研究者詳細 - 榎本　篤

論文 - 榎本　篤

分割表示 214 件中 21 - 40 件目／全件表示 >>

Cancer-associated Fibroblast-Derived Itaconate Stimulates Pro-tumorigenic Immune Microenvironment in Cervical Cancer

Nakahara, R; Aki, S; Kato, M; Tsuchida, R; Shimamura, T; Enomoto, A; Osawa, T

CANCER SCIENCE 115 巻頁： 555 - 555 2024年3月

Meflin, a New Population Maker of Portal Fibroblasts, Suppress Cholangiocarcinoma

Ito, K; Shiraki, Y; Mii, S; Esaki, N; Sunagawa, M; Baba, T; Ebata, T; Enomoto, A

CANCER SCIENCE 115 巻頁： 2090 - 2090 2024年3月

Functional analyses of immune checkpoint molecule, VISTA, in malignant pleural mesothelioma

Okada, H; Yanagisawa, K; Enomoto, A

CANCER SCIENCE 115 巻頁： 1830 - 1830 2024年3月

Exploring the Role of Transgelin in Cancer-associated Fibroblasts in the Development of Pancreatic Adenocarcinoma

Wang, XX; Shinjo, K; Kumegawa, K; Maruyama, R; Mii, S; Murofushi, Y; Suzuki, M; Enomoto, A; Kondo, Y

CANCER SCIENCE 115 巻頁： 1698 - 1698 2024年3月

Cancer-associated fibroblasts as upstream regulators of the tumor immune microenvironment and therapeutic application

Owaki, T; Miyai, Y; Iida, T; Akamatsu, S; Enomoto, A

CANCER SCIENCE 115 巻頁： 1498 - 1498 2024年3月

Single-cell colocalization analysis using a deep generative model 査読有り

Kojima, Y; Mii, S; Hayashi, S; Hirose, H; Ishikawa, M; Akiyama, M; Enomoto, A; Shimamura, T

CELL SYSTEMS 15 巻 ( 2 ) 頁： 180 - 192.e7 2024年2月

Pivotal role of IL-8 derived from the interaction between osteosarcoma and tumor-associated macrophages in osteosarcoma growth and metastasis via the FAK pathway 査読有り

Tatsuno, R; Ichikawa, J; Komohara, Y; Pan, C; Kawasaki, T; Enomoto, A; Aoki, K; Hayakawa, K; Iwata, S; Jubashi, T; Haro, H

CELL DEATH & DISEASE 15 巻 ( 2 ) 頁： 108 2024年2月

TGF-β signaling promotes desmoid tumor formation via CSRP2 upregulation 査読有り

Li, Y; Fujishita, T; Mishiro-Sato, E; Kojima, Y; Niu, YQ; Taketo, MM; Urano, Y; Sakai, T; Enomoto, A; Nishida, Y; Aoki, M

CANCER SCIENCE 115 巻 ( 2 ) 頁： 401 - 411 2024年2月

頭蓋内における間葉系幹細胞マーカーMeflinの発現解析(Expression of Meflin, a Mesenchymal Stem Cell(MSC) Marker, in the Intracranial Region)

白木之浩, 安藤良太, 三井伸二, 榎本篤

日本病理学会会誌 113 巻 ( 1 ) 頁： 439 - 439 2024年2月

膵星細胞(PSC)の形態と機能

安藤良太, 渡會蒼大, 白木之浩, 三井伸二, 榎本篤

日本病理学会会誌 113 巻 ( 1 ) 頁： 400 - 400 2024年2月

難治性がん腫の克服を目指したがん微小環境を標的とする抗体薬物複合体の研究開発

江崎寛季, 安藤良太, 宮井雄基, 松山誠, 白木之浩, 三井伸二, 高橋雅英, 榎本篤

日本病理学会会誌 113 巻 ( 1 ) 頁： 400 - 400 2024年2月

多発転移を伴う神経内分泌と微小乳頭癌の特徴を示す浸潤性乳癌(Invasive breast cancer showing neuroendocrine and micropapillary features with multiple metastases)

川崎朋範, 田島知明, 村松千左子, 川村隆三, 竹見祥大, 鈴木美穂, 市原周, 榎本篤, 永井宏和, 谷山清巳

日本病理学会会誌 113 巻 ( 1 ) 頁： 302 - 303 2024年2月

Meflin is a marker of pancreatic stellate cells involved in fibrosis and epithelial regeneration in the pancreas 査読有り国際誌

Ando, R; Shiraki, Y; Miyai, Y; Shimizu, H; Furuhashi, K; Minatoguchi, S; Kato, K; Kato, A; Iida, T; Mizutani, Y; Ito, K; Asai, N; Mii, S; Esaki, N; Takahashi, M; Enomoto, A

