Faculty Profiles - KIMURA, Hiroshi

Papers - KIMURA, Hiroshi

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Oncogenesis of CAEBV revealed: Intragenic deletions in the viral genome and leaky expression of lytic genes Reviewed

Murata Takayuki, Okuno Yusuke, Sato Yoshitaka, Watanabe Takahiro, Kimura Hiroshi

REVIEWS IN MEDICAL VIROLOGY Vol. 30 ( 2 ) page： e2095 2020.3

Antitumor activity of CDK inhibitor alsterpaullone in Epstein-Barr virus-associated lymphoproliferative disorders. Reviewed International coauthorship

Watanabe T, Sato Y, Masud HMAA, Takayama M, Matsuda H, Hara Y, Yanagi Y, Yoshida M, Goshima F, Murata T, Kimura H

Cancer science 2020.1

Epstein-Barr Virus BBRF2 Is Required for Maximum Infectivity Open Access

Al Masud H. M. Abdullah, Yanagi Yusuke, Watanabe Takahiro, Sato Yoshitaka, Kimura Hiroshi, Murata Takayuki

MICROORGANISMS Vol. 7 ( 12 ) 2019.12

NK-cell post-transplant lymphoproliferative disease with chronic active Epstein-Barr virus infection-like clinical findings.

Iemura T, Kondo T, Hishizawa M, Yamashita K, Kimura H, Takaori-Kondo A

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2019.8

Editorial: Epstein-Barr Virus-Associated T/NK-Cell Lymphoproliferative Diseases

Fujiwara Shigeyoshi, Kimura Hiroshi

FRONTIERS IN PEDIATRICS Vol. 7 ( JULY ) page： 285 2019.7

Viral DNA loads in various blood components of patients with Epstein-Barr virus-positive T/NK cell lymphoproliferative diseases.

Kawada JI, Kamiya Y, Sawada A, Iwatsuki K, Izutsu K, Torii Y, Kimura H, Ito Y

The Journal of infectious diseases 2019.6

The BOLF1 gene is necessary for effective Epstein-Barr viral infectivity

Al Masud H. M. Abdullah, Watanabe Takahiro, Sato Yoshitaka, Goshima Fumi, Kimura Hiroshi, Murata Takayuki

VIROLOGY Vol. 531 page： 114-125 2019.5

S-Like-Phase Cyclin-Dependent Kinases Stabilize the Epstein-Barr Virus BDLF4 Protein To Temporally Control Late Gene Transcription Open Access

Sato Yoshitaka, Watanabe Takahiro, Suzuki Chihiro, Abe Yuichi, Al Masud H. M. Abdullah, Inagaki Tomoki, Yoshida Masahiro, Suzuki Takeshi, Goshima Fumi, Adachi Jun, Tomonaga Takeshi, Murata Takayuki, Kimura Hiroshi

JOURNAL OF VIROLOGY Vol. 93 ( 8 ) 2019.4

Initial Characterization of the Epstein-Barr Virus BSRF1 Gene Product

Yanagi Yusuke, Al Masud H. M. Abdullah, Watanabe Takahiro, Sato Yoshitaka, Goshima Fumi, Kimura Hiroshi, Murata Takayuki

VIRUSES-BASEL Vol. 11 ( 3 ) 2019.3

Defective Epstein-Barr virus (EBV) in chronic active EBV infection and EBV-related hematological malignancy International coauthorship Open Access

Okuno Y, Murata Y, Sato Y, Muramatsu H, YIto Y, Watanabe T, Okuno T, Murakami N, Yoshida K, Sawada A, Inoue M, Kawa K, Seto M, Ohshima K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Narita Y, Yoshida M, Goshima F, Kawada JI, Nishida T, Kiyoi H, Kato S, Nakamura S, Morishima S, Yoshikawa T, Fujiwara S, Shimizu N, Isobe Y, Noguchi M, Kikuta1 A, Iwatsuki K, Takahashi Y, Kojima S, Ogawa S, Kimura H.

