Faculty Profiles - KANDA Mitsuro

Papers - KANDA Mitsuro

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薬物療法の新展開胃癌転移制御を目指した創薬研究の展開 Reviewed

神田光郎, 田中千恵, 清水大, 中西香企, 高見秀樹, 猪川祥邦, 服部憲史, 林真路, 中山吾郎, 藤原道隆, 小寺泰弘

日本胃癌学会総会記事 Vol. 95回 page： 164 - 164 2023.2

進行胃癌に対しての腹腔鏡下胃切除術の注意点と短期成績 Reviewed

杉田静紀, 宮田一志, 田中千恵, 神田光郎, 中西香企, 小寺泰弘, 江畑智希

日本胃癌学会総会記事 Vol. 95回 page： 345 - 345 2023.2

miR-877-3p as a Potential Tumour Suppressor of Oesophageal Squamous Cell Carcinoma Reviewed

Fukuda Takuma, Baba Hayato, Okumura Tomoyuki, Kanda Mitsuro, Akashi Takahisa, Tanaka Haruyoshi, Miwa Takeshi, Watanabe Toru, Hirano Katsuhisa, Sekine Shinichi, Hashimoto Isaya, Shibuya Kazuto, Hojo Shozo, Yoshioka Isaku, Matsui Koshi, Kodera Yasuhiro, Fujii Tsutomu

ANTICANCER RESEARCH Vol. 43 ( 1 ) page： 35 - 43 2023.1

A multi-institutional study to evaluate the feasibility of next-generation sequencing and genomic analysis using formalin-fixed, paraffin-embedded biopsies of gastric cancer Reviewed

Kanda Mitsuro, Terashima Masanori, Kinoshita Takahiro, Yabusaki Hiroshi, Tokunaga Masanori, Kodera Yasuhiro

GASTRIC CANCER Vol. 26 ( 1 ) page： 108 - 115 2023.1

ASO Author Reflections: Gamma-Aminobutyric Acid Type A Receptor Subunit Delta as a Potential Therapeutic Target in Gastric Cancer Reviewed

Sawaki Koichi, Kanda Mitsuro, Kodera Yasuhiro

ANNALS OF SURGICAL ONCOLOGY Vol. 30 ( 1 ) page： 637 - 638 2023.1

Preoperative indocyanine green fluorescence injection to accurately determine a proximal margin during robotic distal gastrectomy. Reviewed

Koki Nakanishi, Chie Tanaka, Mitsuro Kanda, Dai Shimizu, Kazuhiro Furukawa, Michitaka Fujiwara, Hiroki Kawashima, Yasuhiro Kodera

Asian journal of endoscopic surgery Vol. 16 ( 1 ) page： 152 - 156 2023.1

Language：English Publishing type：Research paper (scientific journal)

INTRODUCTION: Adequate surgical margins following gastrectomy for gastric cancer are required. In addition, a method for accurately detecting tumor location without palpation is needed during robotic surgery. Although several methods have been reported, most of these either lack accuracy or require increased time and effort during intraoperative detection. Herein, we introduce a new method for detecting tumor location using preoperative indocyanine green (ICG) marking and the built-in ICG detection system of the da Vinci Xi Surgical System in robotic gastrectomy to determine appropriate surgical margins. MATERIALS AND SURGICAL TECHNIQUE: We used this method to determine the resection line in six patients who underwent robotic distal gastrectomy for clinical T1 gastric cancer. One to three days before surgery, ICG was diluted to 1.0 mg/mL, and 0.1 mL of this diluted ICG solution was endoscopically injected at one site into the submucosal layer of the stomach, 1 cm proximal to the tumor edge. Gastrectomy was performed using the da Vinci Xi surgical platform, equipped with a near-infrared fluorescence imaging system (Firefly®). The diameter of the fluorescent signal during gastrectomy was estimated to be approximately 2 cm. The resection line was determined on the outer edge of the fluorescent signal, which ensured a tumor-free margin of ≥2 cm. Fluorescent signals were successfully observed in all cases. Moreover, the required 2-cm surgical margin was achieved in all cases. DISCUSSION: We could successfully determine proximal margins using preoperative ICG injection marking during robotic distal gastrectomy for gastric cancer.

