Faculty Profiles - YAMANAKA Koji

Papers - YAMANAKA Koji

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ALS-linked mutant TDP-43 in oligodendrocytes induces oligodendrocyte damage and exacerbates motor dysfunction in mice Reviewed

Horiuchi, M; Watanabe, S; Komine, O; Takahashi, E; Kaneko, K; Itohara, S; Shimada, M; Ogi, T; Yamanaka, K

ACTA NEUROPATHOLOGICA COMMUNICATIONS Vol. 12 ( 1 ) page： 184 2024.11

Microglial cannabinoid receptor type II stimulation improves cognitive impairment and neuroinflammation in Alzheimer's disease mice by controlling astrocyte activation Reviewed

Sobue, A; Komine, O; Endo, F; Kakimi, C; Miyoshi, Y; Kawade, N; Watanabe, S; Saito, Y; Murayama, S; Saido, TC; Saito, T; Yamanaka, K

CELL DEATH & DISEASE Vol. 15 ( 11 ) page： 858 2024.11

Dimethyl fumarate improves cognitive impairment and neuroinflammation in mice with Alzheimer's disease Reviewed Open Access

Wang, T; Sobue, A; Watanabe, S; Komine, O; Saido, TC; Saito, T; Yamanaka, K

JOURNAL OF NEUROINFLAMMATION Vol. 21 ( 1 ) page： 55 2024.2

Genetic background variation impacts microglial heterogeneity and disease progression in amyotrophic lateral sclerosis model mice Reviewed Open Access

Komine, O; Ohnuma, S; Hinohara, K; Hara, Y; Shimada, M; Akashi, T; Watanabe, S; Sobue, A; Kawade, N; Ogi, T; Yamanaka, K

ISCIENCE Vol. 27 ( 2 ) page： 108872 2024.2

Mitochondria- associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS Reviewed

Watanabe, S; Murata, Y; Oka, Y; Oiwa, K; Horiuchi, M; Iguchi, Y; Komine, O; Sobue, A; Katsuno, M; Ogi, T; Yamanaka, K

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 120 ( 47 ) page： e2315347120 2023.11

Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis Reviewed

Oiwa, K; Watanabe, S; Onodera, K; Iguchi, Y; Kinoshita, Y; Komine, O; Sobue, A; Okada, Y; Katsuno, M; Yamanaka, K

SCIENCE ADVANCES Vol. 9 ( 31 ) page： eadf6895 2023.8

Intrinsic structural vulnerability in the hydrophobic core induces species-specific aggregation of canine SOD1 with degenerative myelopathy-linked E40K mutation Reviewed

Hashimoto, K; Watanabe, S; Akutsu, M; Muraki, N; Kamishina, H; Furukawa, Y; Yamanaka, K

JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 229 ( 6 ) page： 104798 2023.6

Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis Reviewed

Watanabe, S; Horiuchi, M; Murata, Y; Komine, O; Kawade, N; Sobue, A; Yamanaka, K

NEUROBIOLOGY OF DISEASE Vol. 179 page： 106031 2023.4

Novel reporters of mitochondria-associated membranes (MAM), MAMtrackers, demonstrate MAM disruption as a common pathological feature in amyotrophic lateral sclerosis Reviewed

Sakai, S; Watanabe, S; Komine, O; Sobue, A; Yamanaka, K

FASEB JOURNAL Vol. 35 ( 7 ) page： e21688 2021.7

Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease Reviewed

Sobue Akira, Komine Okiru, Hara Yuichiro, Endo Fumito, Mizoguchi Hiroyuki, Watanabe Seiji, Murayama Shigeo, Saito Takashi, Saido Takaomi C., Sahara Naruhiko, Higuchi Makoto, Ogi Tomoo, Yamanaka Koji

ACTA NEUROPATHOLOGICA COMMUNICATIONS Vol. 9 ( 1 ) page： 1 2021.1

Aggresome formation and liquid-liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 43. Reviewed

Watanabe S, Inami H, Oiwa K, Murata Y, Sakai S, Komine O, Sobue A, Iguchi Y, Katsuno M, Yamanaka K

Cell Death & Disease Vol. 11 ( 10 ) page： 909 2020.10

Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALS Invited Reviewed International coauthorship

Watanabe S, Ilieva Hristelina, Tamada H, Nomura H, Komine O, Endo F, Jin S, Mancias P, Kiyama H, Yamanaka K