Nat Microbiol Vol. 4 ( 3 ) page： 544 - 544 2019.3

EBV Viral Loads in Diagnosis, Monitoring, and Response Assessment Open Access

Kimura Hiroshi, Kwong Yok-Lam

FRONTIERS IN ONCOLOGY Vol. 9 ( FEB ) page： 62 2019.2

Overview of EBV-Associated T/NK-Cell Lymphoproliferative Diseases

Kimura Hiroshi, Fujiwara Shigeyoshi

FRONTIERS IN PEDIATRICS Vol. 6 2019.1

Clinical features of adult-onset chronic active Epstein-Barr virus infection

KAWAMOTO Keisuke, MIYOSHI Hiroaki, SETO Masao, KIMURA Hiroshi, OHSHIMA Koichi

Rinsho Ketsueki Vol. 60 ( 8 ) page： 944 - 952 2019

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Hematology

<p>Chronic active Epstein-Barr virus infection (CAEBV) presents with mononucleosis-like symptoms such as chronic persistent or recurrent pyrexia, lymphadenopathy, and hepatosplenomegaly because of the reactivation of Epstein-Barr virus (EBV) as demonstrated by the recurrence of EBV-infected cells. The mechanism of CAEBV remains obscure, and CAEBV can lead to fatal conditions such as hemophagocytic syndrome and malignant lymphoma by clonal expansion of EBV-infected T- or NK-cells. Without hematopoietic stem cell transplantation, CAEBV has a poor prognosis. CAEBV is listed in the revised 2016 World Health Organization classification as a chronic active EBV infection of T- and NK-cell types, systemic form, among EBV-positive T- and NK-cell lymphoproliferative diseases of childhood. However, similar clinical conditions have been reported in adult patients. Therefore, we investigated the clinical features of adult patients with CAEBV-like features (adult-onset CAEBV) in a relatively small number of cases. Additionally, genetic alterations related to CAEBV development have also been reported. Along with these results, we reviewed the clinical characteristics of adult-onset CAEBV.</p>

DOI： 10.11406/rinketsu.60.944

PubMed

CiNii Research

EBV and Lymphomagenesis

KIMURA Hiroshi, OKUNO Yusuke

Uirusu Vol. 69 ( 1 ) page： 13 - 22 2019

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Society for Virology

Epstein–Barr virus (EBV) is a double stranded DNA virus of the family Herpesviridae. EBV is associated with a variety of lymphomas, and the mechanisms by which it promotes lymphomagenesis have been elucidated; this includes, for example, by translocation/activation of Myc in Burkitt lymphoma. However, the mechanisms by which it induces lymphoid tumors other than Burkitt lymphoma are unclear. Recently, we reported that the genome of EBV present in EBV-associated lymphomas harbors frequent intragenic deletions and that the deletion of a gene essential for virus replication promotes lymphomagenesis in a mouse model. Although intragenic deletions have been detected in other tumor viruses, little is known about the effects and importance of those of EBV, a large DNA virus whose genome encodes more than 70 genes. In this review, we summarize the role of EBV in lymphomagenesis with a focus on the impact of intragenic deletions.

DOI： 10.2222/jsv.69.13

PubMed

CiNii Research

JAK inhibitors for refractory lymphoma. Open Access

Kimura H

Oncotarget Vol. 9 ( 68 ) page： 32883 - 32884 2018.8

Antitumor effects of duvelisib on Epstein-Barr virus-associated lymphoma cells Reviewed

Kawada Jun-ichi, Ando Shotaro, Torii Yuka, Watanabe Takahiro, Sato Yoshitaka, Ito Yoshinori, Kimura Hiroshi

CANCER MEDICINE Vol. 7 ( 4 ) page： 1275-1284 2018.4

Regulation of Epstein-Barr Virus Life Cycle and Cell Proliferation by Histone H3K27 Methyltransferase EZH2 in Akata Cells

Ichikawa Takaya, Okuno Yusuke, Sato Yoshitaka, Goshima Fumi, Yoshiyama Hironori, Kanda Teru, Kimura Hiroshi, Murata Takayuki

MSPHERE Vol. 3 ( 6 ) 2018

BGLF2 Increases Infectivity of Epstein-Barr Virus by Activating AP-1 upon De Novo Infection Reviewed

Konishi Natsuno, Narita Yohei, Hijioka Fumiya, Al Masud H. M. Abdullah, Sato Yoshitaka, Kimura Hiroshi, Murata Takayuki

MSPHERE Vol. 3 ( 2 ) 2018

EBV in T-/NK-Cell Tumorigenesis.

Kimura H

Advances in experimental medicine and biology Vol. 1045 page： 459-475 2018

Human Herpesviruses Preface

Kimura Hiroshi

HUMAN HERPESVIRUSES Vol. 1045 page： V - V 2018

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Papers - KIMURA, Hiroshi