研究者詳細 - 榎本　篤

論文 - 榎本　篤

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Stiff extracellular matrix activates the transcription factor ATF5 to promote the proliferation of cancer cells

Ishihara, S; Enomoto, A; Sakai, A; Iida, T; Tange, S; Kioka, N; Nukuda, A; Nagasato, AI; Yasuda, M; Tokino, T; Haga, H

ISCIENCE 28 巻 ( 3 ) 2025年3月

Novel cell-to-cell communications between macrophages and fibroblasts regulate obesity-induced adipose tissue fibrosis.

Kohda H, Tanaka M, Shichino S, Arakawa S, Komori T, Ito A, Wada E, Ochi K, Yuan X, Takeda T, Saiki A, Tatsuno I, Ikeda K, Miyai Y, Enomoto A, Morikawa Y, Shimizu S, Ueha S, Matsushima K, Ogawa Y, Suganami T

Diabetes 2025年3月

Vitamin D derivatives inhibit mesenchymal transition of mesothelial cells and mitigate peritoneal dissemination of ovarian cancer

Fujita, K; Hayashi, M; Yoshihara, M; Nomura, S; Kitami, K; Miyamoto, E; Iyoshi, S; Mogi, K; Fujimoto, H; Uno, K; Kunishima, A; Yamakita, Y; Tomita, H; Tsutsumi, R; Sakamoto, R; Nagasawa, K; Masuo, Y; Nishiuchi, T; Shibata, K; Enomoto, A; Kajiyama, H

MEDICAL MOLECULAR MORPHOLOGY 2025年2月

Superoxide dismutase 2 deficiency in mesenchymal stromal cells induces sympathetic denervation and functional impairment of brown adipose tissue 国際誌

Urano, Y; Mii, S; Asai, S; Esaki, N; Ando, R; Shiraki, Y; Iida, T; Kato, K; Hori, M; Hayashi, Y; Shimizu, T; Enomoto, A

PATHOLOGY INTERNATIONAL 75 巻 ( 2 ) 頁： 69 - 81 2025年2月

Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression 査読有り国際誌

Kobayashi, H; Iida, T; Ochiai, Y; Malagola, E; Zhi, XF; White, RA; Qian, J; Wu, FJ; Waterbury, QT; Tu, RH; Zheng, BY; Labella, JS; Zamechek, LB; Ogura, A; Woods, SL; Worthley, DL; Enomoto, A; Wang, TC

CANCER DISCOVERY 15 巻 ( 1 ) 頁： 202 - 226 2025年1月

ALPK2 prevents cardiac diastolic dysfunction in heart failure with preserved ejection fraction 国際誌

Yoshida, T; Yoshida, S; Inukai, K; Kato, K; Yura, Y; Hattori, T; Taki, K; Enomoto, A; Ohashi, K; Okumura, T; Ouchi, N; Kawase, H; Wettschureck, N; Offermanns, S; Murohara, T; Takefuji, M

FASEB JOURNAL 38 巻 ( 22 ) 頁： e70192 2024年11月

Pulmonary metastases of a renal angiomyolipoma: A case report, with whole-exome sequencing analysis. 査読有り国際誌

Sonoda Y, Hirasaki M, Usami Y, Torigoe T, Kawasaki T, Suzuki N, Shiraki Y, Enomoto A, Imada H, Baba Y

Radiology case reports 19 巻 ( 11 ) 頁： 4963 - 4969 2024年11月

Meflin/ISLR is a marker of adipose stem and progenitor cells in mice and humans that suppresses white adipose tissue remodeling and fibrosis 査読有り国際誌

Ishihara, T; Kato, K; Matsumoto, K; Tanaka, M; Hara, A; Shiraki, Y; Morisaki, H; Urano, Y; Ando, R; Ito, K; Mii, S; Esaki, N; Furuhashi, K; Takefuji, M; Suganami, T; Murohara, T; Enomoto, A

GENES TO CELLS 29 巻 ( 10 ) 頁： 902 - 920 2024年10月

Protein kinase N promotes cardiac fibrosis in heart failure by fibroblast-to-myofibroblast conversion 査読有り国際誌

Yoshida, S; Yoshida, T; Inukai, K; Kato, K; Yura, Y; Hattori, T; Enomoto, A; Ohashi, K; Okumura, T; Ouchi, N; Kawase, H; Wettschureck, N; Offermanns, S; Murohara, T; Takefuji, M

NATURE COMMUNICATIONS 15 巻 ( 1 ) 頁： 7638 - 7638 2024年9月

Tumor-associated fibrosis: a unique mechanism promoting ovarian cancer metastasis and peritoneal dissemination 査読有り国際誌

Fujimoto, H; Yoshihara, M; Rodgers, R; Iyoshi, S; Mogi, K; Miyamoto, E; Hayakawa, S; Hayashi, M; Nomura, S; Kitami, K; Uno, K; Sugiyama, M; Koya, Y; Yamakita, Y; Nawa, A; Enomoto, A; Ricciardelli, C; Kajiyama, H

CANCER AND METASTASIS REVIEWS 43 巻 ( 3 ) 頁： 1037 - 1053 2024年9月

進行卵巣癌でMeflin陽性癌関連線維芽細胞が腫瘍進展、生命予後に与える影響(Meflin-positive cancer-associated fibroblasts exhibit anti-tumor effects in advanced ovarian cancer)

宮本絵美里, 吉原雅人, 小屋美博, 藤本裕基, 伊吉祥平, 茂木一将, 宇野枢, 北見和久, 榎本篤, 梶山広明, 梶山広明

日本癌学会総会記事 83回巻頁： E - 3056 2024年9月

骨肉腫微小環境における腫瘍関連マクロファージ由来IL-8の働き

辰野力人, 市川二郎, 菰原義弘, 榎本篤, 川崎朋範, 重橋孝洋, 波呂浩孝

日本整形外科学会雑誌 98 巻 ( 8 ) 頁： S1968 - S1968 2024年9月

Surface Markers and Chemokines/Cytokines of Tumor-Associated Macrophages in Osteosarcoma and Other Carcinoma Microenviornments-Contradictions and Comparisons 査読有り国際誌

Tatsuno, R; Komohara, Y; Pan, C; Kawasaki, T; Enomoto, A; Jubashi, T; Kono, H; Wako, M; Ashizawa, T; Haro, H; Ichikawa, J

CANCERS 16 巻 ( 16 ) 2024年8月

Synthetic retinoid-mediated preconditioning of cancer-associated fibroblasts and macrophages improves cancer response to immune checkpoint blockade 査読有り国際誌

Owaki, T; Iida, T; Miyai, Y; Kato, K; Hase, T; Ishii, M; Ando, R; Hinohara, K; Akashi, T; Mizutani, Y; Ishikawa, T; Mii, S; Shiraki, Y; Esaki, N; Yamamoto, M; Tsukamoto, T; Nomura, S; Murakami, T; Takahashi, M; Yuguchi, Y; Maeda, M; Sano, T; Sassa, N; Matsukawa, Y; Kawashima, H; Akamatsu, S; Enomoto, A

BRITISH JOURNAL OF CANCER 131 巻 ( 2 ) 頁： 372 - 386 2024年7月

Correction: Pivotal role of IL-8 derived from the interaction between osteosarcoma and tumor-associated macrophages in osteosarcoma growth and metastasis via the FAK pathway.

Tatsuno R, Ichikawa J, Komohara Y, Pan C, Kawasaki T, Enomoto A, Aoki K, Hayakawa K, Iwata S, Jubashi T, Haro H

Cell death & disease 15 巻 ( 7 ) 頁： 471 2024年7月

宮井雄基, 白木之浩, 安藤良太, 榎本篤

実験医学 42 巻 ( 11 ) 頁： 1684 - 1690 2024年7月

記述言語：日本語出版者・発行元：(株)羊土社

がん関連線維芽細胞(CAF)はがん促進性の機能をもつと長く認識されてきた.一方で,CAFを除去あるいはその増殖を抑制するとがんの増悪が観察されたことから,CAFにはがん抑制性の機能があることも指摘されている.昨今の解析技術の発展により,CAFの多様性やその臨床的意義に関する理解は得られつつあるが,依然,がん抑制性CAFの本態は不明確である.本稿では,がん抑制性CAFに対する理解の現状と難しさについて,われわれの仮説も交えつつ概説したい.(著者抄録)

非浸潤性乳管癌に対する乳房温存術後の放射線照射は省略できるか? 査読有り

市原周, 伊藤典子, 森谷鈴子, 岩越朱里, 森田孝子, 大岩幹直, 佐久間貴彦, 中井登紀子, 窪田智行, 水谷三浩, 稲田健一, 川崎朋範, 榎本篤

現代医学 71 巻 ( 1 ) 頁： 104 - 109 2024年6月

非浸潤性乳管癌に対する乳房温存術後の放射線照射は省略できるか?

市原周, 伊藤典子, 森谷鈴子, 岩越朱里, 森田孝子, 大岩幹直, 佐久間貴彦, 中井登紀子, 窪田智行, 水谷三浩, 稲田健一, 川崎朋範, 榎本篤

現代医学 71 巻 ( 1 ) 頁： 104 - 109 2024年6月

Successful Treatment of Multiple Systemic Artery-to-Pulmonary Artery Fistulas.

Ryo T, Shigemitsu K, Mori S, Enomoto A, Chen-Yoshikawa TF

Annals of thoracic surgery short reports 2 巻 ( 2 ) 頁： 172 - 174 2024年6月

侵襲性微小乳頭所見と多発リンパ節転移を示す乳房神経内分泌腫瘍(Neuroendocrine tumor of the breast showing invasive micropapillary features and multiple lymph node metastases)

川崎朋範, 田島知明, 村松千左子, 藤本章博, 児玉ひとみ, 市川二郎, 永井宏和, 星田義彦, 谷山清巳, 榎本篤, 川村隆三, 竹見祥大, 鈴木美穂, 村松孝洋, 地主龍平, 宇佐見陽子, 中村泰大, 解良恭一

日本内分泌学会雑誌 99 巻 ( 5 ) 頁： 1674 - 1674 2024年4月

Cancer-associated Fibroblast-Derived Itaconate Stimulates Pro-tumorigenic Immune Microenvironment in Cervical Cancer

Nakahara, R; Aki, S; Kato, M; Tsuchida, R; Shimamura, T; Enomoto, A; Osawa, T

CANCER SCIENCE 115 巻頁： 555 - 555 2024年3月

Meflin, a New Population Maker of Portal Fibroblasts, Suppress Cholangiocarcinoma

Ito, K; Shiraki, Y; Mii, S; Esaki, N; Sunagawa, M; Baba, T; Ebata, T; Enomoto, A

CANCER SCIENCE 115 巻頁： 2090 - 2090 2024年3月

Functional analyses of immune checkpoint molecule, VISTA, in malignant pleural mesothelioma

Okada, H; Yanagisawa, K; Enomoto, A

CANCER SCIENCE 115 巻頁： 1830 - 1830 2024年3月

Exploring the Role of Transgelin in Cancer-associated Fibroblasts in the Development of Pancreatic Adenocarcinoma

Wang, XX; Shinjo, K; Kumegawa, K; Maruyama, R; Mii, S; Murofushi, Y; Suzuki, M; Enomoto, A; Kondo, Y

CANCER SCIENCE 115 巻頁： 1698 - 1698 2024年3月

Cancer-associated fibroblasts as upstream regulators of the tumor immune microenvironment and therapeutic application

Owaki, T; Miyai, Y; Iida, T; Akamatsu, S; Enomoto, A

CANCER SCIENCE 115 巻頁： 1498 - 1498 2024年3月

Single-cell colocalization analysis using a deep generative model 査読有り

Kojima, Y; Mii, S; Hayashi, S; Hirose, H; Ishikawa, M; Akiyama, M; Enomoto, A; Shimamura, T

CELL SYSTEMS 15 巻 ( 2 ) 頁： 180 - 192.e7 2024年2月

Pivotal role of IL-8 derived from the interaction between osteosarcoma and tumor-associated macrophages in osteosarcoma growth and metastasis via the FAK pathway 査読有り

Tatsuno, R; Ichikawa, J; Komohara, Y; Pan, C; Kawasaki, T; Enomoto, A; Aoki, K; Hayakawa, K; Iwata, S; Jubashi, T; Haro, H

CELL DEATH & DISEASE 15 巻 ( 2 ) 頁： 108 2024年2月

TGF-β signaling promotes desmoid tumor formation via CSRP2 upregulation 査読有り

Li, Y; Fujishita, T; Mishiro-Sato, E; Kojima, Y; Niu, YQ; Taketo, MM; Urano, Y; Sakai, T; Enomoto, A; Nishida, Y; Aoki, M

