Faculty Profiles - KIMURA, Hiroshi

Papers - KIMURA, Hiroshi

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Defective Epstein-Barr virus in chronic active infection and haematological malignancy Reviewed International coauthorship

Okuno Yusuke, Murata Takayuki, Sato Yoshitaka, Muramatsu Hideki, Ito Yoshinori, Watanabe Takahiro, Okuno Tatsuya, Murakami Norihiro, Yoshida Kenichi, Sawada Akihisa, Inoue Masami, Kawa Keisei, Seto Masao, Ohshima Koichi, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Miyano Satoru, Narita Yohei, Yoshida Masahiro, Goshima Fumi, Kawada Jun-Ichi, Nishida Tetsuya, Kiyoi Hitoshi, Kato Seiichi, Nakamura Shigeo, Morishima Satoko, Yoshikawa Tetsushi, Fujiwara Shigeyoshi, Shimizu Norio, Isobe Yasushi, Noguchi Masaaki, Kikuta Atsushi, Iwatsuki Keiji, Takahashi Yoshiyuki, Kojima Seiji, Ogawa Seishi, Kimura Hiroshi

NATURE MICROBIOLOGY Vol. 4 ( 3 ) page： 404 - 413 2019.3

The landscape of 142 Epstein-Barr viral whole genomes in gastric cancer

Kojima, Y; Hamada, M; Naruse, A; Goto, K; Khine, HT; Arai, H; Akutsu, Y; Satou, A; Nakaguro, M; Kato, S; Kodera, Y; Yatabe, Y; Torii, Y; Kawada, JI; Murata, T; Kimura, H; Takiguchi, S; Inagaki, H; Kataoka, H; Okuno, Y

JOURNAL OF GASTROENTEROLOGY Vol. 60 ( 1 ) page： 55 - 65 2025.1

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Gastroenterology

Background: A substantial portion of gastric cancer (GC) is linked to Epstein–Barr virus (EBV) infection. The characteristics of this viral genome, such as specific viral strains and large structural variations, influence the progression of diseases like nasopharyngeal carcinoma and hematological malignancy. However, the EBV genomes from GC have not been thoroughly characterized. Methods: Our study involved 849 consecutive GC patients diagnosed at Nagoya City University Hospital, Japan (NCU cohort). We detected EBV from formalin-fixed, paraffin-embedded sections using a novel direct PCR-based rapid detection method. Additionally, we analyzed 142 EBV whole genomes (125 newly sequenced) from GC, comparing them with 205 genomes from other EBV-associated diseases. Results: We identified 32 (3.8%) patients associated with EBVaGC in the NCU cohort. Moreover, the direct PCR identified several GC specimens containing EBV-infected lymphocytes or their follicles. The dominant viral strain in GC was type 1 EBV, prevalent in most parts of the world, and no GC-specific strain was identified. We found no significant associations between single-nucleotide variants in the viral genome and GC. Structural variations of the EBV genome were infrequent in GC (4 cases, 2.1%), contrasting with EBV-associated hematological malignancy, which frequently carries large deletions. Conclusions: This study is the first to uncover the genomic variations of EBV in GC. While EBV is definitively linked to GC, the characteristics of its genomes do not strongly correlate with disease development or progression. Our findings on viral genomes supplement the current understanding of human genomes in EBVaGC.

DOI： 10.1007/s00535-024-02170-3

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特集小児臨床検査2024 XIII.感染症検査 4.ウイルス感染症　2)ヘルペスウイルス感染症 Invited

鈴木高子, 木村宏

小児内科 Vol. 56 ( 13 ) page： 620 - 624 2024.10

Direct evidence of abortive lytic infection-mediated establishment of Epstein-Barr virus latency during B-cell infection (vol 11 , 575255, 2021) International coauthorship Open Access

Inagaki, T; Sato, Y; Ito, J; Takaki, M; Okuno, Y; Yaguchi, M; Al Masud, HMA; Watanabe, T; Sato, K; Iwami, S; Murata, T; Kimura, H

FRONTIERS IN MICROBIOLOGY Vol. 15 page： 1426311 2024.5

Language：English Publishing type：Research paper (scientific journal) Publisher：Frontiers in Microbiology

In the published article, there was an error in Table 2 as published. We have carelessly swapped the rows and columns of Table 2. The corrected Table 2 and its caption appear below. Estimated parameters by fitting the mathematical model to experimental data. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

DOI： 10.3389/fmicb.2024.1426311

Single-Cell Transcriptomic Analysis of Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis

Suzuki, T; Sato, Y; Okuno, Y; Torii, Y; Fukuda, Y; Haruta, K; Yamaguchi, M; Kawamura, Y; Hama, A; Narita, A; Muramatsu, H; Yoshikawa, T; Takahashi, Y; Kimura, H; Ito, Y; Kawada, JI

JOURNAL OF CLINICAL IMMUNOLOGY Vol. 44 ( 4 ) page： 103 2024.4

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Clinical Immunology

Epstein-Barr virus (EBV) infection can lead to infectious mononucleosis (EBV-IM) and, more rarely, EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH), which is characterized by a life-threatening hyperinflammatory cytokine storm with immune dysregulation. Interferon-gamma (IFNγ) has been identified as a critical mediator for primary HLH; however, the detailed role of IFNγ and other cytokines in EBV-HLH is not fully understood. In this study, we used single-cell RNA sequencing to characterize the immune landscape of EBV-HLH and compared it with EBV-IM. Three pediatric patients with EBV-HLH with different backgrounds, one with X-linked lymphoproliferative syndrome type 1 (XLP1), two with chronic active EBV disease (CAEBV), and two patients with EBV-IM were enrolled. The TUBA1B + STMN1 + CD8 + T cell cluster, a responsive proliferating cluster with rich mRNA detection, was explicitly observed in EBV-IM, and the upregulation of SH2D1A—the gene responsible for XLP1—was localized in this cluster. This proliferative cluster was scarcely observed in EBV-HLH cases. In EBV-HLH cases with CAEBV, upregulation of LAG3 was observed in EBV-infected cells, which may be associated with an impaired response by CD8 + T cells. Additionally, genes involved in type I interferon (IFN) signaling were commonly upregulated in each cell fraction of EBV-HLH, and activation of type II IFN signaling was observed in CD4 + T cells, natural killer cells, and monocytes but not in CD8 + T cells in EBV-HLH. In conclusion, impaired responsive proliferation of CD8 + T cells and upregulation of type I IFN signaling were commonly observed in EBV-HLH cases, regardless of the patients’ background, indicating the key features of EBV-HLH.