EMBO Molecular Medicine Vol. 8 ( 12 ) page： 1421-1437 2016.11

Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells Reviewed International coauthorship

Endo F, Komine O, Fujimori-Tonou N, Katsuno M, Jin S, Watanabe S, Sobue G, Dezawa M, Wyss-Coray T, Yamanaka K

Vol. 11 ( 4 ) page： 592-604 2015.4

Optineurin knock-out forms TDP-43 aggregates to regulate TDP-43 protein levels despite autophagic up-regulation and aberrant TDP-43 expression. Reviewed Open Access

Maetani Y, Kurashige T, Tada Y, Kume K, Watanabe T, Sotomaru Y, Yamanaka K, Maruyama H, Kawakami H

Neuroscience research 2025.3

Prenatal inflammation impairs early CD11c-positive microglia induction and delays myelination in neurodevelopmental disorders. Reviewed

Fuma K, Iitani Y, Imai K, Ushida T, Tano S, Yoshida K, Yokoi A, Miki R, Kidokoro H, Sato Y, Hara Y, Ogi T, Nomaki K, Tsuda M, Komine O, Yamanaka K, Kajiyama H, Kotani T

Communications biology Vol. 8 ( 1 ) page： 75 2025.1

A preliminary study on the effects of long-term robot suit exercise training on gait function and quality of life in patients with spinal and bulbar muscular atrophy Reviewed

Hirayama, T; Morioka, H; Sugisawa, T; Shibukawa, M; Ebina, J; Hanashiro, S; Nagasawa, J; Yanagihashi, M; Okuni, I; Nakajima, T; Murakami, Y; Yamanaka, K; Ebihara, S; Kano, O

JOURNAL OF CLINICAL NEUROSCIENCE Vol. 128 page： 110778 2024.10

Prolonged extracellular low sodium concentrations and subsequent their rapid correction modulate nitric oxide production dependent on NFAT5 in microglia Reviewed

Fujisawa, H; Watanabe, T; Komine, O; Fuse, S; Masaki, M; Iwata, N; Murao, N; Seino, Y; Takeuchi, H; Yamanaka, K; Sawada, M; Suzuki, A; Sugimura, Y

FREE RADICAL BIOLOGY AND MEDICINE Vol. 223 page： 458 - 472 2024.10

Aberrant CHCHD2-associated mitochondriopathy in Kii ALS/PDC astrocytes Reviewed

Leventoux, N; Morimoto, S; Ishikawa, M; Nakamura, S; Ozawa, F; Kobayashi, R; Watanabe, H; Supakul, S; Okamoto, S; Zhou, Z; Kobayashi, H; Kato, C; Hirokawa, Y; Aiba, I; Takahashi, S; Shibata, S; Takao, M; Yoshida, M; Endo, F; Yamanaka, K; Kokubo, Y; Okano, H

ACTA NEUROPATHOLOGICA Vol. 147 ( 1 ) page： 84 2024.6

Ebselen analogues delay disease onset and its course in fALS by on-target SOD-1 engagement Reviewed International coauthorship Open Access

Watanabe, S; Amporndanai, K; Awais, R; Latham, C; Awais, M; O'Neill, PM; Yamanaka, K; Hasnain, SS

SCIENTIFIC REPORTS Vol. 14 ( 1 ) page： 12118 2024.5

Novel insights into brain lipid metabolism in Alzheimer's disease: Oligodendrocytes and white matter abnormalities Invited Reviewed

Kawade, N; Yamanaka, K

FEBS OPEN BIO Vol. 14 ( 2 ) page： 194 - 216 2024.2

An open chat with… Koji Yamanaka

Tsagakis, I; Yamanaka, K

FEBS OPEN BIO Vol. 14 ( 2 ) page： 162 - 164 2024.2

Depletion of perivascular macrophages delays ALS disease progression by ameliorating blood-spinal cord barrier impairment in SOD1G93A mice Reviewed

Adachi, K; Miyata, K; Chida, Y; Hirose, M; Morisaki, Y; Yamanaka, K; Misawa, H

FRONTIERS IN CELLULAR NEUROSCIENCE Vol. 17 page： 1291673 2023.11

Investigation of non-motor symptoms in patients with amyotrophic lateral sclerosis Reviewed