CANCER SCIENCE 115 巻 ( 2 ) 頁： 401 - 411 2024年2月

頭蓋内における間葉系幹細胞マーカーMeflinの発現解析(Expression of Meflin, a Mesenchymal Stem Cell(MSC) Marker, in the Intracranial Region)

白木之浩, 安藤良太, 三井伸二, 榎本篤

日本病理学会会誌 113 巻 ( 1 ) 頁： 439 - 439 2024年2月

膵星細胞(PSC)の形態と機能

安藤良太, 渡會蒼大, 白木之浩, 三井伸二, 榎本篤

日本病理学会会誌 113 巻 ( 1 ) 頁： 400 - 400 2024年2月

難治性がん腫の克服を目指したがん微小環境を標的とする抗体薬物複合体の研究開発

江崎寛季, 安藤良太, 宮井雄基, 松山誠, 白木之浩, 三井伸二, 高橋雅英, 榎本篤

日本病理学会会誌 113 巻 ( 1 ) 頁： 400 - 400 2024年2月

多発転移を伴う神経内分泌と微小乳頭癌の特徴を示す浸潤性乳癌(Invasive breast cancer showing neuroendocrine and micropapillary features with multiple metastases)

川崎朋範, 田島知明, 村松千左子, 川村隆三, 竹見祥大, 鈴木美穂, 市原周, 榎本篤, 永井宏和, 谷山清巳

日本病理学会会誌 113 巻 ( 1 ) 頁： 302 - 303 2024年2月

Meflin is a marker of pancreatic stellate cells involved in fibrosis and epithelial regeneration in the pancreas 査読有り国際誌

Ando, R; Shiraki, Y; Miyai, Y; Shimizu, H; Furuhashi, K; Minatoguchi, S; Kato, K; Kato, A; Iida, T; Mizutani, Y; Ito, K; Asai, N; Mii, S; Esaki, N; Takahashi, M; Enomoto, A

JOURNAL OF PATHOLOGY 262 巻 ( 1 ) 頁： 61 - 75 2024年1月

Impact of elobixibat on liver tumors, microbiome, and bile acid levels in a mouse model of nonalcoholic steatohepatitis

Sugiyama, Y; Yamamoto, K; Honda, T; Kato, A; Muto, H; Yokoyama, S; Ito, T; Imai, N; Ishizu, Y; Nakamura, M; Asano, T; Enomoto, A; Zaitsu, K; Ishigami, M; Fujishiro, M; Kawashima, H

HEPATOLOGY INTERNATIONAL 17 巻 ( 6 ) 頁： 1378 - 1392 2023年12月

Wnt activation disturbs cell competition and causes diffuse invasion of transformed cells through NF-κB-MMP21 pathway

Nakai, K; Lin, HC; Yamano, S; Tanaka, S; Kitamoto, S; Saitoh, H; Sakuma, K; Kurauchi, J; Akter, E; Konno, M; Ishibashi, K; Kamata, R; Ohashi, A; Koseki, J; Takahashi, H; Yokoyama, H; Shiraki, Y; Enomoto, A; Abe, S; Hayakawa, Y; Ushiku, T; Mutoh, M; Fujita, Y; Kon, S

NATURE COMMUNICATIONS 14 巻 ( 1 ) 頁： 7048 2023年11月

Neuroendocrine neoplasms in the breast oncology field: dilemmas of nature and morphology

Kawasaki, T; Tashima, T; Enomoto, A; Ichikawa, J; Nagai, H; Muramatsu, C; Nakamura, Y; Kaira, K

FRONTIERS IN ENDOCRINOLOGY 14 巻頁： 1216424 2023年11月

Targeting hyaluronan-mediated motility receptor (HMMR) enhances response to androgen receptor signalling inhibitors in prostate cancer 査読有り国際誌

Josephine A. Hinneh, Joanna L. Gillis, Chui Yan Mah, Swati Irani, Raj K. Shrestha, Natalie K. Ryan, Enomoto Atsushi, Zeyad D. Nassar, David J. Lynn, Luke A. Selth, Masashi Kato, Margaret M. Centenera, Lisa M. Butler

British Journal of Cancer 129 巻 ( 8 ) 頁： 1350 - 1361 2023年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

Background: Resistance to androgen receptor signalling inhibitors (ARSIs) represents a major clinical challenge in prostate cancer. We previously demonstrated that the ARSI enzalutamide inhibits only a subset of all AR-regulated genes, and hypothesise that the unaffected gene networks represent potential targets for therapeutic intervention. This study identified the hyaluronan-mediated motility receptor (HMMR) as a survival factor in prostate cancer and investigated its potential as a co-target for overcoming resistance to ARSIs. Methods: RNA-seq, RT-qPCR and Western Blot were used to evaluate the regulation of HMMR by AR and ARSIs. HMMR inhibition was achieved via siRNA knockdown or pharmacological inhibition using 4-methylumbelliferone (4-MU) in prostate cancer cell lines, a mouse xenograft model and patient-derived explants (PDEs). Results: HMMR was an AR-regulated factor that was unaffected by ARSIs. Genetic (siRNA) or pharmacological (4-MU) inhibition of HMMR significantly suppressed growth and induced apoptosis in hormone-sensitive and enzalutamide-resistant models of prostate cancer. Mechanistically, 4-MU inhibited AR nuclear translocation, AR protein expression and subsequent downstream AR signalling. 4-MU enhanced the growth-suppressive effects of 3 different ARSIs in vitro and, in combination with enzalutamide, restricted proliferation of prostate cancer cells in vivo and in PDEs. Conclusion: Co-targeting HMMR and AR represents an effective strategy for improving response to ARSIs. [Figure not available: see fulltext.]

DOI： 10.1038/s41416-023-02406-8

Scopus

PubMed

腫瘍免疫微小環境の上流制御因子としてのがん関連線維芽細胞、そして臨床応用へ(Cancer-associated fibroblasts as upstream regulators of the tumor immune microenvironment and therapeutic application)

大脇貴之, 宮井雄基, 飯田忠, 赤松秀輔, 榎本篤

日本癌学会総会記事 82回巻頁： 1499 - 1499 2023年9月

骨肉腫微小環境における腫瘍関連マクロファージ由来ケモカインの働き

辰野力人, 市川二郎, 菰原義弘, 榎本篤, 川崎朋範, 波呂浩孝

日本整形外科学会雑誌 97 巻 ( 8 ) 頁： S1891 - S1891 2023年8月

骨肉腫微小環境における腫瘍関連マクロファージ由来ケモカインの働き

辰野力人, 市川二郎, 菰原義弘, 榎本篤, 川崎朋範, 波呂浩孝

日本整形外科学会雑誌 97 巻 ( 8 ) 頁： S1891 - S1891 2023年8月

免疫チェックポイント阻害剤を用いた膵癌治療:基礎から臨床まで癌関連線維芽細胞をターゲットにした免疫チェックポイント阻害剤感受性改善薬の開発

飯田忠, 榎本篤, 川嶋啓揮

膵臓 38 巻 ( 3 ) 頁： A211 - A211 2023年7月

Significance of expression of CD109 in osteosarcoma and its involvement in tumor progression via BMP signaling

Mori, N; Esaki, N; Shimoyama, Y; Shiraki, Y; Asai, N; Sakai, T; Nishida, Y; Takahashi, M; Enomoto, A; Mii, S

PATHOLOGY RESEARCH AND PRACTICE 245 巻頁： 154443 2023年5月

Neuroendocrine neoplasms of the breast: diagnostic confusion and future perspectives 国際誌

Kawasaki, T; Tashima, T; Enomoto, A; Kondo, T; Nagai, H; Nakamura, Y; Ichikawa, J; Taniyama, K; Kaira, K

VIRCHOWS ARCHIV 482 巻 ( 5 ) 頁： 929 - 930 2023年5月

Substrate stiffness induces nuclear localization of myosin regulatory light chain to suppress apoptosis 査読有り国際誌

Onishi, K; Ishihara, S; Takahashi, M; Sakai, A; Enomoto, A; Suzuki, K; Haga, H

FEBS LETTERS 597 巻 ( 5 ) 頁： 643 - 656 2023年3月

The usefulness of meflin expression in cancer-associated fibroblasts as a predictive marker for immune checkpoint inhibitor in clear cell renal cell carcinoma.

Owaki, T; Miyai, Y; Naito, Y; Sano, T; Enomoto, A

JOURNAL OF CLINICAL ONCOLOGY 41 巻 2023年2月

Stiff substrates localize myosin regulatory light chain in nucleus to suppress apoptosis

Katsuya, O; Seiichiro, I; Masayuki, T; Enomoto, A; Haga, H

MOLECULAR BIOLOGY OF THE CELL 34 巻 ( 2 ) 頁： 731 - 732 2023年2月

TGF-β signaling promotes desmoid tumor formation in a mouse model

Li, Y; Fujishita, T; Mishiro, E; Taketo, MM; Enomoto, A; Nishida, Y; Aoki, M

CANCER SCIENCE 114 巻頁： 1833 - 1833 2023年2月

An Effective Therapy that Antibody-Drug Conjugates Targeting Meflin (+) Cells for Osteosarcoma

Sakoda, T; Esaki, N; Ando, R; Miyai, Y; Iida, T; Matsuyama, M; Shiraki, Y; Mii, S; Nishida, Y; Takahashi, M; Enomoto, A

CANCER SCIENCE 114 巻頁： 760 - 760 2023年2月

Cancer-associated Fibroblast-derived Itaconate in Tumor Microenvironment Promotes Tumor Growth in Cervical Cancer

Nakahara, R; Aki, S; Kato, M; Tsuchida, R; Shimamura, T; Enomoto, A; Osawa, T

CANCER SCIENCE 114 巻頁： 1779 - 1779 2023年2月

Cancer-associated Fibroblast-derived Itaconate in Tumor Microenvironment Promotes Tumor Growth in Cervical Cancer

Nakahara, R; Aki, S; Kato, M; Tsuchida, R; Shimamura, T; Enomoto, A; Osawa, T

CANCER SCIENCE 114 巻頁： 1923 - 1923 2023年2月

Identification of tumor suppressor fibroblasts and therapeutic applications

Iida, T; Mizutani, Y; Kawashima, H; Enomoto, A

CANCER SCIENCE 114 巻頁： 1650 - 1650 2023年2月

Meflin is a good predictive biomarker for ICI in urothelial carcinoma

Owaki, T; Miyai, Y; Iida, T; Esaki, N; Shiraki, Y; Mii, S; Enomoto, A

CANCER SCIENCE 114 巻頁： 1399 - 1399 2023年2月

New horizons for cancer research driven by histopathological approaches

Enomoto, A; Kanai, Y

CANCER SCIENCE 114 巻頁： 919 - 919 2023年2月

Peritoneal restoration by repurposing vitamin D inhibits ovarian cancer dissemination via blockade of TGF-β1/THBS1

Kitami, K; Yoshihara, M; Yamakita, Y; Sugiyama, M; Koya, Y; Miyamoto, E; Fujimoto, H; Iyoshi, S; Uno, K; Mogi, K; Kato, K; Nawa, A; Enomoto, A; Kajiyama, H

CANCER SCIENCE 114 巻頁： 1047 - 1047 2023年2月

Therapeutic Strategies to Overcome Fibrotic Barriers to Nanomedicine in the Pancreatic Tumor Microenvironment 査読有り国際誌

Tanaka, HY; Nakazawa, T; Enomoto, A; Masamune, A; Kano, MR

CANCERS 15 巻 ( 3 ) 2023年2月

【新しい技術で解明されてきた膵臓の病態】癌関連線維芽細胞の形質改変による抗癌剤効果増強剤の開発

飯田忠, 水谷泰之, 山雄健太郎, 石川卓哉, 大野栄三郎, 藤城光弘, 榎本篤, 川嶋啓揮

膵臓 38 巻 ( 1 ) 頁： 37 - 43 2023年2月

記述言語：日本語出版者・発行元：(一社)日本膵臓学会

膵癌の特徴として間質の線維化とそれに伴う組織硬化がある.組織硬化は間質内圧上昇と血管虚脱を誘導し,その結果抗癌剤の間質浸透と癌細胞への到達を阻害することが知られている.この間質の線維化に中心的な役割を果たすのが癌関連線維芽細胞(CAF)である.このため,これまで様々な方法でCAFをターゲットにする治療が試みられてきたが未だ成功していない.本研究では癌抑制性CAFのマーカーであり機能分子であるMeflinをCAFに発現誘導することで,膵癌における化学療法への感受性を改善させることを明らかにした.さらにスクリーニングにより合成レチノイドであるAM80がCAFにおけるMeflinの発現を効果的に誘導し,ドラッグデリバリーの改善を伴って化学療法に対する感受性を改善させることを明らかにした.筆者らは本結果を受けて切除不能膵癌に対するAM80と従来の抗癌剤の併用効果を検証する医師主導治験を行っている.(著者抄録)

