Faculty Profiles - YOSHIOKA, Hirofumi

Papers - YOSHIOKA, Hirofumi

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Prognostic impact of geriatric assessment in elderly patients with non-small cell lung cancer: an integrated analysis of two randomized phase III trials (JCOG1115-A)

Katayama, H; Mizusawa, J; Fukuda, H; Nakamura, S; Nakamura, K; Saijo, N; Yokoyama, A; Ohe, Y; Shinkai, T; Nakagawa, K; Abe, T; Mitsuoka, S; Okamoto, H; Yamamoto, N; Yoshioka, H; Ando, M; Tamura, T; Takeda, K

JAPANESE JOURNAL OF CLINICAL ONCOLOGY Vol. 51 ( 5 ) page： 685 - 692 2021.5

Oral RNAi ofdiap1results in rapid reduction of damage to potatoes inHenosepilachna vigintioctopunctata

Chikami, Y; Kawaguchi, H; Suzuki, T; Yoshioka, H; Sato, Y; Yaginuma, T; Niimi, T

JOURNAL OF PEST SCIENCE Vol. 94 ( 2 ) page： 505 - 515 2021.3

Phase III Study Comparing Nab-Paclitaxel With Docetaxel in Patients With Previously Treated Advanced Non-Small-Cell Lung Cancer

Nakamura, A; Yoneshima, Y; Morita, S; Ando, M; Iwasawa, S; Yoshioka, H; Goto, Y; Takeshita, M; Harada, T; Hirano, K; Oguri, T; Kondo, M; Miura, S; Hosomi, Y; Kato, T; Kubo, T; Kishimoto, J; Yamamoto, N; Nakanishi, Y; Okamoto, I

JOURNAL OF THORACIC ONCOLOGY Vol. 16 ( 3 ) page： S107 - S108 2021.3

Role of salicylic acid glucosyltransferase in balancing growth and defence for optimum plant fitness. Reviewed International journal

Yudai Kobayashi, Noriho Fukuzawa, Ayaka Hyodo, Hangil Kim, Shota Mashiyama, Tsuyoshi Ogihara, Hirofumi Yoshioka, Hideyuki Matsuura, Chikara Masuta, Takeshi Matsumura, Minoru Takeshita

Molecular plant pathology Vol. 21 ( 3 ) page： 429 - 442 2020.3

Language：English Publishing type：Research paper (scientific journal)

Salicylic acid (SA), an essential secondary messenger for plant defence responses, plays a role in maintaining a balance (trade-off) between plant growth and resistance induction, but the detailed mechanism has not been explored. Because the SA mimic benzothiadiazole (BTH) is a more stable inducer of plant defence than SA after exogenous application, we analysed expression profiles of defence genes after BTH treatment to better understand SA-mediated immune induction. Transcript levels of the salicylic acid glucosyltransferase (SAGT) gene were significantly lower in BTH-treated Nicotiana tabacum (Nt) plants than in SA-treated Nt control plants, suggesting that SAGT may play an important role in SA-related host defence responses. Treatment with BTH followed by SA suppressed SAGT transcription, indicating that the inhibitory effect of BTH is not reversible. In addition, in BTH-treated Nt and Nicotiana benthamiana (Nb) plants, an early high accumulation of SA and SA 2-O-β-d-glucoside was only transient compared to the control. This observation agreed well with the finding that SAGT-overexpressing (OE) Nb lines contained less SA and jasmonic acid (JA) than in the Nb plants. When inoculated with a virus, the OE Nb plants showed more severe symptoms and accumulated higher levels of virus, while resistance increased in SAGT-silenced (IR) Nb plants. In addition, the IR plants restricted bacterial spread to the inoculated leaves. After the BTH treatment, OE Nb plants were slightly larger than the Nb plants. These results together indicate that SAGT has a pivotal role in the balance between plant growth and SA/JA-mediated defence for optimum plant fitness.

