Faculty Profiles - MARUYAMA Kazuaki

Displaying live 3-D video from a multi-view camera on a layered display

Ota Y., Maruyama K., Matsumoto R., Takahashi K., Fujii T.

Proceedings of the International Display Workshops Vol. 3 page： 1081 - 1084 2019

A 3-D DISPLAY PIPELINE FROM CODED-APERTURE CAMERA TO TENSOR LIGHT-FIELD DISPLAY THROUGH CNN

Maruyama, K; Inagaki, Y; Takahashi, K; Fujii, T; Nagahara, H

2019 IEEE INTERNATIONAL CONFERENCE ON IMAGE PROCESSING (ICIP) Vol. 2019-September page： 1064 - 1068 2019

Publisher：Proceedings - International Conference on Image Processing, ICIP

We propose an efficient pipeline from input to output for a tensor light-field display. Conventionally, a dense light field (i.e., tens of images taken with narrow viewpoint intervals) is required as an input in such displays. However, obtaining dense light fields is a challenging task for real scenes. To make the acquisition process more efficient, we adopted a coded-aperture camera as an input device, which is suitable for acquiring dense light fields in a compressive manner. Moreover, we modeled the entire process from acquisition to display using a convolutional neural network. As a result of training the network on a massive light field data, we can reproduce the whole light field on the display from only a few images taken with the camera. Both simulative and real experiments were conducted to show the effectiveness of our method.

DOI： 10.1109/icip.2019.8803741

Comparative study on layered light-field displays and optimization methods

Maruyama K., Takahashi K., Fujii T., Date M., Kimata H.

Proceedings of the International Display Workshops Vol. 3 page： 1073 - 1076 2019

The association between self-rated health and high-sensitivity C-reactive protein level: a cross-sectional and 5-year longitudinal study

Tamura, T; Naito, M; Maruyama, K; Tsukamoto, M; Sasakabe, T; Okada, R; Kawai, S; Hishida, A; Wakai, K

BMC PUBLIC HEALTH Vol. 18 ( 1 ) page： 1380 2018.12

Language：English Publisher：BMC Public Health

Background: Although self-rated health (SRH) independently predicts mortality, the biological background of this association remains unexplained. This study aimed to examine the association between SRH and serum high-sensitivity C-reactive protein (hsCRP) level. Methods: Subjects were 899 participants aged 35-69 years (237 men and 662 women) in the Daiko Study, part of the Japan Multi-Institutional Collaborative Cohort Study. They were enrolled from 2008 to 2010. Of the subjects, 666 participated in a second survey 5 years later. Lifestyle factors and SRH were assessed using a self-administered questionnaire. Serum hsCRP level was measured using a latex-enhanced immunonephelometric assay. The association between SRH and serum hsCRP level was evaluated using a general linear model with covariates. We further longitudinally investigated whether higher serum hsCRP level at baseline predicts poor SRH after 5 years using an unconditional logistic regression model. Results: A higher serum hsCRP level was significantly associated with poor SRH at baseline after adjusting for covariates (p for trend = 0.023). The age- and sex-adjusted odds ratio and 95% confidence interval (CI) for poor SRH after 5 years was 1.45 (95% CI: 0.76-2.78) for the highest tertile compared with the lowest tertile of serum hsCRP level at baseline with a significant linear trend (p for trend = 0.033), although the risk increase disappeared after adjustment for other covariates. Conclusions: The present study demonstrated that poor SRH is cross-sectionally associated with higher serum hsCRP level. However, the longitudinal data did not support the relationship between serum hsCRP level at baseline and future SRH. Further longitudinal studies that include data on mortality and multiple inflammatory markers are warranted to elucidate the possible role of low-grade inflammation in the association between SRH and mortality risk.

DOI： 10.1186/s12889-018-6251-6

Is hiragana decoding impaired in children with periventricular leukomalacia?

