Faculty Profiles - KIMURA, Hiroshi

Papers - KIMURA, Hiroshi

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Comprehensive Analyses of Intraviral Epstein-Barr Virus Protein-Protein Interactions Hint Central Role of BLRF2 in the Tegument Network International coauthorship Open Access

Hara Yuya, Watanabe Takahiro, Yoshida Masahiro, Al Masud H. M. Abdullah, Kato Hiromichi, Kondo Tomohiro, Suzuki Reiji, Kurose Shutaro, Uddin Md Kamal, Arata Masataka, Miyagi Shouhei, Yanagi Yusuke, Sato Yoshitaka, Kimura Hiroshi, Murata Takayuki

JOURNAL OF VIROLOGY Vol. 96 ( 14 ) page： e0051822 2022.7

Genome-wide CRISPR screen for HSV-1 host factors reveals PAPSS1 contributes to heparan sulfate synthesis Open Access

Suzuki Takeshi, Sato Yoshitaka, Okuno Yusuke, Goshima Fumi, Mikami Tadahisa, Umeda Miki, Murata Takayuki, Watanabe Takahiro, Watashi Koichi, Wakita Takaji, Kitagawa Hiroshi, Kimura Hiroshi

COMMUNICATIONS BIOLOGY Vol. 5 ( 1 ) page： 694 2022.7

Elderly-onset systemic Epstein-Barr virus-positive T-cell lymphoma of childhood Open Access

Nishikubo Masashi, Hiramoto Nobuhiro, Yamashita Daisuke, Imoto Hiroharu, Sato Yoshitaka, Okuno Yusuke, Haga Hironori, Nannya Yasuhito, Ogawa Seishi, Kimura Hiroshi, Ishikawa Takayuki

PATHOLOGY INTERNATIONAL Vol. 72 ( 7 ) page： 376 - 378 2022.7

EBV genome variations enhance clinicopathological features of nasopharyngeal carcinoma in a non-endemic region Open Access

Kondo Satoru, Okuno Yusuke, Murata Takayuki, Dochi Hirotomo, Wakisaka Naohiro, Mizokami Harue, Moriyama-Kita Makiko, Kobayashi Eiji, Kano Makoto, Komori Takeshi, Hirai Nobuyuki, Ueno Takayoshi, Nakanishi Yosuke, Endo Kazuhira, Sugimoto Hisashi, Kimura Hiroshi, Yoshizaki Tomokazu

CANCER SCIENCE Vol. 113 ( 7 ) page： 2446 - 2456 2022.7

Epstein-Barr virus tegument protein BGLF2 in exosomes released from virus-producing cells facilitates de novo infection International coauthorship Open Access

Sato, Y; Yaguchi, M; Okuno, Y; Ishimaru, H; Sagou, K; Ozaki, S; Suzuki, T; Inagaki, T; Umeda, M; Watanabe, T; Fujimuro, M; Murata, T; Kimura, H

CELL COMMUNICATION AND SIGNALING Vol. 20 ( 1 ) page： 95 2022.6

Language：English Publishing type：Research paper (scientific journal) Publisher：Cell Communication and Signaling

Background: Viruses must adapt to the environment of their host cells to establish infection and persist. Diverse mammalian cells, including virus-infected cells, release extracellular vesicles such as exosomes containing proteins and miRNAs, and use these vesicles to mediate intercellular communication. However, the roles of exosomes in viral infection remain unclear. Results: We screened viral proteins to identify those responsible for the exosome-mediated enhancement of Epstein–Barr virus (EBV) infection. We identified BGLF2 protein encapsulated in exosomes, which were released by EBV-infected cells. BGLF2 protein is a tegument protein that exists in the space between the envelope and nucleocapsid, and it is released into the cytoplasm shortly after infection. BGLF2 protein-containing exosomes enhanced viral gene expression and repressed innate immunity, thereby supporting the EBV infection. Conclusions: The EBV tegument protein BGLF2 is encapsulated in exosomes and released by infected cells to facilitate the establishment of EBV infection. These findings suggest that tegument proteins support viral infection not only between the envelope and nucleocapsid, as well as in extraviral particles such as exosomes. Graphical abstract: [Figure not available: see fulltext.] [MediaObject not available: see fulltext.].