DOI： 10.1111/mpp.12906

Web of Science

PubMed

植物を元気にして病気を防ぐ―植物活力剤によるイチゴの病害抑制技術― Invited

鳴坂義弘, 鳴坂真理, 吉岡博文, 吉岡美樹, 谷口伸治, 石川美友紀, 紀岡雄三, 野口勝憲

植物防疫 Vol. 73 ( 11 ) page： 684-688 2019.11

Ph3 Study of Maintenance Therapy with S-1 vs BSC After Induction Therapy with Carboplatin + S-1 for Advanced Squamous Cell Lung Cancer (WJOG7512L)

Tanaka, K; Morita, S; Ando, M; Yokoyama, T; Nakamura, A; Yoshioka, H; Ishiguro, T; Miura, S; Toyozawa, R; Oguri, T; Daga, H; Ko, R; Bessho, A; Tachihara, M; Iwamoto, Y; Hirano, K; Nakanishi, Y; Nakagawa, K; Yamamoto, N; Okamoto, I

JOURNAL OF THORACIC ONCOLOGY Vol. 14 ( 10 ) page： S302 - S302 2019.10

Randomized phase 3 study of maintenance therapy with S-1 plus best supportive care (BSC) versus BSC alone after induction therapy with carboplatin plus S-1 for advanced or relapsed squamous cell lung carcinoma (WJOG7512L).

JOURNAL OF CLINICAL ONCOLOGY Vol. 37 ( 15 ) 2019.5

WRKYs phosphorylated by MAPK regulate chloroplast-mediated ROS burst in plant immunity

Yoshioka, H; Adachi, H; Yoshioka, M

PHYTOPATHOLOGY Vol. 108 ( 10 ) 2018.10

Phase Competition, Solitons, and Domain Walls in Neutral-Ionic Transition Systems

Tsuchiizu, M; Yoshioka, H; Seo, H

JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN Vol. 85 ( 10 ) 2016.10

*WRKY transcription factors phosphorylated by MAPK regulate a plant immune NADPH oxidase in Nicotiana benthamiana. Reviewed

Adachi, H, Nakano, T, Miyagawa, N, Ishihama, N, Yoshioka, M, Katou, Y, Yaeno, T, Shirasu, K, Yoshioka, H

The Plant Cell Vol. 27 ( 9 ) page： 2645-2663. 2015.10

リン酸化反応が制御するROSバーストの分子機構 Invited Reviewed

吉岡博文, 安達広明, 石濱伸明, 中野孝明, 白石佑太郎, 宮川典子, 野村裕也, 吉岡美樹, 浅井秀太

日本植物病理学会報 Vol. 81 page： 1-8. 2015.2

SEC14 Phospholipid Transfer Protein Is Involved in Lipid Signaling-Mediated Plant Immune Responses in Nicotiana benthamiana Reviewed

Akinori Kiba, Ivan Galis, Yuko Hojo, Kouhei Ohnishi, Hirofumi Yoshioka, Yasufumi Hikichi

PLOS ONE Vol. 9 ( 5 ) page： e98150 2014.5

Language：English Publishing type：Research paper (scientific journal) Publisher：PUBLIC LIBRARY SCIENCE

We previously identified a gene related to the SEC14-gene phospholipid transfer protein superfamily that is induced in Nicotiana benthamiana (NbSEC14) in response to infection with Ralstonia solanacearum. We here report that NbSEC14 plays a role in plant immune responses via phospholipid-turnover. NbSEC14-silencing compromised expression of defense-related PR-4 and accumulation of jasmonic acid (JA) and its derivative JA-Ile. Transient expression of NbSEC14 induced PR-4 gene expression. Activities of diacylglycerol kinase, phospholipase C and D, and the synthesis of diacylglycerol and phosphatidic acid elicited by avirulent R. solanacearum were reduced in NbSEC14-silenced plants. Accumulation of signaling lipids and activation of diacylglycerol kinase and phospholipases were enhanced by transient expression of NbSEC14. These results suggest that the NbSEC14 protein plays a role at the interface between lipid signaling-metabolism and plant innate immune responses.

