Faculty Profiles - YOSHIMURA, Takashi

Papers - YOSHIMURA, Takashi

Division display 61 - 80 of about 214 ／ All the affair displays >>

Animals' clever adaptation strategy for seasonal changes in environment

Ikegami Keisuke, Yoshimura Takashi

JAPANESE JOURNAL OF NEUROPSYCHOPHARMACOLOGY Vol. 35 ( 4 ) page： 103 - 106 2015.8

The highest-ranking rooster has priority to announce the break of dawn Reviewed

Tsuyoshi Shimmura, Shosei Ohashi, Takashi Yoshimura

SCIENTIFIC REPORTS Vol. 5 2015.7

Language：English Publishing type：Research paper (scientific journal) Publisher：NATURE PUBLISHING GROUP

The "cock-a-doodle-doo" crowing of roosters, which symbolizes the break of dawn in many cultures, is controlled by the circadian clock. When one rooster announces the break of dawn, others in the vicinity immediately follow. Chickens are highly social animals, and they develop a linear and fixed hierarchy in small groups. We found that when chickens were housed in small groups, the top-ranking rooster determined the timing of predawn crowing. Specifically, the top-ranking rooster always started to crow first, followed by its subordinates, in descending order of social rank. When the top-ranking rooster was physically removed from a group, the second-ranking rooster initiated crowing. The presence of a dominant rooster significantly reduced the number of predawn crows in subordinates. However, the number of crows induced by external stimuli was independent of social rank, confirming that subordinates have the ability to crow. Although the timing of subordinates' predawn crowing was strongly dependent on that of the top-ranking rooster, free-running periods of body temperature rhythms differed among individuals, and crowing rhythm did not entrain to a crowing sound stimulus. These results indicate that in a group situation, the top-ranking rooster has priority to announce the break of dawn, and that subordinate roosters are patient enough to wait for the top-ranking rooster's first crow every morning and thus compromise their circadian clock for social reasons.

DOI： 10.1038/srep11683

Web of Science

Scopus

C-H Activation Generates Period-Shortening Molecules That Target Cryptochrome in the Mammalian Circadian Clock

Oshima Tsuyoshi, Yamanaka Iori, Kumar Anupriya, Yamaguchi Junichiro, Nishiwaki-Ohkawa Taeko, Muto Kei, Kawamura Rika, Hirota Tsuyoshi, Yagita Kazuhiro, Irle Stephan, Kay Steve A., Yoshimura Takashi, Itami Kenichiro

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION Vol. 54 ( 24 ) page： 7193 - 7197 2015.6

Low Temperature-Induced Circulating Triiodothyronine Accelerates Seasonal Testicular Regression

Ikegami Keisuke, Atsumi Yusuke, Yorinaga Eriko, Ono Hiroko, Murayama Itaru, Nakane Yusuke, Ota Wataru, Arai Natsumi, Tega Akinori, Iigo Masayuki, Darras Veerle M., Tsutsui Kazuyoshi, Hayashi Yoshitaka, Yoshida Shosei, Yoshimura Takashi

ENDOCRINOLOGY Vol. 156 ( 2 ) page： 647 - 659 2015.2

A unique mechanism of successful fertilization in a domestic bird

Tomohiro Sasanami, Shunsuke Izumi, Naoki Sakurai, Toshifumi Hirata, Shusei Mizushima, Mei Matsuzaki, Gen Hiyama, Eriko Yorinaga, Takashi Yoshimura, Kazuyoshi Ukena, Kazuyoshi Tsutsui

SCIENTIFIC REPORTS Vol. 5 2015.1

Language：English Publishing type：Research paper (scientific journal) Publisher：NATURE PUBLISHING GROUP

Fertilization is an indispensable step for formation of a zygote in sexual reproduction, leading to species survival. When mating occurs, sperm is transported to the female reproductive tracts via the seminal plasma (SP). SP is derived from male accessory sex glands and it plays pivotal roles for fertilization in animals. However, molecular mechanisms of SP or a fluid derived from male accessory sex glands for successful fertilization remain unclear. Here, we report that in male quail the cloacal gland (CG) produces prostaglandin F-2 alpha (PGF(2 alpha)) that contributes to successful fertilization. PGF(2 alpha), as well as the secretion of CG (CGS), induced vaginal contractions and caused the opening of the entrance of the sperm storage tubules, the structures responsible for the long-term sperm storage and fertilization. The removal of CGS from the male before mating reduced the fertility, but the supplementation of CGS or PGF(2 alpha) rescued the subfertility. We further showed that male CG contains glucose that is utilized as energy source for the intrinsic sperm mobility after transportation to female vagina. This mechanism, in concert with the excitatory effects of PGF(2 alpha) enables successful fertilization in the domestic bird.