Kurahashi, N; Futamura, Y; Nonobe, N; Ogaya, S; Maki, Y; Yoshimura, I; Suzuki, T; Hosokawa, Y; Yamada, K; Aso, K; Maruyama, K; Nakamura, M

BRAIN & DEVELOPMENT Vol. 40 ( 10 ) page： 850 - 856 2018.11

Language：English Publisher：Brain and Development

Background: There are few studies on hiragana reading skill and phonological awareness in Japanese schoolchildren with periventricular leukomalacia (PVL). Methods: Three seven-year-old children with PVL who had no intellectual disabilities or dysarthria were recruited. Their perinatal information, brain magnetic resonance image (MRI) at term equivalent age, accompanying neurodevelopmental disorders, ophthalmologic features, Kaufman Assessment Battery for Children (K-ABC), a hiragana reading test (four tasks), and a phonological awareness task (mora reversal tasks) were analyzed. Results: Patient (Pt) 1 and pt2 were male. Pt2 and pt3 were siblings of triplets. Their gestational age was 28 or 32 weeks, and their birth weights were 1196, 1554, and 1848 g, respectively. Their brain MRI revealed cystic or non-cystic periventricular white matter injury involving the deep white matter at the trigone of both lateral ventricles. Pt1 had attention-deficit/hyperactivity disorder and pt3 had pervasive developmental disorder not otherwise specified. All patients had strabismus with spared best-corrected visual acuity. Scores of Reading/Decoding in K-ABC ranged from 89 to 99. As for the single mora reading task or the non-word reading task in the kana reading test, Z scores of their reading time ranged from 2.3 to 5.9 compared to control children. Pt1 and pt3 made significant errors in the mora reversal task of three-mora words, whereas all patients could answer all words correctly in the mora reversal task of two-mora words. Conclusion: All children showed significantly prolonged reading time despite their adequate letter recognition. Two patients showed delayed phonological awareness. It was suggested that hiragana decoding impairment due to subcortical and/or cortical injury related to PVL affected their reading ability.

DOI： 10.1016/j.braindev.2018.05.018

A patient with a GNAO1 mutation with decreased spontaneous movements, hypotonia, and dystonic features

Okumura, A; Maruyama, K; Shibata, M; Kurahashi, H; Ishii, A; Numoto, S; Hirose, S; Kawai, T; Iso, M; Kataoka, S; Okuno, Y; Muramatsu, H; Kojima, S

BRAIN & DEVELOPMENT Vol. 40 ( 10 ) page： 926 - 930 2018.11

Language：English Publisher：Brain and Development

We report on a 4-year-old girl with a de novo GNAO1 mutation who had neurological findings, including decreased spontaneous movements, hypotonia, and dystonic features. She was referred to our hospital because of delayed psychomotor development. She showed hypotonia and decreased spontaneous movements. Voluntary movements of the limbs were more frequent in the lower extremities than in the upper extremities. Occasional dyskinetic features, such as awkward hand/foot posturing and grimacing, were seen during the voluntary movements. Serum metabolic screening, head magnetic resonance imaging, and electroencephalography were unremarkable. Whole-exome sequencing revealed a de novo mutation in the patient's GNAO1 gene, c.709 G > A (p.E237K). We calculated the free-energy change using the FoldX Suite to evaluate the impact of the E237K mutation. The FoldX calculations showed an increased free-energy change in the active state of the GNAO1 protein, indicating that the E237K mutation destabilizes the active state complexes. No seizures, chorea, tremor, or myoclonia, which are frequently reported in patients with GNAO1 mutations, were observed as of the last follow up. Our patient will improve the understanding of early neurological features in patients with GNAO1 mutations.