Hirayama, T; Shibukawa, M; Yanagihashi, M; Warita, H; Atsuta, N; Yamanaka, K; Kano, O

ACTA NEUROLOGICA BELGICA Vol. 123 ( 5 ) page： 1797 - 1804 2023.10

The necessity to improve disaster preparedness among patients with amyotrophic lateral sclerosis and their families Reviewed

Hirayama, T; Shibukawa, M; Morioka, H; Hozumi, M; Tsuda, H; Atsuta, N; Izumi, Y; Nakayama, Y; Shimizu, T; Inoue, H; Urushitani, M; Yamanaka, K; Aoki, M; Ebihara, S; Takeda, A; Kano, O

JOURNAL OF CLINICAL NEUROSCIENCE Vol. 116 page： 87 - 92 2023.10

Cellular senescence in white matter microglia is induced during ageing in mice and exacerbates the neuroinflammatory phenotype Reviewed

Matsudaira, T; Nakano, S; Konishi, Y; Kawamoto, S; Uemura, K; Kondo, T; Sakurai, K; Ozawa, T; Hikida, T; Komine, O; Yamanaka, K; Fujita, Y; Yamashita, T; Matsumoto, T; Hara, E

COMMUNICATIONS BIOLOGY Vol. 6 ( 1 ) page： 665 2023.6

Neuroinflammation in Alzheimer's disease: microglial signature and their relevance to disease

Sobue, A; Komine, O; Yamanaka, K

INFLAMMATION AND REGENERATION Vol. 43 ( 1 ) page： 26 2023.5

Comprehensive expression analysis with cell-type-specific transcriptome in ALS-linked mutant SOD1 mice: Revisiting the active role of glial cells in disease (Volume-17, page-1, year-2023)

Yamashita, H; Komine, O; Fujimori-Tonou, N; Yamanaka, K

FRONTIERS IN CELLULAR NEUROSCIENCE Vol. 17 page： 1160444 2023.3

Role of sex hormones in neuroinflammation in Alzheimer's disease. Invited Reviewed

Maekawa K, Yamanaka K.

Clinical and Experimental Neuroimmunology Vol. 14 2023.2

Neuroinflammation in neurodegenerative disease Invited Reviewed

Yamanaka, K

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 85 ( 1 ) page： 30 - 32 2023.2

Comprehensive expression analysis with cell-type-specific transcriptome in ALS-linked mutant SOD1 mice: Revisiting the active role of glial cells in disease Reviewed

Yamashita, H; Komine, O; Fujimori-Tonou, N; Yamanaka, K

FRONTIERS IN CELLULAR NEUROSCIENCE Vol. 16 page： 1045647 2023.1

Stagnation of glymphatic interstitial fluid flow and delay in waste clearance in the SOD1-G93A mouse model of ALS. Reviewed

Hirose M, Asano M, Watanabe-Matsumoto S, Yamanaka K, Abe Y, Yasui M, Tokuda E, Furukawa Y, Misawa H

Neuroscience Research Vol. 171 page： 74 - 82 2021.10

Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction Reviewed

Konishi, H; Okamoto, T; Hara, Y; Komine, O; Tamada, H; Maeda, M; Osako, F; Kobayashi, M; Nishiyama, A; Kataoka, Y; Takai, T; Udagawa, N; Jung, SF; Ozato, K; Tamura, T; Tsuda, M; Yamanaka, K; Ogi, T; Sato, K; Kiyama, H

EMBO JOURNAL Vol. 39 ( 22 ) page： e104464 2020.11

Touchscreen-based location discrimination and paired associate learning tasks detect cognitive impairment at an early stage in an App knock-in mouse model of Alzheimer's disease Reviewed

Saifullah Md. AB, Komine O, Dong Y, Fukumoto K, Sobue A, Endo F, Saito T, Saido T, Yamanaka K, Mizoguchi H

Molecular Brain Vol. 13 ( 1 ) page： 147 2020.11

Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosis Reviewed International coauthorship

Amporndanai Kangsa, Rogers Michael, Watanabe Seiji, Yamanaka Koji, O'Neill Paul M., Hasnain S. Samar

EBioMedicine Vol. 59 page： 102980 2020.9

The regulation of glucose metabolism by astrocytes in diet induced obesity mice

Sugiyama, M; Banno, R; Sun, R; Yaginuma, H; Taki, K; Takagi, H; Ito, Y; Yamanaka, K; Arima, H

