Faculty Profiles - KANDA Mitsuro

Papers - KANDA Mitsuro

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Downregulation of ROBO4 in Pancreatic Cancer Serves as a Biomarker of Poor Prognosis and Indicates Increased Cell Motility and Proliferation Through Activation of MMP-9 Reviewed

Yamanaka Masaya, Hayashi Masamichi, Sonohara Fuminori, Yamada Suguru, Tanaka Haruyoshi, Sakai Akihiro, Mii Shinji, Kobayashi Daigo, Kurimoto Keisuke, Tanaka Nobutake, Inokawa Yoshikuni, Takami Hideki, Hattori Norifumi, Kanda Mitsuro, Tanaka Chie, Nakayama Goro, Koike Masahiko, Kodera Yasuhiro

ANNALS OF SURGICAL ONCOLOGY Vol. 29 ( 11 ) page： 7180 - 7189 2022.10

ASO Visual Abstract: Downregulation of ROBO4 in Pancreatic Cancer Serves as a Biomarker of Poor Prognosis and Indicates Increased Cell Motility and Proliferation Through Activation of MMP-9 Reviewed

ANNALS OF SURGICAL ONCOLOGY Vol. 29 ( 11 ) page： 7192 - 7193 2022.10

高齢者に対する周術期感染症の予防策高齢者胃癌に対する術後感染性合併症発生の現状と対策肺炎を中心に Reviewed

田中千恵, 中西香企, 清水大, 猪川祥邦, 高見秀樹, 服部憲史, 神田光郎, 林真路, 中山吾郎, 藤原道隆, 小寺泰弘

日本外科感染症学会雑誌 Vol. 19 ( 1 ) page： 216 - 216 2022.10

術前治療後の食道癌患者における術前PLR値の術後合併症・予後予測因子としての意義 Reviewed

笹原正寛, 神田光郎, 清水大, 中西香企, 田中千恵, 猪川祥邦, 高見秀樹, 服部憲史, 林真路, 中山吾郎, 藤原道隆, 小寺泰弘

日本癌治療学会学術集会抄録集 Vol. 60回 page： P33 - 2 2022.10

術前治療後の食道癌患者における術前PLR値の術後合併症・予後予測因子としての意義 Reviewed

笹原正寛, 神田光郎, 清水大, 中西香企, 田中千恵, 猪川祥邦, 高見秀樹, 服部憲史, 林真路, 中山吾郎, 藤原道隆, 小寺泰弘

日本癌治療学会学術集会抄録集 Vol. 60回 page： P33 - 2 2022.10

高齢者に対する周術期感染症の予防策高齢者胃癌に対する術後感染性合併症発生の現状と対策肺炎を中心に Reviewed

田中千恵, 中西香企, 清水大, 猪川祥邦, 高見秀樹, 服部憲史, 神田光郎, 林真路, 中山吾郎, 藤原道隆, 小寺泰弘

日本外科感染症学会雑誌 Vol. 19 ( 1 ) page： 216 - 216 2022.10

胃癌に対するナビゲーションサージェリーの工夫胃癌に対する低侵襲手術における術中マーキング法 Reviewed

田中千恵, 中西香企, 清水大, 猪川祥邦, 高見秀樹, 服部憲史, 神田光郎, 林真路, 中山吾郎, 藤原道隆, 小寺泰弘

日本臨床外科学会雑誌 Vol. 83 ( 増刊 ) page： S161 - S161 2022.10

食道扁平上皮癌におけるOPLAHタンパク発現意義 Reviewed

清水大, 神田光郎, 佐藤雄亮, 本山悟, 小寺泰弘

日本分子腫瘍マーカー研究会プログラム・講演抄録 Vol. 42回 page： 110 - 111 2022.9

Transcriptomic profiling on localized gastric cancer identified CPLX1 as a gene promoting malignant phenotype of gastric cancer and a predictor of recurrence after surgery and subsequent chemotherapy Reviewed

Haruyoshi Tanaka, Mitsuro Kanda, Dai Shimizu, Chie Tanaka, Yoshikuni Inokawa, Norifumi Hattori, Masamichi Hayashi, Goro Nakayama, Yasuhiro Kodera

Journal of Gastroenterology Vol. 57 ( 9 ) page： 640 - 653 2022.9

ASO Author Reflections: Optimized Cutoff Value of Albumin-Bilirubin Score to Predict Prognosis of Patients with Esophageal Squamous Cell Carcinoma After Radical Resection. Reviewed International journal

Takahiro Shinozuka, Mitsuro Kanda, Yasuhiro Kodera

Annals of surgical oncology Vol. 29 ( 8 ) page： 4897 - 4898 2022.8

Prognostic Value of a Modified Albumin-Bilirubin Score Designed for Patients with Esophageal Squamous Cell Carcinoma After Radical Resection. Reviewed International journal

Takahiro Shinozuka, Mitsuro Kanda, Dai Shimizu, Chie Tanaka, Yoshikuni Inokawa, Norifumi Hattori, Masamichi Hayashi, Masahiko Koike, Yasuhiro Kodera

