Faculty Profiles - YAMANAKA Koji

Papers - YAMANAKA Koji

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ALS-linked mutant TDP-43 in oligodendrocytes induces oligodendrocyte damage and exacerbates motor dysfunction in mice Reviewed

Horiuchi, M; Watanabe, S; Komine, O; Takahashi, E; Kaneko, K; Itohara, S; Shimada, M; Ogi, T; Yamanaka, K

ACTA NEUROPATHOLOGICA COMMUNICATIONS Vol. 12 ( 1 ) page： 184 2024.11

Microglial cannabinoid receptor type II stimulation improves cognitive impairment and neuroinflammation in Alzheimer's disease mice by controlling astrocyte activation Reviewed

Sobue, A; Komine, O; Endo, F; Kakimi, C; Miyoshi, Y; Kawade, N; Watanabe, S; Saito, Y; Murayama, S; Saido, TC; Saito, T; Yamanaka, K

CELL DEATH & DISEASE Vol. 15 ( 11 ) page： 858 2024.11

Dimethyl fumarate improves cognitive impairment and neuroinflammation in mice with Alzheimer's disease Reviewed Open Access

Wang, T; Sobue, A; Watanabe, S; Komine, O; Saido, TC; Saito, T; Yamanaka, K

JOURNAL OF NEUROINFLAMMATION Vol. 21 ( 1 ) page： 55 2024.2

Genetic background variation impacts microglial heterogeneity and disease progression in amyotrophic lateral sclerosis model mice Reviewed Open Access

Komine, O; Ohnuma, S; Hinohara, K; Hara, Y; Shimada, M; Akashi, T; Watanabe, S; Sobue, A; Kawade, N; Ogi, T; Yamanaka, K

ISCIENCE Vol. 27 ( 2 ) page： 108872 2024.2

Mitochondria- associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS Reviewed

Watanabe, S; Murata, Y; Oka, Y; Oiwa, K; Horiuchi, M; Iguchi, Y; Komine, O; Sobue, A; Katsuno, M; Ogi, T; Yamanaka, K

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 120 ( 47 ) page： e2315347120 2023.11

Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis Reviewed

Oiwa, K; Watanabe, S; Onodera, K; Iguchi, Y; Kinoshita, Y; Komine, O; Sobue, A; Okada, Y; Katsuno, M; Yamanaka, K

SCIENCE ADVANCES Vol. 9 ( 31 ) page： eadf6895 2023.8

Intrinsic structural vulnerability in the hydrophobic core induces species-specific aggregation of canine SOD1 with degenerative myelopathy-linked E40K mutation Reviewed

Hashimoto, K; Watanabe, S; Akutsu, M; Muraki, N; Kamishina, H; Furukawa, Y; Yamanaka, K

JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 229 ( 6 ) page： 104798 2023.6

Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis Reviewed

Watanabe, S; Horiuchi, M; Murata, Y; Komine, O; Kawade, N; Sobue, A; Yamanaka, K

NEUROBIOLOGY OF DISEASE Vol. 179 page： 106031 2023.4

Novel reporters of mitochondria-associated membranes (MAM), MAMtrackers, demonstrate MAM disruption as a common pathological feature in amyotrophic lateral sclerosis Reviewed

Sakai, S; Watanabe, S; Komine, O; Sobue, A; Yamanaka, K

FASEB JOURNAL Vol. 35 ( 7 ) page： e21688 2021.7

Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease Reviewed

Sobue Akira, Komine Okiru, Hara Yuichiro, Endo Fumito, Mizoguchi Hiroyuki, Watanabe Seiji, Murayama Shigeo, Saito Takashi, Saido Takaomi C., Sahara Naruhiko, Higuchi Makoto, Ogi Tomoo, Yamanaka Koji

ACTA NEUROPATHOLOGICA COMMUNICATIONS Vol. 9 ( 1 ) page： 1 2021.1

Aggresome formation and liquid-liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 43. Reviewed