その他リンク： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J02025&link_issn=&doc_id=20230308380005&doc_link_id=10.2958%2Fsuizo.38.37&url=https%3A%2F%2Fdoi.org%2F10.2958%2Fsuizo.38.37&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Novel Therapeutic Potentials of Taxifolin for Obesity-Induced Hepatic Steatosis, Fibrogenesis, and Tumorigenesis 査読有り

Inoue, T; Fu, B; Nishio, M; Tanaka, M; Kato, H; Tanaka, M; Itoh, M; Yamakage, H; Ochi, K; Ito, A; Shiraki, Y; Saito, S; Ihara, M; Nishimura, H; Kawamoto, A; Inoue, S; Saeki, K; Enomoto, A; Suganami, T; Satoh-Asahara, N

NUTRIENTS 15 巻 ( 2 ) 頁： 350 - 350 2023年1月

Wnt activation-induced disturbance of cell competition causes diffuse invasion of transformed cells through upregulation of NF-κB-mediated MMP21

Kazuki Nakai, Hancheng Lin, Shotaro Yamano, Shinya Tanaka, Sho Kitamoto, Kenta Sakuma, Junpei Kurauchi, Eilma Akter, Masamitsu Konno, Jun Koseki, Hirotaka Takahashi, Hideshi Yokoyama, Yukihiro Shiraki, Atsushi Enomoto, Sohei Abe, Yoku Hayakawa, Tetsuo Ushiku, Michihiro Mutoh, Yasuyuki Fujita, Shunsuke Kon

2022年12月

出版者・発行元：Research Square Platform LLC

Abstract

Normal epithelial cells exert their competitive advantage over RasV12-transformed cells and eliminate them into the apical lumen via cell competition. However, the internal or external factors that compromise cell competition and provoke carcinogenesis remains unknown. In this study, we examined the effect of sequential accumulation of gene mutations, mimicking multi-sequential carcinogenesis on RasV12-induced cell competition in intestinal epithelial tissues. Consequently, we found that directionality of RasV12-cell extrusion in Wnt-activated epithelia is reversed, and transformed cells are delaminated into the basal lamina via non-cell autonomous MMP21 upregulation. Subsequently, diffusively infiltrating, transformed cells develop into highly invasive carcinomas. Elevated production of MMP21 is elicited partly through NF-κB signaling, blockage of which restores apical elimination of RasV12 cells. We further found that the NF-κB-MMP21 axis is significantly bolstered in early colorectal carcinoma in humans. Collectively, this study shows that cells with high mutational burdens exploit cell competition for their benefit by behaving as unfit cells, endowing them with an invasion advantage.

DOI： 10.21203/rs.3.rs-2314559/v1

その他リンク： https://www.researchsquare.com/article/rs-2314559/v1.html

Girdin Promotes Tumorigenesis and Chemoresistance in Lung Adenocarcinoma by Interacting with PKM2

Cao, FY; Yang, DS; Tang, FY; Lu, C; He, X; Chen, SM; Yang, ZH; Gong, SY; Sun, LQ; Enomoto, A; Takahashi, M; Weng, L

CANCERS 14 巻 ( 22 ) 2022年11月

Mammaglobin 1 mediates progression of trastuzumab-resistant breast cancer cells through regulation of cyclins and NF-κB 査読有り国際誌

Kusumastuti, R; Kumagai, Y; Ishihara, S; Enomoto, A; Murakami, T; Yasuda, M; Haga, H

FEBS OPEN BIO 12 巻 ( 10 ) 頁： 1797 - 1813 2022年10月

BMP3b Is a Novel Antifibrotic Molecule Regulated by Meflin in Lung Fibroblasts 査読有り国際誌

Suzuki, A; Sakamoto, K; Nakahara, Y; Enomoto, A; Hino, J; Ando, A; Inoue, M; Shiraki, Y; Omote, N; Kusaka, M; Fukihara, J; Hashimoto, N

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 67 巻 ( 4 ) 頁： 446 - 458 2022年10月

Insulinoma-associated protein 1 (INSM1) expression in breast carcinomas with neuroendocrine morphologies: application and future perspectives

Kawasaki, T; Tashima, T; Ryozawa, S; Nakamura, Y; Fujimoto, A; Usami, Y; Inozume, T; Saitoh, M; Kondo, T; Enomoto, A; Nagai, H; Taniyama, K; Muramatsu, C; Kaira, K

HISTOPATHOLOGY 81 巻頁： 31 - 31 2022年10月

【免疫チェックポイント阻害薬の"耐性"に挑むがん免疫サイクルから見出す戦略】がん間質の線維芽細胞・腫瘍血管と免疫チェックポイント阻害薬の耐性機構

榎本篤, 宮井雄基, 飯田忠, 大脇貴之

実験医学 40 巻 ( 16 ) 頁： 2580 - 2586 2022年10月

記述言語：日本語出版者・発行元：(株)羊土社

ヒトのがんの間質の免疫細胞の浸潤、線維化、および腫瘍血管の増生の程度はがんの種類あるいは症例間で実に多様である。同一症例の標本でも視野を少し動かしただけで、同じがんとは思えないような組織像の違いを見せることもある。免疫チェックポイント阻害薬(ICI)の勃興によりがん治療の概念が変わり、それに伴いヒト免疫学も飛躍的に発展したと聞く。しかしながら、一部の特殊なゲノム異常を有するがんを除き、前述の腫瘍内(intratumor)および腫瘍間(intertumor)の多様性がICIの奏功予測や一律な奏効率の押し上げを困難なものにしていると推測される。本稿では、主に線維芽細胞と腫瘍血管に焦点をあて、これらが抗腫瘍免疫応答およびICIの効果に及ぼす影響、およびその知見に基づく治療戦略について概説したい。(著者抄録)

骨肉腫におけるMeflin陽性細胞を標的とした抗体薬物複合体の研究開発(An Effective Therapy that Antibody-Drug Conjugates Targeting Meflin(+) Cells for Osteosarcoma)

迫田朋佳, 江崎寛季, 安藤良太, 宮井雄基, 飯田忠, 松山誠, 白木之浩, 三井伸二, 西田佳弘, 高橋雅英, 榎本篤

日本癌学会総会記事 81回巻頁： E - 2021 2022年9月

腫瘍促進的腹膜環境の正常化を標的とした難治性卵巣癌に対する新規治療戦略の開発(Peritoneal restoration by repurposing vitamin D inhibits ovarian cancer dissemination via blockade of TGF-β1/THBS1)

北見和久, 吉原雅人, 山北由彦, 杉山麻衣, 小屋美博, 宮本絵美里, 藤本裕基, 伊吉祥平, 宇野枢, 茂木一将, 加藤一喜, 那波明宏, 榎本篤, 梶山広明

日本癌学会総会記事 81回巻頁： MS1 - 3 2022年9月

Meflinは尿路上皮癌における免疫チェックポイント阻害剤治療の効果予測バイオマーカーである(Meflin is a good predictive biomarker for ICI in urothelial carcinoma)

大脇貴之, 宮井雄基, 飯田忠, 江崎寛季, 白木之浩, 三井伸二, 榎本篤

日本癌学会総会記事 81回巻頁： P - 2185 2022年9月

癌抑制性線維芽細胞の同定と治療応用(Identification of tumor suppressor fibroblasts and therapeutic applications)

飯田忠, 水谷泰之, 川嶋啓揮, 榎本篤

日本癌学会総会記事 81回巻頁： J - 3026 2022年9月

Possible disease-protective roles of fibroblasts in cancer and fibrosis and their therapeutic application 査読有り

Shiraki, Y; Mii, S; Esaki, N; Enomoto, A

NAGOYA JOURNAL OF MEDICAL SCIENCE 84 巻 ( 3 ) 頁： 484 - 496 2022年8月

【膵臓の発生・生理・解剖から膵炎・膵癌の病態解明に至る最新の知見】がん抑制性線維芽細胞の本態の理解とその治療応用について

水谷泰之, 飯田忠, 石川卓哉, 大野栄三郎, 川嶋啓揮, 藤城光弘, 榎本篤

胆と膵 43 巻 ( 8 ) 頁： 787 - 794 2022年8月

記述言語：日本語出版者・発行元：医学図書出版(株)

膵癌治療のボトルネックは、その豊富な間質に起因する薬剤送達(drug delivery)の障害であり、これを解決する治療法の開発が強く求められている。膵癌の豊富な間質の原因は、がん関連線維芽細胞(CAF)の増生であり、がんを促進する形質を有することから治療標的として注目されて久しい。しかしながら、線維芽細胞の活性化および増殖を阻害する薬剤を臨床応用する試みはうまくいっていない。それらの結果より近年では、線維芽細胞はがん促進性と抑制性の二つの極性(性質の連続的な差異)を有していること、さらに同細胞の極性はがん発育の文脈に沿って容易に変換されることの2点が原因であると考えられるようになった。われわれは最近、meflin陽性線維芽細胞が、がん抑制性線維芽細胞であり、その機能は従来の活性化線維芽細胞(筋線維芽細胞やCAF)とは異なっていること、および、線維芽細胞の極性を制御することで抗がん剤の送達性の向上が図れることをマウスモデルで示してきた。これらの知見をベースに、現在、われわれは線維芽細胞の極性の変化を誘導する薬剤の効果を検証する医師主導治験を行っている。(著者抄録)

Efficacy of auranofin as an inhibitor of desmoid progression 査読有り国際誌

Ito, K; Nishida, Y; Hamada, S; Shimizu, K; Sakai, T; Ohkawara, B; Alman, BA; Enomoto, A; Ikuta, K; Koike, H; Zhang, JR; Ohno, K; Imagama, S

SCIENTIFIC REPORTS 12 巻 ( 1 ) 頁： 11918 - 11918 2022年7月

Recurrent fulminant non-rheumatic streptococcal myocarditis proven by endomyocardial biopsy and autopsy. 査読有り

Hiraiwa H, Morimoto R, Ando R, Ito R, Araki T, Mizutani T, Kazama S, Kimura Y, Oishi H, Kuwayama T, Yamaguchi S, Kondo T, Okumura T, Enomoto A, Murohara T

Journal of cardiology cases 26 巻 ( 1 ) 頁： 62 - 65 2022年7月

Good and Bad Stroma in Pancreatic Cancer: Relevance of Functional States of Cancer-Associated Fibroblasts 査読有り国際誌

Ando, R; Sakai, A; Iida, T; Kataoka, K; Mizutani, Y; Enomoto, A

CANCERS 14 巻 ( 14 ) 2022年7月

Pharmacologic conversion of cancer-associated fibroblasts from a protumor phenotype to an antitumor phenotype improves the sensitivity of pancreatic cancer to chemotherapeutics (Apr, 10.1038/s41388-022-02288-9, 2022) 査読有り国際誌

Iida, T; Mizutani, Y; Esaki, N; Ponik, SM; Burkel, BM; Weng, L; Kuwata, K; Masamune, A; Ishihara, S; Haga, H; Kataoka, K; Mii, S; Shiraki, Y; Ishikawa, T; Ohno, E; Kawashima, H; Hirooka, Y; Fujishiro, M; Takahashi, M; Enomoto, A

ONCOGENE 41 巻 ( 23 ) 頁： 3302 - 3302 2022年6月

Spindle Cell Lipoma with Ossification Mimicking Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma: A Case Report 査読有り国際誌

Ichikawa, J; Kawasaki, T; Imada, H; Enomoto, A; Taniguchi, N; Tatsuno, R; Kanno, S; Haro, H

INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY 30 巻 ( 4 ) 頁： 413 - 418 2022年6月

Letter to Editor Regarding "Nuclear Insulinoma-Associated Protein 1 Expression as a Marker of Neuroendocrine Differentiation in Neoplasms of the Breast" by Seijnhaeve et al 査読有り国際誌

Kawasaki, T; Tashima, T; Nakamura, Y; Kondo, T; Enomoto, A; Kaira, K

INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY 30 巻 ( 4 ) 頁： 470 - 471 2022年6月

The interferon-β/STAT1 axis drives the collective invasion of skin squamous cell carcinoma with sealed intercellular spaces 査読有り国際誌

Kumagai, Y; Nio-Kobayashi, J; Ishihara, S; Enomoto, A; Akiyama, M; Ichihara, R; Haga, H

