Faculty Profiles - YOSHIMURA, Takashi

Papers - YOSHIMURA, Takashi

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Comparative Endocrinology Vol. 40 ( 152 ) page： 65 - 67 2014

Regulation of seasonal reproduction by hypothalamic activation of thyroid hormone. Reviewed International journal Open Access

Shinomiya A, Shimmura T, Nishiwaki-Ohkawa, T, Yoshimura T

Frontiers in Endocrinology Vol. 5 ( FEB ) page： 12 - 12 2014

Language：English Publishing type：Research paper (scientific journal)

Organisms living outside the tropics measure the changes in the length of the day to adapt to seasonal changes in the environment. Animals that breed during spring and summer are called long-day breeders, while those that breed during fall are called short-day breeders. Although the influence of thyroid hormone in the regulation of seasonal reproduction has been known for several decades, its precise mechanism remained unknown. Recent studies revealed that the activation of thyroid hormone within the mediobasal hypothalamus plays a key role in this phenomenon. This localized activation of the thyroid hormone is controlled by thyrotropin (thyroid-stimulating hormone) secreted from the pars tuberalis of the pituitary gland. Although seasonal reproduction is a rate-limiting factor in animal production, genes involved in photoperiodic signal transduction pathway could emerge as potential targets to facilitate domestication.

DOI： 10.3389/fendo.2014.00012

季節リズムの制御メカニズム Invited

大川妙子, 吉村崇

睡眠医療 Vol. 8 page： 203 - 209 2014

Helix-loop-helix protein Id2 stabilizes mammalian circadian oscillation under constant light conditions. Reviewed

Akihito A Adachi, Atsuko Fujioka, Mamoru Nagano, Koh-hei Masumoto, Toru Takumi, Takashi Yoshimura, Shizufumi Ebihara, Kentaro Mori, Yoshifumi Yokota, Yasufumi Shigeyoshi

Zoological science Vol. 30 ( 12 ) page： 1011 - 1018 2013.12

Language：English Publishing type：Research paper (scientific journal)

The mammalian circadian oscillator is composed of interacting positive and negative transcription events. The clock proteins PER1 and PER2 play essential roles in a negative limb of the feedback loop that generates the circadian rhythm in mammals. In addition, the proteins CLOCK and BMAL1 (also known as ARNTL) form a heterodimer that drives the Per genes via the E-box consensus sequences within their promoter regions. In the present study, we demonstrate that Id2 is involved in stabilization of the amplitudes of the circadian oscillations by suppressing transcriptional activation of clock genes Clock and Bmal1. Id2 shows dynamic oscillation in the SCN, with a peak in the late subjective night. Under constant dark conditions (DD), Id2(-/-) mice showed no apparent difference in locomotor activity, however, under constant light conditions (LL), Id2(-/-) mice exhibit aberrant locomotor activity, with lower circadian oscillation amplitudes, although the free running periods in Id2(-/-) mice show no differences from those in either wild type or heterozygous mice. Id2(-/-) animals also exhibit upregulation of Per1 in constant light, during both the subjective night and day. In wild type mice, Id2 is upregulated by constant light exposure during the subjective night. We propose that Id2 expression in the SCN contributes to maintenance of dynamic circadian oscillations.

DOI： 10.2108/zsj.30.1011

Web of Science

Scopus

PubMed

Thyroid hormone and seasonal regulation of reproduction Invited Reviewed

Yoshimura T

Frontiers in Neuroendocrinology Vol. 34 ( 3 ) page： 157 - 166 2013.8

Seasonal time measurement during reproduction. Reviewed Open Access

Keisuke Ikegami, Takashi Yoshimura

The Journal of reproduction and development Vol. 59 ( 4 ) page： 327 - 333 2013.8

Language：English Publishing type：Research paper (scientific journal)