DOI： 10.1038/srep07700

Web of Science

Scopus

季節感知機構の解析から見えてきた動物の巧みな戦略 Invited Reviewed

池上啓介, 吉村崇

日本神経精神薬理学雑誌 Vol. 35 ( 4 ) page： 103 - 106 2015

ホルモンの糖鎖修飾による巧みな生理機能の分担戦略 Invited Reviewed

池上啓介, 吉村崇

日本比較内分泌学会 Vol. 41 ( 156 ) page： 127 - 128 2015

Circannual Cycles and Photoperiodism

Cassone Vincent M., Yoshimura Takashi

STURKIE'S AVIAN PHYSIOLOGY, 6TH EDITION page： 829 - 845 2015

季節感知機構の解析から見えてきた動物の巧みな戦略 Invited

池上啓介, 吉村崇

日本神経精神薬理学雑誌 Vol. 35 page： 103 - 106 2015

触媒で体内時計のリズムを変える－異分野融合がもたらした新分子の発見 Invited

伊丹健一郎, 吉村崇

月刊化学 Vol. 70 page： 32 - 36 2015

ホルモンの糖鎖修飾による巧みな生理機能の分担戦略 Invited

池上啓介, 吉村崇

比較内分泌学 Vol. 41 page： 129 - 130 2015

Takashi Yoshimura

Yoshimura Takashi

CURRENT BIOLOGY Vol. 24 ( 23 ) page： R1108 - R1109 2014.12

Tissue-specific post-translational modification allows functional targeting of thyrotropin Reviewed

Ikegami K, Liao XH, Hoshino Y, Ono H, Ota W, Ito Y, Nishiwaki-Ohkawa T, Sato C, Kitajima K, Iigo M, Shigeyoshi Y, Yamada M, Murata Y, Refetoff S, Yoshimura T

Cell Reports Vol. 9 page： 801-809 2014.11

Thyrotoropin receptor knockout changes monoaminergic neuronal system and produces methylphenidate-sensitive emotional and cognitive dysfunction. Reviewed International journal

Akihiro Mouri, Yuta Hoshino, Shiho Narusawa, Keisuke Ikegami, Hiroyuki Mizoguchi, Yoshiharu Murata, Takashi Yoshimura, Toshitaka Nabeshima

Psychoneuroendocrinology Vol. 48 page： 147 - 161 2014.10

Language：English Publishing type：Research paper (scientific journal)

Attention deficit/hyperactivity disorder (ADHD) has been reported in association with resistance to thyroid hormone, a disease caused by a mutation in the thyroid hormone receptor β (TRβ) gene. TRβ is a key protein mediating down-regulation of thyrotropin (TSH) expression by 3,3',5-tri-iodothyronine (T3), an active form of thyroid hormone. Dysregulation of TSH and its receptor (TSHR) is implicated in the pathophysiology of ADHD but the role of TSHR remains elusive. Here, we clarified a novel role for TSHR in emotional and cognitive functions related to monoaminergic nervous systems. TSHR knockout mice showed phenotypes of ADHD such as hyperactivity, impulsiveness, a decrease in sociality and increase in aggression, and an impairment of short-term memory and object recognition memory. Administration of methylphenidate (1, 5 and 10mg/kg) reversed impulsiveness, aggression and object recognition memory impairment. In the knockout mice, monoaminergic changes including decrease in the ratio of 3-methoxy-4-hydroxyphenylglycol/noradrenaline and increase in the ratio of homovanillic acid/dopamine were observed in some brain regions, accompanied by increase in the expression of noradrenaline transporter in the frontal cortex. When TSH was completely suppressed by the supraphysiological administration of T3 to the adult mice, some behavioral and neurological changes in TSHR KO mice were also observed, suggesting that these changes were not due to developmental hypothyroidism induced by the inactivation of TSHR but to the loss of the TSH-TSHR pathway itself. Taken together, the present findings suggest a novel role for TSHR in behavioral and neurological phenotypes of ADHD.

DOI： 10.1016/j.psyneuen.2014.05.021

Web of Science

Scopus

PubMed

Intrinsic photosensitivity of a deep brain photoreceptor

Yusuke Nakane, Tsuyoshi Shimmura, Hideki Abe, Takashi Yoshimura

CURRENT BIOLOGY Vol. 24 ( 13 ) page： R596 - R597 2014.7

Universality and diversity in the signal transduction pathway that regulates seasonal reproduction in vertebrates Invited Reviewed