DIABETOLOGIA Vol. 63 ( SUPPL 1 ) page： S266 - S266 2020.9

Hypothalamic glial cells isolated by MACS reveal that microglia and astrocytes induce hypothalamic inflammation via different processes under high-fat diet conditions Reviewed

Sugiyama M, Banno R, Yaginuma H, Taki K, Mizoguchi A, Tsunekawa T, Onoue T, Takagi H, Ito Y, Iwama S, Goto M, Suga H, Komine O, Yamanaka K, Arima H

Neurochemistry International Vol. 136 page： 104733 2020.6

Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair Reviewed International coauthorship

Nakazawa Yuka, Hara Yuichiro, Oka Yasuyoshi, Komine Okiru, van den Heuvel Diana, Guo Chaowan, Daigaku Yasukazu, Isono Mayu, He Yuxi, Shimada Mayuko, Kato Kana, Jia Nan, Hashimoto Satoru, Kotani Yuko, Miyoshi Yuka, Tanaka Miyako, Sobue Akira, Mitsutake Norisato, Suganami Takayoshi, Masuda Akio, Ohno Kinji, Nakada Shinichiro, Mashimo Tomoji, Yamanaka Koji, Luijsterburg Martijn S., Ogi Tomoo

CELL Vol. 180 ( 6 ) page： 1228 - + 2020.3

ALS-linked TDP-43M337V knock-in mice exhibit splicing deregulation without neurodegeneration. Reviewed

Watanabe S, Oiwa K, Murata Y, Komine O, Sobue A, Endo F, Takahashi E, Yamanaka K

Molecular brain Vol. 13 ( 1 ) page： 8 2020.1

Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1-Akt signaling pathway. Reviewed International coauthorship

Nishino K, Watanabe S, Shijie J, Murata Y, Oiwa K, Komine O, Endo F, Tsuiji H, Abe M, Sakimura K, Mishra A, Yamanaka K

Acta neuropathologica communications Vol. 7 ( 1 ) page： 118 2019.7

Phenotypic heterogeneity of astrocytes in motor neuron disease. Invited Reviewed International coauthorship

Trias E, Barbeito L, Yamanaka K

Clinical & experimental neuroimmunology Vol. 9 ( 4 ) page： 225 - 234 2018.11

Dissociation of blood-brain barrier disruption and disease manifestation in an aquaporin-4-deficient mouse model of amyotrophic lateral sclerosis Reviewed

Watanabe-Matsumoto S, Moriwaki Y, Okuda T, Ohara S, Yamanaka K, Abe Y, Yasui M, Misawa H

Neuroscience Research Vol. 133 page： 48-57 2018.8

A copper-deficient form of mutant Cu/Zn-superoxide dismutase as an early pathological species in amyotrophic lateral sclerosis

Tokuda Eiichi, Nomura Takao, Ohara Shinji, Watanabe Seiji, Yamanaka Koji, Morisaki Yuta, Misawa Hidemi, Furukawa Yoshiaki

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE Vol. 1864 ( 6 ) page： 2119 - 2130 2018.6

Intracerebroventricular administration of Cystatin C ameliorates disease in SOD1-linked amyotrophic lateral sclerosis mice Reviewed

Watanabe S, Komine O, Endo F, Wakasugi K, Yamanaka K

Journal of Neurochemistry Vol. 145 ( 1 ) page： 80-89 2018.4

Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes. Reviewed

Komine O, Yamashita H, Fujimori-Tonou N, Koike M, Jin S, Moriwaki Y, Endo F, Watanabe S, Uematsu S, Akira S, Uchiyama Y, Takahashi R, Misawa H, Yamanaka K

Cell Death and Differentiation Vol. 25 ( 12 ) page： 2130-2146 2018.3

The Multi-dimensional roles of astrocytes in ALS. Invited Reviewed

Yamanaka K, Komine O

Neuroscience Research Vol. 126 page： 31 - 38 2018.1

TDP-43 accelerates age-dependent degeneration of interneurons Reviewed

Tsuiji H, Inoue I, Takeuchi M, Furuya A, Yamakage Y, Watanabe S, Koike M, Hattori M, Yamanaka K

Scientific Reports Vol. 7 page： 14972 2017.11

Astrocyte-derived extracellular vesicles contribute to the propagation of pathogenic protein in ALS

Endo F., Kurita T., Yamanaka K.