DOI： 10.1111/ases.13121

Web of Science

PubMed

Gamma-aminobutyric Acid Type A Receptor Subunit Delta as a Potential Therapeutic Target in Gastric Cancer Reviewed

Sawaki Koichi, Kanda Mitsuro, Baba Hayato, Inokawa Yoshikuni, Hattori Norifumi, Hayashi Masamichi, Tanaka Chie, Kodera Yasuhiro

ANNALS OF SURGICAL ONCOLOGY Vol. 30 ( 1 ) page： 628 - 636 2023.1

Controlling Nutritional Status Score Serves as a Prognosticator in Esophageal Squamous Cell Carcinoma: Optimal Timing of Evaluation of Patients Undergoing Neoadjuvant Treatment Reviewed

Nonogaki Ikue, Kanda Mitsuro, Shimizu Dai, Inokawa Yoshikuni, Hattori Norifumi, Hayashi Masamichi, Tanaka Chie, Koike Masahiko, Nakayama Goro, Kodera Yasuhiro

WORLD JOURNAL OF SURGERY Vol. 47 ( 1 ) page： 217 - 226 2023.1

OPLAH Protein Expression Stratifies the Prognosis of Patients With Squamous Cell Carcinoma of the Esophagus Reviewed

Shimizu Dai, Kanda Mitsuro, Kishida Takayoshi, Nakamura Shunsuke, Sasahara Masahiro, Ueda Sei, Sato Yusuke, Inokawa Yoshikuni, Hattori Norifumi, Hayashi Masamichi, Tanaka Chie, Motoyama Satoru, Kodera Yasuhiro

CANCER GENOMICS & PROTEOMICS Vol. 20 ( 4 ) page： 343 - 353 2023

A Multicenter Randomized Phase II Trial Investigating the Effect of Polyglycolic Acid Sheet on the Prevention of Pancreatic Fistula After Gastrectomy with Prophylactic Lymph Node Dissection. Reviewed International journal

Dai Shimizu, Chie Tanaka, Mitsuro Kanda, Koki Nakanishi, Seiji Ito, Yachiyo Kuwatsuka, Masahiko Ando, Kenta Murotani, Michitaka Fujiwara, Yasuhiro Kodera

Clinical and experimental gastroenterology Vol. 16 page： 169 - 172 2023

Language：English Publishing type：Research paper (scientific journal)

Pancreatic fistula after gastrectomy with lymph node dissection is associated with prolonged hospital stay and critical complications such as intra-abdominal bleeding and sepsis. Polyglycolic acid (PGA) sheets are absorbable suture reinforcement materials. A randomized Phase II trial has been planned to evaluate the effect of PGA sheets on preventing postoperative pancreatic fistula. A total of 320 patients will be recruited from thirteen institutions. Patients who are scheduled to undergo distal or total gastrectomy will be randomly allocated into the PGA group or control group, and the dissected area around the pancreas will be covered by the PGA sheet in the PGA group. The primary endpoint will be the maximum value of drain amylase concentration up to 5 days after surgery. The secondary endpoints will be as follows: transition of value of amylases of drain discharge, incidence of pancreatic fistula, incidence of intra-abdominal abscess, white blood cell count, value of C-reactive protein, incidence of postoperative complication, duration of antibiotic agents administration, duration of abdominal drainage, usage of octreotide, duration of hospital stay, incidence of bleeding in abdominal cavity, mortality, and incidence of reoperation.

DOI： 10.2147/CEG.S421531

Web of Science

PubMed

Preoperative docetaxel, cisplatin, and fluorouracil treatment with pegfilgrastim on day 7 for patients with esophageal cancer: A phase II study. Reviewed International journal

Osamu Maeda, Masahide Fukaya, Masahiko Koike, Kazushi Miyata, Mitsuro Kanda, Kazuki Nishida, Masahiko Ando, Yasuhiro Kodera, Yuichi Ando

Asia-Pacific journal of clinical oncology Vol. 18 ( 6 ) page： 578 - 585 2022.12

Language：English Publishing type：Research paper (scientific journal)

AIMS: The docetaxel and cisplatin plus 5-fluorouracil (5-FU) (DCF) regimen is expected to be superior to cisplatin plus 5-FU for the preoperative treatment of esophageal cancer. However, a high risk of adverse effects, including febrile neutropenia (FN), has been reported. To evaluate the effectiveness and safety of DCF with prophylactic pegfilgrastim, we conducted a phase II study. METHODS: The regimen consisted of intravenous administration of docetaxel (70 mg/m2 per day) and cisplatin (70 mg/m2 per day) on day 1 and a continuous infusion of 5-FU (750 mg/m2 per day) on days 1-5. A single 3.6-mg dose of pegfilgrastim was given as a subcutaneous injection on day 7 of each cycle. This regimen was repeated every 3 weeks for a maximum of three cycles. The primary endpoint was the grade-2/3 histopathological response rate. RESULTS: Thirty-seven eligible patients were enrolled and received DCF. Thirty-four patients underwent esophagectomy. Two patients received chemoradiotherapy or radiotherapy without surgery. One patient withdrew consent and ended his hospital visit. One patient received additional radiotherapy before surgery. Histopathological responses of grade 3, grade 2, grade 1b, and grade 1a were observed in two (5.4%), 14 (37.8%), 10 (27.0%), and seven (18.9%) patients, respectively, and the primary endpoint was met. Of the 37 eligible patients, 11 (29.7%) developed FN in the first cycle. CONCLUSIONS: Since the histopathological responses were as expected, DCF with prophylactic pegfilgrastim is considered to be effective as preoperative chemotherapy. However, the prophylactic use of pegfilgrastim on day 7 was insufficient to prevent FN.