Yusuke Nakane, Takashi Yoshimura

FRONTIERS IN NEUROSCIENCE Vol. 8 ( 8 MAY ) page： 115 2014.5

Language：English Publisher：FRONTIERS RESEARCH FOUNDATION

Most vertebrates living outside the tropical zone show robust physiological responses in response to seasonal changes in photoperiod, such as seasonal reproduction, molt, and migration. The highly sophisticated photoperiodic mechanism in Japanese quail has been used to uncover the mechanism of seasonal reproduction. Molecular analysis of quail mediobasal hypothalamus (MBH) revealed that local thyroid hormone activation within the MBH plays a critical role in the photoperiodic response of gonads. This activation is accomplished by two gene switches: thyroid hormone-activating (DIO2) and thyroid hormone-inactivating enzymes (DIO3). Functional genomics studies have shown that long-day induced thyroid-stimulating hormone (TSH) in the pars tuberalis (PT) of the pituitary gland regulates DIO2/3 switching. In birds, light information received directly by deep brain photoreceptors regulates PT TSH. Recent studies demonstrated that Opsin 5-positive cerebrospinal fluid (CSF)-contacting neurons are deep brain photoreceptors that regulate avian seasonal reproduction. Although the involvement of TSH and DIO2/3 in seasonal reproduction has been confirmed in various mammals, the light input pathway that regulates PT TSH in mammals differs from that of birds. In mammals, the eye is the only photoreceptor organ and light information received by the eye is transmitted to the pineal gland through the circadian pacemaker, the suprachiasmatic nucleus. Nocturnal melatonin secretion from the pineal gland indicates the length of night and regulates the PT TSH. In fish, the regulatory machinery for seasonal reproduction, from light input to neuroendocrine output, has been recently demonstrated in the coronet cells of the saccus vasculosus (SV). The SV is unique to fish and coronet cells are CSF-contacting neurons. Here, we discuss the universality and diversity of signal transduction pathways that regulate vertebrate seasonal reproduction.

DOI： 10.3389/fnins.2014.00115

Web of Science

Scopus

Sperm activation by heat shock protein 70 supports the migration of sperm released from sperm storage tubules in Japanese quail (Coturnix japonica). Reviewed International journal

Gen Hiyama, Mei Matsuzaki, Shusei Mizushima, Hideo Dohra, Keisuke Ikegami, Takashi Yoshimura, Kogiku Shiba, Kazuo Inaba, Tomohiro Sasanami

Reproduction (Cambridge, England) Vol. 147 ( 2 ) page： 167 - 178 2014.2

Language：English Publishing type：Research paper (scientific journal)

Systems for maintaining the viability of ejaculated sperm in the female reproductive tract are widespread among vertebrates and invertebrates. In birds, this sperm storage function is performed by specialized simple tubular invaginations called sperm storage tubules (SSTs) in the uterovaginal junction (UVJ) of the oviduct. Although the incidence and physiological reasons for sperm storage in birds have been reported extensively, the mechanisms of sperm uptake by the SSTs, sperm maintenance within the SSTs, and control of sperm release from the SSTs are poorly understood. In this study, we demonstrated that the highly conserved heat shock protein 70 (HSP70) stimulates sperm motility in vitro and also that HSP70 expressed in the UVJ may facilitate the migration of sperm released from the SSTs. Quantitative RT-PCR analysis demonstrated that the expression of HSP70 mRNA in the UVJ increases before ovulation/oviposition. Gene-specific in situ hybridization and immunohistochemical analysis with a specific antibody to HSP70 demonstrated that HSP70 is localized in the surface epithelium of the UVJ. Furthermore, injection of anti-HSP70 antibody into the vagina significantly inhibited fertilization in vivo. In addition, we found that recombinant HSP70 activates flagellar movement in the sperm and that the binding of recombinant HSP70 to the sperm surface is mediated through an interaction with voltage-dependent anion channel protein 2 (VDAC2). Our results suggest that HSP70 binds to the sperm surface by interacting with VDAC2 and activating sperm motility. This binding appears to play an important role in sperm migration within the oviduct.

DOI： 10.1530/REP-13-0439

Web of Science

Scopus

PubMed

Seasonal sensor in fish

Comparative Endocrinology Vol. 40 ( 152 ) page： 65 - 67 2014

Regulation of seasonal reproduction by hypothalamic activation of thyroid hormone. Reviewed International journal

Shinomiya A, Shimmura T, Nishiwaki-Ohkawa, T, Yoshimura T

Frontiers in Endocrinology Vol. 5 ( FEB ) page： 12 - 12 2014

Language：English Publishing type：Research paper (scientific journal)

Organisms living outside the tropics measure the changes in the length of the day to adapt to seasonal changes in the environment. Animals that breed during spring and summer are called long-day breeders, while those that breed during fall are called short-day breeders. Although the influence of thyroid hormone in the regulation of seasonal reproduction has been known for several decades, its precise mechanism remained unknown. Recent studies revealed that the activation of thyroid hormone within the mediobasal hypothalamus plays a key role in this phenomenon. This localized activation of the thyroid hormone is controlled by thyrotropin (thyroid-stimulating hormone) secreted from the pars tuberalis of the pituitary gland. Although seasonal reproduction is a rate-limiting factor in animal production, genes involved in photoperiodic signal transduction pathway could emerge as potential targets to facilitate domestication.

DOI： 10.3389/fendo.2014.00012

Web of Science

Scopus

PubMed

季節リズムの制御メカニズム Invited

大川妙子, 吉村崇

睡眠医療 Vol. 8 page： 203 - 209 2014

　 PREV - NEXT 　

<YOSHIMURA, Takashi>

Papers - YOSHIMURA, Takashi