研究者詳細 - 榎本　篤

論文 - 榎本　篤

分割表示 214 件中 161 - 180 件目／全件表示 >>

The role of CD109 in PDGFB-induced glioma mouse model for sensitivity to Temozolomide

Shiraki, Y; Mii, S; Asai, N; Enomoto, A; Momota, H; Natsume, A; Wakabayashi, T; Takahashi, M

CANCER SCIENCE 109 巻頁： 1130 - 1130 2018年1月

ASC amino acid transporter 2, defined by enzyme-mediated activation of radical sources, enhances malignancy of GD2-positive small-cell lung cancer 査読有り国際誌

Esaki, N; Ohkawa, Y; Hashimoto, N; Tsuda, Y; Ohmi, Y; Bhuiyan, RH; Kotani, N; Honke, K; Enomoto, A; Takahashi, M; Furukawa, K; Furukawa, K

CANCER SCIENCE 109 巻 ( 1 ) 頁： 141 - 153 2018年1月

Aberrant super-enhancers associated with downregulation of RET finger protein overcomes chemoresistance in glioblastoma

Hirano, M; Ranjit, M; Yamamichi, A; Aoki, K; Ohka, F; Kato, T; Enomoto, A; Takahashi, M; Wakabayashi, T; Natsume, A

CANCER SCIENCE 109 巻頁： 461 - 461 2018年1月

Ganglioside GD2 coordinately works with ASCT2, which enhances malignant phenotypes in small cell lung cancer

Esaki, N; Ohkawa, Y; Hashimoto, N; Tuna, Y; Ohmi, Y; Bhuiya, R; Kotani, N; Honk, C; Enomoto, A; Takahashi, M; Furukawa, K; Furukawa, K

CANCER SCIENCE 109 巻頁： 94 - 94 2018年1月

Mechanisms for the control of amino acid signaling and drug resistance in cancer stem cells

Enomoto, A; Takahashi, M

CANCER SCIENCE 109 巻頁： 813 - 813 2018年1月

Aberrant super-enhancers associated with downregulation of RET finger protein overcomes chemoresistance in glioblastoma

Hirano Masaki, Ranjit Melissa, Yamamichi Akane, Aoki Kosuke, Ohka Fumiharu, Kato Takuya, Enomoto Atsushi, Takahashi Masahide, Wakabayashi Toshihiko, Natsume Atsushi

CANCER SCIENCE 109 巻頁： 461-461 2018年1月

Cullin-associated NEDD8-dissociated protein a novel interactor of rabphilin-3A, deubiquitylates rabphilin-3A and regulates arginine vasopressin secretion in PC12 cells 査読有り

Nakashima, K; Takeuchi, S; Iwama, S; Kiyota, A; Yasuda, Y; Iwata, N; Enomoto, A; Arima, H; Sugimura, Y

ENDOCRINE JOURNAL 65 巻 ( 3 ) 頁： 325 - 334 2018年

Significance of perivascular tumour cells defined by CD109 expression in progression of glioma 査読有り

Shiraki, Y; Mii, S; Enomoto, A; Momota, H; Han, YP; Kato, T; Ushida, K; Kato, A; Asai, N; Murakumo, Y; Aoki, K; Suzuki, H; Ohka, F; Wakabayashi, T; Todo, T; Ogawa, S; Natsume, A; Takahashi, M

JOURNAL OF PATHOLOGY 243 巻 ( 4 ) 頁： 468 - 480 2017年12月

ABERRANT SUPER-ENHANCERS ASSOCIATED WITH DOWNREGULATION OF RET FINGER PROTEIN OVERCOMES CHEMORESISTANCE IN GLIOBLASTOMA

Hirano, M; Ranjit, M; Yamamichi, A; Aoki, K; Ohka, F; Kato, T; Enomoto, A; Takahashi, M; Wakabayashi, T; Natsume, A

NEURO-ONCOLOGY 19 巻頁： 103 - 103 2017年11月

Correlation between SPARC expression and efficacy of nab-paclitaxel for advanced gastric cancer refractory to fluoropyrimidine: An exploratory analysis of a phase II trial, CCOG1303

Kobayashi, D; Enomoto, A; Mochizuki, Y; Matsui, T; Nakayama, H; Kawase, Y; Ishigure, K; Shikano, T; Torii, K; Kodera, Y

ANNALS OF ONCOLOGY 28 巻 2017年9月

脳腫瘍マウスモデルにおけるテモゾロミド感受性に対するCD109の機能解析

白木之浩, 三井伸二, 浅井直也, 榎本篤, 百田洋之, 夏目敦至, 若林俊彦, 高橋雅英

日本癌学会総会記事 76回巻頁： P - 3324 2017年9月

Daple Coordinates Planar Polarized Microtubule Dynamics in Ependymal Cells and Contributes to Hydrocephalus 査読有り