Annals of surgical oncology Vol. 29 ( 8 ) page： 4889 - 4896 2022.8

Language：Japanese Publishing type：Research paper (scientific journal)

BACKGROUND: The albumin-bilirubin (ALBI) score was originally developed to assess the severity of liver dysfunction in patients with hepatocellular carcinoma and has subsequently been used as a prognostic marker for that disease. Here, we examined the value of the preoperative ALBI score as a prognostic marker for patients with esophageal squamous cell carcinoma (ESCC) after radical esophagectomy. METHODS: We retrospectively analyzed data from 449 patients who underwent curative resection for ESCC. The ALBI score was calculated as (log10 serum bilirubin [μmol/l] × 0.66) + (serum albumin [g/l] × - 0.0852). Receiver operating characteristic curve analysis was used to define a preoperative modified ALBI (mALBI) score for patient stratification. RESULTS: Of the 449 ESCC patients, 232 and 217 were assigned to mALBI Grade 1 or Grade 2 groups based on preoperative ALBI scores of ≤ - 3.33 or > - 3.33, respectively. Preoperative mALBI grade was significantly associated with age, excessive alcohol consumption, squamous cell carcinoma antigen level, and clinical disease stage. The mALBI Grade 2 group had significantly shorter disease-specific and recurrence-free survival than the mALBI Grade 1 group. Multivariate analysis demonstrated that mALBI Grade 2 was an independent prognostic factor for disease-specific survival (hazard ratio 1.86, 95% confidence interval 1.18-2.93, P = 0.0074). In most subgroup analyses, mALBI Grade 2 was associated with a greater risk of disease-specific death. CONCLUSIONS: mALBI grade serves as a simple and useful prognostic marker for disease-specific survival in patients with ESCC after radical esophagectomy.

DOI： 10.1245/s10434-022-11654-6

Web of Science

PubMed

Comparison Between FOLFIRINOX and nal-IRI/FL as Second-line Treatment After Gemcitabine Plus Nab-paclitaxel for Pancreatic Cancer br Reviewed

Otsu Tomohisa, Inokawa Yoshikuni, Takami Hideki, Hayashi Masamichi, Kurimoto Keisuke, Tanaka Nobutake, Tanaka Haruyoshi, Shimizu Dai, Hattori Norifumi, Kanda Mitsuro, Tanaka Chie, Nakayama Goro, Kodera Yasuhiro

ANTICANCER RESEARCH Vol. 42 ( 8 ) page： 3889 - 3894 2022.8

胃癌術後早期ドレーンアミラーゼ値の有用性早期治療介入にむけて Reviewed

中西香企, 神田光郎, 田中千恵, 清水大, 猪川祥邦, 服部憲史, 林真路, 中山吾郎, 藤原道隆, 小寺泰弘

日本消化器外科学会総会 Vol. 77回 page： O6 - 4 2022.7

局所進行食道扁平上皮癌に対する術前ドセタキセル、オキサリプラチン、S-1併用療法の開発臨床試験 Reviewed

神田光郎, 清水大, 宮田一志, 江畑智希, 小寺泰弘

日本消化器外科学会総会 Vol. 77回 page： O1 - 3 2022.7

E-PASS scoring system serves as a predictor of short- and long-term outcomes in gastric cancer surgery. Reviewed

Koki Nakanishi, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Daisuke Kobayashi, Dai Shimizu, Chie Tanaka, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera

Surgery today Vol. 52 ( 6 ) page： 914 - 922 2022.6

Language：Japanese Publishing type：Research paper (scientific journal)

PURPOSES: This study aimed to evaluate the estimation of the physiological ability and surgical stress (E-PASS) scoring system for predicting the short- and long-term outcomes in gastric cancer (GC) surgery. METHODS: We analyzed a multi-institutional dataset to study patients who underwent gastrectomy with a curative intent between 2010 and 2014. This study evaluated the associations between the optimal E-PASS score cutoff value and the following outcomes: (1) the incidence of postoperative complications in stage I-III GC patients and (2) the prognosis in stage II-III GC patients. RESULTS: A total of 2495 GC patients were included. A cutoff value of 0.419 was determined using the ROC curve analysis. Postoperative complications were observed more frequently in the E-PASS-high group than that in the E-PASS-low group (30% vs. 17%, p < 0.0001). Among pStage II-III GC patients (n = 1009), the overall survival time of the E-PASS-high group was significantly shorter than that of the E-PASS-low group (hazard ratio 2.08; 95% confidence interval 1.64-2.65; p < 0.0001). A forest plot revealed that E-PASS-high was associated with a greater prognostic factor for overall survival in most subgroups. CONCLUSIONS: The E-PASS scoring system may therefore be a useful predictor of the short- and long-term outcomes in patients with GC who have undergone radical gastrectomy.