DOI： 10.1007/s10875-024-01701-0

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Epstein-Barr virus lytic gene BNRF1 promotes B-cell lymphomagenesis via IFI27 upregulation Open Access

Sagou, K; Sato, Y; Okuno, Y; Watanabe, T; Inagaki, T; Motooka, Y; Toyokuni, S; Murata, T; Kiyoi, H; Kimura, H

PLOS PATHOGENS Vol. 20 ( 2 ) page： e1011954 2024.2

Language：English Publishing type：Research paper (scientific journal) Publisher：PLoS Pathogens

Epstein-Barr virus (EBV) is a ubiquitous human lymphotropic herpesvirus that is causally associated with several malignancies. In addition to latent factors, lytic replication contributes to cancer development. In this study, we examined whether the lytic gene BNRF1, which is conserved among gamma-herpesviruses, has an important role in lymphomagenesis. We found that lymphoblastoid cell lines (LCLs) established by BNRF1-knockout EBV exhibited remarkably lower pathogenicity in a mice xenograft model than LCLs produced by wild-type EBV (LCLs-WT). RNA-seq analyses revealed that BNRF1 elicited the expression of interferon-inducible protein 27 (IFI27), which promotes cell proliferation. IFI27 knockdown in LCLs-WT resulted in excessive production of reactive oxygen species, leading to cell death and significantly decreased their pathogenicity in vivo. We also confirmed that IFI27 was upregulated during primary infection in B-cells. Our findings revealed that BNRF1 promoted robust proliferation of the B-cells that were transformed by EBV latent infection via IFI27 upregulation both in vitro and in vivo.

DOI： 10.1371/journal.ppat.1011954

Updated guidelines for chronic active Epstein-Barr virus disease Open Access

Kawada, JI; Ito, Y; Ohshima, K; Yamada, M; Kataoka, S; Muramatsu, H; Sawada, A; Wada, T; Imadome, KI; Arai, A; Iwatsuki, K; Ohga, S; Kimura, H

INTERNATIONAL JOURNAL OF HEMATOLOGY Vol. 118 ( 5 ) page： 568 - 576 2023.11

Language：English Publishing type：Research paper (scientific journal) Publisher：International Journal of Hematology

Chronic active Epstein–Barr virus disease (CAEBV), formerly named chronic active Epstein–Barr virus infection, is characterized by systemic inflammation and clonal proliferation of Epstein–Barr virus (EBV)-infected T or NK cells. As CAEBV is a potentially life-threatening illness, appropriate diagnosis and therapeutic interventions are necessary for favorable clinical outcomes. Substantial evidence regarding the pathogenesis and treatment of CAEBV has been accumulated since previous guidelines for the diagnosis of CAEBV were proposed. To reflect this evidence, we updated the guidelines for the diagnosis and treatment of CAEBV to improve clinical management of the disease. The details of the updated guidelines are presented in this report. Diagnosis of CAEBV now requires confirmation of a high copy number of EBV genome and EBV-infected T or NK cells. An EBV DNA load ≥ 10,000 IU/mL in whole blood is proposed as the diagnostic cutoff value for CAEBV in this updated guideline. A standard treatment approach for CAEBV has not been established, and hematopoietic stem cell transplantation (HSCT) is considered the only curative treatment. Chemotherapy can be administered to control disease activity before HSCT.

DOI： 10.1007/s12185-023-03660-5

Correction: "The 5th edition of The World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms" Leukemia. 2022 Jul;36(7):1720-1748. International coauthorship Open Access

Alaggio R, Amador C, Anagnostopoulos I, Attygalle AD, de Oliveira Araujo IB, Berti E, Bhagat G, Borges AM, Boyer D, Calaminici M, Chadburn A, Chan JKC, Cheuk W, Chng WJ, Choi JK, Chuang SS, Coupland SE, Czader M, Dave SS, de Jong D, Di Napoli A, Du MQ, Elenitoba-Johnson KS, Ferry J, Geyer J, Gratzinger D, Guitart J, Gujral S, Harris M, Harrison CJ, Hartmann S, Hochhaus A, Jansen PM, Karube K, Kempf W, Khoury J, Kimura H, Klapper W, Kovach AE, Kumar S, Lazar AJ, Lazzi S, Leoncini L, Leung N, Leventaki V, Li XQ, Lim MS, Liu WP, Louissaint A Jr, Marcogliese A, Medeiros LJ, Michal M, Miranda RN, Mitteldorf C, Montes-Moreno S, Morice W, Nardi V, Naresh KN, Natkunam Y, Ng SB, Oschlies I, Ott G, Parrens M, Pulitzer M, Rajkumar SV, Rawstron AC, Rech K, Rosenwald A, Said J, Sarkozy C, Sayed S, Saygin C, Schuh A, Sewell W, Siebert R, Sohani AR, Suzuki R, Tooze R, Traverse-Glehen A, Vega F, Vergier B, Wechalekar AD, Wood B, Xerri L, Xiao W, International Agency for Research on Cancer/World Health Organization

Leukemia Vol. 37 ( 9 ) page： 1944 - 1951 2023.9

Growth Transformation of B Cells by Epstein-Barr Virus Requires IMPDH2 Induction and Nucleolar Hypertrophy International coauthorship Open Access

Sugimoto, A; Watanabe, T; Matsuoka, K; Okuno, Y; Yanagi, Y; Narita, Y; Mabuchi, S; Nobusue, H; Sugihara, E; Hirayama, M; Ide, T; Onouchi, T; Sato, Y; Kanda, T; Saya, H; Iwatani, Y; Kimura, H; Murata, T

MICROBIOLOGY SPECTRUM Vol. 11 ( 4 ) page： e0044023 2023.8

Language：English Publishing type：Research paper (scientific journal) Publisher：Microbiology Spectrum

The in vitro growth transformation of primary B cells by Epstein-Barr virus (EBV) is the initial step in the development of posttransplant lymphoproliferative disorder (PTLD). We performed electron microscopic analysis and immunostaining of primary B cells infected with wild-Type EBV. Interestingly, the nucleolar size was increased by two days after infection. A recent study found that nucleolar hypertrophy, which is caused by the induction of the IMPDH2 gene, is required for the efficient promotion of growth in cancers. In the present study, RNA-seq revealed that the IMPDH2 gene was significantly induced by EBV and that its level peaked at day 2. Even without EBV infection, the activation of primary B cells by the CD40 ligand and interleukin-4 increased IMPDH2 expression and nucleolar hypertrophy. Using EBNA2 or LMP1 knockout viruses, we found that EBNA2 and MYC, but not LMP1, induced the IMPDH2 gene during primary infections. IMPDH2 inhibition by mycophenolic acid (MPA) blocked the growth transformation of primary B cells by EBV, leading to smaller nucleoli, nuclei, and cells. Mycophenolate mofetil (MMF), which is a prodrug of MPA that is approved for use as an immunosuppressant, was tested in a mouse xenograft model. Oral MMF significantly improved the survival of mice and reduced splenomegaly. Taken together, these results indicate that EBV induces IMPDH2 expression through EBNA2-dependent and MYC-dependent mechanisms, leading to the hypertrophy of the nucleoli, nuclei, and cells as well as efficient cell proliferation. Our results provide basic evidence that IMPDH2 induction and nucleolar enlargement are crucial for B cell transformation by EBV. In addition, the use of MMF suppresses PTLD. IMPORTANCE EBV infections cause nucleolar enlargement via the induction of IMPDH2, which are essential for B cell growth transformation by EBV. Although the significance of IMPDH2 induction and nuclear hypertrophy in the tumorigenesis of glioblastoma has been reported, EBV infection brings about the change quickly by using its transcriptional cofactor, EBNA2, and MYC. Moreover, we present here, for the novel, basic evidence that an IMPDH2 inhibitor, namely, MPA or MMF, can be used for EBV-positive posttransplant lymphoproliferative disorder (PTLD).