JOURNAL OF THE NEUROLOGICAL SCIENCES Vol. 381 page： 203 - 204 2017.10

Collapse of mitochondria-associated membrane as common pathomechanism for amyotrophic lateral sclerosis

Watanabe S., Ilieva H., Tamada H., Nomura H., Komine O., Endo F., Jin S., Mancias P., Kiyama H., Yamanaka K.

JOURNAL OF THE NEUROLOGICAL SCIENCES Vol. 381 page： 104 - 104 2017.10

Mice heterozygously lacking C-terminal domain of TDP-43 show age-dependent motor dysfunction

Nishino K, Watanabe S, Komine O, Yamanaka K.

Journal of the Neurological Sciences Vol. 381 page： 570 2017.10

Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. Reviewed

Yamasaki T, Deki-Arima N, Kaneko A, Miyamura N, Iwatsuki M, Matsuoka M, Fujimori-Tonou N, Okamoto-Uchida Y, Hirayama J, Marth JD, Yamanashi Y, Kawasaki H, Yamanaka K, Penninger JM, Shibata S, Nishina H

Scientific Reports Vol. 7 page： 7348 2017.8

A misfolded dimer of Cu/Zn-superoxide dismutase leading to pathological oligomerization in amyotrophic lateral sclerosis. Reviewed

Anzai I, Tokuda E, Mukaiyama A, Akiyama S, Endo F, Yamanaka K, Misawa H, Furukawa Y.

Protein Sci Vol. 26 ( 3 ) page： 484-496 2017.3

A misfolded dimer of Cu/Zn-superoxide dismutase leading to pathological oligomerization in amyotrophic lateral sclerosis

Anzai Itsuki, Tokuda Eiichi, Mukaiyama Atsushi, Akiyama Shuji, Endo Fumito, Yamanaka Koji, Misawa Hidemi, Furukawa Yoshiaki

PROTEIN SCIENCE Vol. 26 ( 3 ) page： 484 - 496 2017.3

Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis. Reviewed

Tokuda E, Anzai I, Nomura T, Toichi K, Watanabe M, Ohara S, Watanabe S, Yamanaka K, Morisaki Y, Misawa H, Furukawa Y.

Molecular Neurodegeneration Vol. 12 page： 2 2017.1

Immunochemical characterization on pathological oligomers of mutant Cu/Znsuperoxide dismutase in amyotrophic lateral sclerosis

Tokuda Eiichi, Anzai Itsuki, Nomura Takao, Toichi Keisuke, Watanabe Masahiko, Ohara Shinji, Watanabe Seiji, Yamanaka Koji, Morisaki Yuta, Misawa Hidemi, Furukawa Yoshiaki

MOLECULAR NEURODEGENERATION Vol. 12 ( 1 ) page： 2 2017.1

Proteasomal dysfunction induced by diclofenac engenders apoptosis through mitochondrial pathway

Amanullah A, Upadhyay A, Chhangani D, Joshi V, Mishra R, Yamanaka K, Mishra A

J. Cell. Biochem. 2016.8

Selective Expression of Osteopontin in ALS-resistant Motor Neurons is a Critical Determinant of Late Phase Neurodegeneration Mediated by Matrix Metalloproteinase-9 Reviewed

Morisaki Y, Niikura M, Watanabe M, Onishi K, Tanabe S, Moriwaki Y, Okuda T, Ohara S, Murayama S, Takao M, Uchida S, Yamanaka K, Misawa H.

Scientific Reports Vol. 6 page： 27354 2016.6

Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons. Reviewed

Lasiene J, Komine O, Fujimori-Tonou. N, Powers B, Endo F, Watanabe S, Shjie J, Ravits J, Horner P, Misawa H, Yamanaka K

Acta Neuropathologica Communications Vol. 18 ( 4 ) 2016.2

Mahogunin ring finger 1 confers cytoprotection against mutant SOD1 aggresomes and is defective in an ALS mouse model. Reviewed International coauthorship

Chhangani D, Endo F, Amanullah A, Upadhyay A, Watanabe S, Mishra R, Yamanaka K, Mishra A

Neurobiology of Disease Vol. 86 page： 16-28 2015.11

Neuroinflammation in motor neuron disease.

