Faculty Profiles - YOSHIMURA, Takashi

Papers - YOSHIMURA, Takashi

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Genetic and molecular analysis of wild-derived arrhythmic mice. Reviewed

Watanabe T, Suzuki T, Ishikawa A, Yokota Y, Ueda HR, Yamada RG, Tei H, Imai S, Tomida S, Kobayashi J, Naito E, Yasuo S, Nakao N, Namikawa T, Yoshimura T, Ebihara S

PloS one Vol. 4 ( 1 ) page： e4301 2009.1

Language：English Publishing type：Research paper (scientific journal) Publisher：PUBLIC LIBRARY SCIENCE

A new circadian variant was isolated by screening the intercross offspring of wild-caught mice (Mus musculus castaneus). This variant was characterized by an initial maintenance of damped oscillations and subsequent loss of rhythmicity after being transferred from light-dark (LD) cycles to constant darkness (DD). To map the genes responsible for the persistence of rhythmicity (circadian ratio) and the length of free-running period (tau), quantitative trait locus (QTL) analysis was performed using F-2 mice obtained from an F-1 cross between the circadian variant and C57BL/6J mice. As a result, a significant QTL with a main effect for circadian ratio (Arrhythmicity; Arrh-1) was mapped on Chromosome (Chr) 8. For tau, four significant QTLs, Short free-running period (Sfp-1) (Chr 1), Sfp-2 (Chr 6), Sfp-3 (Chr 8), Sfp-4 (Chr 11) were determined. An epistatic interaction was detected between Chr 3 (Arrh-2) and Chr 5 (Arrh-3). An in situ hybridization study of clock genes and mouse Period1::luciferase (mPer1::luc) real-time monitoring analysis in the suprachiasmatic nucleus (SCN) suggested that arrhythmicity in this variant might not be attributed to core circadian mechanisms in the SCN neurons. Our strategy using wild-derived variant mice may provide a novel opportunity to evaluate circadian and its related disorders in human that arise from the interaction between multiple variant genes.

DOI： 10.1371/journal.pone.0004301

Web of Science

Scopus

PubMed

Identification of the photoperiodic signal transduction pathway regulating seasonal reproduction using the functional genomics approach. Invited Reviewed

Ono H, Nakao N, Yoshimura T

General and Comparative Endocrinology Vol. 163 page： 2-6 2009

Molecular mechanism of seasonal time measurement in vertebrates

Yoshimura Takashi

NEUROSCIENCE RESEARCH Vol. 65 page： S23 - S23 2009

Localization of circadian clock protein in the photoperiodic signal transduction machinery

Ikegami Keisuke, Katou Yasuhiro, Higashi Kumiko, Yoshimura Takashi

NEUROSCIENCE RESEARCH Vol. 65 page： S232 - S232 2009

Effect of dorsal hypothalamic lesion on seasonal reproduction in Japanese quail

Nakane Yusuke, Higashi Kumiko, Iigo Masayuki, Ebihara Shizufumi, Yoshimura Takashi

NEUROSCIENCE RESEARCH Vol. 65 page： S232 - S232 2009

QTL analysis of behavioral despair in mice

Saki Imai, Shigeru Tomida, Takashi Yoshimura, Shizufumi Ebihara

GENES & GENETIC SYSTEMS Vol. 83 ( 6 ) page： 491 - 491 2008.12

Functional genomics of seasonal time measurement

Yoshimura Takashi

GENES & GENETIC SYSTEMS Vol. 83 ( 6 ) page： 530 - 530 2008.12

Identification of a quantitative trait gene underlying behavioral despair using CS mice with abnormal circadian rhythms

Shizufumi Ebihara, Shigeru Tomida, Takayoshi Mamiya, Hirotake Sakamaki, Tsutomu Kameyama, Toshitaka Nabeshima, Junya Kobayashi, Yuka Iwaki, Saki Imai, Akira Ishikawa, Kuniya Abe, Takashi Yoshimura

GENES & GENETIC SYSTEMS Vol. 83 ( 6 ) page： 531 - 531 2008.12

Involvement of thyrotropin in photoperiodic signal transduction in mice

Ono Hiroko, Hoshino Yuta, Yasuo Shinobu, Watanabe Miwa, Nakane Yusuke, Murai Atsushi, Ebihara Shizufumi, Korf Horst-Werner, Yoshimura Takashi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 105 ( 47 ) page： 18238 - 18242 2008.11

Thyroid hormones and seasonal reproductive neuroendocrine interactions

Nakao Nobuhiro, Ono Hiroko, Yoshimura Takashi

REPRODUCTION Vol. 136 ( 1 ) page： 1 - 8 2008.7

Reorganization of the suprachiasmatic nucleus by photic and non-photic environments Reviewed

Shizufumi Ebihara, Emiko Naito, Tsuyoshi Watanabe, Takashi Yoshimura

SLEEP AND BIOLOGICAL RHYTHMS Vol. 6 ( 2 ) page： 62 - 66 2008.4

Language：English Publishing type：Research paper (scientific journal) Publisher：BLACKWELL PUBLISHING