DOI： 10.1128/spectrum.00440-23

Diagnostic and disease severity determination criteria for hydroa vacciniforme lymphoproliferative disorders and severe mosquito bite allergy Open Access

Hirai, Y; Asada, H; Hamada, T; Kawada, J; Kimura, H; Arai, A; Ohshima, K; Ohga, S; Iwatsuki, K

JOURNAL OF DERMATOLOGY Vol. 50 ( 7 ) page： E198 - E205 2023.7

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Dermatology

Hydroa vacciniforme lymphoproliferative disorder (HV-LPD) and severe mosquito bite allergy (SMBA) are both cutaneous forms of Epstein–Barr virus (EBV)-associated T/natural killer (NK) cell LPDs and are closely related to chronic active EBV disease (CAEBV) and EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH). HV-LPD is further divided into classic HV, a benign subtype mediated by EBV-positive γδT cells, and systemic HV, another life-threatening subtype mainly associated with EBV-positive αβT or γδT cells. The vast majority of patients with SMBA have increased numbers of EBV-infected NK cells in the blood. Clinical symptoms of HV-LPD and SMBA often overlap in the same patient and may progress to more serious disease conditions equivalent to the systemic form of CAEBV. To define the disease spectrum of HV-LPD and SMBA, we propose the diagnostic criteria and the determination criteria for disease severity. The proposed diagnostic criteria are consistent with those for CAEBV and EBV-HLH in the guidelines for the management for CAEBV and related disorders 2023.

DOI： 10.1111/1346-8138.16842

Epstein-Barr Virus BBLF1 Mediates Secretory Vesicle Transport to Facilitate Mature Virion Release Open Access

Uddin, MK; Watanabe, T; Arata, M; Sato, Y; Kimura, H; Murata, T

JOURNAL OF VIROLOGY Vol. 97 ( 6 ) page： e0043723 2023.6

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Virology

Enveloped viruses undergo a complex multistep process of assembly, maturation, and release into the extracellular space utilizing host secretory machinery. Several studies of the herpesvirus subfamily have shown that secretory vesicles derived from the trans-Golgi network (TGN) or endosomes transport virions into the extracellular space. However, the regulatory mechanism underlying the release of Epstein-Barr virus, a human oncovirus, remains unclear. We demonstrate that disruption of BBLF1, a tegument component, suppressed viral release and resulted in the accumulation of viral particles on the inner side of the vesicular membrane. Organelle separation revealed the accumulation of infectious viruses in fractions containing vesicles derived from the TGN and late endosomes. Deficiency of an acidic amino acid cluster in BBLF1 reduced viral secretion. Moreover, truncational deletion of the C-terminal region of BBLF1 increased infectious virus production. These findings suggest that BBLF1 regulates the viral release pathway and reveal a new aspect of tegument protein function.

DOI： 10.1128/jvi.00437-23

特集新しい時代の小児感染症各論:原因微生物別ウイルスヘルペスウイルス科 Invited

川田潤一, 木村宏

小児内科 Vol. 55 ( 4 ) page： 623 - 628 2023.4

Salvage Human Leukocyte Antigen-Haploidentical Hematopoietic Cell Transplant With Posttransplant Cyclophosphamide for Graft Failure in a Patient With Chronic Active Epstein-Barr Virus Infection

Nakaya, Y; Koh, H; Harada, N; Okamura, H; Misugi, T; Suekane, T; Tachibana, D; Kimura, H; Hino, M; Nakamae, H

EXPERIMENTAL AND CLINICAL TRANSPLANTATION Vol. 21 ( 2 ) page： 184 - 188 2023.3

Language：English Publishing type：Research paper (scientific journal) Publisher：Experimental and Clinical Transplantation

Salvage human leukocyte antigen-haploidentical hematopoietic cell transplant using posttransplant cyclophosphamide has shown promising results for graft failure in various hematological disorders. However, to our knowledge, no such findings have been reported for a case of chronic active Epstein-Barr virus infection, although graft failure is relatively common in patients with chronic active Epstein-Barr virus infection. We report a case of a 32-year-old woman with natural killer-cell type chronic active Epstein-Barr virus infection who experienced graft failure after a first allogeneic hematopoietic cell transplant from an unrelated human leukocyte antigen-matched donor. The patient received a second allogeneic hematopoietic cell transplant with human leukocyte antigen-haploidentical hematopoietic cell transplant using posttransplant cyclophosphamide (cyclophosphamide, 50 mg/kg, on day 3 and day 4) following reduced-intensity conditioning as rescue therapy. Neutrophils successfully engrafted on day 19, and the patient sustained remission without severe transplant-related complication 10 months after salvage human leukocyte antigen-haploidentical hematopoietic cell transplant using posttransplant cyclophosphamide. This report suggests that salvage human leukocyte antigen-haploidentical hematopoietic cell transplant using posttransplant cyclophosphamide may be a feasible therapeutic option for graft failure in patients with chronic active Epstein-Barr virus infection.

DOI： 10.6002/ect.2022.0322

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症例 CD8＋αβT細胞優位型種痘様水疱症リンパ増殖異常症の1例

大林三裕佳, 中村賢人, 古橋卓也, 岩月啓氏, 三宅智子, 平井陽至, 谷田けい, 金兼弘和, 西田徹也, 木村宏, 森田明理

皮膚科の臨床 Vol. 65 ( 2 ) page： 273 - 278 2023.2

N6-methyladenosine Modification of Hepatitis B Virus RNA in the Coding Region of HBx Open Access

Murata, T; Iwahori, S; Okuno, Y; Nishitsuji, H; Yanagi, Y; Watashi, K; Wakita, T; Kimura, H; Shimotohno, K

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol. 24 ( 3 ) 2023.2

Language：English Publishing type：Research paper (scientific journal) Publisher：International Journal of Molecular Sciences

N6-methyladenosine (m6A) is a post-transcriptional modification of RNA involved in transcript transport, degradation, translation, and splicing. We found that HBV RNA is modified by m6A predominantly in the coding region of HBx. The mutagenesis of methylation sites reduced the HBV mRNA and HBs protein levels. The suppression of m6A by an inhibitor or knockdown in primary hepatocytes decreased the viral RNA and HBs protein levels in the medium. These results suggest that the m6A modification of HBV RNA is needed for the efficient replication of HBV in hepatocytes.