DOI： 10.1111/ajco.13755

Web of Science

PubMed

胃切除術におけるインドシアニングリーンを用いた病変のマーキング法 Reviewed

飯塚彬光, 田中千恵, 中西香企, 清水大, 神田光郎, 林真路, 中山吾郎, 小寺泰弘

日本内視鏡外科学会雑誌 Vol. 27 ( 7 ) page： 2072 - 2072 2022.12

女性医師の活躍できる内視鏡外科手術と働き方改革の在り方とは? 腹腔鏡下手術における使用デバイスの操作性に関する検討 Reviewed

田中千恵, 中西香企, 清水大, 梅田晋一, 猪川祥邦, 田中伸孟, 高見秀樹, 服部憲史, 林真路, 神田光郎, 中山吾郎, 小寺泰弘

日本内視鏡外科学会雑誌 Vol. 27 ( 7 ) page： 415 - 415 2022.12

女性医師の活躍できる内視鏡外科手術と働き方改革の在り方とは? 腹腔鏡下手術における使用デバイスの操作性に関する検討 Reviewed

田中千恵, 中西香企, 清水大, 梅田晋一, 猪川祥邦, 田中伸孟, 高見秀樹, 服部憲史, 林真路, 神田光郎, 中山吾郎, 小寺泰弘

日本内視鏡外科学会雑誌 Vol. 27 ( 7 ) page： 415 - 415 2022.12

当院におけるロボット支援下胃切除術教育の工夫 Reviewed

田中千恵, 中西香企, 清水大, 梅田晋一, 猪川祥邦, 高見秀樹, 服部憲史, 林真路, 神田光郎, 中山吾郎, 小寺泰弘

日本内視鏡外科学会雑誌 Vol. 27 ( 7 ) page： 1649 - 1649 2022.12

当院におけるロボット支援下胃切除術教育の工夫 Reviewed

田中千恵, 中西香企, 清水大, 梅田晋一, 猪川祥邦, 高見秀樹, 服部憲史, 林真路, 神田光郎, 中山吾郎, 小寺泰弘

日本内視鏡外科学会雑誌 Vol. 27 ( 7 ) page： 1649 - 1649 2022.12

胃切除術におけるインドシアニングリーンを用いた病変のマーキング法 Reviewed

飯塚彬光, 田中千恵, 中西香企, 清水大, 神田光郎, 林真路, 中山吾郎, 小寺泰弘

日本内視鏡外科学会雑誌 Vol. 27 ( 7 ) page： 2072 - 2072 2022.12

胃癌腹膜播種に対するPTEGの使用経験 Reviewed

杉山史剛, 中西香企, 田中千恵, 神田光郎, 清水大, 高見秀樹, 猪川祥邦, 服部憲史, 林真路, 中山吾郎, 藤原道隆, 小寺泰弘

日本消化器病学会東海支部例会プログラム抄録集 Vol. 137回 page： 73 - 73 2022.11

胃癌腹膜播種に対するPTEGの使用経験 Reviewed

杉山史剛, 中西香企, 田中千恵, 神田光郎, 清水大, 高見秀樹, 猪川祥邦, 服部憲史, 林真路, 中山吾郎, 藤原道隆, 小寺泰弘

日本消化器病学会東海支部例会プログラム抄録集 Vol. 137回 page： 73 - 73 2022.11

ASO Visual Abstract: Gamma-Aminobutyric Acid Type A Receptor Subunit Delta as a Potential Therapeutic Target in Gastric Cancer Reviewed

Sawaki Koichi, Kanda Mitsuro, Baba Hayato, Inokawa Yoshikuni, Hattori Norifumi, Hayashi Masamichi, Tanaka Chie, Kodera Yasuhiro

ANNALS OF SURGICAL ONCOLOGY Vol. 30 ( 1 ) page： 639 - 640 2022.10

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Papers - KANDA Mitsuro