To better understand alterations in suprachiasmatic nucleus (SCN) physiology by photic and non-photic environments, we analyzed clock gene expression in the mouse SCN by in situ hybridization and real-time monitoring of mPerl::luc bioluminescence. An artificial light : dark : light : dark 7:5:7:S condition induced antiphase oscillation of the clock gene in the dorsomedial-like (DM-like) and the ventrolateral-like (VL-like) subdivisions of the SCN, in parallel with maintaining synchronization between the two sides of the SCN. This antiphase oscillation seems to be responsible for the bimodal rhythms of mPer1 bioluminescence observed in the entire SCN and the components of splitting locomotor activity. A long photoperiod (LP) induced the phase advance of the rhythms of clock gene expression in the caudal SCN relative to those in the rostral SCN. In addition, in the middle SCN, the rhythms of the VL-like subdivision phase-led those in the DM-like subdivision. The mPer1::luc rhythms in the entire coronal slice obtained from the middle SCN exhibited two peaks with a wide peak width under LP conditions. Imaging analysis of the mPerl::luc rhythms revealed wide regional variations in the peak time in the rostral half of the SCN. These variations were not due to alterations in the waveform of a single SCN neuronal rhythm. In CS mice which easily entrain to daily restricted feeding (RF) cycles, the peak width for mPer1::luc bioluminescence rhythms in the SCN markedly increased during the RF schedule under LID conditions. These data in CS mice suggest non-photic cues alter SCN organization and provided a new method to reveal subdivisional changes of the SCN by feeding cues.

DOI： 10.1111/j.1479-8425.2008.00345.x

Web of Science

Reorganization of the suprachiasmatic nucleus coding for day length Reviewed

Emiko Naito, Tsuyoshi Watanabe, Hajime Tei, Takashi Yoshimura, Shizufumi Ebihara

JOURNAL OF BIOLOGICAL RHYTHMS Vol. 23 ( 2 ) page： 140 - 149 2008.4

Language：English Publishing type：Research paper (scientific journal) Publisher：SAGE PUBLICATIONS INC

In mammals, the suprachiasmatic nucleus (SCN), the circadian pacemaker, receives light information via the retina and functions in the entrainment of circadian rhythms and in phasing the seasonal responses of behavioral and physiological functions. To better understand photoperiod-related alterations in the SCN physiology, we analyzed the clock gene expression in the mouse SCN by performing in situ hybridization and real-time monitoring of the mPer1::luc bioluminescence. Under long photoperiod ( LP) conditions, the expression rhythms of mPer1 and Bma11 in the caudal SCN phase-led those in the rostral SCN; further, within the middle SCN, the rhythms in the ventrolateral (VL)-like subdivision advanced compared with those in the dorsomedial (DM)-like subdivision. The mPer1::luc rhythms in the entire coronal slice obtained from the middle SCN exhibited 2 peaks with a wide peak width under LP conditions. Imaging analysis of the mPer1::luc rhythms in several subdivisions of the rostral, middle, caudal, and horizontal SCN revealed wide regional variations in the peak time in the rostral half of the SCN under LP conditions. These variations were not due to alterations in the waveform of a single SCN neuronal rhythm. Our results indicate that LP conditions induce phase changes in the rhythms in multiple regions in the rostral half of the SCN; this leads to different circadian waveforms in the entire SCN, coding for day length.

DOI： 10.1177/0748730408314572

Web of Science

Scopus

PubMed

Thyrotrophin in the pars tuberalis triggers photoperiodic response

Nakao Nobuhiro, Ono Hiroko, Yamamura Takashi, Anraku Tsubasa, Takagi Tsuyoshi, Higashi Kumiko, Yasuo Shinobu, Katou Yasuhiro, Kageyama Saburo, Uno Yumiko, Kasukawa Takeya, Iigo Masayuki, Sharp Peter J., Iwasawa Atsushi, Suzuki Yutaka, Sugano Sumio, Niimi Teruyuki, Mizutani Makoto, Namikawa Takao, Ebihara Shizufumi, Ueda Hiroki R., Yoshimura Takashi

NATURE Vol. 452 ( 7185 ) page： 317 - U1 2008.3

春を告げる甲状腺刺激ホルモン Invited

中尾暢宏、小野ひろ子、吉村崇

比較内分泌学 Vol. 34 page： 77-82 2008

脊椎動物が春を感知するしくみをさぐる Invited

吉村崇

蛋白質　核酸　酵素 Vol. 53 page： 1865-1872 2008

鳥類の光周性の機能ゲノミクス Invited

小野ひろ子、中尾暢宏、吉村崇

時間生物学 Vol. 14 page： 2-8 2008

春を告げる甲状腺刺激ホルモン Invited

中尾暢宏, 小野ひろ子, 吉村崇

比較内分泌学 Vol. 34 page： 77-82 2008

Positional identification of a quantitative trait gene that controls "behavioral despair" in mice

Shigeru Tomida, Hirotake Sakamaki, Junya Kobayashi, Kuniya Abe, Tsutomu Kameyama, Takayoshi Mamiya, Akira Ishikawa, Takashi Yoshimura, Shizufumi Ebihara

NEUROSCIENCE RESEARCH Vol. 61 page： S70 - S70 2008

Molecular mechanisms of vertebrate photoperiodism

Shizufumi Ebihara, Shinobu Yasuo, Nobuhiro Nakao, Takashi Yoshimura

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY Vol. 148 ( 3 ) page： 338 - 338 2007.11

Temporal dynamics of type 2 deiodinase expression after melatonin injections in Syrian hamsters

Yasuo Shinobu, Yoshimura Takashi, Ebihara Shizufumi, Korf Horst-Werner

ENDOCRINOLOGY Vol. 148 ( 9 ) page： 4385 - 4392 2007.9

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Papers - YOSHIMURA, Takashi