Takagishi, M; Sawada, M; Ohata, S; Asai, N; Enomoto, A; Takahashi, K; Weng, L; Ushida, K; Ara, H; Matsui, S; Kaibuchi, K; Sawamoto, K; Takahashi, M

CELL REPORTS 20 巻 ( 4 ) 頁： 960 - 972 2017年7月

Corrigendum: Girdin maintains the stemness of glioblastoma stem cells (Oncogene (2012) 31 (2715-2724) DOI: 10.1038/onc.2011.466) 査読有り

A. Natsume, T. Kato, S. Kinjo, A. Enomoto, H. Toda, S. Shimato, F. Ohka, K. Motomura, Y. Kondo, T. Miyata, M. Takahashi, T. Wakabayashi

Oncogene 31 巻 ( 22 ) 頁： 2715 - 2724 2017年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nature Publishing Group

Glioblastomas (GBMs) are the most common and aggressive type of brain tumor. GBMs usually show hyperactivation of the PI3K-Akt pathway, a pro-tumorigenic signaling cascade that contributes to pathogenesis. Girdin, an actin-binding protein identified as a novel substrate of Akt, regulates the sprouting of axons and the migration of neural progenitor cells during early postnatal-stage neurogenesis in the hippocampus. Here, we show that Girdin is highly expressed in human glioblastoma (GBM). Stable Girdin knockdown in isolated GBM stem cells resulted in decreased expression of stem cell markers, including CD133, induced multilineage neural differentiation, and inhibited in vitro cell motility, ex vivo invasion, sphere-forming capacity and in vivo tumor formation. Furthermore, exogenous expression of the Akt-binding domain of Girdin, which competitively inhibits its Akt-mediated phosphorylation, diminished the expression of stem cell markers, SOX2 and nestin, and migration on the brain slice and induced the expression of neural differentiation markers glial fibrillary acidic protein/ΒIII Tubulin. Our results reveal that Girdin is required for GBM-initiating stem cells to sustain the stemness and invasive properties. © 2012 Macmillan Publishers Limited All rights reserved.

DOI： 10.1038/onc.2011.466

Scopus

Tyrosine Phosphorylation of an Actin-Binding Protein Girdin Specifically Marks Tuft Cells in Human and Mouse Gut 査読有り

Kuga, D; Ushida, K; Mii, S; Enomoto, A; Asai, N; Nagino, M; Takahashi, M; Asai, M

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 65 巻 ( 6 ) 頁： 347 - 366 2017年6月

Girdin maintains the stemness of glioblastoma stem cells (vol 31, pg 2715, 2012) 査読有り

A. Natsume, T. Kato, S. Kinjo, A. Enomoto, H. Toda, S. Shimato, F. Ohka, K. Motomura, Y. Kondo, T. Miyata, M. Takahashi, T. Wakabayashi

ONCOGENE 36 巻 ( 26 ) 頁： 3796 - 3796 2017年6月

Significance of low mTORC1 activity in defining the characteristics of brain tumor stem cells 査読有り

Han, YP; Enomoto, A; Shiraki, Y; Wang, SQ; Wang, XZ; Toyokuni, S; Asai, N; Ushida, K; Ara, H; Ohka, F; Wakabayashi, T; Ma, J; Natsume, A; Takahashi, M

NEURO-ONCOLOGY 19 巻 ( 5 ) 頁： 636 - 647 2017年5月

Meflin/Islrは心臓線維化における筋線維芽細胞起源のマーカーである

原昭壽, 榎本篤, 室原豊明, 高橋雅英

日本病理学会会誌 106 巻 ( 1 ) 頁： 317 - 317 2017年3月

癌性リンパ管症を呈した乳腺神経内分泌腫瘍(Neuroendocrine tumor of the breast showing carcinomatous lymphangiosis)

川崎朋範, 中井登紀子, 市原周, 長谷川正規, 岩越朱里, 榎本篤, 佐藤朋子, 浅井昌美, 西川恵理, 大林千穂

日本病理学会会誌 106 巻 ( 1 ) 頁： 335 - 335 2017年3月

慢性皮膚炎症を伴うCD109ノックアウトマウスにおいて皮膚腫瘍形成は抑制される(Suppression of skin tumorigenesis in CD109-deficient mice with chronic skin inflammation)

三井伸二, 砂川真輝, 榎本篤, 村雲芳樹, 梛野正人, 高橋雅英

日本病理学会会誌 106 巻 ( 1 ) 頁： 361 - 361 2017年3月

ヒトgliiomaにおけるCD109の発現(Significance of Perivascular Tumor Cells Defined by CD109 Expression)

白木之浩, 三井伸二, 榎本篤, 高橋雅英

日本病理学会会誌 106 巻 ( 1 ) 頁： 395 - 395 2017年3月

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