DOI： 10.1016/j.braindev.2018.06.005

De novo PHACTR1 mutations in West syndrome and their pathophysiological effects

Hamada, N; Ogaya, S; Nakashima, M; Nishijo, T; Sugawara, Y; Iwamoto, I; Ito, H; Maki, Y; Shirai, K; Baba, S; Maruyama, K; Saitsu, H; Kato, M; Matsumoto, N; Momiyama, T; Nagata, K

BRAIN Vol. 141 ( 11 ) page： 3098 - 3114 2018.11

Language：English Publisher：Brain

Trio-based whole exome sequencing identified two de novo heterozygous missense mutations [c.1449T > C/p.(Leu500Pro) and c.1436A > T/p.(Asn479Ile)] in PHACTR1, encoding a molecule critical for the regulation of protein phosphatase 1 (PP1) and the actin cytoskeleton, in unrelated Japanese individuals with West syndrome (infantile spasms with intellectual disability). We then examined the role of Phactr1 in the development of mouse cerebral cortex and the pathophysiological significance of these two mutations and others [c.1561C > T/p.(Arg521Cys) and c.1553T > A/p.(Ile518Asn)], which had been reported in undiagnosed patients with intellectual disability. Immunoprecipitation analyses revealed that actin-binding activity of PHACTR1 was impaired by the p.Leu500Pro, p.Asn479Ile and p.Ile518Asn mutations while the p.Arg521Cys mutation exhibited impaired binding to PP1. Acute knockdown of mouse Phactr1 using in utero electroporation caused defects in cortical neuron migration during corticogenesis, which were rescued by an RNAi-resistant PHACTR1 but not by the four mutants. Experiments using knockdown combined with expression mutants, aimed to mimic the effects of the heterozygous mutations under conditions of haploinsufficiency, suggested a dominant negative effect of the mutant allele. As for dendritic development in vivo, only the p.Arg521Cys mutant was determined to have dominant negative effects, because the three other mutants appeared to be degraded with these experimental conditions. Electrophysiological analyses revealed abnormal synaptic properties in Phactr1-deficient excitatory cortical neurons. Our data show that the PHACTR1 mutations may cause morphological and functional defects in cortical neurons during brain development, which is likely to be related to the pathophysiology of West syndrome and other neurodevelopmental disorders.

DOI： 10.1093/brain/awy246

WEIGHT GAIN IN ADULTHOOD AND PARENTAL HYPERTENSION AS THE RISK OF HYPERTENSION: FROM THE J-MICC STUDY

Okada, R; Naito, M; Maruyama, K; Tsukamoto, M; Sasakabe, T; Tamura, T; Kawai, S; Hishida, A; Wakai, K

JOURNAL OF HYPERTENSION Vol. 36 page： E320 - E320 2018.10

Dietary magnesium intake and risk of incident coronary heart disease in men: A prospective cohort study

Kokubo Y., Saito I., Iso H., Yamagishi K., Yatsuya H., Ishihara J., Maruyama K., Inoue M., Sawada N., Tsugane S., Iwasaki M., Sasazuki S., Yamaji T., Shimazu T., Hanaoka T., Ogata J., Baba S., Mannami T., Okayama A., Miyakawa K., Saito F., Koizumi A., Sano Y., Hashimoto I., Ikuta T., Tanaba Y., Sato H., Roppongi Y., Takashima T., Suzuki H., Miyajima Y., Suzuki N., Nagasawa S., Furusugi Y., Nagai N., Ito Y., Komatsu S., Minamizono T., Sanada H., Hatayama Y., Kobayashi F., Uchino H., Shirai Y., Kondo T., Sasaki R., Watanabe Y., Miyagawa Y., Kobayashi Y., Machida M., Kobayashi K., Tsukada M., Kishimoto Y., Takara E., Fukuyama T., Kinjo M., Irei M., Sakiyama H., Imoto K., Yazawa H., Seo T., Seiko A., Ito F., Shoji F., Saito R., Murata A., Minato K., Motegi K., Fujieda T., Yamato S., Matsui K., Abe T., Katagiri M., Suzuki M., Doi M., Terao A., Ishikawa Y., Tagami T., Sueta H., Doi H., Urata M., Okamoto N., Ide F., Goto H., Fujita R., Onga N., Takaesu H., Uehara M., Nakasone T., Yamakawa M., Horii F., Asano I., Yamaguchi H., Aoki K., Maruyama S., Ichii M., Takano M., Tsubono Y., Suzuki K., Honda Y.

