Faculty Profiles - KANDA Mitsuro

Papers - KANDA Mitsuro

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膵癌に対する膵頭十二指腸切除術の分子生物学的なsurgical marginの評価 Reviewed

砂川祐輝, 山田豪, 林真路, 高見秀樹, 猪川祥邦, 園原史訓, 栗本景介, 田中伸孟, 加藤吉康, 中川暢彦, 鈴木雄之典, 神田光郎, 田中千恵, 小林大介, 中山吾郎, 小池聖彦, 藤原道隆, 小寺泰弘

日本外科学会定期学術集会抄録集 Vol. 120回 page： SF - 2 2020.8

高齢者胃切除手術症例における前向き高齢者機能評価 Reviewed

田中千恵, 神田光郎, 猪川祥邦, 小林大介, 清水大, 園原史訓, 高見秀樹, 服部憲史, 林真路, 山田豪, 中山吾郎, 小池聖彦, 藤原道隆, 小寺泰弘

日本外科学会定期学術集会抄録集 Vol. 120回 page： SF - 4 2020.8

食道癌術前化学療法中にRenal Salt-Wasting Syndromeを生じた1例 Reviewed

山本周平, 神田光郎, 小池聖彦, 高見秀樹, 清水大, 田中千恵, 小林大介, 園原史訓, 猪川祥邦, 服部憲史, 林真路, 山田豪, 中山吾郎, 藤原道隆, 小寺泰弘

日本外科学会定期学術集会抄録集 Vol. 120回 page： RS - 4 2020.8

食道扁平上皮癌の術後長期予後因子としてのmodified systemic inflammation scoreの意義 Reviewed

清水大, 神田光郎, 小池聖彦, 園原史訓, 高見秀樹, 猪川祥邦, 服部憲史, 林真路, 田中千恵, 小林大介, 山田豪, 中山吾郎, 藤原道隆, 小寺泰弘

日本外科学会定期学術集会抄録集 Vol. 120回 page： DP - 5 2020.8

食道扁平上皮癌におけるMAGE-D4蛋白の発現、機能、予後の検討 Reviewed

宇野泰朗, 神田光郎, 佐藤雄亮, 清水大, 梅田晋一, 服部憲史, 林真路, 田中千恵, 小林大介, 山田豪, 中山吾郎, 小池聖彦, 本山悟, 小寺泰弘

日本外科学会定期学術集会抄録集 Vol. 120回 page： SF - 5 2020.8

食道扁平上皮癌におけるKCNJ15遺伝子の機能解析と、その組織中発現における臨床的意義の検討 Reviewed

中村俊介, 神田光郎, 小池聖彦, 清水大, 小林大介, 田中千恵, 園原史訓, 高見秀樹, 猪川祥邦, 服部憲史, 林真路, 山田豪, 中山吾郎, 藤原道隆, 小寺泰弘

日本外科学会定期学術集会抄録集 Vol. 120回 page： DP - 8 2020.8

食道亜全摘術後肺炎予測因子に関する検討 Reviewed

澤木康一, 神田光郎, 小池聖彦, 清水大, 田中千恵, 小林大介, 園原史訓, 服部憲史, 猪川祥邦, 高見秀樹, 林真路, 山田豪, 中山吾郎, 藤原道隆, 小寺泰弘

日本外科学会定期学術集会抄録集 Vol. 120回 page： SF - 4 2020.8

術前CT画像を利用した膵内脂肪量と体組成による膵液瘻予測因子の検討 Reviewed

田中克仁, 山田豪, 園原史訓, 猪川祥邦, 高見秀樹, 服部憲史, 林真路, 神田光郎, 田中千恵, 小林大介, 中山吾郎, 小池聖彦, 藤原道隆, 小寺泰弘

日本外科学会定期学術集会抄録集 Vol. 120回 page： SF - 1 2020.8

膵頸部癌における臨床病理学的特徴 Reviewed

栗本景介, 山田豪, 鈴木雄之典, 中川暢彦, 加藤吉康, 田中伸孟, 砂川祐輝, 園原史訓, 猪川祥邦, 高見秀樹, 林真路, 神田光郎, 田中千恵, 中山吾郎, 小池聖彦, 小寺泰弘

日本外科学会定期学術集会抄録集 Vol. 120回 page： SF - 3 2020.8

膵頭十二指腸切除術施行膵癌患者における周術期メインおよびリパクレオン投与の安全性と有用性 Reviewed

中川暢彦, 山田豪, 多代充, 栗本景介, 園原史訓, 清水大, 猪川祥邦, 高見秀樹, 服部憲史, 林真路, 神田光郎, 田中千恵, 小林大介, 中山吾郎, 小池聖彦, 藤原道隆, 小寺泰弘, 小寺泰弘