ONCOGENESIS 11 巻 ( 1 ) 頁： 27 - 27 2022年5月

Pharmacologic conversion of cancer-associated fibroblasts from a protumor phenotype to an antitumor phenotype improves the sensitivity of pancreatic cancer to chemotherapeutics 査読有り国際誌

ONCOGENE 41 巻 ( 19 ) 頁： 2764 - 2777 2022年5月

The Critical Role of Meflin-Positive Fibroblasts Against Acute Lung Injury

Hashimoto, N; Sakamoto, K; Nakahara, Y; Omote, N; Ando, A; Inoue, M; Suzuki, A; Fukihara, J; Kusaka, M; Wakahara, K; Enomoto, A

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 205 巻 2022年5月

Meflin-BMP3b Axis Is a Novel Anti-Fibrotic Pathway Against TGF-β-Induced Lung Fibrogenesis

Suzuki, A; Sakamoto, K; Nakahara, Y; Enomoto, A; Hino, J; Ando, A; Inoue, M; Omote, N; Kusaka, M; Fukihara, J; Hashimoto, N

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 205 巻 2022年5月

Peritoneal restoration by repurposing vitamin D inhibits ovarian cancer dissemination via blockade of the TGF-β1/thrombospondin-1 axis 査読有り国際誌

Kitami, K; Yoshihara, M; Tamauchi, S; Sugiyama, M; Koya, Y; Yamakita, Y; Fujimoto, H; Iyoshi, S; Uno, K; Mogi, K; Ikeda, Y; Yokoi, A; Yoshikawa, N; Nishino, K; Niimi, K; Nawa, A; Enomoto, A; Kajiyama, H

MATRIX BIOLOGY 109 巻頁： 70 - 90 2022年5月

CD109 expression in tumor cells and stroma correlates with progression and prognosis in pancreatic cancer 査読有り国際誌

Adachi, K; Sakurai, Y; Ichinoe, M; Tadehara, M; Tamaki, A; Kesen, Y; Kato, T; Mii, S; Enomoto, A; Takahashi, M; Koizumi, W; Murakumo, Y

VIRCHOWS ARCHIV 480 巻 ( 4 ) 頁： 819 - 829 2022年4月

Metastatic Voyage of Ovarian Cancer Cells in Ascites with the Assistance of Various Cellular Components 査読有り国際誌

Uno, K; Iyoshi, S; Yoshihara, M; Kitami, K; Mogi, K; Fujimoto, H; Sugiyama, M; Koya, Y; Yamakita, Y; Nawa, A; Kanayama, T; Tomita, H; Enomoto, A; Kajiyama, H

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23 巻 ( 8 ) 2022年4月

A novel renal perivascular mesenchymal cell subset gives rise to fibroblasts distinct from classic myofibroblasts 査読有り国際誌

Minatoguchi, S; Saito, S; Furuhashi, K; Sawa, Y; Okazaki, M; Shimamura, Y; Kaihan, AB; Hashimoto, Y; Yasuda, Y; Hara, A; Mizutani, Y; Ando, R; Kato, N; Ishimoto, T; Tsuboi, N; Esaki, N; Matsuyama, M; Shiraki, Y; Kobayashi, H; Asai, N; Enomoto, A; Maruyama, S

SCIENTIFIC REPORTS 12 巻 ( 1 ) 頁： 5389 - 5389 2022年3月

The Origin and Contribution of Cancer-Associated Fibroblasts in Colorectal Carcinogenesis 査読有り国際誌

Kobayashi, H; Gieniec, KA; Lannagan, TRM; Wang, TT; Asai, N; Mizutani, Y; Iida, T; Ando, R; Thomas, EM; Sakai, A; Suzuki, N; Ichinose, M; Wright, JA; Vrbanac, L; Ng, JQ; Goyne, J; Radford, G; Lawrence, MJ; Sammour, T; Hayakawa, Y; Klebe, S; Shin, AE; Asfaha, S; Bettington, ML; Rieder, F; Arpaia, N; Danino, T; Butler, LM; Burt, AD; Leedham, SJ; Rustgi, AK; Mukherjee, S; Takahashi, M; Wang, TC; Enomoto, A; Woods, SL; Worthley, DL

GASTROENTEROLOGY 162 巻 ( 3 ) 頁： 890 - 906 2022年3月

Meflin-positive cancer-associated fibroblasts enhance tumor response to immune checkpoint blockade 査読有り国際誌

Miyai, Y; Sugiyama, D; Hase, T; Asai, N; Taki, T; Nishida, K; Fukui, T; Chen-Yoshikawa, TF; Kobayashi, H; Mii, S; Shiraki, Y; Hasegawa, Y; Nishikawa, H; Ando, Y; Takahashi, M; Enomoto, A

LIFE SCIENCE ALLIANCE 5 巻 ( 6 ) 2022年3月

Matrix remodeling-associated protein 8 is a marker of a subset of cancer-associated fibroblasts in pancreatic cancer 査読有り国際誌

Ichihara, R; Shiraki, Y; Mizutani, Y; Iida, T; Miyai, Y; Esaki, N; Kato, A; Mii, S; Ando, R; Hayashi, M; Takami, H; Fujii, T; Takahashi, M; Enomoto, A

PATHOLOGY INTERNATIONAL 72 巻 ( 3 ) 頁： 161 - 175 2022年3月

骨肉腫におけるGPIアンカー型膜タンパク質CD109の発現とその機能解析

三井伸二, 森田悠聖, 大河内凱翔, 下山芳江, 高橋雅英, 榎本篤

日本病理学会会誌 111 巻 ( 1 ) 頁： 293 - 293 2022年3月

Insulinoma-associated protein 1(INSM1) expression in breast carcinomas with neuroendocrine morphologies: application and future prospective(和訳中) 査読有り

川崎朋範, 田島知明, 良沢昭銘, 藤本章博, 堀田洋介, 宇佐見陽子, 馬場康貴, 藤田曜, 椙田浩文, 櫻本信一, 濱口哲弥, 石田博徳, 中平光彦, 佐藤弘, 平能康充, 岡本光順, 各務博, 今井久雄, 中村泰大, 解良恭一, 星田義彦, 寺本典弘, 村田有也, 伊東正博, 川島篤弘, 岩下寿秀, 立山義朗, 谷山大樹, 倉岡和矢, 谷山清己, 永井宏和, 村松千左子, 齋藤正夫, 榎本篤, 近藤哲夫, NEN project team

日本内分泌学会雑誌 97 巻 ( 5 ) 頁： 1611 - 1611 2022年3月

Insulinoma-associated protein 1 expression in breast carcinomas with neuroendocrine morphologies(和訳中) 査読有り

川崎朋範, 解良恭一, 田島知明, 中村泰大, 近藤哲夫, 榎本篤, 村田有也, 星田義彦, 寺本典弘, 谷山清己, NENprojectteam

日本病理学会会誌 111 巻 ( 1 ) 頁： 254 - 254 2022年3月

神経内分泌形態を伴う乳癌におけるインスリノーマ関連タンパク質1(INSM1)の発現応用と将来展望(Insulinoma-associated protein 1(INSM1) expression in breast carcinomas with neuroendocrine morphologies: application and future prospective)

日本内分泌学会雑誌 97 巻 ( 5 ) 頁： 1611 - 1611 2022年3月

神経内分泌細胞の形態を持つ乳がんにおけるインスリノーマ関連タンパク質1の発現(Insulinoma-associated protein 1 expression in breast carcinomas with neuroendocrine morphologies)

川崎朋範, 解良恭一, 田島知明, 中村泰大, 近藤哲夫, 榎本篤, 村田有也, 星田義彦, 寺本典弘, 谷山清己, NEN project team

日本病理学会会誌 111 巻 ( 1 ) 頁： 254 - 254 2022年3月

Safety and efficacy of MIKE-1 in patients with advanced pancreatic cancer: a study protocol for an open-label phase I/II investigator-initiated clinical trial based on a drug repositioning approach that reprograms the tumour stroma 査読有り国際誌

Mizutani, Y; Iida, T; Ohno, E; Ishikawa, T; Kinoshita, F; Kuwatsuka, Y; Imai, M; Shimizu, S; Tsuruta, T; Enomoto, A; Kawashima, H; Fujishiro, M

BMC CANCER 22 巻 ( 1 ) 頁： 205 - 205 2022年2月

Metabolically distinct glioma stem cells differentially require Girdin for stem cell behavior and tumor development

Watanabe, T; Yanagi, H; Enomoto, A; Sampetrean, O; Saya, H; Shimono, Y

CANCER SCIENCE 113 巻頁： 988 - 988 2022年2月

Fibroblasts positive for meflin have anti-fibrotic properties in pulmonary fibrosis 査読有り国際誌

Nakahara, Y; Hashimoto, N; Sakamoto, K; Enomoto, A; Adams, TS; Yokoi, T; Omote, N; Poli, S; Ando, A; Wakahara, K; Suzuki, A; Inoue, M; Hara, A; Mizutani, Y; Imaizumi, K; Kawabe, T; Rosas, IO; Takahashi, M; Kaminski, N; Hasegawa, Y

EUROPEAN RESPIRATORY JOURNAL 58 巻 ( 6 ) 2021年12月

Anti-Malignant Effect of Tensile Loading to Adherens Junctions in Cutaneous Squamous Cell Carcinoma Cells 査読有り国際誌

Dobrokhotov, O; Sunagawa, M; Torii, T; Mii, S; Kawauchi, K; Enomoto, A; Sokabe, M; Hirata, H

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 9 巻頁： 728383 - 728383 2021年11月

Newly established patient-derived organoid model of intracranial meningioma 査読有り国際誌

Yamazaki, S; Ohka, F; Hirano, M; Shiraki, Y; Motomura, K; Tanahashi, K; Tsujiuchi, T; Motomura, A; Aoki, K; Shinjo, K; Murofushi, Y; Kitano, Y; Maeda, S; Kato, A; Shimizu, H; Yamaguchi, J; Adilijiang, A; Wakabayashi, T; Saito, R; Enomoto, A; Kondo, Y; Natsume, A

NEURO-ONCOLOGY 23 巻 ( 11 ) 頁： 1936 - 1948 2021年11月

Ring artifact removal for differential phase-contrast X-ray computed tomography using a conditional generative adversarial network 査読有り国際誌

Huang, ZR; Sunaguchi, N; Shimao, D; Enomoto, A; Ichihara, S; Yuasa, T; Ando, M

INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY 16 巻 ( 11 ) 頁： 1889 - 1900 2021年11月

Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin/Islr in Cancer Fibrosis 査読有り国際誌

Takahashi, M; Kobayashi, H; Mizutani, Y; Hara, A; Iida, T; Miyai, Y; Asai, N; Enomoto, A

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 9 巻頁： 749924 - 749924 2021年10月

Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma 査読有り国際誌

Kobayashi, H; Gieniec, KA; Ng, JQ; Goyne, J; Lannagan, TRM; Thomas, EM; Radford, G; Wang, TT; Suzuki, N; Ichinose, M; Wright, JA; Vrbanac, L; Burt, AD; Takahashi, M; Enomoto, A; Worthley, DL; Woods, SL

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS ( 175 ) 2021年9月

Girdinは代謝特性の異なるグリオーマ幹細胞の幹細胞性、腫瘍形成を特徴的な様式で制御する

渡辺崇, 柳久乃, 榎本篤, サンペトラ・オルテア, 佐谷秀行, 下野洋平

日本癌学会総会記事 80回巻頁： [P11 - 2] 2021年9月

神経内分泌細胞の形態を有する乳がんにおけるインスリノーマ関連タンパク質1(INSM1)の発現応用法と将来の展望(Insulinoma-associated protein 1(INSM1) expression in breast carcinomas with neuroendocrine morphologies: application and future prospective)

川崎朋範, 田島知明, 中村泰大, 堀田洋介, 藤本章博, 宮口和也, 宇佐見陽子, 今井久雄, 解良恭一, 村田有也, 谷山清己, 村松千左子, 齋藤正夫, 榎本篤, 近藤哲夫, 良沢昭銘, NEN project team

日本組織細胞化学会総会・学術集会講演プログラム・予稿集 62回巻頁： 72 - 72 2021年9月

The sodium-glucose cotransporter-2 inhibitor Tofogliflozin prevents the progression of nonalcoholic steatohepatitis-associated liver tumors in a novel murine model 査読有り国際誌

Yoshioka, N; Tanaka, M; Ochi, K; Watanabe, A; Ono, K; Sawada, M; Ogi, T; Itoh, M; Ito, A; Shiraki, Y; Enomoto, A; Ishigami, M; Fujishiro, M; Ogawa, Y; Suganami, T