DOI： 10.1371/journal.pone.0098150

Web of Science

PubMed

In Vivo Phosphorylation of WRKY Transcription Factor by MAPK

Nobuaki Ishihama, Hiroaki Adachi, Miki Yoshioka, Hirofumi Yoshioka

Methods in Molecular Biology Vol. 1171 page： 171 - 181 2014

Suppression of DS1 Phosphatidic Acid Phosphatase Confirms Resistance to Ralstonia solanacearum in Nicotiana benthamiana Reviewed

Masahito Nakano, Masahiro Nishihara, Hirofumi Yoshioka, Hirotaka Takahashi, Tatsuya Sawasaki, Kouhei Ohnishi, Yasufumi Hikichi, Akinori Kiba

PLOS ONE Vol. 8 ( 9 ) page： e75124. 2013.9

Language：English Publishing type：Research paper (scientific journal) Publisher：PUBLIC LIBRARY SCIENCE

Nicotiana benthamiana is susceptible to Ralstonia solanacearum. To analyze molecular mechanisms for disease susceptibility, we screened a gene-silenced plant showing resistance to R. solanacearum, designated as DS1 (Disease suppression 1). The deduced amino acid sequence of DS1 cDNA encoded a phosphatidic acid phosphatase (PAP) 2. DS1 expression was induced by infection with a virulent strain of R. solanacearum in an hrp-gene-dependent manner. DS1 rescued growth defects of the temperature-sensitive Delta lpp1 Delta dpp1 Delta pah1 mutant yeast. Recombinant DS1 protein showed Mg2+-independent PAP activity. DS1 plants showed reduced PAP activity and increased phosphatidic acid (PA) content. After inoculation with R. solanacearum, DS1 plants showed accelerated cell death, over-accumulation of reactive oxygen species (ROS), and hyper-induction of PR-4 expression. In contrast, DS1-overexpressing tobacco plants showed reduced PA content, greater susceptibility to R. solanacearum, and reduced ROS production and PR-4 expression. The DS1 phenotype was partially compromised in the plants in which both DS1 and NbCoi1 or DS1 and NbrbohB were silenced. These results show that DS1 PAP may affect plant immune responses related to ROS and JA cascades via regulation of PA levels. Suppression of DS1 function or DS1 expression could rapidly activate plant defenses to achieve effective resistance against Ralstonia solanacearum.

DOI： 10.1371/journal.pone.0075124

Web of Science

PubMed

A translationally controlled tumor protein negatively regulates the hypersensitive response in Nicotiana benthamiana. Reviewed

Gupta, M, Yoshioka, H, Ohnishi, K, Mizumoto, H, Hikichi, Y, Kiba, A

Plant and Cell Physiology Vol. 54 ( 8 ) page： 1403-1414. 2013.8

タンパク質のリン酸化によるROSバーストの分子機構 Invited

吉岡博文, 安達広明, 石濱伸明, 中野孝明, 白石佑太郎, 宮川典子, 野村裕也, 吉岡美樹, 浅井秀太

植物−微生物相互作用とビオトロフ感染 Vol. 48 page： 105-114. 2013.8

Ethylene responsive AP2/ERF transcription factor MACD1 participates in phytotoxin-triggered programmed cell death. Reviewed

Mase, K, Ishihama, N, Mori, H, Takahashi, H, Kaminaka, H, Kodama, M, Yoshioka, H

Molecular Plant-Microbe Interactions Vol. 26 page： 868-879. 2013.7

*The variable domain of a plant calcium-dependent protein kinase (CDPK) confers subcellular localization and substrate recognition for NADPH oxidase. Reviewed

Asai, S, Ichikawa, T, Nomura, H, Kobayashi, M, Kamiyoshihara, Y, Mori, H, Kadota, Y, Zipfel, C, Jones, J.D.G, Yoshioka, H

The Journal of Biological Chemistry Vol. 288 page： 14332-14340. 2013.5

The Variable Domain of a Plant Calcium-dependent Protein Kinase (CDPK) Confers Subcellular Localization and Substrate Recognition for NADPH Oxidase

Asai, S; Ichikawa, T; Nomura, H; Kobayashi, M; Kamiyoshihara, Y; Mori, H; Kadota, Y; Zipfel, C; Jones, JDG; Yoshioka, H

JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 288 ( 20 ) page： 14332 - 14340 2013.5

Nitric Oxide as a Mediator for Defense Responses

Bellin, D; Asai, S; Delledonne, M; Yoshioka, H

MOLECULAR PLANT-MICROBE INTERACTIONS Vol. 26 ( 3 ) page： 271 - 277 2013.3

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Papers - YOSHIOKA, Hirofumi