日本外科学会定期学術集会抄録集 Vol. 120回 page： DP - 5 2020.8

膵頭十二指腸切除術における胆管空腸吻合部狭窄のリスクファクターに関する検討 Reviewed

鈴木雄之典, 山田豪, 園原史訓, 猪川祥邦, 高見秀樹, 服部憲史, 林真路, 神田光郎, 小林大介, 田中千恵, 中山吾郎, 小池聖彦, 藤原道隆, 小寺泰弘

日本外科学会定期学術集会抄録集 Vol. 120回 page： DP - 4 2020.8

膵癌組織における癌幹細胞マーカー発現が切除後予後に与える影響についての検討 Reviewed

猪川祥邦, 山田豪, 林真路, 砂川祐輝, 園原史訓, 高見秀樹, 服部憲史, 神田光郎, 小林大介, 田中千恵, 中山吾郎, 小池聖彦, 小寺泰弘

日本外科学会定期学術集会抄録集 Vol. 120回 page： DP - 5 2020.8

胃癌における術前血清腫瘍マーカーの再発予測としての至適カットオフ値の検討 Reviewed

佐藤敏, 神田光郎, 伊藤誠二, 望月能成, 寺本仁, 石榑清, 村井俊文, 浅田崇洋, 石山聡治, 松下英信, 清水大, 宮田一志, 小林大介, 田中千恵, 深谷昌秀, 小池聖彦, 藤原道隆, 小寺泰弘

日本外科学会定期学術集会抄録集 Vol. 120回 page： SF - 2 2020.8

ASO Author Reflections: KCNJ15 Expression and Malignant Behavior of Esophageal Squamous Cell Carcinoma. Reviewed International journal

Shunsuke Nakamura, Mitsuro Kanda, Yasuhiro Kodera

Annals of surgical oncology Vol. 27 ( 7 ) page： 2569 - 2570 2020.7

KCNJ15 Expression and Malignant Behavior of Esophageal Squamous Cell Carcinoma. Reviewed International journal

Shunsuke Nakamura, Mitsuro Kanda, Masahiko Koike, Dai Shimizu, Shinichi Umeda, Norifumi Hattori, Masamichi Hayashi, Chie Tanaka, Daisuke Kobayashi, Suguru Yamada, Kenji Omae, Yasuhiro Kodera

Annals of surgical oncology Vol. 27 ( 7 ) page： 2559 - 2568 2020.7

Language：Japanese Publishing type：Research paper (scientific journal)

BACKGROUND: We aimed to clarify the role of potassium voltage-gated channel subfamily J member 15 (KCNJ15) in esophageal squamous cell carcinoma (ESCC) cells and its potential as a prognosticator in ESCC patients. METHODS: KCNJ15 transcription levels were evaluated in 13 ESCC cell lines and polymerase chain reaction (PCR) array analysis was conducted to detect coordinately expressed genes with KCNJ15. The biological functions of KCNJ15 in cell invasion, proliferation, migration, and adhesion were validated through small interfering RNA-mediated knockdown experiments. Cell proliferation was further evaluated through the forced expression experiment. KCNJ15 expression was detected in 200 ESCC tissues by quantitative real-time reverse transcription PCR (qRT-PCR) and analyzed in 64 representative tissues by immunohistochemistry. Correlations between KCNJ15 expression levels and clinicopathological features were also analyzed. RESULTS: The KCNJ15 expression levels varied widely in ESCC cell lines and correlated with COL3A1, JAG1, and F11R. Knockdown of KCNJ15 expression significantly repressed cell invasion, proliferation, and migration of ESCC cells in vitro. Furthermore, overexpression of KCNJ15 resulted in increased cell proliferation. Patients were stratified using the cut-off value of KCNJ15 messenger RNA (mRNA) levels in 200 ESCC tissues using receiver operating characteristic curve analysis; the high KCNJ15 expression group had significantly shorter overall and disease-free survival times. In multivariable analysis, high expression of KCNJ15 was identified as an independent poor prognostic factor. Staining intensity of in situ KCNJ15 protein expression tended to be associated with KCNJ15 mRNA expression levels. CONCLUSIONS: KCNJ15 is involved in aggressive tumor phenotypes of ESCC cells and its tissue expression levels may be useful as a prognosticator of patients with ESCC.

