Faculty Profiles - KANDA Mitsuro

Papers - KANDA Mitsuro

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ASO Author Reflections: Expression and Malignant Potential of B4GALNT4 in Esophageal Squamous Cell Carcinoma. Reviewed International journal

Hayato Baba, Mitsuro Kanda, Yasuhiro Kodera, Tsutomu Fujii

Annals of surgical oncology Vol. 27 ( 9 ) page： 3257 - 3258 2020.9

Characteristics Associated with Nodal and Distant Recurrence After Radical Esophagectomy for Squamous Cell Carcinoma of the Thoracic Esophagus. Reviewed International journal

Mitsuro Kanda, Masahiko Koike, Dai Shimizu, Chie Tanaka, Norifumi Hattori, Masamichi Hayashi, Suguru Yamada, Kenji Omae, Yasuhiro Kodera

Annals of surgical oncology Vol. 27 ( 9 ) page： 3195 - 3205 2020.9

Language：Japanese Publishing type：Research paper (scientific journal)

BACKGROUND: Recurrence after radical resection of esophageal squamous cell carcinoma (ESCC) is common. Limited evidence is available about the differences in clinical characteristics, risk factors, and prognostic significance between nodal and distant recurrence of thoracic ESCC. PATIENTS AND METHODS: We retrospectively analyzed 341 patients who underwent radical resection of thoracic ESCC and experienced (1) initial recurrence only in lymph nodes (n = 39), (2) recurrence only at distant organs (n = 57), or (3) no recurrences (n = 245) after follow-up ≥ 24 months. Clinicopathological characteristics, survival times, and risk factors were compared between the nodal and distant recurrence groups. RESULTS: The median follow-up time was 57.8 months. Metastasectomy as initial treatment for the recurrence was performed for six (15.4%) patients in the nodal recurrence group and one patient in the distant recurrence group. Compared with the nodal recurrence group, patients with distant recurrence had significantly shorter disease-free survival [hazard ratio (HR) 1.68, 95% confidence interval (CI) 1.10-2.57, P = 0.0169], postrecurrence survival (HR 1.77, 95% CI 1.01-3.10, P = 0.0476), and overall survival (HR 1.98, 95% CI 1.12-3.51, P = 0.0193). The distant recurrence group had significantly larger macroscopic tumor size and more advanced pathological T stage than the nodal recurrence group, whereas preoperative treatment, tumor location, number of fields dissected, tumor differentiation, lymphatic involvement, and vessel invasion were not significantly different between the two groups. CONCLUSIONS: Survival times and recurrence risk factors differed between patients with nodal and distant recurrence after radical resection of thoracic ESCC.

DOI： 10.1245/s10434-020-08433-6

Web of Science

PubMed

Expression and Malignant Potential of B4GALNT4 in Esophageal Squamous Cell Carcinoma. Reviewed International journal

Hayato Baba, Mitsuro Kanda, Yusuke Sato, Koichi Sawaki, Dai Shimizu, Masahiko Koike, Satoru Motoyama, Yasuhiro Kodera, Tsutomu Fujii

Annals of surgical oncology Vol. 27 ( 9 ) page： 3247 - 3256 2020.9

Language：Japanese Publishing type：Research paper (scientific journal)

BACKGROUND: β-1,4-N-Acetyl-galactosaminyltransferase 4 (B4GALNT4), an enzyme involved in ganglioside synthesis, is upregulated in many cancers. We examine B4GALNT4 expression and its relationship to prognosis in esophageal squamous cell carcinoma (ESCC). PATIENTS AND METHODS: Expression of B4GALNT4 mRNA and B4GALNT4 protein was analyzed by quantitative reverse-transcription polymerase chain reaction (qRT-PCR) and immunohistochemistry, respectively, in 17 human ESCC cell lines and/or clinical specimens from two independent cohorts of 147 and 159 ESCC patients. The contributions of B4GALNT4 to proliferation, invasion, migration, and adhesion was evaluated in ESCC cells subjected to siRNA-mediated gene knockdown. Correlations between clinicopathological parameters and B4GALNT4 expression in clinical specimens were analyzed in both patient cohorts. RESULTS: B4GALNT4 mRNA expression levels varied widely in ESCC cell lines, regardless of differentiation status or the originating tissue. Knockdown of B4GALNT4 significantly suppressed the proliferation, invasion, migration, and adhesion of ESCC cell lines compared with control cells. B4GALNT4 mRNA was overexpressed in ESCC tissues compared with adjacent normal esophageal tissues. High mRNA expression was significantly associated with poor disease-free survival and hematogenous recurrence, and high B4GALNT4 protein expression was also significantly related to poor disease-specific survival. On multivariable analysis, high B4GALNT4 expression was an independent predictor of poor prognosis. In both patient cohorts, high B4GALNT4 expression did not correlate with known prognostic factors, such as disease stage, lymphovascular invasion, or squamous cell-carcinoma-related antigen level. CONCLUSIONS: B4GALNT4 influences the malignant behavior of ESCC cells. B4GALNT4 expression may serve as a novel prognostic marker, independent of established risk factors, for ESCC patients.