DOI： 10.1186/s12964-022-00902-7

EBV Exploits RNA m(6)A Modification to Promote Cell Survival and Progeny Virus Production During Lytic Cycle Open Access

Yanagi Yusuke, Watanabe Takahiro, Hara Yuya, Sato Yoshitaka, Kimura Hiroshi, Murata Takayuki

FRONTIERS IN MICROBIOLOGY Vol. 13 page： 870816 2022.6

PD-L1 upregulation by lytic induction of Epstein-Barr Virus. Open Access

Yanagi Y, Hara Y, Mabuchi S, Watanabe T, Sato Y, Kimura H, Murata T

Virology Vol. 568 page： 31 - 40 2022.3

In Silico Analysis and Synthesis of Nafamostat Derivatives and Evaluation of Their Anti-SARS-CoV-2 Activity Open Access

Fujimoto Kazuhiro J., Hobbs Daniel C. F., Umeda Miki, Nagata Akihiro, Yamaguchi Rie, Sato Yoshitaka, Sato Ayato, Ohmatsu Kohsuke, Ooi Takashi, Yanai Takeshi, Kimura Hiroshi, Murata Takayuki

VIRUSES-BASEL Vol. 14 ( 2 ) 2022.2

Molecular Basis of Epstein-Barr Virus Latency Establishment and Lytic Reactivation International coauthorship Open Access

Murata Takayuki, Sugimoto Atsuko, Inagaki Tomoki, Yanagi Yusuke, Watanabe Takahiro, Sato Yoshitaka, Kimura Hiroshi

VIRUSES-BASEL Vol. 13 ( 12 ) 2021.12

A STING inhibitor suppresses EBV-induced B cell transformation and lymphomagenesis International coauthorship Open Access

Miyagi Shouhei, Watanabe Takahiro, Hara Yuya, Arata Masataka, Uddin Md. Kamal, Mantoku Keisuke, Sago Ken, Yanagi Yusuke, Suzuki Takeshi, Masud H. M. Abdullah Al, Kawada Jun-ichi, Nakamura Shigeo, Miyake Yasuyuki, Sato Yoshitaka, Murata Takayuki, Kimura Hiroshi

CANCER SCIENCE Vol. 112 ( 12 ) page： 5088 - 5099 2021.12

Deletion of Viral microRNAs in the Oncogenesis of Epstein-Barr Virus-Associated Lymphoma Open Access

Kimura Hiroshi, Okuno Yusuke, Sato Yoshitaka, Watanabe Takahiro, Murata Takayuki

FRONTIERS IN MICROBIOLOGY Vol. 12 page： 667968 2021.7

RNAseq analysis identifies involvement of EBNA2 in PD-L1 induction during Epstein-Barr virus infection of primary B cells Reviewed International coauthorship

Yusuke Yanagi, Yusuke Okuno, Yohei Narita, H M Abdullah Al Masud , Takahiro Watanabe , Yoshitaka Sato, Teru Kanda, Hiroshi Kimura, Takayuki Murata

Virology Vol. 557 page： 44 - 54 2021.5

Oncolytic activity of naturally attenuated herpes-simplex virus HF10 against an immunocompetent model of oral carcinoma. Reviewed

Takano G, Esaki S, Goshima F, Enomoto A, Hatano Y, Ozaki H, Watanabe T, Sato Y, Kawakita D, Murakami S, Murata T, Nishiyama Y, Iwasaki S, Kimura H.