DOI： 10.3390/ijms24032265

The 100th anniversary of the Nagoya Journal of Medical Science: a message from the Dean

Kimura, H

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 85 ( 1 ) page： 5 - 6 2023.2

The Epstein-Barr Virus Enhancer Interaction Landscapes in Virus-Associated Cancer Cell Lines International coauthorship Open Access

Ding Weiyue, Wang Chong, Narita Yohei, Wang Hongbo, Leong Merrin Man Long, Huang Alvin, Liao Yifei, Liu Xuefeng, Okuno Yusuke, Kimura Hiroshi, Gewurz Benjamin, Teng Mingxian, Jin Shuilin, Sato Yoshitaka, Zhao Bo

JOURNAL OF VIROLOGY Vol. 96 ( 18 ) page： e0073922 2022.9

EBV-associated NK and T-cell lymphoid neoplasms. International coauthorship Open Access

Kimura H, de Leval L, Cai Q, Kim WS

Current opinion in oncology Vol. 34 ( 5 ) page： 422 - 431 2022.9

Comprehensive Analyses of Intraviral Epstein-Barr Virus Protein-Protein Interactions Hint Central Role of BLRF2 in the Tegument Network International coauthorship Open Access

Hara Yuya, Watanabe Takahiro, Yoshida Masahiro, Al Masud H. M. Abdullah, Kato Hiromichi, Kondo Tomohiro, Suzuki Reiji, Kurose Shutaro, Uddin Md Kamal, Arata Masataka, Miyagi Shouhei, Yanagi Yusuke, Sato Yoshitaka, Kimura Hiroshi, Murata Takayuki

JOURNAL OF VIROLOGY Vol. 96 ( 14 ) page： e0051822 2022.7

Genome-wide CRISPR screen for HSV-1 host factors reveals PAPSS1 contributes to heparan sulfate synthesis Open Access

Suzuki Takeshi, Sato Yoshitaka, Okuno Yusuke, Goshima Fumi, Mikami Tadahisa, Umeda Miki, Murata Takayuki, Watanabe Takahiro, Watashi Koichi, Wakita Takaji, Kitagawa Hiroshi, Kimura Hiroshi

COMMUNICATIONS BIOLOGY Vol. 5 ( 1 ) page： 694 2022.7

Elderly-onset systemic Epstein-Barr virus-positive T-cell lymphoma of childhood Open Access

Nishikubo Masashi, Hiramoto Nobuhiro, Yamashita Daisuke, Imoto Hiroharu, Sato Yoshitaka, Okuno Yusuke, Haga Hironori, Nannya Yasuhito, Ogawa Seishi, Kimura Hiroshi, Ishikawa Takayuki

PATHOLOGY INTERNATIONAL Vol. 72 ( 7 ) page： 376 - 378 2022.7

The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms International coauthorship Open Access

Alaggio Rita, Amador Catalina, Anagnostopoulos Ioannis, Attygalle Ayoma D., Araujo Iguaracyra Barreto de Oliveira, Berti Emilio, Bhagat Govind, Borges Anita Maria, Boyer Daniel, Calaminici Mariarita, Chadburn Amy, Chan John K. C., Cheuk Wah, Chng Wee-Joo, Choi John K., Chuang Shih-Sung, Coupland Sarah E., Czader Magdalena, Dave Sandeep S., de Jong Daphne, Du Ming-Qing, Elenitoba-Johnson Kojo S., Ferry Judith, Geyer Julia, Gratzinger Dita, Guitart Joan, Gujral Sumeet, Harris Marian, Harrison Christine J., Hartmann Sylvia, Hochhaus Andreas, Jansen Patty M., Karube Kennosuke, Kempf Werner, Khoury Joseph, Kimura Hiroshi, Klapper Wolfram, Kovach Alexandra E., Kumar Shaji, Lazar Alexander J., Lazzi Stefano, Leoncini Lorenzo, Leung Nelson, Leventaki Vasiliki, Li Xiao-Qiu, Lim Megan S., Liu Wei-Ping, Louissaint Abner Jr., Marcogliese Andrea, Medeiros L. Jeffrey, Michal Michael, Miranda Roberto N., Mitteldorf Christina, Montes-Moreno Santiago, Morice William, Nardi Valentina, Naresh Kikkeri N., Natkunam Yasodha, Ng Siok-Bian, Oschlies Ilske, Ott German, Parrens Marie, Pulitzer Melissa, Rajkumar S. Vincent, Rawstron Andrew C., Rech Karen, Rosenwald Andreas, Said Jonathan, Sarkozy Clementine, Sayed Shahin, Saygin Caner, Schuh Anna, Sewell William, Siebert Reiner, Sohani Aliyah R., Tooze Reuben, Traverse-Glehen Alexandra, Vega Francisco, Vergier Beatrice, Wechalekar Ashutosh D., Wood Brent, Xerri Luc, Xiao Wenbin

LEUKEMIA Vol. 36 ( 7 ) page： 1720 - 1748 2022.7

EBV genome variations enhance clinicopathological features of nasopharyngeal carcinoma in a non-endemic region Open Access

Kondo Satoru, Okuno Yusuke, Murata Takayuki, Dochi Hirotomo, Wakisaka Naohiro, Mizokami Harue, Moriyama-Kita Makiko, Kobayashi Eiji, Kano Makoto, Komori Takeshi, Hirai Nobuyuki, Ueno Takayoshi, Nakanishi Yosuke, Endo Kazuhira, Sugimoto Hisashi, Kimura Hiroshi, Yoshizaki Tomokazu

CANCER SCIENCE Vol. 113 ( 7 ) page： 2446 - 2456 2022.7

Epstein-Barr virus tegument protein BGLF2 in exosomes released from virus-producing cells facilitates de novo infection International coauthorship Open Access

Sato, Y; Yaguchi, M; Okuno, Y; Ishimaru, H; Sagou, K; Ozaki, S; Suzuki, T; Inagaki, T; Umeda, M; Watanabe, T; Fujimuro, M; Murata, T; Kimura, H

CELL COMMUNICATION AND SIGNALING Vol. 20 ( 1 ) page： 95 2022.6

Language：English Publishing type：Research paper (scientific journal) Publisher：Cell Communication and Signaling

Background: Viruses must adapt to the environment of their host cells to establish infection and persist. Diverse mammalian cells, including virus-infected cells, release extracellular vesicles such as exosomes containing proteins and miRNAs, and use these vesicles to mediate intercellular communication. However, the roles of exosomes in viral infection remain unclear. Results: We screened viral proteins to identify those responsible for the exosome-mediated enhancement of Epstein–Barr virus (EBV) infection. We identified BGLF2 protein encapsulated in exosomes, which were released by EBV-infected cells. BGLF2 protein is a tegument protein that exists in the space between the envelope and nucleocapsid, and it is released into the cytoplasm shortly after infection. BGLF2 protein-containing exosomes enhanced viral gene expression and repressed innate immunity, thereby supporting the EBV infection. Conclusions: The EBV tegument protein BGLF2 is encapsulated in exosomes and released by infected cells to facilitate the establishment of EBV infection. These findings suggest that tegument proteins support viral infection not only between the envelope and nucleocapsid, as well as in extraviral particles such as exosomes. Graphical abstract: [Figure not available: see fulltext.] [MediaObject not available: see fulltext.].

