Faculty Profiles - YOSHIMURA, Takashi

Papers - YOSHIMURA, Takashi

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光とサーカディアンリズム

"吉村崇,海老原史樹文"

医学のあゆみ Vol. 190 page： 269-272 1999.1

鳥類の概日リズムの分子機構

"吉村崇,海老原史樹文"

日本比較内分泌学会ニュース Vol. 95 page： 34-37 1999.1

Decline of circadian photosensitivity associated with retinal degeneration in CBA/J-rd/rd mice

Yoshimura T, Ebihara S

BRAIN RESEARCH Vol. 779 ( 1-2 ) page： 188 - 193 1998.1

時計遺伝子

海老原史樹文、吉村崇

ファルマシア Vol. 34 page： 563-567 1998.1

Chromosomal mapping of the gene encoding serotonin N-acetyltransferase to rat chromosome 10q32.3 and mouse Chromosome 11E2 Reviewed

Takashi Yoshimura, A. Nagabukuro, Y. Matsuda, T. Suzuki, A. Kuroiwa, M. Ligo, T. Namikawa, S. Ebihara

Cytogenetic and Genome Research Vol. 79 ( 3-4 ) page： 172 - 175 1997.1

Language：English Publishing type：Research paper (scientific journal)

Pineal melatonin is produced during the night. Its nocturnal increase regulates circadian rhythms and the photo-periodic reproductive response. Serotonin is acetylated to N-acetylserotonin by serotonin N-acetyltransferase (SNAT) and then methylated to form melatonin by hydroxyindole-O-methyltransferase (HIOMT). The rhythmicity of melatonm synthesis is regulated by the rhythmic activity of SNAT. Most laboratory mice do not have melatonin because of a genetic defect in the activity of SNAT and/or HIOMT. In a previous study using a recombinant inbred strain, we have found that the locus controlling pineal SNAT activity (Nat4) is located on mouse Chromosome 11. Recently, SNAT has been cloned in the rat. In the present study, the gene encoding SNAT was localized, using a rat cDNA fragment, on rat and mouse chromosomes by direct R-banding fluorescence in situ hybridization (FISH). In addition, using molecular linkage analysis with interspecific back-cross mice, a gene encoding SNAT was mapped on a mouse chromosome. The gene encoding SNAT was localized to rat chromosome 10q32.3 and mouse Chromosome 11E2 by FISH. The molecular linkage analysis demonstrated that the gene encoding SNAT maps 1.5 cM distal to DUMit11. The data suggest that Nat4 encodes SNAT. These chromosomal locations are in a region of conserved linkage homology between the two species. © 1997 S. Karger AG, Basel.

DOI： 10.1159/000134713

Scopus

PubMed

In vivo microdialysis studies of pineal a ocular melatonin rhythms in birds. Reviewed

Ebihara S, Adachi A, Hasegawa M, Nogi T, Yoshimura T, Hirunagi K

Biological Signals Vol. 6 page： 233-240 1997.1

メラトニンの基礎

海老原史樹文、吉村崇

神経精神薬理 Vol. 19 page： 177-184 1997.1

脊椎動物の時計遺伝子

海老原史樹文、吉村崇、鈴木亨

日本時間生物学会誌 Vol. 3 page： 30-45 1997.1

Vitamin B-12 affects non-photic entrainment of circadian locomotor activity rhythms in mice

Ebihara S, Mano N, Kurono N, Komuro G, Yoshimura T

BRAIN RESEARCH Vol. 727 ( 1-2 ) page： 31 - 39 1996.7

Spectral sensitivity of photoreceptors mediating phase-shifts of circadian rhythms in retinally degenerate CBA/J (rd/rd) a CBA/N (+/+) mice. Reviewed

Yoshimura T, Ebihara S.

Journal of Comparative Physiology A Vol. 178 page： 797-802 1996.1

CIRCADIAN RESPONSES TO LIGHT AND FOS INDUCTION IN THE SCN AND RETINA OF CBA-AND-C57 RD/RD MICE

IRELAN W, ARTHUR M, YOSHIMURA T, EBIHARA S, FOSTER RG

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 36 ( 4 ) page： S913 - S913 1995.3

RETINALLY PERCEIVED LIGHT IS NOT ESSENTIAL FOR PHOTIC REGULATION OF PINEAL MELATONIN RHYTHMS IN THE PIGEON - STUDIES WITH MICRODIALYSIS

HASEGAWA M, ADACHI A, YOSHIMURA T, EBIHARA S

JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY Vol. 175 ( 5 ) page： 581 - 586 1994.11

Retinally perceived light is not essential for photic regulation of pineal melatonin rhythms in the pigeon: studies with microdialysis

Hasegawa M., Adachi A., Yoshimura T., Ebihara S.

Journal of Comparative Physiology A Vol. 175 ( 5 ) page： 581 - 586 1994.11

Publisher：Journal of Comparative Physiology A

Using in vivo microdialysis, effects of retinally perceived light on pineal melatonin release and its rhythmicity was examined in the pigeon. In the first experiment, light-induced suppression of pineal melatonin release was studied. Although light given to the whole body during the dark strongly suppressed pineal melatonin release to a daytime level, light exclusively delivered to the eyes did not remarkably inhibit melatonin release. In the second experiment, in order to determine whether retinally perceived light has phase-shifting effects on pineal melatonin rhythms, pigeons were given a single light pulse of 2 h at circadian time (CT) 18 and the phases of the second cycle after the light pulse were compared with those of control pigeons without the light pulse. In this experiment, phase advances of pineal melatonin rhythms were observed when the light was given to the whole body but not when only the eyes were illuminated. In a third experiment, after entrainment to light-dark 12:12 (LD 12:12) cycles, birds whose heads were covered with black tapes were transferred into constant light (LL) conditions and only the eyes were exposed to new LD cycles for 7 days (the phase was advanced by 6 h from the previous cycles) using a patching protocol. This procedure, however, could not entrain pineal melatonin rhythms to the retinal LD cycles. These results indicate that the eyes are not essential for photic regulation of pineal melatonin release and its rhythmicity in the pigeon. © 1994 Springer-Verlag.

DOI： 10.1007/BF00199479

Scopus

Differences in circadian photosensitivity between retinally degenerate CBA/J mice (rd/rd) and normal CBA/N mice (+/+) Reviewed

Yoshimura T, Nishio M, Goto M, Ebihara S

Journal of Biological Rhythms Vol. 9 ( 1 ) page： 51-60 1994

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