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The actin-binding protein girdin and its akt-mediated phosphorylation regulate neointima formation after vascular injury 査読有り

Miyake H, Maeda K, Asai N, Shibata R, Ichimiya H, Isotani-Sakakibara M, Yamamura Y, Kato K, Enomoto A, Takahashi M, Murohara T.

108 巻 ( 10 ) 頁： 1170-1179 2011年

Girdin Is an Intrinsic Regulator of Neuroblast Chain Migration in the Rostral Migratory Stream of the Postnatal Brain 査読有り

Wang Y, Kaneko N, Asai N, Enomoto A, Isotani-Sakakibara M, Kato T, Asai M, Murakumo Y, Ota H, Hikita T, Namba T, Kuroda K, Kaibuchi K, Ming GL, Song H, Sawamoto K, Takahashi M.

Journal of Neuroscience 31 巻 ( 22 ) 頁： 8109-8122 2011年

Girding for migratory cues: roles of the Akt substrate Girdin in cancer progression and angiogenesis 招待有り査読有り

Weng L, Enomoto A, Ishida-Takagishi M, Asai N, Takahashi M.

Cancer Science 101 巻 ( 4 ) 頁： 836-842 2010年

Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus 査読有り

Enomoto A, Asai N, Namba T, Wang Y, Kato T, Tanaka M, Tatsumi H, Taya S, Tsuboi D, Kuroda K, Kaneko N, Sawamoto K, Miyamoto R, Jijiwa M, Murakumo Y, Sokabe M, Seki T, Kaibuchi K, Takahashi M.

Neuron 63 巻 ( 6 ) 頁： 774-787 2009年

An actin-binding protein Girdin regulates the motility of breast cancer cells 査読有り

Jiang, P., Enomoto, A., Jijiwa, M., Kato, T., Hasegawa, T., Ishida, M., Sato, T., Asai, N., Murakumo, Y., Takahashi, M.

Cancer Res 68 巻頁： 1310-1318 2008年

Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin. 査読有り

Kitamura, T.*, Asai, N.*, Enomoto, A.* (*joint first authorship), Maeda, K., Kato, T., Ishida, M., Jiang, P., Watanabe, T., Usukura, J., Kondo, T., Costantini, F., Murohara, T.

Nat Cell Biol 10 巻頁： 329-337 2008年

Dok-4 regulates GDNF-dependent neurite outgrowth through downstream activation of Rap1 and mitogen-activated protein kinase 査読有り

Uchida, M., A. Enomoto, T. Fukuda, K. Kurokawa, K. Maeda, Y. Kodama, N. Asai, T. Hasegawa, Y. Shimono, M. Jijiwa, M. Ichihara, Y. Murakumo, M. Takahashi

J Cell Sci 119 巻頁： 3067-3077 2006年

Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells 査読有り

Asai, N., T. Fukuda, Z. Wu, A. Enomoto, V. Pachnis, M. Takahashi, F. Costantini

Development 133 巻頁： 4507-4716 2006年

Girdin, a novel actin-binding protein, and its family of proteins possess versatile functions in the Akt and Wnt signaling pathways 査読有り

Enomoto, A., P. Jiang, M. Takahashi

Ann N Y Acad Sci 1086 巻頁： 169-184 2006年

Roles of organic anion transporters (OATs) and a urate transporter (URAT1) in the pathophysiology of human disease 招待有り査読有り

Enomoto, A., H. Endou

Clin Exp Nephrol 9 巻頁： 195-205 2005年

Akt/PKB regulates actin organization and cell motility via Girdin/APE 査読有り

Enomoto, A., H. Murakami, N. Asai, N. Morone, T. Watanabe, K. Kawai, Y. Murakumo, J. Usukura, K. Kaibuchi, M. Takahashi

Developmental Cell 9 巻頁： 389-402 2005年

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

The serine/threonine kinase Akt (also called protein kinase B) is well known as an important regulator of cell survival and growth and has also been shown to be required for cell migration in different organisms. However, the mechanism by which Akt functions to promote cell migration is not understood. Here, we identify an Akt substrate, designated Girdin/APE (Akt-phosphorylation enhancer), which is an actin binding protein. Girdin expresses ubiquitously and plays a crucial role in the formation of stress fibers and lamellipodia. Akt phosphorylates serine at position 1416 in Girdin, and phosphorylated Girdin accumulates at the leading edge of migrating cells. Cells expressing mutant Girdin, in which serine 1416 was replaced with alanine, formed abnormal elongated shapes and exhibited limited migration and lamellipodia formation. These findings suggest that Girdin is essential for the integrity of the actin cytoskeleton and cell migration and provide a direct link between Akt and cell motility.

Role of organic anion transporters in the tubular transport of indoxyl sulfate and the induction of its nephrotoxicity 査読有り

Enomoto, A., M. Takeda, A. Tojo, T. Sekine, S. H. Cha, S. Khamdang, F. Takayama, I. Aoyama, S. Nakamura, H. Endou, T. Niwa

J Am Soc Nephrol 133 巻頁： 1711-1720 2002年

Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition 査読有り

Enomoto, A., M. F. Wempe, H. Tsuchida, H. J. Shin, S. H. Cha, N. Anzai, A. Goto, A. Sakamoto, T. Niwa, Y. Kanai, M. W. Anders, H. Endou

J Biol Chem 277 巻頁： 36262-36271 2002年

Molecular identification of a renal urate anion exchanger that regulates blood urate levels 査読有り

Enomoto, A., H. Kimura, A. Chairoungdua, Y. Shigeta, P. Jutabha, S. H. Cha, M. Hosoyamada, M. Takeda, T. Sekine, T. Igarashi, H. Matsuo, Y. Kikuchi, T. Oda, K. Ichida, T. Hosoya, K. Shimokata, T. Niwa, Y. Kanai, H. Endou

Nature 417 巻頁： 447-452 2002年

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