BIOMEDICINE & PHARMACOTHERAPY 140 巻頁： 111738 - 111738 2021年8月

The CD44/COL17A1 pathway promotes the formation of multilayered, transformed epithelia 査読有り国際誌

Kozawa, K; Sekai, M; Ohba, K; Ito, S; Sako, H; Maruyama, T; Kakeno, M; Shirai, T; Kuromiya, K; Kamasaki, T; Kohashi, K; Tanaka, S; Ishikawa, S; Sato, N; Asano, S; Suzuki, H; Tanimura, N; Mukai, Y; Gotoh, N; Tanino, M; Tanaka, S; Natsuga, K; Soga, T; Nakamura, T; Yabuta, Y; Saitou, M; Ito, T; Matsuura, K; Tsunoda, M; Kikumori, T; Iida, T; Mizutani, Y; Miyai, Y; Kaibuchi, K; Enomoto, A; Fujita, Y

CURRENT BIOLOGY 31 巻 ( 14 ) 頁： 3086 - + 2021年7月

Meflin defines mesenchymal stem cells and/or their early progenitors with multilineage differentiation capacity 査読有り国際誌

Hara, A; Kato, K; Ishihara, T; Kobayashi, H; Asai, N; Mii, S; Shiraki, Y; Miyai, Y; Ando, R; Mizutani, Y; Iida, T; Takefuji, M; Murohara, T; Takahashi, M; Enomoto, A

GENES TO CELLS 26 巻 ( 7 ) 頁： 495 - 512 2021年7月

The BMP antagonist gremlin 1 contributes to the development of cortical excitatory neurons, motor balance and fear responses 査読有り国際誌

Ichinose, M; Suzuki, N; Wang, TT; Kobayashi, H; Vrbanac, L; Ng, JQ; Wright, JA; Lannagan, TRM; Gieniec, KA; Lewis, M; Ando, R; Enomoto, A; Koblar, S; Thomas, P; Worthley, DL; Woods, SL

DEVELOPMENT 148 巻 ( 14 ) 2021年7月

Size and surface modification of silica nanoparticles affect the severity of lung toxicity by modulating endosomal ROS generation in macrophages 査読有り国際誌

Inoue, M; Sakamoto, K; Suzuki, A; Nakai, S; Ando, A; Shiraki, Y; Nakahara, Y; Omura, M; Enomoto, A; Nakase, I; Sawada, M; Hashimoto, N

PARTICLE AND FIBRE TOXICOLOGY 18 巻 ( 1 ) 頁： 21 - 21 2021年6月

A new primate model of hypophyseal dysfunction 国際誌

Kawabata, T; Suga, H; Takeuchi, K; Nagata, Y; Sakakibara, M; Ushida, K; Ozone, C; Enomoto, A; Kawamoto, I; Itagaki, I; Tsuchiya, H; Arima, H; Wakabayashi, T

SCIENTIFIC REPORTS 11 巻 ( 1 ) 頁： 10729 - 10729 2021年5月

CD4+ T cells are essential for the development of destructive thyroiditis induced by anti-PD-1 antibody in thyroglobulin-immunized mice 査読有り国際誌

Yasuda, Y; Iwama, S; Sugiyama, D; Okuji, T; Kobayashi, T; Ito, M; Okada, N; Enomoto, A; Ito, S; Yan, Y; Sugiyama, M; Onoue, T; Tsunekawa, T; Ito, Y; Takagi, H; Hagiwara, D; Goto, M; Suga, H; Banno, R; Takahashi, M; Nishikawa, H; Arima, H

SCIENCE TRANSLATIONAL MEDICINE 13 巻 ( 593 ) 2021年5月

Oncolytic activity of naturally attenuated herpes-simplex virus HF10 against an immunocompetent model of oral carcinoma 査読有り国際誌

Takano, G; Esaki, S; Goshima, F; Enomoto, A; Hatano, Y; Ozaki, H; Watanabe, T; Sato, Y; Kawakita, D; Murakami, S; Murata, T; Nishiyama, Y; Iwasaki, S; Kimura, H

MOLECULAR THERAPY-ONCOLYTICS 20 巻頁： 220 - 227 2021年3月

The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis 査読有り国際誌

Kobayashi, H; Gieniec, KA; Wright, JA; Wang, TT; Asai, N; Mizutani, Y; Lida, T; Ando, R; Suzuki, N; Lannagan, TRM; Ng, JQ; Hara, A; Shiraki, Y; Mii, S; Ichinose, M; Vrbanac, L; Lawrence, MJ; Sammour, T; Uehara, K; Davies, G; Lisowski, L; Alexander, IE; Hayakawa, Y; Butler, LM; Zannettino, ACW; Din, MO; Hasty, J; Burt, AD; Leedham, SJ; Rustgi, AK; Mukherjee, S; Wang, TC; Enomoto, A; Takahashi, M; Worthley, DL; Woods, SL

GASTROENTEROLOGY 160 巻 ( 4 ) 頁： 1224 - + 2021年3月

Vascular PDGFR-alpha protects against BBB dysfunction after stroke in mice 査読有り国際誌

Nguyen, QL; Okuno, N; Hamashima, T; Dang, ST; Fujikawa, M; Ishii, Y; Enomoto, A; Maki, T; Nguyen, HN; Nguyen, VT; Fujimori, T; Mori, H; Andrae, J; Betsholtz, C; Takao, K; Yamamoto, S; Sasahara, M

ANGIOGENESIS 24 巻 ( 1 ) 頁： 35 - 46 2021年2月

Tumor microenvironment stimulates induction of cancer associated fibroblasts

Nakahara, R; Kato, M; Jiang, JR; Nishida, M; Tsuchida, R; Shimamura, T; Enomoto, A; Osawa, T

CANCER SCIENCE 112 巻頁： 723 - 723 2021年2月

CD109 regulates in vivo tumor invasion in lung adenocarcinoma through TGF-β signaling

Mii, S; Taki, T; Shiraki, Y; Enomoto, A; Takahashi, M

CANCER SCIENCE 112 巻頁： 815 - 815 2021年2月

CD109 regulates in vivo tumor invasion in lung adenocarcinoma through TGF-β signaling 査読有り国際誌

Taki, T; Shiraki, Y; Enomoto, A; Weng, L; Chen, C; Asai, N; Murakumo, Y; Yokoi, K; Takahashi, M; Mii, S

CANCER SCIENCE 111 巻 ( 12 ) 頁： 4616 - 4628 2020年12月

The Daple-CK1ε complex regulates Dvl2 phosphorylation and canonical Wnt signaling 査読有り国際誌

Esaki, N; Enomoto, A; Takagishi, M; Mizutani, Y; Iida, T; Ushida, K; Shiraki, Y; Mii, S; Takahashi, M

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 532 巻 ( 3 ) 頁： 406 - 413 2020年11月

Stromal imbalance of bone morphogenetic protein signaling drives colorectal carcinogenesis

Kobayashi, H; Gieniec, K; Wright, J; Wang, T; Asai, N; Mizutani, Y; Ida, T; Ando, R; Suzuki, N; Lannagan, T; Ng, J; Hara, A; Shiraki, Y; Mii, S; Ichinose, M; Vrbanac, L; Lawrence, M; Sammour, T; Uehara, K; Davies, G; Lisowski, L; Alexander, I; Hayakawa, Y; Butler, L; Zannettino, A; Din, MO; Hasty, J; Burt, A; Leedham, S; Rustgi, A; Wang, ST; Wang, TC; Enomoto, A; Takahashi, M; Worthley, D; Woods, S

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 35 巻頁： 160 - 160 2020年11月

Complex roles of the actin-binding protein Girdin/GIV in DNA damage-induced apoptosis of cancer cells 査読有り国際誌

Chen, C; Enomoto, A; Weng, L; Taki, T; Shiraki, Y; Mii, S; Ichihara, R; Kanda, M; Koike, M; Kodera, Y; Takahashi, M

CANCER SCIENCE 111 巻 ( 11 ) 頁： 4303 - 4317 2020年11月

Generation of a mouse model of gastric adenocarcinoma and proximal polyposis of the stomach that causes stomach hyperplasia

Suzuki, N; Wright, J; Kobayashi, H; Wang, T; Ichinose, M; Vrbanac, L; Ng, J; Gieniec, K; Lannagan, T; Fujiwara, H; Enomoto, A; Chenevix-Trench, G; Hayakawa, Y; Koike, K; Woods, S; Worthley, D

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 35 巻頁： 165 - 165 2020年11月

Melanoma cell adhesion molecule defines a proliferative subset of leptin receptor-lineage cells that substantially contribute to the colorectal cancer stroma

Gieniec, K; Kobayashi, H; Lannagan, T; Wang, T; Asai, N; Mizutani, Y; Ida, T; Ando, R; Suzuki, N; Ichinose, M; Wright, J; Vrbanac, L; Ng, J; Lawrence, M; Sammour, T; Hayakawa, Y; Klebe, S; Shin, AE; Asfaha, S; Arpaia, N; Butler, L; Burt, A; Leedham, S; Rustgi, A; Mukherjee, S; Takahashi, M; Wang, T; Enomoto, A; Woods, S; Worthley, D

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 35 巻頁： 163 - 163 2020年11月

Connective tissue growth factor produced by cancer-associated fibroblasts correlates with poor prognosis in epithelioid malignant pleural mesothelioma 査読有り国際誌

Ohara, Y; Enomoto, A; Tsuyuki, Y; Sato, K; Iida, T; Kobayashi, H; Mizutani, Y; Miyai, Y; Hara, A; Mii, S; Suzuki, J; Yamashita, K; Ito, F; Motooka, Y; Misawa, N; Fukui, T; Kawaguchi, K; Yokoi, K; Toyokuni, S

ONCOLOGY REPORTS 44 巻 ( 3 ) 頁： 838 - 848 2020年9月

Significance of meflin-positive cancer-associated fibroblasts in predicting response to immune checkpoint inhibitors in non-small cell lung cancer.

Miyai, Y; Enomoto, A; Ando, Y; Takahashi, M

JOURNAL OF CLINICAL ONCOLOGY 38 巻 ( 15 ) 2020年5月

Significance of meflin-positive cancer-associated fibroblasts in predicting response to immune checkpoint inhibitors in non-small cell lung cancer.

Yuki Miyai, Atsushi Enomoto, Yuichi Ando, Masahide Takahashi

Journal of Clinical Oncology 38 巻 ( 15_suppl ) 頁： 3118 - 3118 2020年5月

掲載種別：研究論文（学術雑誌）出版者・発行元：American Society of Clinical Oncology (ASCO)

3118

Background: Tumor immunity is regulated by complex interactions between cancer and immune cells, which also involves other components of the tumor microenvironment (TME). Recently, cancer-associated fibroblasts (CAFs), a major constituent of the TME, have emerged as important regulators of tumor immunity. Specifically, for example, α-smooth muscle actin or leucine-rich repeat containing 15-positive CAFs have been shown to be crucial for the suppression of tumor immunity. However, a comprehensive picture of how other CAF subset(s) are involved in tumor immunity is still lacking. Here, we show the involvement of a CAF subset highly expressing Meflin, which was recently identified as a marker of cancer-restraining CAFs in pancreatic cancer (Mizutani et al., Cancer Res, 2019), in the response of non-small cell lung cancer (NSCLC) patients to immune checkpoint inhibitors (ICIs). Methods: A sample cohort of 122 subjects with NSCLC who had received ICI monotherapy with nivolumab, pembrolizumab, or atezolizumab was identified at the Department of Respiratory Medicine at Nagoya University Hospital. We selected 92 eligible patients, collected formalin-fixed paraffin-embedded tumor tissues, and prepared 4–µm-thick slides for the analysis of Meflin expression by RNA-in situ hybridization assay, followed by the evaluation of treatment response of 88 patients using the iRECIST criteria. We assessed the number of Meflin-positive CAFs and divided the patients into Meflin-High (20% and more CAFs express Meflin) and -Low groups. The cut-off value was obtained by the ROC analysis. Primarily, objective response rate (ORR) was compared between Meflin-High and –Low groups. Overall survival (OS), and progression free survival (PFS) were also assessed. Results: Patients who started to receive ICIs till the end of March 2019 were enrolled and followed-up until the end of 2019. Analysis of the tumor tissues revealed that 24 (40.7%) of 59 Meflin-High patients responded to the ICI monotherapy. In contrast, none (0%) of 29 Meflin-Low patients showed any significant response (p-value: 0.0000174). Meflin-High groups showed statistically significant prolongations in both OS and PFS with the hazard ratios of 0.3114 [0.1591-0.6094] and 0.3997 [0.2290-0.6976], respectively. Conclusions: This retrospective observation indicated that the high infiltration of Meflin-positive CAFs may shape tumor-suppressive immune response and increase the sensitivity to ICIs, which differs from those of other CAF subsets.