DOI： 10.1007/s00595-021-02394-3

Web of Science

PubMed

Expression of cellular retinoic acid binding protein 1 predicts peritoneal recurrence of gastric cancer. Reviewed International journal

Kazuki Sakata, Mitsuro Kanda, Dai Shimizu, Shunsuke Nakamura, Yoshikuni Inokawa, Norifumi Hattori, Masamichi Hayashi, Chie Tanaka, Goro Nakayama, Yasuhiro Kodera

International journal of oncology Vol. 60 ( 6 ) 2022.6

Language：Japanese Publishing type：Research paper (scientific journal)

To improve the outcome of gastric cancer, novel markers that predict postoperative prognosis are required. For this purpose, the function of cellular retinoic acid binding protein 1 (CRABP1) in gastric cancer cells was investigated and it was determined whether it serves as a novel biomarker for gastric cancer. Reverse transcription‑quantitative (RT‑q)PCR and a PCR‑array method were used to determine whether the expression of CRABP1 mRNA in gastric cancer cell lines correlated with the expression of cancer‑related genes. The correlations of CRABP1 mRNA expression in tissues with clinicopathological factors of 230 patients who underwent radical gastrectomy were further evaluated. CRABP1 mRNA levels varied among gastric cancer cell lines and showed significant positive correlations with numerous epithelial‑mesenchymal transition factors. Additionally, CRABP1 knockdown significantly suppressed the proliferation, migration and invasion of gastric cancer cell lines. In a mouse xenograft model of peritoneal metastasis of gastric cancer, it was found that the total weight of disseminated nodules was lower in the group, in which CRABP1 mRNA levels were knocked down compared with those of the untransfected group. Disease‑free survival (DFS) was significantly shorter in patients with high expression of CRABP1, and multivariate analysis of DFS revealed that high expression of CRABP1 in the tumor area and lymph node metastasis served as an independent factor associated with poor prognosis. High expression of CRABP1 in cancer tissues was associated with a greater incidence of peritoneal recurrences after curative gastrectomy. These findings indicated that CRABP1 contributes to the malignant phenotype of gastric cancer cells and may serve as a biomarker for prognosing recurrence after curative resection, particularly peritoneal dissemination.

DOI： 10.3892/ijo.2022.5353

Web of Science

PubMed

Lysosomal-associated membrane protein family member 5 promotes the metastatic potential of gastric cancer cells. Reviewed

Shinichi Umeda, Mitsuro Kanda, Dai Shimizu, Shunsuke Nakamura, Koichi Sawaki, Yoshikuni Inokawa, Norifumi Hattori, Masamichi Hayashi, Chie Tanaka, Goro Nakayama, Yasuhiro Kodera

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association Vol. 25 ( 3 ) page： 558 - 572 2022.5

Language：Japanese Publishing type：Research paper (scientific journal)

BACKGROUND: Metastatic gastric cancer (GC) has a poor prognosis, and elucidating the molecular mechanisms involved in metastasis may lead to the development of novel therapeutic modalities. METHODS: Transcriptome analysis of surgically resected metastatic tissue from GC patients and noncancerous tissue was performed to identify novel metastasis-related genes. Analyses of in vitro cell function, apoptosis, the cell cycle and cancer stemness were performed using GC cell lines with a stable knockout of a candidate gene. In vivo percutaneous, peritoneal dissemination and liver metastasis xenograft models were also generated. PCR array and proteome analyses were performed. Expression of the candidate gene was analyzed in GC tissues from 300 patients. RESULTS: Lysosomal Associated Membrane Protein Family Member 5 (LAMP5) was upregulated in the metastatic tissues. LAMP5 knockout significantly suppressed proliferation, invasion, and migration of GC cells and increased apoptosis, cell cycle arrest and cancer stemness. LAMP5 knockout virtually suppressed tumor growth in in vivo percutaneous, peritoneal dissemination and liver metastasis models. EMT- and autophagy-related genes were associated with LAMP5. High LAMP5 mRNA levels were significantly associated with a worse prognosis. CONCLUSION: LAMP5 plays a vital role in metastasis formation and may be a promising novel target of drug development for metastatic GC in the future.

DOI： 10.1007/s10120-022-01284-y

Web of Science

PubMed

がんトランスレーショナルリサーチ外科臨床検体を用いたトランスクリプトーム解析からの癌治療抗体医薬開発研究 Reviewed

神田光郎, 清水大, 中西香企, 田中千恵, 猪川祥邦, 高見秀樹, 服部憲史, 林真路, 中山吾郎, 藤原道隆, 小寺泰弘

日本外科系連合学会誌 Vol. 47 ( 3 ) page： 401 - 401 2022.5

特集そろそろ真剣に考えよう胃癌に対するロボット支援手術ロボット支援手術を始めるためにロボット支援下胃切除術の準備と立ち上げ-マイナスからのスタート Reviewed

田中千恵, 中西香企, 神田光郎, 小寺泰弘

臨床外科 Vol. 77 ( 4 ) page： 393 - 397 2022.4

ASO Visual Abstract: Prognostic Value of a Modified Albumin-Bilirubin Grade Designed for Patients with Esophageal Squamous Cell Carcinoma after Radical Resection. Reviewed International journal

Takahiro Shinozuka, Mitsuro Kanda, Dai Shimizu, Chie Tanaka, Yoshikuni Inokawa, Norifumi Hattori, Masamichi Hayashi, Masahiko Koike, Yasuhiro Kodera

Annals of surgical oncology 2022.4

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Papers - KANDA Mitsuro