DOI： 10.1186/s12964-022-00902-7

EBV Exploits RNA m(6)A Modification to Promote Cell Survival and Progeny Virus Production During Lytic Cycle Open Access

Yanagi Yusuke, Watanabe Takahiro, Hara Yuya, Sato Yoshitaka, Kimura Hiroshi, Murata Takayuki

FRONTIERS IN MICROBIOLOGY Vol. 13 page： 870816 2022.6

PD-L1 upregulation by lytic induction of Epstein-Barr Virus. Open Access

Yanagi Y, Hara Y, Mabuchi S, Watanabe T, Sato Y, Kimura H, Murata T

Virology Vol. 568 page： 31 - 40 2022.3

In Silico Analysis and Synthesis of Nafamostat Derivatives and Evaluation of Their Anti-SARS-CoV-2 Activity Open Access

Fujimoto Kazuhiro J., Hobbs Daniel C. F., Umeda Miki, Nagata Akihiro, Yamaguchi Rie, Sato Yoshitaka, Sato Ayato, Ohmatsu Kohsuke, Ooi Takashi, Yanai Takeshi, Kimura Hiroshi, Murata Takayuki

VIRUSES-BASEL Vol. 14 ( 2 ) 2022.2

Molecular Basis of Epstein-Barr Virus Latency Establishment and Lytic Reactivation International coauthorship Open Access

Murata Takayuki, Sugimoto Atsuko, Inagaki Tomoki, Yanagi Yusuke, Watanabe Takahiro, Sato Yoshitaka, Kimura Hiroshi

VIRUSES-BASEL Vol. 13 ( 12 ) 2021.12

A STING inhibitor suppresses EBV-induced B cell transformation and lymphomagenesis International coauthorship Open Access

Miyagi Shouhei, Watanabe Takahiro, Hara Yuya, Arata Masataka, Uddin Md. Kamal, Mantoku Keisuke, Sago Ken, Yanagi Yusuke, Suzuki Takeshi, Masud H. M. Abdullah Al, Kawada Jun-ichi, Nakamura Shigeo, Miyake Yasuyuki, Sato Yoshitaka, Murata Takayuki, Kimura Hiroshi

CANCER SCIENCE Vol. 112 ( 12 ) page： 5088 - 5099 2021.12

Deletion of Viral microRNAs in the Oncogenesis of Epstein-Barr Virus-Associated Lymphoma Open Access

Kimura Hiroshi, Okuno Yusuke, Sato Yoshitaka, Watanabe Takahiro, Murata Takayuki

FRONTIERS IN MICROBIOLOGY Vol. 12 page： 667968 2021.7

RNAseq analysis identifies involvement of EBNA2 in PD-L1 induction during Epstein-Barr virus infection of primary B cells Reviewed International coauthorship

Yusuke Yanagi, Yusuke Okuno, Yohei Narita, H M Abdullah Al Masud , Takahiro Watanabe , Yoshitaka Sato, Teru Kanda, Hiroshi Kimura, Takayuki Murata

Virology Vol. 557 page： 44 - 54 2021.5

Oncolytic activity of naturally attenuated herpes-simplex virus HF10 against an immunocompetent model of oral carcinoma. Reviewed

Takano G, Esaki S, Goshima F, Enomoto A, Hatano Y, Ozaki H, Watanabe T, Sato Y, Kawakita D, Murakami S, Murata T, Nishiyama Y, Iwasaki S, Kimura H.

Molecular Therapy – Oncolytics Vol. 20 page： 220 - 227 2021.3

Role of Epstein-Barr Virus C Promoter Deletion in Diffuse Large B Cell Lymphoma Reviewed International coauthorship

Mabuchi Seiyo, Hijioka Fumiya, Watanabe Takahiro, Yanagi Yusuke, Okuno Yusuke, Al Masud H. M. Abdullah, Sato Yoshitaka, Murata Takayuki, Kimura Hiroshi

CANCERS Vol. 13 ( 3 ) 2021.2

Direct Evidence of Abortive Lytic Infection-Mediated Establishment of Epstein-Barr Virus Latency During B-Cell Infection Reviewed International coauthorship

Inagaki Tomoki, Sato Yoshitaka, Ito Jumpei, Takaki Mitsuaki, Okuno Yusuke, Yaguchi Masahiro, Al Masud H. M. Abdullah, Watanabe Takahiro, Sato Kei, Iwami Shingo, Murata Takayuki, Kimura Hiroshi

FRONTIERS IN MICROBIOLOGY Vol. 11 2021.1

Chronic active EB virus infection

Kimura Hiroshi

Journal of Hematopoietic Cell Transplantation Vol. 10 ( 2 ) page： 87 - 93 2021

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Society for Transplantation and Cellular Therapy

Chronic active EB virus infection is an intractable disease. EBV latently infects T cells or NK cells, proliferates in a clonal manner, infiltrates organs, and triggers various symptoms. The prognosis is generally poor; in the absence of treatment, organ complications and a blast crisis often cause death. Recently, we performed a large-scale, comprehensive genetic analysis of patients with chronic active EB virus infection, and found: 1) it is unlikely that any primary immunodeficiency is in play (because mutations in germ cell sequences were rarely observed); 2) EBV-infected cells contained mutations in driver genes such as DDX3X and KMT2D and, in cases that could be observed over time, clonal evolution of EBV-infected cells was evident; and, 3) defective EBV was frequently observed and may be involved in disease onset. This review outlines the pathology of chronic active EB virus infection revealed by our genetic analyses, and the latest views on optimal diagnosis and treatment.

DOI： 10.7889/hct-20-026

CiNii Research

Oncolytic activity of HF10 in head and neck squamous cell carcinomas. Reviewed

Esaki S, Goshima F, Ozaki H, Takano G, Hatano Y, Kawakita D, Ijichi K, Watanabe T, Sato Y, Murata T, Iwata H, Shibamoto Y, Murakami S, Nishiyama Y, Kimura H

Cancer gene therapy Vol. 27 ( 7-8 ) page： 585 - 598 2020.8

Number of concomitant drugs with thrombocytopenic adverse effects and the extent inflammatory response resolution are risk factors for thrombocytopenia in patients treated with linezolid for more than 14 days Reviewed

Sato Yoshitaka, Iguchi Mitsutaka, Kato Yoshiaki, Morioka Hiroshi, Hirabayashi Aki, Tetsuka Nobuyuki, Tomita Yuka, Kato Daizo, Yamada Kiyofumi, Kimura Hiroshi, Yagi Tetsuya

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 82 ( 3 ) page： 407-414 2020.8

Nationwide survey of systemic chronic active EBV infection in Japan in accordance with the new WHO classification Reviewed

Yonese Ichiro, Sakashita Chizuko, Imadome Ken-Ichi, Kobayashi Tohru, Yamamoto Masahide, Sawada Akihisa, Ito Yoshinori, Fukuhara Noriko, Hirose Asao, Takeda Yusuke, Makita Masanori, Endo Tomoyuki, Kimura Shun-Ichi, Ishimura Masataka, Miura Osamu, Ohga Shouichi, Kimura Hiroshi, Fujiwara Shigeyoshi, Arai Ayako

BLOOD ADVANCES Vol. 4 ( 13 ) page： 2918-2926 2020.7

A systemic form chronic active Epstein-Barr virus infection diagnosed from erythema nodosum-like skin lesions. Reviewed

Shibata A, Ishiguro Y, Makita S, Yamaga Y, Kimura H, Akiyama M

European journal of dermatology : EJD Vol. 30 ( 3 ) page： 314-316 2020.6

Epstein-Barr virus NK and T cell lymphoproliferative disease: report of a 2018 international meeting Reviewed International coauthorship

Cohena Jeffrey I., Iwatsuki Keiji, Ko Young-Hyeh, Kimura Hiroshi, Manoli Irini, Ohshima Koichi, Pittaluga Stefania, Quintanilla-Martinez Leticia, Jaffe Elaine S.