Komine O, Yamanaka K

Nagoya Journal of Medical Science Vol. 77 ( 4 ) page： 537-549 2015.11

Cystatin C protects neuronal cells against mutant copper-zinc superoxide dismutase-mediated toxicity. Reviewed

Watanabe S, Hayakawa T, Wakasugi K, Yamanaka K

Cell Death and Disease Vol. 5 page： e1497 2014.10

SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system. Reviewed

Watanabe S, Ageta-Ishihara N, Nagatsu S, Takao K, Komine O, Endo F, Miyakawa T, Misawa H, Takahashi R, Kinoshita M, Yamanaka K

Molecular Brain Vol. 7 ( 62 ) 2014.8

Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life. Reviewed

Austin James J., Wright Gareth S., Watanabe S, Grossman G, Antonyuk S V., Yamanaka K, Hasnan S. S

Proceedings of the National Academy of Sciences of the United States of America Vol. 111 ( 11 ) page： 4309-4314 2014.3

Case of familial amyotrophic lateral sclerosis showing gadolinium-enhanced cranial nerves on magnetic resonance imaging associated with rapid progression of facial nerve palsy Reviewed

Mizuno M, Ueki Y, Sakurai K, Okita K, Endo F, Yamanaka K, Morita M, Matsukawa N

Neurology and Clinical Neuroscience page： -- 2014.2

Intranuclear aggregation of mutant FUS/TLS as a molecular pathomechanism of amyotrophic lateral sclerosis Reviewed

Nomura T, Watanabe S, Kaneko K, Yamanaka K, Nukina N, Furukawa Y

Journal of Biological Chemistry Vol. 289 ( 2 ) page： 1192-1202 2014.1

Animal models for neurodegenerative disorders

Tsuiji H, Yamanaka K

Animal Biotechnology page： 39-56 2013.12

Intracellular seeded aggregation of mutant Cu,Zn-superoxide dismutase associated with amyotrophic lateral sclerosis Reviewed

Furukawa Y, Kaneko K, Watanabe S, Yamanaka K, Nukina N

FEBS Letters Vol. 587 ( 16 ) page： 2500-2505 2013.8

E6-AP association promotes SOD1 aggresomes degradation and suppresses toxicity. Reviewed

Mishra Amit K, Maheshiwari M, Chhangani D, Fujimori-T N, Endo F, Joshi Ajai P, Jana Nihar R, Yamanaka K

Neurobiology of Aging Vol. 34 ( 4 ) page： 1310.e11-23 2013.4

Loss of TDP-43 causes age-dependent progressive motor neuron degeneration. Reviewed

Iguchi Y, Katsuno M, Niwa J, Takagi S, Ishigaki S, Ikenaka , Kawai K, Watanabe H, Yamanaka K, Takahashi R, Misawa H, Sasaki Shoichi, Tanaka F, Sobue G

Brain Vol. 136 ( 5 ) page： 1371-1382 2013.2

Spliceosome integrity is defective in the motor neuron diseases ALS and SMA. Reviewed

Tsuiji H, Iguchi Y, Furuya A, Kataoka A, Hatsuta H, Atsuta N, Tanaka F, Hashizume Y, Akatsu H, Murayama S, Sobue G, Yamanaka K

EMBO Molecular Medicine Vol. 5 ( 2 ) page： 221-234 2013.2

Deletion of TLR-Associted signaling adaptor TRIF significantly accelerates disease progression of ALS mice. Reviewed

Komine O, Fujimori-Tonou N, Yamashita H, Moriwaki Y, Misawa H, Yamanaka K

Vol. 61 page： S75-S76 2013

The role of microglia-immune interaction in neurodegeneration of ALS mouse model.

Yamanaka K

Journal of Neurochemistry Vol. 125 page： 89 2013

Accelerated disease onset with stabilized familial amyotrophic lateral sclerosis (ALS)-linked TDP-43 mutations. Reviewed

Watanabe S, Kaneko K, Yamanaka K

J Biol Chem Vol. 288 page： 3641-3654 2012.12

Disulfide scrambling describes the oligomer formation of SOD1 proteins in the familial form of ALS. Reviewed

Toichi K, Yamanaka K, Furukawa Y

J Biol Chem Vol. 288 page： 4970-1980 2012.12

E6-AP association promotes SOD1 aggresomes degradation and suppresses toxicity. Reviewed

Mishra A, Maheshwari M, Chhangani D, Fujimori-Tonou N, Endo, F, Joshi AP, Jana NR, Yamanaka K