Most species living outside the tropical zone undergo physiological adaptations to seasonal environmental changes and changing day length (photoperiod); this phenomenon is called photoperiodism. It is well known that the circadian clock is involved in the regulation of photoperiodism such as seasonal reproduction, but the mechanism underlying circadian clock regulation of photoperiodism remains unclear. Recent molecular analysis have revealed that, in mammals and birds, the pars tuberalis (PT) of the pituitary gland acts as the relay point from light receptors, which receive information about the photoperiod, to the endocrine responses. Long-day (LD)-induced thyroid-stimulating hormone (TSH) in the PT acts as a master regulator of seasonal reproduction in the ependymal cells (ECs) within the mediobasal hypothalamus (MBH) and activates thyroid hormone (TH) by inducing the expression of type 2 deiodinase in both LD and short-day (SD) breeding animals. Furthermore, the circadian clock has been found to be localized in the PT and ECs as well as in the circadian pacemaker(s). This review purposes to summarize the current knowledge concerning the involvement of the neuroendocrine system and circadian clock in seasonal reproduction.

DOI： 10.1262/jrd.2013-035

The saccus vasculosus of fish is a sensor of seasonal changes in day length Open Access

Nakane Yusuke, Ikegami Keisuke, Iigo Masayuki, Ono Hiroko, Takeda Korenori, Takahashi Daisuke, Uesaka Maiko, Kimijima Meita, Hashimoto Ramu, Arai Natsumi, Suga Takuya, Kosuge Katsuya, Abe Tomotaka, Maeda Ryosuke, Senga Takumi, Amiya Noriko, Azuma Teruo, Amano Masafumi, Abe Hideki, Yamamoto Naoyuki, Yoshimura Takashi

NATURE COMMUNICATIONS Vol. 4 2013.7

Next-generation sequencing reveals genomic features in the Japanese quail Reviewed Open Access

Ryouka Kawahara-Miki, Satoshi Sano, Mitsuo Nunome, Tsuyoshi Shimmura, Takehito Kuwayama, Shinji Takahashi, Takaharu Kawashima, Yoichi Matsuda, Takashi Yoshimura, Tomohiro Kono

GENOMICS Vol. 101 ( 6 ) page： 345 - 353 2013.6

Language：English Publishing type：Research paper (scientific journal) Publisher：ACADEMIC PRESS INC ELSEVIER SCIENCE

The Japanese quail has several advantages as a laboratory animal for biological and biomedical investigations. In this study, the draft genome of the Japanese quail was sequenced and assembled using next-generation sequencing technology. To improve the quality of the assembly, the sequence reads from the Japanese quail were aligned against the reference genome of the chicken. The final draft assembly consisted of 1.75 Gbp with an N50 contig length of 11,409 bp. On the basis of the draft genome sequence obtained, we developed 100 microsatellite markers and used these markers to evaluate the genetic variability and diversity of 11 lines of Japanese quail. Furthermore, we identified Japanese quail orthologs of spermatogenesis markers and analyzed their expression using in situ hybridization. The Japanese quail genome sequence obtained in the present study could enhance the value of this species as a model animal. (C) 2013 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.ygeno.2013.03.006

Web of Science

Scopus

PubMed

Other Link： http://orcid.org/0000-0003-2072-8851

Circadian clock determines the timing of rooster crowing Reviewed Open Access

Tsuyoshi Shimmura, Takashi Yoshimura

CURRENT BIOLOGY Vol. 23 ( 6 ) page： R231 - R233 2013.3

Circadian clock gene Per2 is not necessary for the photoperiodic response in mice. Reviewed International journal Open Access

Keisuke Ikegami, Masayuki Iigo, Takashi Yoshimura

PloS one Vol. 8 ( 3 ) page： e58482 2013.3

Language：English Publishing type：Research paper (scientific journal)