LEUKEMIA & LYMPHOMA Vol. 61 ( 4 ) page： 808-819 2020.3

Oncogenesis of CAEBV revealed: Intragenic deletions in the viral genome and leaky expression of lytic genes Reviewed

Murata Takayuki, Okuno Yusuke, Sato Yoshitaka, Watanabe Takahiro, Kimura Hiroshi

REVIEWS IN MEDICAL VIROLOGY Vol. 30 ( 2 ) page： e2095 2020.3

Antitumor activity of CDK inhibitor alsterpaullone in Epstein-Barr virus-associated lymphoproliferative disorders. Reviewed International coauthorship

Watanabe T, Sato Y, Masud HMAA, Takayama M, Matsuda H, Hara Y, Yanagi Y, Yoshida M, Goshima F, Murata T, Kimura H

Cancer science 2020.1

Epstein-Barr Virus BBRF2 Is Required for Maximum Infectivity Open Access

Al Masud H. M. Abdullah, Yanagi Yusuke, Watanabe Takahiro, Sato Yoshitaka, Kimura Hiroshi, Murata Takayuki

MICROORGANISMS Vol. 7 ( 12 ) 2019.12

NK-cell post-transplant lymphoproliferative disease with chronic active Epstein-Barr virus infection-like clinical findings.

Iemura T, Kondo T, Hishizawa M, Yamashita K, Kimura H, Takaori-Kondo A

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2019.8

Editorial: Epstein-Barr Virus-Associated T/NK-Cell Lymphoproliferative Diseases

Fujiwara Shigeyoshi, Kimura Hiroshi

FRONTIERS IN PEDIATRICS Vol. 7 ( JULY ) page： 285 2019.7

Viral DNA loads in various blood components of patients with Epstein-Barr virus-positive T/NK cell lymphoproliferative diseases.

Kawada JI, Kamiya Y, Sawada A, Iwatsuki K, Izutsu K, Torii Y, Kimura H, Ito Y

The Journal of infectious diseases 2019.6

The BOLF1 gene is necessary for effective Epstein-Barr viral infectivity

Al Masud H. M. Abdullah, Watanabe Takahiro, Sato Yoshitaka, Goshima Fumi, Kimura Hiroshi, Murata Takayuki

VIROLOGY Vol. 531 page： 114-125 2019.5

S-Like-Phase Cyclin-Dependent Kinases Stabilize the Epstein-Barr Virus BDLF4 Protein To Temporally Control Late Gene Transcription Open Access

Sato Yoshitaka, Watanabe Takahiro, Suzuki Chihiro, Abe Yuichi, Al Masud H. M. Abdullah, Inagaki Tomoki, Yoshida Masahiro, Suzuki Takeshi, Goshima Fumi, Adachi Jun, Tomonaga Takeshi, Murata Takayuki, Kimura Hiroshi

JOURNAL OF VIROLOGY Vol. 93 ( 8 ) 2019.4

Initial Characterization of the Epstein-Barr Virus BSRF1 Gene Product

Yanagi Yusuke, Al Masud H. M. Abdullah, Watanabe Takahiro, Sato Yoshitaka, Goshima Fumi, Kimura Hiroshi, Murata Takayuki

VIRUSES-BASEL Vol. 11 ( 3 ) 2019.3

Defective Epstein-Barr virus (EBV) in chronic active EBV infection and EBV-related hematological malignancy International coauthorship Open Access

Okuno Y, Murata Y, Sato Y, Muramatsu H, YIto Y, Watanabe T, Okuno T, Murakami N, Yoshida K, Sawada A, Inoue M, Kawa K, Seto M, Ohshima K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Narita Y, Yoshida M, Goshima F, Kawada JI, Nishida T, Kiyoi H, Kato S, Nakamura S, Morishima S, Yoshikawa T, Fujiwara S, Shimizu N, Isobe Y, Noguchi M, Kikuta1 A, Iwatsuki K, Takahashi Y, Kojima S, Ogawa S, Kimura H.

Nat Microbiol Vol. 4 ( 3 ) page： 544 - 544 2019.3

EBV Viral Loads in Diagnosis, Monitoring, and Response Assessment Open Access

Kimura Hiroshi, Kwong Yok-Lam

FRONTIERS IN ONCOLOGY Vol. 9 ( FEB ) page： 62 2019.2

Overview of EBV-Associated T/NK-Cell Lymphoproliferative Diseases

Kimura Hiroshi, Fujiwara Shigeyoshi

FRONTIERS IN PEDIATRICS Vol. 6 2019.1

Clinical features of adult-onset chronic active Epstein-Barr virus infection

KAWAMOTO Keisuke, MIYOSHI Hiroaki, SETO Masao, KIMURA Hiroshi, OHSHIMA Koichi

Rinsho Ketsueki Vol. 60 ( 8 ) page： 944 - 952 2019

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Hematology

Chronic active Epstein-Barr virus infection (CAEBV) presents with mononucleosis-like symptoms such as chronic persistent or recurrent pyrexia, lymphadenopathy, and hepatosplenomegaly because of the reactivation of Epstein-Barr virus (EBV) as demonstrated by the recurrence of EBV-infected cells. The mechanism of CAEBV remains obscure, and CAEBV can lead to fatal conditions such as hemophagocytic syndrome and malignant lymphoma by clonal expansion of EBV-infected T- or NK-cells. Without hematopoietic stem cell transplantation, CAEBV has a poor prognosis. CAEBV is listed in the revised 2016 World Health Organization classification as a chronic active EBV infection of T- and NK-cell types, systemic form, among EBV-positive T- and NK-cell lymphoproliferative diseases of childhood. However, similar clinical conditions have been reported in adult patients. Therefore, we investigated the clinical features of adult patients with CAEBV-like features (adult-onset CAEBV) in a relatively small number of cases. Additionally, genetic alterations related to CAEBV development have also been reported. Along with these results, we reviewed the clinical characteristics of adult-onset CAEBV.

DOI： 10.11406/rinketsu.60.944

PubMed

CiNii Research

EBV and Lymphomagenesis

KIMURA Hiroshi, OKUNO Yusuke

Uirusu Vol. 69 ( 1 ) page： 13 - 22 2019

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Society for Virology

Epstein–Barr virus (EBV) is a double stranded DNA virus of the family Herpesviridae. EBV is associated with a variety of lymphomas, and the mechanisms by which it promotes lymphomagenesis have been elucidated; this includes, for example, by translocation/activation of Myc in Burkitt lymphoma. However, the mechanisms by which it induces lymphoid tumors other than Burkitt lymphoma are unclear. Recently, we reported that the genome of EBV present in EBV-associated lymphomas harbors frequent intragenic deletions and that the deletion of a gene essential for virus replication promotes lymphomagenesis in a mouse model. Although intragenic deletions have been detected in other tumor viruses, little is known about the effects and importance of those of EBV, a large DNA virus whose genome encodes more than 70 genes. In this review, we summarize the role of EBV in lymphomagenesis with a focus on the impact of intragenic deletions.