Neurobiol Aging Vol. 34 ( 1310 ) page： e11-23 2012.10

A seeding reaction recapitulates intracellular formation of sarkosyl-insoluble TAR DNA binding protein-43 inclusions. Reviewed

Furukawa Y, Kaneko K, Watanabe S, Yamanaka K, Nukina N

J. Biol. Chem Vol. 286 page： 18664-18672 2011

Blockade of Gap Junction Hemichannel Suppresses Disease Progression in Mouse Models of Amyotrophic Lateral Sclerosis and Alzheimer's Reviewed

Takeuchi H, Mizoguchi H, Doi Y, Jin S, Noda M, Liang J, Li H, Zhou Y, Mori R, Yasuoka S, Li E, Parajuli B, Kawanokuchi J, Sonobe Y, Sato J, Yamanaka K, Sobue G, Mizuno T, Suzumura A

PLoS One Vol. 6 ( 6 ) page： e21108 2011

Glial cells in Amyotrophic Lateral Sclerosis. Reviewed

Lasiene J, Yamanaka K

Neurol Res Int page： 718987 2011

Mutation-dependent polymorphism of Cu, Zn-superoxide dismutase aggregates in the familial form of amyotrophic lateral sclerosis. Reviewed

Furukawa Y, Kaneko K, Yamanaka K, Nukina N

J. Biol. Chem. Vol. 285 page： 22221-22231 2010

Misfolded Mutant SOD1 Directly Inhibits VDAC1 Conductance in a Mouse Model of Inherited ALS. Reviewed

Israelson A, Arbel N, Da Cruz S, Ilieva H, Yamanaka K, Shoshan-Barmatz V, Clevalend DW

Neuron Vol. 67 page： 575-587 2010

Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice. Reviewed

Lobsiger CS, Boillee S, McAlonis-Downes M, Khan AM, Feltri ML, Yamanaka K, Cleveland DW

Proc. Natl. Acad. Sci., USA. Vol. 106 page： 4465-4470 2009

Gigaxonin controls vimentin organization through tubulin chaperone-independent pathway. Reviewed

Cleveland DW, Yamanaka K, Bomont P

Hum. Mol. Genet. Vol. 18 page： 1384-1394 2009

Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death. Reviewed

Ilieva H, Yamanaka K, Malkmus S, Kakinohana O, Yaksh T, Marsala M, Cleveland DW

Proc. Natl. Acad. Sci., USA. Vol. 105 page： 12599-12604 2008

Complete loss of post-translational modifications triggers fibrillar aggregation of SOD1 in familial form of ALS. Reviewed

Furukawa Y, Kaneko K, Yamanaka K, O'Halloran, TV, Nukina N

J. Biol. Chem. Vol. 283 page： 24167-24176 2008

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Reviewed

Yamanaka K, Chun SJ, Boillee S, Fujimori-Tonou N, Yamashita H, Gutmann DH, Takahashi R, Misawa H, Cleveland DW

Nat. Neurosci. Vol. 11 page： 251-253 2008

Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice. Reviewed

Yamanaka K, Boillee S, Roberts EA, Garcia ML, McAlonis-Downes M, Mikse OR, Cleveland DW, Goldstein LSB

Proc. Natl. Acad. Sci., USA. Vol. 105 page： 7594-7599 2008

Heat-shock protein 105 interacts with and suppresses aggregation of mutant Cu/Zn superoxide dismutase; clues to a possible strategy for treating ALS. Reviewed

Yamashita H, Kawamata J, Okawa K, Kanki R, Nakamizo T, Hatayama T, Yamanaka K, Takahashi R, Shimohama S

J. Neurochem. Vol. 102 page： 1497-1505 2007

Onset and Progression in Inherited ALS determined by Motor Neurons and Microglia. Reviewed

Boillee S, Yamanaka K, Lobsiger CS, Copeland NG, Jenkins NA, Kassiotis G, Kollias G, Cleveland DW

Science Vol. 312 page： 1389-1392 2006

Novel Missense Mutation in ALS2 gene results in Infantile Ascending Hereditary Spastic Paralysis. Reviewed

Eymard-Pierre E, Yamanaka K, Haeussler M, Kress W, Gauthier-Barichard F, Combes P, Cleveland DW, Boespflug-Tanguy O