DOI： 10.1245/s10434-019-08189-8

Web of Science

PubMed

Propensity-score-matched analysis of a multi-institutional dataset to compare postoperative complications between Billroth I and Roux-en-Y reconstructions after distal gastrectomy. Reviewed

Koki Nakanishi, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Dai Shimizu, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association Vol. 23 ( 4 ) page： 734 - 745 2020.7

Language：Japanese Publishing type：Research paper (scientific journal)

BACKGROUND: Few well-controlled studies have compared postoperative complications between Billroth I (B-I) and Roux-en-Y (R-Y). The aim of the present study was to compare the incidence of overall and severe postoperative complications by reconstruction method after distal gastrectomy. METHODS: We performed a multi-institutional dataset study of patients who underwent distal gastrectomy with B-I or R-Y reconstruction from 2010 to 2014. Using propensity scores to strictly balance the significant variables, we compared postoperative complications between the techniques. RESULTS: After matching, we enrolled 1014 patients (n = 507 in each group). The incidence of postoperative complications in the R-Y group was significantly higher vs the B-I group (29% vs 17%, P < 0.0001). The incidence of intra-abdominal abscess (4.3% vs 1.8%, P = 0.0177), bowel obstruction (2.6% vs 0.6%, P = 0.0203), and delayed gastric emptying (5.3% vs 1.0%, P < 0.0001) in the R-Y group was significantly higher vs the B-I group, respectively; we saw no significant difference in leakage (3.4% vs 4.1%, P = 0.5084). The incidence of grade ≥ III severe postoperative complications in the R-Y group was significantly higher vs the B-I group (13% vs 7.1%, P = 0.0013). Multivariable analysis showed that R-Y reconstruction was a strong independent risk factor for overall postoperative complications (odds ratio 1.58, P = 0.0044) and grade ≥ III severe postoperative complications (odds ratio 1.75, P = 0.0127). A forest plot revealed that R-Y reconstruction was associated with a greater risk of both overall and grade ≥ III severe postoperative complications in any subgroups. CONCLUSIONS: R-Y reconstruction was associated with increasing overall postoperative complications, as well as severe postoperative complications.

DOI： 10.1007/s10120-020-01048-6

Web of Science

PubMed

Novel Prognostic Implications of DUPAN-2 in the Era of Initial Systemic Therapy for Pancreatic Cancer. Reviewed International journal

Sunagawa Y, Yamada S, Sato Y, Morimoto D, Sonohara F, Takami H, Inokawa Y, Hayashi M, Kanda M, Tanaka C, Kobayashi D, Nakayama G, Koike M, Fujiwara M, Fujii T, Kodera Y

Annals of surgical oncology Vol. 27 ( 6 ) page： 2081 - 2089 2020.6

Language：Japanese Publishing type：Research paper (scientific journal)

BACKGROUND: This study aimed to explore the impact of serum tumor markers on survival for patients with pancreatic cancer (PC) who received initial systemic therapy (IST) followed by surgery. METHODS: Between April 2010 and July 2018, 285 consecutive patients who underwent curative intent surgery for PC were enrolled in the study. The relation between carbohydrate antigen 19-9 and duke pancreatic monoclonal antigen type 2 (DUPAN-2) after IST was analyzed as well as PC prognosis. RESULTS: The study identified 95 patients who underwent systemic chemotherapy with or without radiotherapy as IST from the our prospectively maintained database at the Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Japan. Survival analysis of the 95 patients showed significant differences in recurrence-free survival (RFS) and overall survival (OS) between the DUPAN-2-normalized (D-normalized) and DUPAN-2-unnormalized (D-unnormalized) groups (median RFS, 24.1 vs. 14.2 months, p = 0.003; median OS, not reached vs. 29.6 months, p = 0.003). In addition, a tendency of differences in survival was observed between the D-normalized and D-unnormalized groups with borderline resectable PC (RFS, 20.1 vs. 14.2 months, p = 0.052; OS, not reached vs. 29.6 months, p = 0.081), and significant differences in survival were observed between the D-normalized and D-unnormalized groups with unresectable PC (RFS, 25.1 vs. 12.1 months, p < 0.001; OS, not reached vs. 11.4 months, p < 0.001). Furthermore, multivariate analysis demonstrated that normalized DUPAN-2 independently predicted survival of resected PC [RFS: hazard ratio (HR) 2.180; 95% confidence interval (CI) 1.16-4.08, p = 0.015; OS: HR 2.806; 95% CI 1.19-6.62, p = 0.018]. CONCLUSIONS: During IST, DUPAN-2 normalization may potentially predict prolonged survival for PC patients and optimal timing for conversion surgery in IST.