Clinical Nutrition Vol. 37 ( 5 ) page： 1602 - 1608 2018.10

Language：English Publisher：Clinical Nutrition

Background & aims: The associations between dietary magnesium intake and stroke and coronary heart disease (CHD) incidences are inconsistent and not established in Asian. We aimed to determine the association between dietary magnesium intake and the risk of stroke and CHD in a Japanese population. Subjects/Methods: We studied 85,293 Japanese subjects by questionnaire at baseline (age 45–74 years, without cardiovascular disease or cancer in 1995 and 1998 for Cohorts I and II, respectively). The participants were followed until the end of 2009 and 2010 in Cohorts I and II, respectively. Dietary magnesium intake was estimated from a self-administered 138-item food-frequency questionnaire. Results: After 1,305,738 person-years of follow-up, 4110 strokes and 1283 cases of CHD were documented. The multivariable-adjusted hazard ratios (HRs, 95% confidence intervals, 95%CIs) of CHD for the fourth and fifth quintiles of dietary magnesium intake were 0.70 (0.50–0.99) and 0.66 (0.44–0.97) in men (P for trend = 0.036), respectively, and third quintile of dietary magnesium intake was 0.61 (0.39–0.96) in women (P for trend = 0.241), compared with the lowest quintile in men and women. We observed no decreased risks of incident stroke in men or women with higher dietary magnesium intakes. Conclusions: Higher dietary magnesium intake was associated with a reduced risk of CHD in Japanese men.

DOI： 10.1016/j.clnu.2017.08.006

Femtosecond resonant magneto-optical Kerr effect measurement on an ultrathin magnetic film in a soft X-ray free electron laser

Yamamoto, S; Kubota, Y; Yamamoto, K; Takahashi, Y; Maruyama, K; Suzuki, Y; Hobara, R; Fujisawa, M; Oshima, D; Owada, S; Togashi, T; Tono, K; Yabashi, M; Hirata, Y; Yamamoto, S; Kotsugi, M; Wadati, H; Kato, T; Iwata, S; Shin, S; Matsuda, I

JAPANESE JOURNAL OF APPLIED PHYSICS Vol. 57 ( 9 ) 2018.9

Publisher：Japanese Journal of Applied Physics

Time-resolved magneto-optical Kerr effect (MOKE) measurement was demonstrated on a sample of the Au/Fe/Au heterostructure with the Fe layer of 0.35 nm thickness under Fe M-edge resonance condition. An ultrabrilliant free electron laser (FEL) in the soft X-ray range was facilitated for the detection of transient signals of resonant MOKE from the ultrathin Fe film. A variation in the Kerr rotation angle was successfully observed on the femtosecond timescale. This technique enables us to reveal the transient magnetization dynamics of such a-few-monolayer magnetic films, which promote the development of spintronic devices.

DOI： 10.7567/JJAP.57.09TD02

Distinctive facies, macrocephaly, and developmental delay are signs of a PTEN mutation in childhood

Kato, K; Mizuno, S; Inaba, M; Fukumura, S; Kurahashi, N; Maruyama, K; Ieda, D; Ohashi, K; Hori, I; Negishi, Y; Hattori, A; Saitoh, S

BRAIN & DEVELOPMENT Vol. 40 ( 8 ) page： 678 - 684 2018.9

Language：English Publisher：Brain and Development

Background: Germline mutations of the PTEN gene are responsible for several PTEN hamartoma tumor syndromes. They are also implicated as a cause of macrocephaly and mild to severe developmental delay, regardless of the presence or absence of hamartomas in childhood. Nevertheless, because of limited information, the clinical features present during childhood in patients with a PTEN mutation are yet to be elucidated. Methods: PTEN mutations were investigated by multiplex targeted sequencing of genomic DNA from 33 children with increased head circumference (>+2 SD) and developmental delay. The clinical features of all the patients with a PTEN mutation were abstracted by dysmorphologists. Results: We have identified six children with a PTEN mutation. Clinical dissection of these six patients, in addition to patient reports in the literature, revealed distinctive facial features that included frontal bossing, dolichocephaly, horizontal eyebrows, and a depressed nasal bridge. Macrocephaly (+3.2 to +6.0 SD) was noticeable compared to their height (−0.8 to +2.1 SD), and the difference in the SD value of head circumference and height was more than 3 SD in all patients. Conclusion: The presence of distinctive facies, extreme macrocephaly with normal to mildly high stature, and developmental delay may be useful for identifying patients with a PTEN mutation in childhood. Early identification of patients with a PTEN mutation would help uncover the natural course of tumor development in this group of individuals who have a possible predisposition to cancer, and be important for the development of an optimal surveillance strategy.