DOI： 10.1245/s10434-020-08431-8

Web of Science

PubMed

Systemic Inflammation Score as a Predictor of Pneumonia after Radical Resection of Gastric Cancer: Analysis of a Multi-Institutional Dataset. Reviewed International journal

Michita Shoka, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera

Digestive surgery Vol. 37 ( 5 ) page： 401 - 410 2020.9

Language：Japanese Publishing type：Research paper (scientific journal)

BACKGROUND: Curative treatment for gastric cancer (GC) comprising gastrectomy with systematic lymph node dissection can result in postoperative complications. Postoperative pneumonia is sometimes fatal, like surgery-related complications such as anastomotic leakage. In this retrospective study, we analyzed a multi-institutional collaborative dataset with the aim of identifying predictors of postgastrectomy pneumonia. METHODS: From a retrospective database of 3,484 patients who had undergone gastrectomy for GC at nine Japanese institutions between 2010 and 2014, 1,415 patients who met all eligibility criteria were identified as eligible for analysis. Predictive values of 31 candidate variables for postoperative pneumonia were assessed. RESULTS: Forty-two patients (3.0%) had grade II or higher postoperative pneumonia. Preoperative systemic inflammation score (SIS) had the greatest area under the curve (0.655) for predicting postoperative pneumonia (optimal cutoff value = 2). The odds ratio (OR) of high SISs associated with postoperative pneumonia was 3.10 (95% confidence interval [CI], 1.54-6.07; p < 0.001). Multivariate binomial logistic analysis identified high SIS as an independent risk factor for postoperative pneumonia (OR, 2.31; 95% CI, 1.19-4.48; p = 0.013). A forest plot revealed that ORs of high SISs were highest in female patients. CONCLUSIONS: Our findings indicate that the preoperative SIS may serve as a simple predictor of postgastrectomy pneumonia, assisting physicians' efforts to take preventive measures against this complication.

DOI： 10.1159/000506940

Web of Science

PubMed

Therapeutic monoclonal antibody targeting of neuronal pentraxin receptor to control metastasis in gastric cancer. Reviewed International journal

Mitsuro Kanda, Dai Shimizu, Koichi Sawaki, Shunsuke Nakamura, Shinichi Umeda, Takashi Miwa, Haruyoshi Tanaka, Chie Tanaka, Masamichi Hayashi, Yohei Iguchi, Suguru Yamada, Masahisa Katsuno, Yasuhiro Kodera

Molecular cancer Vol. 19 ( 1 ) page： 131 - 131 2020.8

Language：Japanese Publishing type：Research paper (scientific journal)

BACKGROUND: Controlling metastasis is essential for improving the prognosis of patients with gastric cancer (GC). Here, we aimed to identify a molecule required for GC metastasis and to investigate its potential utility as a target for the development of therapeutic antibodies (Abs). METHODS: Transcriptome and bioinformatics analyses of human GC cell lines identified the neuronal pentraxin receptor (NPTXR) as a candidate molecule. NPTXR function was probed by modulating its expression in GC cells and assessing the effects on intracellular signaling and malignant behaviors in vitro and in mouse xenograft models. We also generated anti-NPTXR Abs and Nptxr-/- mice, and assessed the clinical significance of NPTXR expression in GC specimens. RESULTS: NPTXR mRNA expression in clinical specimens was associated with disease progression and was significantly higher in tissues from GC patients with distant metastasis compared with those without. NPTXR regulated expression of genes involved in metastatic behaviors as well as activation of the PI3K-AKT-mTOR, FAK-JNK, and YAP signaling pathways. NPTXR silencing promoted caspase-mediated apoptosis and attenuated GC cell proliferation, cell cycle progression, migration, invasion, adhesion, stem cell-like properties, and resistance to 5-fluorouracil in vitro, and also inhibited the tumorigenicity of GC cells in vivo. Anti-NPTXR Abs inhibited GC peritoneal metastasis in mice. Nptxr-/- mice showed no abnormalities in reproduction, development, metabolism, or motor function. CONCLUSIONS: NPTXR plays an essential role in controlling the malignant behavior of GC cells in vitro and in vivo. NPTXR-targeting Abs may thus have utility as novel diagnostic tools and/or treatment modalities for GC.