DOI： 10.1200/jco.2020.38.15_suppl.3118

Cancer-associated fibroblasts that restrain cancer progression: Hypotheses and perspectives 査読有り国際誌

Miyai, Y; Esaki, N; Takahashi, M; Enomoto, A

CANCER SCIENCE 111 巻 ( 4 ) 頁： 1047 - 1057 2020年4月

The Role of Meflin Expression in Fibroblasts During Development of Pulmonary Fibrosis

Hashimoto, N; Nakahara, Y; Sakamoto, K; Enomoto, A; Yokoi, T; Suzuki, A; Inoue, M; Wakahara, K; Hasegawa, Y

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 201 巻 2020年

Meflin-positive cancer-associated fibroblasts inhibit pancreatic carcinogenesis

Mizutani, Y; Kobayashi, H; Enomoto, A; Takahashi, M

CANCER RESEARCH 79 巻 ( 24 ) 2019年12月

Protein Kinase N Promotes Stress-Induced Cardiac Dysfunction Through Phosphorylation of Myocardin-Related Transcription Factor A and Disruption of Its Interaction With Actin 査読有り国際誌

Sakaguchi, T; Takefuji, M; Wettschureck, N; Hamaguchi, T; Amano, M; Kato, K; Tsuda, T; Eguchi, S; Ishihama, S; Mori, Y; Yura, Y; Yoshida, T; Unno, K; Okumura, T; Ishii, H; Shimizu, Y; Bando, YK; Ohashi, K; Ouchi, N; Enomoto, A; Offermanns, S; Kaibuchi, K; Murohara, T

CIRCULATION 140 巻 ( 21 ) 頁： 1737 - 1752 2019年11月

Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis 査読有り国際誌

Mizutani, Y; Kobayashi, H; Iida, T; Asai, N; Masamune, A; Hara, A; Esaki, N; Ushida, K; Mii, S; Shiraki, Y; Ando, K; Weng, L; Ishihara, S; Ponik, SM; Conklin, MW; Haga, H; Nagasaka, A; Miyata, T; Matsuyama, M; Kobayashi, T; Fujii, T; Yamada, S; Yamaguchi, J; Wang, TT; Woods, SL; Worthley, D; Shimamura, T; Fujishiro, M; Hirooka, Y; Enomoto, A; Takahashi, M

CANCER RESEARCH 79 巻 ( 20 ) 頁： 5367 - 5381 2019年10月

The new-defined mesenchymal stromal/stem cell marker has a protective role in the development of acute lung injury

Nakahara, Y; Hashimoto, N; Sakamoto, K; Ando, A; Inoue, M; Suzuki, A; Enomoto, A; Hasegawa, Y

EUROPEAN RESPIRATORY JOURNAL 54 巻 2019年9月

TDP-43 regulates early-phase insulin secretion via CaV1.2-mediated exocytosis in islets 査読有り国際誌

Araki, K; Araki, A; Honda, D; Izumoto, T; Hashizume, A; Hijikata, V; Yamada, S; Iguchi, Y; Hara, A; Ikumi, K; Kawai, K; Ishigaki, S; Nakamichi, Y; Tsunekawa, S; Seino, Y; Yamamoto, A; Takayama, Y; Hidaka, S; Tominaga, M; Ohara-Imaizumi, M; Suzuki, A; Ishiguro, H; Enomoto, A; Yoshida, M; Arima, H; Muramatsu, SI; Sobue, G; Katsuno, M

JOURNAL OF CLINICAL INVESTIGATION 129 巻 ( 9 ) 頁： 3578 - 3593 2019年9月

Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction 査読有り国際誌

Hara, A; Kobayashi, H; Asai, N; Saito, S; Higuchi, T; Kato, K; Okumura, T; Bando, YK; Takefuji, M; Mizutani, Y; Miyai, Y; Saito, S; Maruyama, S; Maeda, K; Ouchi, N; Nagasaka, A; Miyata, T; Mii, S; Kioka, N; Worthley, DL; Murohara, T; Takahashi, M; Enomoto, A

CIRCULATION RESEARCH 125 巻 ( 4 ) 頁： 414 - 430 2019年8月

The intercellular expression of type-XVII collagen, laminin-332, and integrin-β1 promote contact following during the collective invasion of a cancer cell population 査読有り国際誌

Kumagai, Y; Nio-Kobayashi, J; Ishida-Ishihara, S; Tachibana, H; Omori, R; Enomoto, A; Ishihara, S; Haga, H

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 514 巻 ( 4 ) 頁： 1115 - 1121 2019年7月

Identification of cancer-associated fibroblasts that suppress pancreatic cancer progression

Enomoto, A; Mizutani, Y; Kobayashi, H; Iida, T; Woods, SL; Worthley, DL; Takahashi, M

CANCER RESEARCH 79 巻 ( 13 ) 2019年7月

Dephosphorylation of Girdin by PP2A inhibits breast cancer metastasis 査読有り

Li, J; Enomoto, A; Weng, L; Sun, LQ; Takahashi, M

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 513 巻 ( 1 ) 頁： 28 - 34 2019年5月

Cancer-associated fibroblasts in gastrointestinal cancer 査読有り

Kobayashi, H; Enomoto, A; Woods, SL; Burt, AD; Takahashi, M; Worthley, DL

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY 16 巻 ( 5 ) 頁： 282 - 295 2019年5月

CD109: a multifunctional GPI-anchored protein with key roles in tumor progression and physiological homeostasis 査読有り国際誌

Mii, S; Enomoto, A; Shiraki, Y; Taki, T; Murakumo, Y; Takahashi, M

PATHOLOGY INTERNATIONAL 69 巻 ( 5 ) 頁： 249 - 259 2019年5月

Aberrant Active cis-Regulatory Elements Associated with Downregulation of RET Finger Protein Overcome Chemoresistance in Glioblastoma 査読有り国際誌

Ranjit, M; Hirano, M; Aoki, K; Okuno, Y; Ohka, F; Yamamichi, A; Kato, A; Maeda, S; Motomura, K; Matsuo, K; Enomoto, A; Ino, Y; Todo, T; Takahashi, M; Wakabayashi, T; Kato, T; Natsume, A

CELL REPORTS 26 巻 ( 9 ) 頁： 2274 - + 2019年2月

Cancer-associated fibroblasts in gastrointestinal cancer 査読有り

Kobayashi H, Enomoto A, Woods SL, Burt AD, Takahashi M, Worthley DL.

Nat Rev Gastroenterol Hepatol. 2019年2月

Aberrant Active cis-Regulatory Elements Associated with Downregulation of RET Finger Protein Overcome Chemoresistance in Glioblastoma 査読有り

Ranjit M, Hirano M, Aoki K, Okuno Y, Ohka F, Yamamichi A, Kato A, Maeda S, Motomura K, Matsuo K, Enomoto A, Ino Y, Todo T, Takahashi M, Wakabayashi T, Kato T, Natsume A.

Cell Rep 26 巻 ( 9 ) 頁： 2274-2281.e5. 2019年2月

A rare pseudo tumour in the extraembryonic coelom in first trimester of pregnancy: ultrasound and pathology 査読有り国際誌

Sumigama, S; Enomoto, A; Matsukawa, S; Ushida, T; Imai, K; Nakano, T; Kotani, T; Kikkawa, F

JOURNAL OF OBSTETRICS AND GYNAECOLOGY 39 巻 ( 4 ) 頁： 545 - 546 2019年

Force-dependent arrest of keratinocyte proliferation and its potential defect in skin cancer.

Hirata, H; Enomoto, A; Sunagawa, M; Dobrokhotov, O; Takahashi, M; Samsonov, M; Sokabe, M

MOLECULAR BIOLOGY OF THE CELL 29 巻 ( 26 ) 2018年12月

Aberrant active-enhancers associated with downregulation of HDAC1-RFP complex overcome chemoresistance in glioblastoma

Hirano, M; Melissa, R; Ohka, F; Aoki, K; Yamamichi, A; Kato, T; Matsuo, K; Enomoto, A; Takahashi, M; Wakabayashi, T; Natsume, A

CANCER SCIENCE 109 巻頁： 207 - 207 2018年12月

A role of undifferentiated mesenchymal stem cells in cancer progression

Enomoto, A; Takahashi, M

CANCER SCIENCE 109 巻頁： 182 - 182 2018年12月

Analysis of the involvement of cancer-associated fibroblasts in the progression of malignant mesothelioma

Ohara, Y; Enomoto, A; Takahashi, M; Toyokuni, S

CANCER SCIENCE 109 巻頁： 454 - 454 2018年12月

Chemerin promotes angiogenesis in vivo. 査読有り国際誌

Nakamura N, Naruse K, Kobayashi Y, Miyabe M, Saiki T, Enomoto A, Takahashi M, Matsubara T

Physiological reports 6 巻 ( 24 ) 頁： e13962 2018年12月

Dissection of the function of CD109 in lung adenocarcinoma

Taki, T; Mii, S; Shiraki, Y; Enomoto, A; Takahashi, M

CANCER SCIENCE 109 巻頁： 1407 - 1407 2018年12月

Identification of cancer restraining CAF

Mizutani, Y; Enomoto, A; Takahashi, M

CANCER SCIENCE 109 巻頁： 1396 - 1396 2018年12月

Maintenance of Undifferentiated Mesenchymal Stromal Cells-Like Fibroblast by Meflin is Crucial for Heart Repair and Homeostasis

Hara, A; Enomoto, A; Murohara, T

CIRCULATION 138 巻 2018年11月

ABERRANT ACTIVE-ENHANCERS ASSOCIATED WITH DOWNREGULATION OF HDAC1-RET FINGER PROTEIN COMPLEX OVERCOME CHEMORESISTANCE IN GLIOBLASTOMA

Hirano, M; Ranjit, M; Ohka, F; Aoki, K; Yamamichi, A; Kato, T; Matsuo, K; Enomoto, A; Takahashi, M; Wakabayashi, T; Natsume, A

NEURO-ONCOLOGY 20 巻頁： 111 - 111 2018年11月

Girdin/GIV regulates collective cancer cell migration by controlling cell adhesion and cytoskeletal organization 査読有り国際誌

Wang, XZ; Enomoto, A; Weng, L; Mizutani, Y; Abudureyimu, S; Esaki, N; Tsuyuki, Y; Chen, C; Mii, S; Asai, N; Haga, H; Ishida, S; Yokota, K; Akiyama, M; Takahashi, M

CANCER SCIENCE 109 巻 ( 11 ) 頁： 3643 - 3656 2018年11月

Large cell neuroendocrine carcinoma of the breast showing triple negative, basal-like subtype 査読有り

Kawasaki T, Hasebe T, Ichihara S, Oiwa M, Sato Y, Morita T, Hayashi T, Kato A, Sugiyama K, Nozawa K, Enomoto A, Takahashi M, Horibe K, Naoe T, Osaki A, Saeki T

VIRCHOWS ARCHIV 473 巻頁： S208 2018年9月

Trefoil factor 1 inhibits epithelial-mesenchymal transition of pancreatic intraepithelial neoplasm 査読有り

Yamaguchi, J; Yokoyama, Y; Kokuryo, T; Ebata, T; Enomoto, A; Nagino, M

JOURNAL OF CLINICAL INVESTIGATION 128 巻 ( 8 ) 頁： 3619 - 3629 2018年8月

The actin-binding protein Girdin/GIV regulates collective cancer cell migration by controlling cell adhesion and cytoskeletal organization

Wang, XZ; Enomoto, A; Weng, L; Haga, H; Ishida, S; Takahashi, M

CANCER RESEARCH 78 巻 ( 13 ) 2018年7月

CD109 deficiency induces osteopenia with an osteoporosis-like phenotype in vivo 査読有り国際誌

Mii, S; Hoshino, A; Enomoto, A; Murakumo, Y; Ito, M; Yamaguchi, A; Takahashi, M

GENES TO CELLS 23 巻 ( 7 ) 頁： 590 - 598 2018年7月

INHIBITION OF MTORC1 THROUGH AMINO ACID TRANSPORTER CD98/LAT1 MAINTAINS THE STEMNESS OF GLIOMA STEM CELL

Han, YP; Enomoto, A; Takahashi, M; Ma, J

NEURO-ONCOLOGY 20 巻頁： 180 - 180 2018年6月

Essential Role of Linx/Islr2 in the Development of the Forebrain Anterior Commissure 査読有り