DOI： 10.1016/j.braindev.2018.04.008

Thermally Assisted Superconductor Transistors for Josephson-CMOS Hybrid Memories

Sano, K; Suzuki, M; Maruyama, K; Taniguchi, S; Tanaka, M; Fujimaki, A; Inoue, M; Yoshikawa, N

IEICE TRANSACTIONS ON ELECTRONICS Vol. E101C ( 5 ) page： 370 - 377 2018.5

Publisher：IEICE Transactions on Electronics

We have studied on thermally assisted nano-structured transistors made of superconductor ultra-thin films. These transistors potentially work as interface devices for Josephson-CMOS (complementary metal oxide semiconductor) hybrid memory systems, because they can generate a high output voltage of sub-V enough to drive a CMOS transistor. In addition, our superconductor transistors are formed with very fine lines down to several tens of nm in widths, leading to very small foot print enabling us to make large capacity hybrid memories. Our superconductor transistors are made with niobium titanium nitride (NbTiN) thin films deposited on thermally-oxidized silicon substrates, on which other superconductor circuits or semiconductor circuits can be formed. The NbTiN thickness dependence of the critical temperature and of resistivity suggest thermally activated vortex or anti-vortex behavior in pseudo-two-dimensional superconducting films plays an important role for the operating principle of the transistors. To show the potential that the transistors can drive MOS transistors, we analyzed the driving ability of the superconductor transistors with HSPICE simulation. We also showed the turn-on behavior of a MOS transistor used for readout of a CMOS memory cell experimentally. These results showed the high potential of superconductor transistors for Josephson-CMOS hybrid memories.

DOI： 10.1587/transele.E101.C.370

Immune-Mediated Hematopoietic Failure after Allogeneic Hematopoietic Stem Cell Transplantation: A Common Cause of Late Graft Failure in Patients with Complete Donor Chimerism

Maruyama K., Aotsuka N., Kumano Y., Sato N., Kawashima N., Onda Y., Maruyama H., Katagiri T., Zaimoku Y., Nakagawa N., Hosomichi K., Ogawa S., Nakao S.

Biology of Blood and Marrow Transplantation Vol. 24 ( 1 ) page： 43 - 49 2018.1

Publisher：Biology of Blood and Marrow Transplantation

Late graft failure (LGF) without evidence of residual recipient cells is a serious complication after allogeneic hematopoietic stem cell transplantation (allo-SCT) and often requires stem cell infusion from the same donor when the patient fails to respond to conventional therapies. We screened the peripheral blood (PB) of 14 patients who developed donor-type LGF at 2 to 132 months after allo-SCT for the presence of the markers for immune-mediated bone marrow (BM) failure. Increased glycosylphosphatidyl inositol-anchored protein-deficient (GPI-AP - ) leukocytes, which accounted for.009% to 0.147% of the total granulocytes, were detected in 5 patients (severe aplastic anemia, n = 2; follicular lymphoma, n = 1; acute lymphoblastic leukemia, n = 1; myelodysplastic syndromes; n = 1) and 4.7% to 81.2% HLA-allele–lacking leukocytes (HLA-LLs) were detected in 2 patients (acute myelogenous leukemia, n = 1; and myelodysplastic syndromes, n = 1). Three of the 5 patients with increased GPI-AP - leukocytes were treated with antithymocyte globulin (ATG), and 2 patients achieved transfusion independence. These results suggest that immune mechanisms that are similar to acquired aplastic anemia underlie condition of approximately one-half of the patients with donor-type LGF, and that in patients with increased GPI-AP - cells, donor-derived hematopoiesis may be restored by ATG therapy alone without donor stem cell infusion.

