriasis complicated with microscopic polyangiitis 査読有り国際誌

Shukuin, R; Koizumi, H; Ebata, A; Imai, S; Yamashita, Y; Ogawa-Momohara, M; Takeichi, T; Muro, Y; Takami, N; Akiyama, M

JOURNAL OF DERMATOLOGY 50 巻 ( 6 ) 頁： E181 - E182 2023年6月

Current understanding of the phenotypic spectrum of patients with NLRP1 variants 査読有り国際誌

Takeichi, T; Akiyama, M

BRITISH JOURNAL OF DERMATOLOGY 188 巻 ( 2 ) 頁： 160 - + 2023年2月

Development of pemphigus vegetans and exacerbation of pemphigus foliaceus after secukinumab loading in a patient with complicated generalized pustular psoriasis and pyoderma gangrenosum 査読有り国際誌

Minai, L; Takeichi, T; Ogawa, Y; Honobe-Tabuchi, A; Okamoto, T; Mitsui, H; Shimada, S; Akiyama, M; Kawamura, T

JOURNAL OF DERMATOLOGY 50 巻 ( 2 ) 頁： 245 - 249 2023年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Dermatology

In dermatology, biologics that block signaling pathways of TNF-α, IL-4/IL13, IL-17s, and IL-23 are widely used for the treatment of several inflammatory skin diseases, such as atopic dermatitis and psoriasis. They have shown excellent efficacy with an acceptable safety profile. However, these biologics targeting pathogenic cytokines and their receptors could modulate immunological balance, leading to the development of other inflammatory or autoimmune skin diseases in some cases. In this study, we present a patient who suffered pemphigus vegetans and showed an exacerbation of pemphigus foliaceus after secukinumab loading for the treatment of complicated generalized pustular psoriasis and pyoderma gangrenosum.

DOI： 10.1111/1346-8138.16563

Web of Science

Scopus

PubMed

Exploring biomarkers to predict clinical improvement of atopic dermatitis in patients treated with dupilumab (B-PAD study) 査読有り国際誌

Nakahara, T; Izuhara, K; Onozuka, D; Saeki, H; Nunomura, S; Takenaka, M; Matsumoto, M; Kataoka, Y; Fujimoto, R; Kaneko, S; Morita, E; Tanaka, A; Hide, M; Okano, T; Miyagaki, T; Aoki, N; Nakajima, K; Ichiyama, S; Kido-Nakahara, M; Tonomura, K; Nakagawa, Y; Tamagawa-Mineoka, R; Masuda, K; Takeichi, T; Akiyama, M; Ishiuji, Y; Katsuta, M; Kinoshita, Y; Tateishi, C; Yamamoto, A; Morita, A; Matsuda-Hirose, H; Hatano, Y; Kawasaki, H; Tanese, K; Ohtsuki, M; Kamiya, K; Kabata, Y; Abe, R; Mitsui, H; Kawamura, T; Tsuji, G; Katoh, N; Furue, M

CLINICAL AND EXPERIMENTAL ALLERGY 53 巻 ( 2 ) 頁： 233 - 238 2023年2月

Whole-exome sequencing reveals a retinitis pigmentosa-causative PRPH2 variant as a secondary finding in a patient with pseudoxanthoma elasticum 国際誌

Miyazaki, A; Takeichi, T; Tanahashi, K; Taki, T; Taki, Y; Muro, Y; Akiyama, M

JOURNAL OF DERMATOLOGY 50 巻 ( 2 ) 頁： e85 - e86 2023年2月

Prominent dermal accumulation of Russell bodies underlying pseudocarcinomatous hyperplasia with fungal infection 査読有り

Noda, T; Akashi, N; Shimomura, M; Koizumi, H; Mizuta, M; Nakajima, K; Takeichi, T; Mitsuma, T; Akiyama, M

NAGOYA JOURNAL OF MEDICAL SCIENCE 85 巻 ( 1 ) 頁： 123 - 126 2023年2月

記述言語：英語出版者・発行元：Nagoya Journal of Medical Science

Blockade of the secretion of immunoglobulins leads to their accumulation in plasma cells, resulting in condensed immunoglobulins in the rough endoplasmic reticulum of plasma cells, termed Russell bodies. They are sometimes found in lymphoplasmacellular inflammation of the intestinal mucosa and in lymphoid cell malignancies, but only very rarely in skin diseases. Here, we report an 86-year-old female who presented with a lesion with the prominent accumulation of Russell bodies underlying pseudocarcinomatous hyperplasia with fungal infection in the face. Immunohistochemical staining showed the cells containing Russell bodies to be positive for CD138 and the Russell bodies to be positive for immunoglobulin k and l light chains. The present case suggests that when inflammatory cell infiltration with abundant round intracellular eosinophilic materials is observed in the dermis, the dermal accumulation of Russell bodies should be considered in cases with reactive pseudocarcinomatous hyperplasia with fungal infection.