JOURNAL OF PATHOLOGY 262 巻 ( 1 ) 頁： 61 - 75 2024年1月

Impact of elobixibat on liver tumors, microbiome, and bile acid levels in a mouse model of nonalcoholic steatohepatitis

Sugiyama, Y; Yamamoto, K; Honda, T; Kato, A; Muto, H; Yokoyama, S; Ito, T; Imai, N; Ishizu, Y; Nakamura, M; Asano, T; Enomoto, A; Zaitsu, K; Ishigami, M; Fujishiro, M; Kawashima, H

HEPATOLOGY INTERNATIONAL 17 巻 ( 6 ) 頁： 1378 - 1392 2023年12月

Wnt activation disturbs cell competition and causes diffuse invasion of transformed cells through NF-κB-MMP21 pathway

Nakai, K; Lin, HC; Yamano, S; Tanaka, S; Kitamoto, S; Saitoh, H; Sakuma, K; Kurauchi, J; Akter, E; Konno, M; Ishibashi, K; Kamata, R; Ohashi, A; Koseki, J; Takahashi, H; Yokoyama, H; Shiraki, Y; Enomoto, A; Abe, S; Hayakawa, Y; Ushiku, T; Mutoh, M; Fujita, Y; Kon, S

NATURE COMMUNICATIONS 14 巻 ( 1 ) 頁： 7048 2023年11月

Neuroendocrine neoplasms in the breast oncology field: dilemmas of nature and morphology

Kawasaki, T; Tashima, T; Enomoto, A; Ichikawa, J; Nagai, H; Muramatsu, C; Nakamura, Y; Kaira, K

FRONTIERS IN ENDOCRINOLOGY 14 巻頁： 1216424 2023年11月

Targeting hyaluronan-mediated motility receptor (HMMR) enhances response to androgen receptor signalling inhibitors in prostate cancer 査読有り国際誌

Josephine A. Hinneh, Joanna L. Gillis, Chui Yan Mah, Swati Irani, Raj K. Shrestha, Natalie K. Ryan, Enomoto Atsushi, Zeyad D. Nassar, David J. Lynn, Luke A. Selth, Masashi Kato, Margaret M. Centenera, Lisa M. Butler

British Journal of Cancer 129 巻 ( 8 ) 頁： 1350 - 1361 2023年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

Background: Resistance to androgen receptor signalling inhibitors (ARSIs) represents a major clinical challenge in prostate cancer. We previously demonstrated that the ARSI enzalutamide inhibits only a subset of all AR-regulated genes, and hypothesise that the unaffected gene networks represent potential targets for therapeutic intervention. This study identified the hyaluronan-mediated motility receptor (HMMR) as a survival factor in prostate cancer and investigated its potential as a co-target for overcoming resistance to ARSIs. Methods: RNA-seq, RT-qPCR and Western Blot were used to evaluate the regulation of HMMR by AR and ARSIs. HMMR inhibition was achieved via siRNA knockdown or pharmacological inhibition using 4-methylumbelliferone (4-MU) in prostate cancer cell lines, a mouse xenograft model and patient-derived explants (PDEs). Results: HMMR was an AR-regulated factor that was unaffected by ARSIs. Genetic (siRNA) or pharmacological (4-MU) inhibition of HMMR significantly suppressed growth and induced apoptosis in hormone-sensitive and enzalutamide-resistant models of prostate cancer. Mechanistically, 4-MU inhibited AR nuclear translocation, AR protein expression and subsequent downstream AR signalling. 4-MU enhanced the growth-suppressive effects of 3 different ARSIs in vitro and, in combination with enzalutamide, restricted proliferation of prostate cancer cells in vivo and in PDEs. Conclusion: Co-targeting HMMR and AR represents an effective strategy for improving response to ARSIs. [Figure not available: see fulltext.]

DOI： 10.1038/s41416-023-02406-8

Scopus

PubMed

腫瘍免疫微小環境の上流制御因子としてのがん関連線維芽細胞、そして臨床応用へ(Cancer-associated fibroblasts as upstream regulators of the tumor immune microenvironment and therapeutic application)

大脇貴之, 宮井雄基, 飯田忠, 赤松秀輔, 榎本篤

日本癌学会総会記事 82回巻頁： 1499 - 1499 2023年9月

骨肉腫微小環境における腫瘍関連マクロファージ由来ケモカインの働き

辰野力人, 市川二郎, 菰原義弘, 榎本篤, 川崎朋範, 波呂浩孝

日本整形外科学会雑誌 97 巻 ( 8 ) 頁： S1891 - S1891 2023年8月

骨肉腫微小環境における腫瘍関連マクロファージ由来ケモカインの働き

辰野力人, 市川二郎, 菰原義弘, 榎本篤, 川崎朋範, 波呂浩孝

日本整形外科学会雑誌 97 巻 ( 8 ) 頁： S1891 - S1891 2023年8月

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