Watanabe S, Inami H, Oiwa K, Murata Y, Sakai S, Komine O, Sobue A, Iguchi Y, Katsuno M, Yamanaka K

Cell Death & Disease Vol. 11 ( 10 ) page： 909 2020.10

Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALS Invited Reviewed International coauthorship

Watanabe S, Ilieva Hristelina, Tamada H, Nomura H, Komine O, Endo F, Jin S, Mancias P, Kiyama H, Yamanaka K

EMBO Molecular Medicine Vol. 8 ( 12 ) page： 1421-1437 2016.11

Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells Reviewed International coauthorship

Endo F, Komine O, Fujimori-Tonou N, Katsuno M, Jin S, Watanabe S, Sobue G, Dezawa M, Wyss-Coray T, Yamanaka K

Vol. 11 ( 4 ) page： 592-604 2015.4

Optineurin knock-out forms TDP-43 aggregates to regulate TDP-43 protein levels despite autophagic up-regulation and aberrant TDP-43 expression. Reviewed Open Access

Maetani Y, Kurashige T, Tada Y, Kume K, Watanabe T, Sotomaru Y, Yamanaka K, Maruyama H, Kawakami H

Neuroscience research 2025.3

Prenatal inflammation impairs early CD11c-positive microglia induction and delays myelination in neurodevelopmental disorders. Reviewed

Fuma K, Iitani Y, Imai K, Ushida T, Tano S, Yoshida K, Yokoi A, Miki R, Kidokoro H, Sato Y, Hara Y, Ogi T, Nomaki K, Tsuda M, Komine O, Yamanaka K, Kajiyama H, Kotani T

Communications biology Vol. 8 ( 1 ) page： 75 2025.1

A preliminary study on the effects of long-term robot suit exercise training on gait function and quality of life in patients with spinal and bulbar muscular atrophy Reviewed

Hirayama, T; Morioka, H; Sugisawa, T; Shibukawa, M; Ebina, J; Hanashiro, S; Nagasawa, J; Yanagihashi, M; Okuni, I; Nakajima, T; Murakami, Y; Yamanaka, K; Ebihara, S; Kano, O

JOURNAL OF CLINICAL NEUROSCIENCE Vol. 128 page： 110778 2024.10

Prolonged extracellular low sodium concentrations and subsequent their rapid correction modulate nitric oxide production dependent on NFAT5 in microglia Reviewed

Fujisawa, H; Watanabe, T; Komine, O; Fuse, S; Masaki, M; Iwata, N; Murao, N; Seino, Y; Takeuchi, H; Yamanaka, K; Sawada, M; Suzuki, A; Sugimura, Y

FREE RADICAL BIOLOGY AND MEDICINE Vol. 223 page： 458 - 472 2024.10

Aberrant <i>CHCHD2</i>-associated mitochondriopathy in Kii ALS/PDC astrocytes Reviewed

Leventoux, N; Morimoto, S; Ishikawa, M; Nakamura, S; Ozawa, F; Kobayashi, R; Watanabe, H; Supakul, S; Okamoto, S; Zhou, Z; Kobayashi, H; Kato, C; Hirokawa, Y; Aiba, I; Takahashi, S; Shibata, S; Takao, M; Yoshida, M; Endo, F; Yamanaka, K; Kokubo, Y; Okano, H

ACTA NEUROPATHOLOGICA Vol. 147 ( 1 ) page： 84 2024.6

Ebselen analogues delay disease onset and its course in fALS by on-target SOD-1 engagement Reviewed International coauthorship Open Access

Watanabe, S; Amporndanai, K; Awais, R; Latham, C; Awais, M; O'Neill, PM; Yamanaka, K; Hasnain, SS

SCIENTIFIC REPORTS Vol. 14 ( 1 ) page： 12118 2024.5

Novel insights into brain lipid metabolism in Alzheimer's disease: Oligodendrocytes and white matter abnormalities Invited Reviewed

Kawade, N; Yamanaka, K

FEBS OPEN BIO Vol. 14 ( 2 ) page： 194 - 216 2024.2

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Papers - YAMANAKA Koji