DOI： 10.18999/nagjms.85.1.123

Web of Science

Scopus

PubMed

A case of juvenile amyopathic dermatomyositis with anti-transcription intermediary factor 1-α antibody showing negative anti-TIF1-γ ELISA results: Comment on "Case of pembrolizumab-induced dermatomyositis with anti-transcription intermediary factor 1-γ antibody" 査読有り国際誌

Koizumi, H; Muro, Y; Imai, S; Yamashita, Y; Ogawa-Momohara, M; Takeichi, T; Murakami, M; Mitsuma, T; Akiyama, M

JOURNAL OF DERMATOLOGY 50 巻 ( 1 ) 頁： E39 - E40 2023年1月

Novel homozygous missense mutation c.1654G>T in the ALOX12B gene causing congenital ichthyosiform erythroderma 査読有り国際誌

Mae, K; Kawakami, Y; Kajita, A; Takeichi, T; Noda, T; Hirai, Y; Akiyama, M; Morizane, S

JOURNAL OF DERMATOLOGY 50 巻 ( 1 ) 頁： E37 - E38 2023年1月

Comment on: Disease evolution in a long-term follow-up of 104 undifferentiated connective tissue disease patients. 査読有り国際誌

Yamashita Y, Muro Y, Koizumi H, Ogawa-Momohara M, Takeichi T, Akiyama M

Clinical and experimental rheumatology 41 巻 ( 1 ) 頁： 195 - 196 2023年1月

Occurrence of cholangiocarcinoma, three years after negative seroconversion of anti-TIF1γ antibody, in a dermatomyositis patient 査読有り国際誌

Horisaki, K; Muro, Y; Ogawa-Momohara, M; Yamashita, Y; Koizumi, H; Takeichi, T; Akiyama, M

EUROPEAN JOURNAL OF DERMATOLOGY 33 巻 ( 1 ) 頁： 48 - 49 2023年1月

Comment on: Disease evolution in a long-term follow-up of 104 undifferentiated connective tissue disease patients 査読有り国際誌

Yamashita Y., Muro Y., Koizumi H., Ogawa-Momohara M., Takeichi T., Akiyama M.

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 41 巻 ( 1 ) 頁： 195 - 196 2023年1月

Appropriate immunoassay systems are needed to evaluate various anticentromere antibodies as biomarkers for disease progression in systemic sclerosis 査読有り国際誌

Muro, Y; Yamashita, Y; Koizumi, H; Takeichi, T; Akiyama, M; Ogawa-Momohara, M

JOURNAL OF IMMUNOLOGICAL METHODS 512 巻頁： 113400 - 113400 2023年1月

Two novel anti-aminoacyl tRNA synthetase antibodies: Autoantibodies against cysteinyl-tRNA synthetase and valyl-tRNA synthetase 査読有り国際誌

Muro, Y; Yamashita, Y; Koizumi, H; Ogawa-Momohara, M; Takeichi, T; Mitsuma, T; Akiyama, M

AUTOIMMUNITY REVIEWS 21 巻 ( 12 ) 頁： 103204 - 103204 2022年12月

記述言語：英語出版者・発行元：Autoimmunity Reviews

Anti-aminoacyl-tRNA synthetase (anti-ARS) antibodies are useful for identifying a clinical subset of patients with inflammatory myopathies. Since the myositis of anti-ARS-positive patients is characterized by a unique set of non-myopathic manifestations, including interstitial lung disease, mechanic's hands, and arthralgia, the patients are classified as having anti-synthetase syndrome. Autoantibodies have been identified to eight kinds of ARSs. Of the other 12 ARSs, eight are components of the “OJ” multi-synthetase complex. Autoantibodies to the four remaining ARSs (CysARS, ValARS, SerARS, and TrpARS) have not been reported to be present in patients with inflammatory myopathies. In this study, we first screened samples from more than 300 Japanese patients majorly consisting of those with dermatomyositis (DM) by our established in-house ELISA to find autoantibodies against the four ARSs described above. Since sera from two DM patients specifically reacted to CysARS or ValARS, we determined their reactivities by immunoprecipitation (IP) with the corresponding recombinant proteins and IP–Western blotting with cellular extract. One patient had several features found in anti-synthetase syndrome, but the other did not. The clinical differences among the various anti-ARS antibodies should be explored in a future work.

DOI： 10.1016/j.autrev.2022.103204

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論文 - 武市 拓也

<武市　拓也>

論文 - 武市　拓也