DOI： 10.1186/s12943-020-01251-0

Web of Science

PubMed

Surveillance of Esophageal Cancer in the Republic of Uzbekistan from 2000 to 2018. Reviewed

Yusupbekov A, Kanda M, Usmanov B, Tuychiev O, Baymakov S, Sakamoto J, Yusupbekov A

Asian Pacific journal of cancer prevention : APJCP Vol. 21 ( 8 ) page： 2281 - 2285 2020.8

The impact of cancer stem cell markers in the tissues of pancreatic ductal adenocarcinoma for prognosis after surgical resections Reviewed

Inokawa Yoshikuni, Yamada Suguru, Hayashi Masamichi, Sunagawa Yuki, Sonohara Fuminori, Takami Hideki, Hattori Norifumi, Kanda Mitsuro, Kobayashi Daisuke, Tanaka Chie, Nakayama Goro, Koike Masahiko, Kodera Yasuhiro

CANCER RESEARCH Vol. 80 ( 16 ) 2020.8

Survival times are similar among patients with peritoneal, hematogenous, and nodal recurrences after curative resections for gastric cancer. Reviewed International journal

Koichi Sawaki, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera

Cancer medicine Vol. 9 ( 15 ) page： 5392 - 5399 2020.8

Language：Japanese Publishing type：Research paper (scientific journal)

BACKGROUND: The three dominant recurrence patterns of gastric cancer are peritoneal, hematogenous, and nodal recurrence. Correlation between initial recurrence site and prognosis is poorly understood, particularly after standardization of postoperative S-1 adjuvant chemotherapy. METHODS: We analyzed a multi-institutional database of 3484 patients who underwent gastrectomy for gastric cancer between 2010 and 2014. Patients who experienced recurrences after curative gastrectomy classified into peritoneal, hematogenous, or nodal recurrence groups, according to their initial recurrence sites, and their prognoses were compared. RESULTS: We included 313 patients in the analysis, of whom 190 patients (63%) were treated with postoperative adjuvant chemotherapy. Pathological disease states were stage I: n = 20 (6%), stage II: n = 62 (20%), and stage III: n = 231 (74%). Patients were categorized into groups by peritoneal (n = 127), hematogenous (n = 123), and nodal (n = 63) recurrence. The peritoneal recurrence group tended to have longer recurrence-free survival, but shorter post-recurrence survival, than the other two groups. Median disease-specific survival after curative resection by group were peritoneal: 25.8 months, hematogenous: 29.0 months, and nodal: 27.8 months (peritoneal vs hematogenous, P = .152; hematogenous vs nodal, P = .955; peritoneal vs nodal, P = .213). CONCLUSIONS: Prognoses after curative resection for gastric cancer were similar among patients with peritoneal, hematogenous, or nodal recurrences.

DOI： 10.1002/cam4.3208

Web of Science

PubMed

ETNK2のアポトーシス調節を介した胃癌細胞肝転移への関与 Reviewed

三輪高嗣, 神田光郎, 田中千恵, 小林大介, 清水大, 園原史訓, 高見秀樹, 服部憲史, 林真路, 山田豪, 中山吾郎, 小池聖彦, 藤原道隆, 小寺泰弘

日本外科学会定期学術集会抄録集 Vol. 120回 page： SF - 5 2020.8

Ivor Lewis手術は超高齢者に対する低侵襲手術となり得るか? Reviewed

小池聖彦, 神田光郎, 高見秀樹, 服部憲史, 林真路, 田中千恵, 山田豪, 中山吾郎, 藤原道隆, 小寺泰弘

日本外科学会定期学術集会抄録集 Vol. 120回 page： DP - 6 2020.8

Initial systemic therapy時代における高齢者膵癌集学的治療の意義と限界 Reviewed

園原史訓, 山田豪, 高見秀樹, 猪川祥邦, 林真路, 清水大, 服部憲史, 神田光郎, 田中千恵, 小林大介, 中山吾郎, 小池聖彦, 藤原道隆, 藤井努, 小寺泰弘