Abudureyimu, S; Asai, N; Enomoto, A; Weng, L; Kobayashi, H; Wang, XZ; Chen, C; Mii, S; Takahashi, M

SCIENTIFIC REPORTS 8 巻 ( 1 ) 頁： 7292 2018年5月

金属接着凍結法による脂肪を含む凍結標本作製の試み

牛田かおり, 内山孝蔵, 浅井直也, 榎本篤, 高橋雅英

病理と臨床 36 巻 ( 5 ) 頁： 493 - 497 2018年5月

Regulation of keratin 5/14 intermediate filaments by CDK1, Aurora-B, and Rho-kinase 査読有り

Inaba, H; Yamakawa, D; Tomono, Y; Enomoto, A; Mii, S; Kasahara, K; Goto, H; Inagaki, M

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 498 巻 ( 3 ) 頁： 544 - 550 2018年4月

Critical role of rabphilin-3A in the pathophysiology of experimental lymphocytic neurohypophysitis 査読有り

Yasuda, Y; Iwama, S; Kiyota, A; Izumida, H; Nakashima, K; Iwata, N; Ito, Y; Morishita, Y; Goto, M; Suga, H; Banno, R; Enomoto, A; Takahashi, M; Arima, H; Sugimura, Y

JOURNAL OF PATHOLOGY 244 巻 ( 4 ) 頁： 469 - 478 2018年4月

Development of a method to preliminarily embed tissue samples using low melting temperature fish gelatin before sectioning: A technical note 査読有り

Ushida, K; Asai, N; Uchiyama, K; Enomoto, A; Takahashi, M

PATHOLOGY INTERNATIONAL 68 巻 ( 4 ) 頁： 241 - 245 2018年4月

Negative regulation of amino acid signaling by MAPK-regulated 4F2hc/Girdin complex 査読有り国際誌

Weng, L; Han, YP; Enomoto, A; Kitaura, Y; Nagamori, S; Kanai, Y; Asai, N; An, J; Takagishi, M; Asai, M; Mii, S; Masuko, T; Shimomura, Y; Takahashi, M

PLOS BIOLOGY 16 巻 ( 3 ) 頁： e2005090 2018年3月

The role of CD109 in PDGFB-induced glioma mouse model for sensitivity to Temozolomide

Shiraki, Y; Mii, S; Asai, N; Enomoto, A; Momota, H; Natsume, A; Wakabayashi, T; Takahashi, M

CANCER SCIENCE 109 巻頁： 1130 - 1130 2018年1月

ASC amino acid transporter 2, defined by enzyme-mediated activation of radical sources, enhances malignancy of GD2-positive small-cell lung cancer 査読有り国際誌

Esaki, N; Ohkawa, Y; Hashimoto, N; Tsuda, Y; Ohmi, Y; Bhuiyan, RH; Kotani, N; Honke, K; Enomoto, A; Takahashi, M; Furukawa, K; Furukawa, K

CANCER SCIENCE 109 巻 ( 1 ) 頁： 141 - 153 2018年1月

Aberrant super-enhancers associated with downregulation of RET finger protein overcomes chemoresistance in glioblastoma

Hirano, M; Ranjit, M; Yamamichi, A; Aoki, K; Ohka, F; Kato, T; Enomoto, A; Takahashi, M; Wakabayashi, T; Natsume, A

CANCER SCIENCE 109 巻頁： 461 - 461 2018年1月

Ganglioside GD2 coordinately works with ASCT2, which enhances malignant phenotypes in small cell lung cancer

Esaki, N; Ohkawa, Y; Hashimoto, N; Tuna, Y; Ohmi, Y; Bhuiya, R; Kotani, N; Honk, C; Enomoto, A; Takahashi, M; Furukawa, K; Furukawa, K

CANCER SCIENCE 109 巻頁： 94 - 94 2018年1月

Mechanisms for the control of amino acid signaling and drug resistance in cancer stem cells

Enomoto, A; Takahashi, M

CANCER SCIENCE 109 巻頁： 813 - 813 2018年1月

Aberrant super-enhancers associated with downregulation of RET finger protein overcomes chemoresistance in glioblastoma

Hirano Masaki, Ranjit Melissa, Yamamichi Akane, Aoki Kosuke, Ohka Fumiharu, Kato Takuya, Enomoto Atsushi, Takahashi Masahide, Wakabayashi Toshihiko, Natsume Atsushi

CANCER SCIENCE 109 巻頁： 461-461 2018年1月

Cullin-associated NEDD8-dissociated protein a novel interactor of rabphilin-3A, deubiquitylates rabphilin-3A and regulates arginine vasopressin secretion in PC12 cells 査読有り

Nakashima, K; Takeuchi, S; Iwama, S; Kiyota, A; Yasuda, Y; Iwata, N; Enomoto, A; Arima, H; Sugimura, Y

ENDOCRINE JOURNAL 65 巻 ( 3 ) 頁： 325 - 334 2018年

Significance of perivascular tumour cells defined by CD109 expression in progression of glioma 査読有り

Shiraki, Y; Mii, S; Enomoto, A; Momota, H; Han, YP; Kato, T; Ushida, K; Kato, A; Asai, N; Murakumo, Y; Aoki, K; Suzuki, H; Ohka, F; Wakabayashi, T; Todo, T; Ogawa, S; Natsume, A; Takahashi, M

JOURNAL OF PATHOLOGY 243 巻 ( 4 ) 頁： 468 - 480 2017年12月

ABERRANT SUPER-ENHANCERS ASSOCIATED WITH DOWNREGULATION OF RET FINGER PROTEIN OVERCOMES CHEMORESISTANCE IN GLIOBLASTOMA

Hirano, M; Ranjit, M; Yamamichi, A; Aoki, K; Ohka, F; Kato, T; Enomoto, A; Takahashi, M; Wakabayashi, T; Natsume, A

NEURO-ONCOLOGY 19 巻頁： 103 - 103 2017年11月

Correlation between SPARC expression and efficacy of nab-paclitaxel for advanced gastric cancer refractory to fluoropyrimidine: An exploratory analysis of a phase II trial, CCOG1303

Kobayashi, D; Enomoto, A; Mochizuki, Y; Matsui, T; Nakayama, H; Kawase, Y; Ishigure, K; Shikano, T; Torii, K; Kodera, Y

ANNALS OF ONCOLOGY 28 巻 2017年9月

脳腫瘍マウスモデルにおけるテモゾロミド感受性に対するCD109の機能解析

白木之浩, 三井伸二, 浅井直也, 榎本篤, 百田洋之, 夏目敦至, 若林俊彦, 高橋雅英

日本癌学会総会記事 76回巻頁： P - 3324 2017年9月

Daple Coordinates Planar Polarized Microtubule Dynamics in Ependymal Cells and Contributes to Hydrocephalus 査読有り

Takagishi, M; Sawada, M; Ohata, S; Asai, N; Enomoto, A; Takahashi, K; Weng, L; Ushida, K; Ara, H; Matsui, S; Kaibuchi, K; Sawamoto, K; Takahashi, M

CELL REPORTS 20 巻 ( 4 ) 頁： 960 - 972 2017年7月

Corrigendum: Girdin maintains the stemness of glioblastoma stem cells (Oncogene (2012) 31 (2715-2724) DOI: 10.1038/onc.2011.466) 査読有り

A. Natsume, T. Kato, S. Kinjo, A. Enomoto, H. Toda, S. Shimato, F. Ohka, K. Motomura, Y. Kondo, T. Miyata, M. Takahashi, T. Wakabayashi

Oncogene 31 巻 ( 22 ) 頁： 2715 - 2724 2017年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nature Publishing Group

Glioblastomas (GBMs) are the most common and aggressive type of brain tumor. GBMs usually show hyperactivation of the PI3K-Akt pathway, a pro-tumorigenic signaling cascade that contributes to pathogenesis. Girdin, an actin-binding protein identified as a novel substrate of Akt, regulates the sprouting of axons and the migration of neural progenitor cells during early postnatal-stage neurogenesis in the hippocampus. Here, we show that Girdin is highly expressed in human glioblastoma (GBM). Stable Girdin knockdown in isolated GBM stem cells resulted in decreased expression of stem cell markers, including CD133, induced multilineage neural differentiation, and inhibited in vitro cell motility, ex vivo invasion, sphere-forming capacity and in vivo tumor formation. Furthermore, exogenous expression of the Akt-binding domain of Girdin, which competitively inhibits its Akt-mediated phosphorylation, diminished the expression of stem cell markers, SOX2 and nestin, and migration on the brain slice and induced the expression of neural differentiation markers glial fibrillary acidic protein/ΒIII Tubulin. Our results reveal that Girdin is required for GBM-initiating stem cells to sustain the stemness and invasive properties. © 2012 Macmillan Publishers Limited All rights reserved.

DOI： 10.1038/onc.2011.466

Scopus

Tyrosine Phosphorylation of an Actin-Binding Protein Girdin Specifically Marks Tuft Cells in Human and Mouse Gut 査読有り

Kuga, D; Ushida, K; Mii, S; Enomoto, A; Asai, N; Nagino, M; Takahashi, M; Asai, M

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 65 巻 ( 6 ) 頁： 347 - 366 2017年6月

Girdin maintains the stemness of glioblastoma stem cells (vol 31, pg 2715, 2012) 査読有り

A. Natsume, T. Kato, S. Kinjo, A. Enomoto, H. Toda, S. Shimato, F. Ohka, K. Motomura, Y. Kondo, T. Miyata, M. Takahashi, T. Wakabayashi

ONCOGENE 36 巻 ( 26 ) 頁： 3796 - 3796 2017年6月

Significance of low mTORC1 activity in defining the characteristics of brain tumor stem cells 査読有り

Han, YP; Enomoto, A; Shiraki, Y; Wang, SQ; Wang, XZ; Toyokuni, S; Asai, N; Ushida, K; Ara, H; Ohka, F; Wakabayashi, T; Ma, J; Natsume, A; Takahashi, M

NEURO-ONCOLOGY 19 巻 ( 5 ) 頁： 636 - 647 2017年5月

Meflin/Islrは心臓線維化における筋線維芽細胞起源のマーカーである

原昭壽, 榎本篤, 室原豊明, 高橋雅英

日本病理学会会誌 106 巻 ( 1 ) 頁： 317 - 317 2017年3月

癌性リンパ管症を呈した乳腺神経内分泌腫瘍(Neuroendocrine tumor of the breast showing carcinomatous lymphangiosis)

川崎朋範, 中井登紀子, 市原周, 長谷川正規, 岩越朱里, 榎本篤, 佐藤朋子, 浅井昌美, 西川恵理, 大林千穂

日本病理学会会誌 106 巻 ( 1 ) 頁： 335 - 335 2017年3月

慢性皮膚炎症を伴うCD109ノックアウトマウスにおいて皮膚腫瘍形成は抑制される(Suppression of skin tumorigenesis in CD109-deficient mice with chronic skin inflammation)

三井伸二, 砂川真輝, 榎本篤, 村雲芳樹, 梛野正人, 高橋雅英

日本病理学会会誌 106 巻 ( 1 ) 頁： 361 - 361 2017年3月

ヒトgliiomaにおけるCD109の発現(Significance of Perivascular Tumor Cells Defined by CD109 Expression)

白木之浩, 三井伸二, 榎本篤, 高橋雅英

日本病理学会会誌 106 巻 ( 1 ) 頁： 395 - 395 2017年3月

Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells 査読有り

Maeda K, Enomoto A, Hara A, Asai N, Kobayashi T, Horinouchi A, Maruyama S, Ishikawa Y, Nishiyama T, Kiyoi H, Kato T, Ando K, Weng L, Mii S, Asai M, Mizutani Y, Watanabe O, Hirooka Y, Goto H, Takahashi M

6 巻頁： 22288 2016年2月

Collective invasion of cancer: Perspectives from pathology and development 査読有り

Wang X, Enomoto A, Asai N, Kato T, Takahashi M

66 巻 ( 4 ) 頁： 183-192 2016年

Rabphilin-3A as a Targeted Autoantigen in Lymphocytic Infundibulo-neurohypophysitis 査読有り

Iwama S, Sugimura Y, Kiyota A, Kato T, Enomoto A, Suzuki H, Iwata N, Takeuchi S, Nakashima K, Takagi H, Izumida H, Ochiai H, Fujisawa H, Suga H, Arima H, Shimoyama Y, Takahashi M, Nishioka H, Ishikawa SE, Shimatsu A, Caturegli P, Oiso Y