DOI： 10.1245/s10434-019-07981-w

Web of Science

PubMed

PRAME as a Potential Biomarker for Liver Metastasis of Gastric Cancer. Reviewed International journal

Hayato Baba, Mitsuro Kanda, Koichi Sawaki, Shinichi Umeda, Takashi Miwa, Dai Shimizu, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Yasuhiro Kodera, Tsutomu Fujii

Annals of surgical oncology Vol. 27 ( 6 ) page： 2071 - 2080 2020.6

Language：Japanese Publishing type：Research paper (scientific journal)

BACKGROUND: Liver metastasis of gastric cancer (GC) is highly associated with poor prognosis. The development of sensitive biomarkers for detecting and predicting liver metastasis is required for better clinical outcome. OBJECTIVE: In this study, we aimed to identify novel genes associated with liver metastasis of GC. METHODS: Global expression profiling of 57,749 genes was performed using surgically resected gastric tissues from four patients with liver metastasis to identify candidate genes. The mRNA expression levels of the selected candidate gene were analyzed in the resected gastric tissues of 300 GC patients and correlated with clinicopathological parameters. Fourteen GC cell lines were subjected to mRNA expression and polymerase chain reaction (PCR) array analysis. RESULTS: Among 25 candidate genes identified by transcriptome analysis, preferentially expressed antigen of melanoma (PRAME) was selected for subsequent analyses. mRNA expression analysis of clinical samples revealed the aberrant expression of PRAME in GC tissues, and its high expression was significantly related to differentiated phenotype and vessel invasion, as well as liver metastasis. High PRAME expression was significantly associated with hepatic recurrence after curative surgery, and cumulative incidences of hepatic recurrence were significantly greater in patients with high PRAME expression compared with patients with low PRAME expression. In an in vitro analysis, overexpression was observed in all GC cell lines compared with a normal epithelial cell line. PCR array analysis revealed the coordinate expression of MMP9, OCLN, IL1RN, and MST1R. CONCLUSIONS: PRAME is related to the malignant potential of GC and could serve as a novel biomarker for the detection and prediction of liver metastasis.

DOI： 10.1245/s10434-019-07985-6

Web of Science

PubMed

集学的治療による病勢コントロール後に外腸骨リンパ節転移を切除しえた膵NETの1例 Reviewed

鈴木雄之典, 山田豪, 高見秀樹, 園原史訓, 猪川祥邦, 服部憲史, 林真路, 神田光郎, 田中千恵, 中山吾郎, 小池聖彦, 藤原道隆, 小寺泰弘

日本消化器病学会東海支部例会プログラム抄録集 Vol. 132回 page： 55 - 55 2020.6

Fraser extracellular matrix complex subunit 1 promotes liver metastasis of gastric cancer. Reviewed International journal

Umeda S, Kanda M, Miwa T, Tanaka H, Tanaka C, Kobayashi D, Hayashi M, Yamada S, Nakayama G, Koike M, Kodera Y

International journal of cancer Vol. 146 ( 10 ) page： 2865 - 2876 2020.5

Language：Japanese Publishing type：Research paper (scientific journal)

Liver metastasis is often fatal in patients with gastric cancer, therefore, we aimed to identify genes associated with the mechanisms of liver metastasis of gastric cancer (GC) and to investigate their potential to predict recurrence and to serve as targets of therapy. Recurrence pattern-specific transcriptome analysis was performed to identify liver metastasis-associated genes. A stable knockout cell line was generated to investigate metabolic pathways that contribute to the malignant phenotype in vitro and vivo. Three hundred GC patients were analyzed to demonstrate an association between gene expression levels and clinicopathological parameters. As a results extracellular matrix complex subunit 1 (FRAS1) was identified as a liver metastasis-associated gene. Pathway analysis revealed that FRAS1 expression was significantly correlated with the expression of genes encoding TGFB1, MAP1B, AHNAK, BMP2, MUC1, BIRC5, MET, CDH1, RB1 and MKI67. FRAS1 expression was associated with the activation of the EGFR and PI3K signaling pathways. The proliferation ability of FRAS1 knockout cell line (FRAS1-KO) was inhibited compared to that of the parent cell line through caspase activity increment and cell cycle alteration. FRAS1-KO cells exhibited increased responsiveness to oxygen stress and diminished stemness, invasiveness, and migration. Mouse models of GC revealed decreases in tumor formation and generation of metastasis by FRAS1-KO cells. Moreover, the cumulative liver recurrence rate was significantly increased in patients with GC with high FRAS1 expression levels. We concluded that FRAS1 contributes to the malignant phenotype of GC, especially liver metastasis, and may therefore serve as a predictive marker or a target for treating liver metastasis.

DOI： 10.1002/ijc.32705

Web of Science

PubMed

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Papers - KANDA Mitsuro