DOI： 10.2222/jsv.69.13

PubMed

CiNii Research

JAK inhibitors for refractory lymphoma. Open Access

Kimura H

Oncotarget Vol. 9 ( 68 ) page： 32883 - 32884 2018.8

Antitumor effects of duvelisib on Epstein-Barr virus-associated lymphoma cells Reviewed

Kawada Jun-ichi, Ando Shotaro, Torii Yuka, Watanabe Takahiro, Sato Yoshitaka, Ito Yoshinori, Kimura Hiroshi

CANCER MEDICINE Vol. 7 ( 4 ) page： 1275-1284 2018.4

Regulation of Epstein-Barr Virus Life Cycle and Cell Proliferation by Histone H3K27 Methyltransferase EZH2 in Akata Cells

Ichikawa Takaya, Okuno Yusuke, Sato Yoshitaka, Goshima Fumi, Yoshiyama Hironori, Kanda Teru, Kimura Hiroshi, Murata Takayuki

MSPHERE Vol. 3 ( 6 ) 2018

BGLF2 Increases Infectivity of Epstein-Barr Virus by Activating AP-1 upon De Novo Infection Reviewed

Konishi Natsuno, Narita Yohei, Hijioka Fumiya, Al Masud H. M. Abdullah, Sato Yoshitaka, Kimura Hiroshi, Murata Takayuki

MSPHERE Vol. 3 ( 2 ) 2018

EBV in T-/NK-Cell Tumorigenesis.

Kimura H

Advances in experimental medicine and biology Vol. 1045 page： 459-475 2018

Human Herpesviruses Preface

Kimura Hiroshi

HUMAN HERPESVIRUSES Vol. 1045 page： V - V 2018

Chronic Active Epstein-Barr Virus Disease

Kimura Hiroshi, Cohen Jeffrey I.

FRONTIERS IN IMMUNOLOGY Vol. 8 page： 1867 2017.12

A distinct subtype of Epstein Barr virus positive T/NK-cell lymphoproliferative disorder: Adult patients with chronic active Epstein Barr virus infection-like features. Reviewed

Kawamoto K, Miyoshi H, Suzuki T, Kozai Y, Kato K, Miyahara M, Yujiri T, Oishi N, Choi I, Fujimaki K, Muta T, Kume M, Moriguchi S, Tamura S, Kato T, Tagawa H, Makiyama J, Kanisawa Y, Sasaki Y, Kurita D, Yamada K, Shimono J, Sone H, Takizawa J, Seto M, Kimura H, Ohshima K

Haematologica 2017.12

Epstein-Barr Virus BKRF4 Gene Product Is Required for Efficient Progeny Production

Al Masud H. M. Abdullah, Watanabe Takahiro, Yoshida Masahiro, Sato Yoshitaka, Goshima Fumi, Kimura Hiroshi, Murata Takayuki

JOURNAL OF VIROLOGY Vol. 91 ( 23 ) 2017.12

Characterization of a Suppressive Cis-acting Element in the Epstein-Barr Virus LMP1 Promoter Reviewed

Yoshida Masahiro, Murata Takayuki, Ashio Keiji, Narita Yohei, Watanabe Takahiro, Al Masud H. M. Abdullah, Sato Yoshitaka, Goshima Fumi, Kimura Hiroshi

FRONTIERS IN MICROBIOLOGY Vol. 8 page： 2302 2017.11

Gene expression analysis of hypersensitivity to mosquito bite, chronic active EBV infection and NK/T-lymphoma/leukemia. Reviewed

Washio K, Oka T, Abdalkader L, Muraoka M, Shimada A, Oda M, Sato H, Takata K, Kagami Y, Shimizu N, Kato S, Kimura H, Nishizaki K, Yoshino T, Tsukahara H

Leukemia & lymphoma Vol. 58 ( 11 ) page： 2683-2694 2017.11

The Epstein-Barr Virus BRRF1 Gene is Dispensable for Viral Replication in HEK293 cells and Transformation. Reviewed

Yoshida M, Watanabe T, Narita Y, Sato Y, Goshima F, Kimura H, Murata T.

Sci Rep 7 Vol. 7 page： 6044 2017.7

Elimination of LMP1-expressing cells from a monolayer of gastric cancer AGS cells

Sato Yoshitaka, Ochiai Shingo, Murata Takayuki, Kanda Teru, Goshima Fumi, Kimura Hiroshi

ONCOTARGET Vol. 8 ( 24 ) page： 39345-39355 2017.6

The C-Terminus of Epstein-Barr Virus BRRF2 Is Required for its Proper Localization and Efficient Virus Production. Reviewed

Watanabe T, Sakaida K, Yoshida M, Masud HMAA, Sato Y, Goshima F, Kimura H, Murata T

Frontiers in microbiology Vol. 8 page： 125 2017

Epstein-Barr virus infection-induced inflammasome activation in human monocytes. Reviewed

Torii Y, Kawada JI, Murata T, Yoshiyama H, Kimura H, Ito Y.

PLoS One Vol. 12 ( 4 ) page： e0175053 2017

The efficacy of combination therapy with oncolytic herpes simplex virus HF10 and dacarbazine in a mouse melanoma model. Reviewed

Tanaka R, Goshima F, Esaki S, Sato Y, Murata T, Nishiyama Y, Watanabe D, Kimura H.

Am J Cancer Res Vol. 7 page： 1693-170 2017

The efficacy of combination therapy with oncolytic herpes simplex virus HF10 and dacarbazine in a mouse melanoma model.

Tanaka R, Goshima F, Esaki S, Sato Y, Murata T, Nishiyama Y, Watanabe D, Kimura H

American journal of cancer research Vol. 7 ( 8 ) page： 1693 - 1703 2017

Diagnostic values for the viral load in peripheral blood mononuclear cells of patients with chronic active Epstein-Barr virus disease. Reviewed

Ito Y, Suzuki M, Kawada J, Kimura H.

J Infect Chemother Vol. 22 page： 268-271 2016

Analysis of circulating human and viral microRNAs in patients with congenital cytomegalovirus infection. Reviewed

Kawano Y, Kawada JI, Kamiya Y, Suzuki M, Torii Y, Kimura H, Ito Y.

J Perinatol Vol. 36 page： 1101-1105 2016

A case of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis with severe cardiac complications. Reviewed

Kawamura Y, Miura H, Matsumoto Y, Uchida H, Kudo K, Hata T, Ito Y, Kimura H, Yoshikawa T.

BMC Pediatrics Vol. 16 page： 172 2016

Tofacitinib induces G1 cell-cycle arrest and inhibits tumor growth in Epstein-Barr virus-associated T and natural killer cell lymphoma cells. Reviewed

Ando S, Kawada JI, Watanabe T, Suzuki M, Sato Y, Torii Y, Asai M, Goshima F, Murata T, Shimizu N, Ito Y, Kimura H.

Oncotarget Vol. 7 page： 76793-76805 2016

HSV-2-related hemophagocytic lymphohistiocytosis in a fingolimod-treated MS patient. Reviewed

Ikumi K, Ando T, Katano H, Katsuno M, Sakai Y, Yoshida M, Saida T, Kimura H, Sobue G.

Neurol Neuroimmunol Neuroinflamm Vol. 3 ( 4 ) page： e247 2016

Induction of Epstein-Barr Virus Oncoprotein Latent Membrane Protein 1 (LMP1) by Transcription Factors Activating Protein 2 (AP-2) and Early B Cell Factor (EBF). Reviewed

Murata T, Noda C, Narita Y, Watanabe T, Yoshida M, Ashio K, Sato Y, Goshima F, Kanda T, Yoshiyama H, Tsurumi T, Kimura H.