J Clin Endocrinol Metab 100 巻 ( 7 ) 頁： E946-954 2015年7月

Akt-Girdin signaling in cancer-associated fibroblasts contributes to tumor progression 査読有り

Yamamura Y, Asai N, Enomoto A, Kato T, Mii S, Kondo Y, Ushida K, Niimi K, Tsunoda N, Nagino M, Ichihara S, Furukawa K, Maeda K, Murohara T, Takahashi M

Cancer Res 75 巻 ( 5 ) 頁： 813-823 2015年5月

Girdin phosphorylation is crucial for synaptic plasticity and memory: a potential role in the interaction of BDNF/TrkB/Akt signaling with NMDA receptor 査読有り

Nakai T, Nagai T, Tanaka M, Itoh N, Asai N, Enomoto A, Asai M, Yamada S, Saifullah AB, Sokabe M, Takahashi M, Yamada K

34 巻 ( 45 ) 頁： 14995-15008 2014年11月

Regulation of cargo-selective endocytosis by dynamin 2 GTPase-activating protein girdin 査読有り

Weng L, Enomoto A, Miyoshi H, Takahashi K, Asai N, Morone N, Jiang P, An J, Kato T, Kuroda K, Watanabe T, Asai M, Ishida-Takagishi M, Murakumo Y, Nakashima H, Kaibuchi K, Takahashi M

33 巻頁： 2098-2112 2014年9月

Speed control for neuronal migration in the postnatal brain by Gmip-mediated local inactivation of RhoA 査読有り

Ota H, Hikita T, Sawada M, Nishioka T, Matsumoto M, Komura M, Ohno A, Kamiya Y, Miyamoto T, Asai N, Enomoto A, Takahashi M, Kaibuchi K, Sobue K, Sawamoto K

5 巻頁： 4532 2014年7月

TRIM27/MRTF-B-dependent integrin β1 expression defines leading cells in cancer cell collectives 査読有り

Kato T, Enomoto A, Watanabe T, Haga H, Ishida S, Kondo Y, Furukawa K, Urano T, Mii S, Weng L, Ishida-Takagishi M, Asai M, Asai N, Kaibuchi K, Murakumo Y, Takahashi M

7 巻 ( 4 ) 頁： 1156-1167 2014年5月

TRIM27/MRTF-B-dependent integrin β1 expression defines leading cells in cancer cell collectives 査読有り

7 巻頁： 1156-1167 2014年5月

Degeneration of retinal on bipolar cells induced by serum including autoantibody against TRPM1 in mouse model of paraneoplastic retinopathy

Ueno S, Nishiguchi KM, Tanioka H, Enomoto A, Yamanouchi T, Kondo M, Yasuma TR, Yasuda S, Kuno N, Takahashi M, Terasaki H.

PLoS One 8 巻 ( 11 ) 頁： e81507 2013年11月

Proteomic analysis of Girdin-interacting proteins in migrating new neurons in the postnatal mouse brain 査読有り

Ota H, Hikita T, Nishioka T, Matsumoto M, Ito J, Asai N, Enomoto A, Takahashi M, Kaibuchi K, Sobue K, Sawamoto K.

Biochem Biophys Res Commun 442 巻 ( 1-2 ) 頁： 16-21 2013年11月

Girdin and its phosphorylation dynamically regulate neonatal vascular development and pathological neovascularization in the retina 査読有り

Ito T, Komeima K, Yasuma T, Enomoto A, Asai N, Asai M, Iwase S, Takahashi M, Terasaki H.

Am J Pathol 182 巻 ( 2 ) 頁： 586-596 2012年11月

Significance of cancer-associated fibroblasts in the regulation of gene expression in the leading cells of invasive lung cancer

An J, Enomoto A, Weng L, Kato T, Iwakoshi A, Ushida K, Maeda K, Ishida-Takagishi M, Ishii G, Ming S, Sun T, Takahashi M.

J Cancer Res Clin Oncol. 頁： Epub ahead of print] 2012年10月

Similar phenotypes of Girdin germ-line and conditional knockout mice indicate a crucial role for Girdin in the nestin lineage

Asai M, Asai N, Murata A, Yokota H, Ohmori K, Mii S, Enomoto A, Murakumo Y, Takahashi M.

Biochem Biophys Res Commun. 426 巻 ( 4 ) 頁： 533-538 2012年10月

The Dishevelled-associating protein Daple controls the non-canonical Wnt/Rac pathway and cell motility 査読有り

Ishida-Takagishi M, Enomoto A, Asai N, Ushida K, Watanabe T, Hashimoto T, Kato T, Weng L, Matsumoto S, Asai M, Murakumo Y, Kaibuchi K, Kikuchi A, Takahashi M.

Nat Commun. 頁： 859 2012年5月

Involvement of Girdin in the determination of cell polarity during cell migration 査読有り

Ohara K, Enomoto A, Kato T, Hashimoto T, Isotani-Sakakibara M, Asai N, Ishida-Takagishi M, Weng L, Nakayama M, Watanabe T, Kato K, Kaibuchi K, Murakumo Y, Hirooka Y, Goto H, Takahashi M.

PLoS One 頁： e36681 2012年5月

Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse 査読有り

Kuroda K, Yamada S, Tanaka M, Iizuka M, Yano H, Mori D, Tsuboi D, Nishioka T, Namba T, Iizuka Y, Kubota S, Nagai T, Ibi D, Wang R, Enomoto A, Isotani-Sakakibara M, Asai N, Kimura K, Kiyonari H, Abe T, Mizoguchi A, Sokabe M, Takahashi M, Yamada K, Kaibuchi K.

Hum Mol Genet. 20 巻 ( 23 ) 頁： 4666-4683 2011年11月

NMDA receptor regulates migration of newly generated neurons in the adult hippocampus via Disrupted-In-Schizophrenia 1 (DISC1) 査読有り

Namba T, Ming GL, Song H, Waga C, Enomoto A, Kaibuchi K, Kohsaka S, Uchino S.

J Neurochem 118 巻 ( 1 ) 頁： 34-44 2011年7月

Loss of Sprouty2 partially rescues renal hypoplasia and stomach hypoganglionosis but not intestinal aganglionosis in Ret Y1062F mutant mice 査読有り

Miyamoto R, Jijiwa M, Asai M, Kawai K, Ishida-Takagishi M, Mii S, Asai N, Enomoto A, Murakumo Y, Yoshimura A, Takahashi M.

Dev Biol 349 巻 ( 2 ) 頁： 160-168 2011年1月

Protective role of Gipie, a Girdin family protein, in endoplasmic reticulum stress responses in endothelial cells 査読有り

Matsushita E, Asai N, Enomoto A, Kawamoto Y, Kato T, Mii S, Maeda K, Shibata R, Hattori S, Hagikura M, Takahashi K, Sokabe M, Murakumo Y, Murohara T, Takahashi M.

Molecular Biology of the Cell 22 巻 ( 6 ) 頁： 736-747 2011年

The actin-binding protein girdin and its akt-mediated phosphorylation regulate neointima formation after vascular injury 査読有り

Miyake H, Maeda K, Asai N, Shibata R, Ichimiya H, Isotani-Sakakibara M, Yamamura Y, Kato K, Enomoto A, Takahashi M, Murohara T.

108 巻 ( 10 ) 頁： 1170-1179 2011年

Girdin Is an Intrinsic Regulator of Neuroblast Chain Migration in the Rostral Migratory Stream of the Postnatal Brain 査読有り

Wang Y, Kaneko N, Asai N, Enomoto A, Isotani-Sakakibara M, Kato T, Asai M, Murakumo Y, Ota H, Hikita T, Namba T, Kuroda K, Kaibuchi K, Ming GL, Song H, Sawamoto K, Takahashi M.

Journal of Neuroscience 31 巻 ( 22 ) 頁： 8109-8122 2011年

Girding for migratory cues: roles of the Akt substrate Girdin in cancer progression and angiogenesis 招待有り査読有り

Weng L, Enomoto A, Ishida-Takagishi M, Asai N, Takahashi M.

Cancer Science 101 巻 ( 4 ) 頁： 836-842 2010年

Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus 査読有り

Enomoto A, Asai N, Namba T, Wang Y, Kato T, Tanaka M, Tatsumi H, Taya S, Tsuboi D, Kuroda K, Kaneko N, Sawamoto K, Miyamoto R, Jijiwa M, Murakumo Y, Sokabe M, Seki T, Kaibuchi K, Takahashi M.

Neuron 63 巻 ( 6 ) 頁： 774-787 2009年

An actin-binding protein Girdin regulates the motility of breast cancer cells 査読有り

Jiang, P., Enomoto, A., Jijiwa, M., Kato, T., Hasegawa, T., Ishida, M., Sato, T., Asai, N., Murakumo, Y., Takahashi, M.

Cancer Res 68 巻頁： 1310-1318 2008年

Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin. 査読有り

Kitamura, T.*, Asai, N.*, Enomoto, A.* (*joint first authorship), Maeda, K., Kato, T., Ishida, M., Jiang, P., Watanabe, T., Usukura, J., Kondo, T., Costantini, F., Murohara, T.

Nat Cell Biol 10 巻頁： 329-337 2008年

Dok-4 regulates GDNF-dependent neurite outgrowth through downstream activation of Rap1 and mitogen-activated protein kinase 査読有り

Uchida, M., A. Enomoto, T. Fukuda, K. Kurokawa, K. Maeda, Y. Kodama, N. Asai, T. Hasegawa, Y. Shimono, M. Jijiwa, M. Ichihara, Y. Murakumo, M. Takahashi

J Cell Sci 119 巻頁： 3067-3077 2006年

Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells 査読有り

Asai, N., T. Fukuda, Z. Wu, A. Enomoto, V. Pachnis, M. Takahashi, F. Costantini

Development 133 巻頁： 4507-4716 2006年

Girdin, a novel actin-binding protein, and its family of proteins possess versatile functions in the Akt and Wnt signaling pathways 査読有り

Enomoto, A., P. Jiang, M. Takahashi

Ann N Y Acad Sci 1086 巻頁： 169-184 2006年

Roles of organic anion transporters (OATs) and a urate transporter (URAT1) in the pathophysiology of human disease 招待有り査読有り

Enomoto, A., H. Endou

Clin Exp Nephrol 9 巻頁： 195-205 2005年

Akt/PKB regulates actin organization and cell motility via Girdin/APE 査読有り

Enomoto, A., H. Murakami, N. Asai, N. Morone, T. Watanabe, K. Kawai, Y. Murakumo, J. Usukura, K. Kaibuchi, M. Takahashi

Developmental Cell 9 巻頁： 389-402 2005年

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

The serine/threonine kinase Akt (also called protein kinase B) is well known as an important regulator of cell survival and growth and has also been shown to be required for cell migration in different organisms. However, the mechanism by which Akt functions to promote cell migration is not understood. Here, we identify an Akt substrate, designated Girdin/APE (Akt-phosphorylation enhancer), which is an actin binding protein. Girdin expresses ubiquitously and plays a crucial role in the formation of stress fibers and lamellipodia. Akt phosphorylates serine at position 1416 in Girdin, and phosphorylated Girdin accumulates at the leading edge of migrating cells. Cells expressing mutant Girdin, in which serine 1416 was replaced with alanine, formed abnormal elongated shapes and exhibited limited migration and lamellipodia formation. These findings suggest that Girdin is essential for the integrity of the actin cytoskeleton and cell migration and provide a direct link between Akt and cell motility.

Role of organic anion transporters in the tubular transport of indoxyl sulfate and the induction of its nephrotoxicity 査読有り

Enomoto, A., M. Takeda, A. Tojo, T. Sekine, S. H. Cha, S. Khamdang, F. Takayama, I. Aoyama, S. Nakamura, H. Endou, T. Niwa

J Am Soc Nephrol 133 巻頁： 1711-1720 2002年

Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition 査読有り

Enomoto, A., M. F. Wempe, H. Tsuchida, H. J. Shin, S. H. Cha, N. Anzai, A. Goto, A. Sakamoto, T. Niwa, Y. Kanai, M. W. Anders, H. Endou

J Biol Chem 277 巻頁： 36262-36271 2002年

Molecular identification of a renal urate anion exchanger that regulates blood urate levels 査読有り

Enomoto, A., H. Kimura, A. Chairoungdua, Y. Shigeta, P. Jutabha, S. H. Cha, M. Hosoyamada, M. Takeda, T. Sekine, T. Igarashi, H. Matsuo, Y. Kikuchi, T. Oda, K. Ichida, T. Hosoya, K. Shimokata, T. Niwa, Y. Kanai, H. Endou

Nature 417 巻頁： 447-452 2002年

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