Molecular Therapy – Oncolytics Vol. 20 page： 220 - 227 2021.3

Role of Epstein-Barr Virus C Promoter Deletion in Diffuse Large B Cell Lymphoma Reviewed International coauthorship

Mabuchi Seiyo, Hijioka Fumiya, Watanabe Takahiro, Yanagi Yusuke, Okuno Yusuke, Al Masud H. M. Abdullah, Sato Yoshitaka, Murata Takayuki, Kimura Hiroshi

CANCERS Vol. 13 ( 3 ) 2021.2

Direct Evidence of Abortive Lytic Infection-Mediated Establishment of Epstein-Barr Virus Latency During B-Cell Infection Reviewed International coauthorship

Inagaki Tomoki, Sato Yoshitaka, Ito Jumpei, Takaki Mitsuaki, Okuno Yusuke, Yaguchi Masahiro, Al Masud H. M. Abdullah, Watanabe Takahiro, Sato Kei, Iwami Shingo, Murata Takayuki, Kimura Hiroshi

FRONTIERS IN MICROBIOLOGY Vol. 11 2021.1

Chronic active EB virus infection

Kimura Hiroshi

Journal of Hematopoietic Cell Transplantation Vol. 10 ( 2 ) page： 87 - 93 2021

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Society for Transplantation and Cellular Therapy

<p> Chronic active EB virus infection is an intractable disease. EBV latently infects T cells or NK cells, proliferates in a clonal manner, infiltrates organs, and triggers various symptoms. The prognosis is generally poor; in the absence of treatment, organ complications and a blast crisis often cause death. Recently, we performed a large-scale, comprehensive genetic analysis of patients with chronic active EB virus infection, and found: 1) it is unlikely that any primary immunodeficiency is in play (because mutations in germ cell sequences were rarely observed); 2) EBV-infected cells contained mutations in driver genes such as DDX3X and KMT2D and, in cases that could be observed over time, clonal evolution of EBV-infected cells was evident; and, 3) defective EBV was frequently observed and may be involved in disease onset. This review outlines the pathology of chronic active EB virus infection revealed by our genetic analyses, and the latest views on optimal diagnosis and treatment.</p>

DOI： 10.7889/hct-20-026

CiNii Research

Oncolytic activity of HF10 in head and neck squamous cell carcinomas. Reviewed

Esaki S, Goshima F, Ozaki H, Takano G, Hatano Y, Kawakita D, Ijichi K, Watanabe T, Sato Y, Murata T, Iwata H, Shibamoto Y, Murakami S, Nishiyama Y, Kimura H

Cancer gene therapy Vol. 27 ( 7-8 ) page： 585 - 598 2020.8

Number of concomitant drugs with thrombocytopenic adverse effects and the extent inflammatory response resolution are risk factors for thrombocytopenia in patients treated with linezolid for more than 14 days Reviewed

Sato Yoshitaka, Iguchi Mitsutaka, Kato Yoshiaki, Morioka Hiroshi, Hirabayashi Aki, Tetsuka Nobuyuki, Tomita Yuka, Kato Daizo, Yamada Kiyofumi, Kimura Hiroshi, Yagi Tetsuya

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 82 ( 3 ) page： 407-414 2020.8

Nationwide survey of systemic chronic active EBV infection in Japan in accordance with the new WHO classification Reviewed

Yonese Ichiro, Sakashita Chizuko, Imadome Ken-Ichi, Kobayashi Tohru, Yamamoto Masahide, Sawada Akihisa, Ito Yoshinori, Fukuhara Noriko, Hirose Asao, Takeda Yusuke, Makita Masanori, Endo Tomoyuki, Kimura Shun-Ichi, Ishimura Masataka, Miura Osamu, Ohga Shouichi, Kimura Hiroshi, Fujiwara Shigeyoshi, Arai Ayako

BLOOD ADVANCES Vol. 4 ( 13 ) page： 2918-2926 2020.7

A systemic form chronic active Epstein-Barr virus infection diagnosed from erythema nodosum-like skin lesions. Reviewed

Shibata A, Ishiguro Y, Makita S, Yamaga Y, Kimura H, Akiyama M

European journal of dermatology : EJD Vol. 30 ( 3 ) page： 314-316 2020.6

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Papers - KIMURA, Hiroshi