DOI： 10.1016/j.bbmt.2017.08.018

給特法の成⽴過程と⽇教組 Open Access

丸山和昭, 荒井英治郎, 眞⼸（⽥中）真秀

日本教育学会大會研究発表要項 Vol. 77 ( 0 ) page： 325 - 326 2018

Results of parent questionnaire regarding school life of patients with Duchenne muscular dystrophy Open Access

Tsuburaya R.S., Saito T., Maruyama K., Hattori A., Fujii T., Kumagai T., Wakisaka A., Mukaida S., Itomi S., Shiraishi K.

No To Hattatsu Vol. 50 ( 5 ) page： 342 - 349 2018

Publisher：No To Hattatsu

Objective: For improvement of educational support for patients with Duchenne muscular dystrophy(DMD), we investigated the current state of school life for patients with Duchenne muscular dystrophy(DMD)and related issues. Methods: A multicenter questionnaire survey was given to parents of DMD patients aged 6 to 20 years who were receiving treatment at 7 hospitals in 5 prefectures in Japan. Results: Parents of a total of 115 patients with DMD returned completed questionnaires. Upon admission to elementary school, 60% of the patients were placed in a regular class, while 5% were enrolled in a special needs school. From the fourth year of elementary school, the number of patients who seemed to enjoy school showed a decreasing trend, while those who did not participate in physical education class showed an increasing trend. At around the fifth year, some required a change to a special needs class or special needs school. Upon admission into junior high school, 60% of the patients were enrolled in a special needs school, while 13% remained in a regular school. Concerning collaboration between physicians and school staff, 77% of the parents expected some level of collaboration, whereas 52% of them answered that there was no collaboration. Conclusions: A large number of DMD patients are placed in a regular class to begin elementary school, though difficulties with school life seem to appear from the fourth year. It is important to share information and adjust the educational environment as necessary in consideration of patient need, as well as consultations among parents, teachers, and attending physicians. The level of collaboration between physicians and school staff in regard to education is lower than expected by parents, thus an effective system for collaboration between the medical and educational fields should be constructed.

DOI： 10.11251/ojjscn.50.342

Open Access

Implementation of table-top light-field display

Maruyama K., Kojima H., Takahashi K., Fujii T.

Proceedings of the International Display Workshops Vol. 2 page： 845 - 848 2018

Acquiring Multiple Satisfied Solutuions in a Unified Objective Optimization Problem

Maruyama, K; Yoshikawa, T

2018 JOINT 10TH INTERNATIONAL CONFERENCE ON SOFT COMPUTING AND INTELLIGENT SYSTEMS (SCIS) AND 19TH INTERNATIONAL SYMPOSIUM ON ADVANCED INTELLIGENT SYSTEMS (ISIS) page： 103 - 108 2018

Publisher：Proceedings - 2018 Joint 10th International Conference on Soft Computing and Intelligent Systems and 19th International Symposium on Advanced Intelligent Systems, SCIS-ISIS 2018

In general, the main purpose of Genetic Algorithm (GA) is to acquire a solution with the highest evaluation value in a single-objective problem or Pareto solutions with various evaluation values in a multi-objective problem. However, in engineering problems, the acquisition of multiple satisfied solutions satisfying certain conditions is often more strongly desired than acquiring a single best solution. In addition, to help set design choices, satisfied solutions should satisfy different design variable patterns from one another. There are multiple objective functions and rather than being maximized/minimized these are intended to approximate certain target values. These multiple objective functions can be unified into a single-objective function by summing up the errors from the target values. Through this unification of objective functions, computing resources for searching can be assigned in terms of the diversity in the design variable space rather than the objective space. Engineering problems often involve numerous constrained optimization problems. In such problems, the unification of objective functions can also be applied to constraints. In this paper, a method for acquiring multiple satisfied solutions by GA in many constrained multi-objective optimization problems is proposed. The proposed method is applied to a real-world problem and compared with Island model to investigate its performance.

DOI： 10.1109/SCIS-ISIS.2018.00028