Ann. Neurol. Vol. 59 page： 976-980 2006

Progressive axonal degeneration and slowness in ALS2-deficient mice. Reviewed

Yamanaka K, Miller TM, McAlonis-Downes M, Chun SJ, Cleveland DW

Ann. Neurol. Vol. 60 page： 95-104 2006

Antisense Oligonucleotides as a Therapy for Neurodegenerative diseases. Reviewed

Smith RA, Miller TM, Yamanaka K, Monia BP, Condon TP, Hung G, Lobsiger CS, Ward CM, McAlonis-Downes M, Wei H, Wancewicz EV, Bennett CF, Cleveland DW

J. Clin. Invest. Vol. 116 page： 2290-2296 2006

Gene transfer demonstrates that muscle is not a primary target for non-cell autonomous toxicity in familial amyotrophic lateral sclerosis. Reviewed

Miller TM, Kim SH, Yamanaka K, Hester M, Umapathi P, Arnson H, Rizo L, Mendell JR, Gage FH, Cleveland DW, Kaspar BK

Proc. Natl. Acad. Sci. USA Vol. 103 page： 19546-19551 2006

Virus-delivered siRNA preserves strength in ALS mice. Reviewed

Miller TM, Kaspar BK, Kops GJ, Yamanaka K, Christian LJ, Gage FH, Cleveland DW

Ann. Neurol. Vol. 57 page： 773-776 2005

ALS2-Related Disorders. Reviewed

Bertini E, Eymard-Pierre E, Boespflug-Tanguy O, Cleveland DW, Yamanaka K

GeneReviews at GeneTests: Medical Genetics Information Resource. page： 00 2005

Cleveland DW: Determinants of rapid disease progression in ALS. Reviewed

Yamanaka K

Neurology Vol. 65 page： 1859-1860 2005

Unstable mutants in the peripheral endosomal membrane component ALS2 cause early onset motor neuron disease. Reviewed

Yamanaka K, Vande Velde C, Eymard-Pierre E, Bertini E, Boespflug-Tanguy O, Cleveland DW

Proc. Natl. Acad. Sci. USA Vol. 100 page： 16041-16046 2003

Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2. Reviewed

Yamanaka K, Ishikawa H, Megumi Y, Tokunaga F, Kanie M, Rouault TA, Morishima I, Minato N, Ishimori K, Iwai K

Nat. Cell Biol. Vol. 5 page： 336-340 2003

NEDD8 recruits E2-ubiquitin to SCF E3 ligase. Reviewed

Kawakami T, Chiba T, Suzuki T, Iwai K, Yamanaka K, Minato N, Suzuki H, Shimbara N, Hidaka Y, Osaka F, Omata M, Tanaka K

EMBO J. Vol. 20 page： 4003-4012 2001

Multiple thymoma with myotonic dystrophy. Reviewed

Hirai T, Yamanaka A, Fujimoto T, Takahashi A, Takayama Y, Yamanaka K

Japanese Journal Thoracic Cardiovascular Surgery Vol. 49 page： 457-460 2001

Stabilization of iron regulatory protein 2, IRP2, by aluminum. Reviewed

Yamanaka K, Minato N, Iwai K

FEBS Lett. Vol. 462 page： 216-220 1999

Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha. Reviewed

Gonen H, Bercovich B, Orian A, Carrano A, Takizawa C, Yamanaka K, Pagano M, Iwai K, Ciechanover A

J. Biol. Chem. Vol. 274 page： 14823-14830 1999

Identification of the von Hippel-Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex. Reviewed

Iwai K, Yamanaka K, Kamura T, Minato N, Conaway RC, Conaway JW, Klausner RD, Pause A

Proc. Natl. Acad. Sci. USA Vol. 96 page： 12436-12441 1999

Abulia from unilateral capsular genu infarction: report of two cases. Reviewed

Yamanaka K, Fukuyama H, Kimura J

J. Neurol. Sci. Vol. 143 page： 181-184 1996

Plaques of multiple sclerosis on the pyramidal tract demonstrated by MRI.

Vol. 42 page： 377-378 1995

Sleep bruxism as a manifestation of subclinical rapid eye movement sleep behavior disorder. Reviewed

Tachibana N, Yamanaka K, Kaji R, Nagamine T, Watatani K, Kimura J, Shibasaki H.

Sleep Vol. 17 page： 555-558 1994

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