In mammals, light information received by the eyes is transmitted to the pineal gland via the circadian pacemaker, i.e., the suprachiasmatic nucleus (SCN). Melatonin secreted by the pineal gland at night decodes night length and regulates seasonal physiology and behavior. Melatonin regulates the expression of the β-subunit of thyroid-stimulating hormone (TSH; Tshb) in the pars tuberalis (PT) of the pituitary gland. Long day-induced PT TSH acts on ependymal cells in the mediobasal hypothalamus to induce the expression of type 2 deiodinase (Dio2) and reduce type 3 deiodinase (Dio3) that are thyroid hormone-activating and hormone-inactivating enzymes, respectively. The long day-activated thyroid hormone T3 regulates seasonal gonadotropin-releasing hormone secretion. It is well established that the circadian clock is involved in the regulation of photoperiodism. However, the involvement of the circadian clock gene in photoperiodism regulation remains unclear. Although mice are generally considered non-seasonal animals, it was recently demonstrated that mice are a good model for the study of photoperiodism. In the present study, therefore, we examined the effect of changing day length in Per2 deletion mutant mice that show shorter wheel-running rhythms under constant darkness followed by arhythmicity. Although the amplitude of clock gene (Per1, Cry1) expression was greatly attenuated in the SCN, the expression profile of arylalkylamine N-acetyltransferase, a rate-limiting melatonin synthesis enzyme, was unaffected in the pineal gland, and robust photoperiodic responses of the Tshb, Dio2, and Dio3 genes were observed. These results suggested that the Per2 clock gene is not necessary for the photoperiodic response in mice.

DOI： 10.1371/journal.pone.0058482

新規光受容器「オプシン5」欠損マウスの行動解析

太田航, 中根右介, 池上啓介, 吉村崇

日本畜産学会大会講演要旨集 Vol. 116回 page： 97 - 97 2013.3

脊椎動物の光周性の制御機構 Invited

頼永恵理子, 吉村崇

生物科学 Vol. 64 page： 205 - 211 2013

脊椎動物が季節を感知する仕組みの解明 Invited Reviewed

前田遼介, 吉村崇

トレーサー Vol. 54 page： 3 - 8 2013

哺乳類における新規光受容器Opsin 5の発現解析

太田航, 中根右介, 池上啓介, 吉村崇

日本畜産学会大会講演要旨集 Vol. 115回 page： 216 - 216 2012.3

Circadian clocks and the measurement of daylength in seasonal reproduction

Ikegami Keisuke, Yoshimura Takashi

MOLECULAR AND CELLULAR ENDOCRINOLOGY Vol. 349 ( 1 ) page： 76 - 81 2012.2

Understanding mechanism of seasonal reproduction and deep brain photoreceptor

Nakane Y., Yoshimura T.

Seikagaku Vol. 83 ( 2 ) page： 114 - 117 2011.12

Photoperiodism in vertebrates.

Wataru Ota, Takashi Yoshimura

Journal of the Society of Biomechanisms Vol. 35 ( 4 ) page： 251 - 257 2011.11

Progesterone Is a Sperm-Releasing Factor from the Sperm-Storage Tubules in Birds Open Access

Ito Tomomi, Yoshizaki Norio, Tokumoto Toshinobu, Ono Hiroko, Yoshimura Takashi, Tsukada Akira, Kansaku Norio, Sasanami Tomohiro

ENDOCRINOLOGY Vol. 152 ( 10 ) page： 3952 - 3962 2011.10

ウズラの季節性精巣退縮機構の解明

渥美優介, 池上啓介, 小野ひろ子, 村山至, 中根右介, 太田航, 新井菜津美, 手賀明倫, 飯郷雅之, 吉田松生, 吉村崇

The Journal of Reproduction and Development Vol. 57 ( Suppl. ) page： j103 - j103 2011.8

Opsin 5 as a deep brain photoreceptor regulating photoperiodism

Yusuke Nakane, Keisuke Ikegami, Hiroko Ono, Naoyuki Yamamoto, Shosei Yoshida, Yasuhiro Kamei, Sho-ichi Higashi, Kanjun Hirunagi, Shizufumi Ebihara, Yoshihiro Kubo, Takashi Yoshimura

NEUROSCIENCE RESEARCH Vol. 71 page： E171 - E171 2011

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Papers - YOSHIMURA, Takashi