日本外科学会定期学術集会抄録集 Vol. 120回 page： SF - 6 2020.8

傾向スコアマッチングを用いた後期高齢者における食道亜全摘術の短期成績と術前免疫栄養因子の検討 Reviewed

神田光郎, 小池聖彦, 清水大, 田中千恵, 小林大介, 園原史訓, 猪川祥邦, 高見秀樹, 服部憲史, 林真路, 山田豪, 中山吾郎, 藤原道隆, 小寺泰弘

日本外科学会定期学術集会抄録集 Vol. 120回 page： DP - 4 2020.8

術前CT画像を利用した膵内脂肪量と体組成による膵液瘻予測因子の検討 Reviewed

田中克仁, 山田豪, 園原史訓, 猪川祥邦, 高見秀樹, 服部憲史, 林真路, 神田光郎, 田中千恵, 小林大介, 中山吾郎, 小池聖彦, 藤原道隆, 小寺泰弘

日本外科学会定期学術集会抄録集 Vol. 120回 page： SF - 1 2020.8

膵頸部癌における臨床病理学的特徴 Reviewed

栗本景介, 山田豪, 鈴木雄之典, 中川暢彦, 加藤吉康, 田中伸孟, 砂川祐輝, 園原史訓, 猪川祥邦, 高見秀樹, 林真路, 神田光郎, 田中千恵, 中山吾郎, 小池聖彦, 小寺泰弘

日本外科学会定期学術集会抄録集 Vol. 120回 page： SF - 3 2020.8

膵頭十二指腸切除術施行膵癌患者における周術期メインおよびリパクレオン投与の安全性と有用性 Reviewed

中川暢彦, 山田豪, 多代充, 栗本景介, 園原史訓, 清水大, 猪川祥邦, 高見秀樹, 服部憲史, 林真路, 神田光郎, 田中千恵, 小林大介, 中山吾郎, 小池聖彦, 藤原道隆, 小寺泰弘, 小寺泰弘

日本外科学会定期学術集会抄録集 Vol. 120回 page： DP - 5 2020.8

膵頭十二指腸切除術における胆管空腸吻合部狭窄のリスクファクターに関する検討 Reviewed

鈴木雄之典, 山田豪, 園原史訓, 猪川祥邦, 高見秀樹, 服部憲史, 林真路, 神田光郎, 小林大介, 田中千恵, 中山吾郎, 小池聖彦, 藤原道隆, 小寺泰弘

日本外科学会定期学術集会抄録集 Vol. 120回 page： DP - 4 2020.8

膵癌組織における癌幹細胞マーカー発現が切除後予後に与える影響についての検討 Reviewed

猪川祥邦, 山田豪, 林真路, 砂川祐輝, 園原史訓, 高見秀樹, 服部憲史, 神田光郎, 小林大介, 田中千恵, 中山吾郎, 小池聖彦, 小寺泰弘

日本外科学会定期学術集会抄録集 Vol. 120回 page： DP - 5 2020.8

膵癌に対する膵頭十二指腸切除術の分子生物学的なsurgical marginの評価 Reviewed

砂川祐輝, 山田豪, 林真路, 高見秀樹, 猪川祥邦, 園原史訓, 栗本景介, 田中伸孟, 加藤吉康, 中川暢彦, 鈴木雄之典, 神田光郎, 田中千恵, 小林大介, 中山吾郎, 小池聖彦, 藤原道隆, 小寺泰弘

日本外科学会定期学術集会抄録集 Vol. 120回 page： SF - 2 2020.8

当院における消化器外科領域のCALNA参入と現状について Reviewed

宮田一志, 深谷昌秀, 山崎健太, 石井健太, 冨永健太, 西村康大, 小池聖彦, 小林大介, 田中千恵, 神田光郎, 清水大, 佐藤敏, 中西香企, 江畑智希, 小寺泰弘, 梛野正人

日本外科学会定期学術集会抄録集 Vol. 120回 page： SF - 7 2020.8

当科におけるUnresectable膵癌治療の検討 Reviewed

加藤吉康, 山田豪, 高見秀樹, 園原史訓, 猪川祥邦, 林真路, 服部憲史, 神田光郎, 小林大介, 田中千恵, 中山吾郎, 小池聖彦, 藤原道隆, 小寺泰弘

日本外科学会定期学術集会抄録集 Vol. 120回 page： SF - 4 2020.8

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Papers - KANDA Mitsuro