J Virol Vol. 90 page： 3873-89 2016

A case of CAEBV showing features of granulomatosis with polyangiitis. Reviewed

Shimomura M, Morishita H, Meguro T, Seto S, Kimura M, Hamazaki M, Hashimoto A, Sugiyama Y, Kimura H.

Pediatr Int Vol. 58 page： 639-42 2016

Increased T-cell responses to EBV with high viral load in patients with EBV-positive diffuse large B-cell lymphoma. Reviewed

Morishima S, Nakamura S, Yamamoto K, Miyauchi H, Kagami Y, Kinoshita T, Onoda H, Yatabe Y, Ito M, Miyamura K, Nagai H, Moritani S, Sugiura I, Tsushita K, Mihara H, Ohbayashi K, Iba S, Emi N, Okamoto M, Iwata S, Kimura H, Kuzushima K, Morishima Y.

Leukemia & Lymphoma Vol. 56 page： 1072-8 2015

Epstein-Barr virus Type 2 latently infects T-cells inducing an atypical activation characterized by expression of lymphotactic cytokines. Reviewed

Coleman CB, Wohlford EM, Smith NA, King CA, Ritchie JA, Baresel PC, Kimura H, Rochford R

J Virol Vol. 89 page： 2301-12 2015

Viral load in children with congenital cytomegalovirus infection identified on newborn hearing screening. Reviewed

Kawada J, Torii Y, Kawano Y, Suzuki M, Kamiya Y, Kotani T, Kikkawa F, Kimura H, Ito Y.

J Clin Virol Vol. 65 page： 41-5 2015

Effectiveness and safety of immunization with live-attenuated and inactivated vaccines for pediatric liver transplantation recipients. Reviewed

Kawano Y, Suzuki M, Kawada JI, Kimura H, Kamei H, Ohnishi Y, Ono Y, Uchida H, Ogura Y, Ito Y.

Vaccine Vol. 33 page： 1440-5 2015

The heat shock protein 90 inhibitor BIIB021 suppresses the growth of T and natural killer cell lymphomas. Reviewed

Suzuki M, Takeda T, Nakagawa H, Iwata S, Watanabe T, Siddiquey MN, Goshima F, Murata T, Kawada JI, Ito Y, Kojima S, Kimura H.

Front Microbiol Vol. 6 page： 280 2015

Reactivation of persistent Epstein-Barr virus (EBV) causes secretion of thyrotropin receptor antibodies (TRAbs) in EBVinfected B lymphocytes with TRAbs on their surface. Reviewed

Nagata K, Nakayama Y, Higaki K, Ochi M, Kanai K, Matsushita M, Kuwamoto S, Kato M, Murakami I, Iwasaki T, Nanba E, Kimura H, Hayashi K.

Autoimmunity Vol. 11 page： 1-8 2015

Roles of Epstein-Barr virus BGLF3.5 Gene and Two Upstream Open Reading Frames in Lytic Viral Replication in HEK293 Cells. Reviewed

Watanabe T, Fuse K, Takano T, Narita Y, Goshima F, Kimura H, Murata T.

Virology Vol. 483 page： 44–53 2015

The Epstein-Barr virus BRRF2 gene product is involved in viral progeny production. Reviewed

Watanabe T, Tsuruoka M, Narita Y, Katsuya R, Goshima F, Kimura H, Murata T.

Virology Vol. 484 page： 33-40 2015

A herpesvirus specific motif of Epstein-Barr virus DNA polymerase is required for the efficient lytic genome synthesis. Reviewed

Narita Y, Sugimoto A, Kawashima D, Watanabe T, Kanda T, Kimura H, Tsurumi T, Murata T.

Sci Rep Vol. 5 page： 11767 2015

Epstein-Barr virus BDLF4 gene is required for efficient expression of viral late lytic genes. Reviewed

Watanabe T, Narita Y, Yoshida M, Sato Y, Goshima F, Kimura H, Murata T.

J Virol Vol. 89 ( 19 ) page： 10120-4 2015

Oncolytic viral therapy with a combination of HF10, a herpes simplex virus type 1 variant, and granulocyte-macrophage colony-stimulating factor for murine ovarian cancer. Reviewed

Goshima F, Esaki S, Luo C, Kamakura M, Kimura H, Nishiyama Y.

Int J Cancer Vol. 134 page： 2865-77 2014

Rare occurrence of JAK3 mutations in NK cell neoplasms in Japan. Reviewed

Kimura H, Karube K, Ito Y, Hirano K, Suzuki M, Iwata S, Seto M.

Leukemia & Lymphoma Vol. 55 page： 962-3 2014

Modes of infection and oncogenesis by the Epstein-Barr virus. Reviewed

Murata T, Sato Y, Kimura H.

Rev Med Virol Vol. 24 page： 242-253 2014

Current Studies on Chronic Active Epstein-Barr virus Infection in Japan. Invited

Fujiwara S, Kimura H, Imadome KI, Arai A, Kodama E, Morio T, Shimizu N, Wakiguchi H.

Pediatr Int Vol. 56 page： 159-166 2014

Presence of Epstein-Barr virus-infected B lymphocytes with thyrotropin receptor antibodies on their surface in Graves' disease patients and in healthy individuals. Reviewed

Nagata K, Higaki K, Nakayama Y, Miyauchi H, Kiritani Y, Kanai K, Matsushita M, Iwasaki T, Sugihara H, Kuwamoto S, Kato M, Murakami I, Nanba E, Kimura H, Hayashi K.

Autoimmunity Vol. 47 page： 193-200 2014

mTOR inhibitors induce cell cycle arrest and inhibit tumor growth in Epstein-Barr virus-associated T and natural killer cell lymphoma cells. Reviewed

Kawada JI, Ito Y, Iwata S, Suzuki M, Kawano Y, Kanazawa T, Siddiquey MN, Kimura H.

Clin Cancer Res Vol. 20 page： 5412-22 2014

Anti-CCR4 monoclonal antibody mogamulizumab for the treatment of EBV-associated T- and NK-cell lymphoproliferative diseases. Reviewed

Kanazawa T, Hiramatsu Y, Iwata S, Siddiquey MN, Sato Y, Suzuki M, Ito Y, Goshima F, Murata T, Kimura H.

Clin Cancer Res Vol. 20 page： 5075-84 2014

Role of latent membrane protein 1 (LMP1) in chronic active Epstein-Barr virus infection (CAEBV)-derived T/NK cell proliferation. Reviewed

Ito T, Kawazu H, Murata T, Iwata S, Arakawa S, Sato Y, Kuzushima K, Goshima F, Kimura H.

Cancer Med Vol. 3 page： 787-95 2014

Anti-tumor effects of suberoylanilide hydroxamic acid on Epstein-Barr virus-associated T- and natural killer- cell lymphoma. Reviewed

Siddiquey MN, Nakagawa H, Iwata S, Kanazawa T, Suzuki M, Imadome KI, Fujiwara S, Goshima F, Murata T, Kimura H.

Cancer Sci Vol. 105 page： 713-722 2014

Epstein-Barr virus-associated lymphoid malignancies: the expanding spectrum of hematopoietic neoplasms. Invited

Kimura H, Kawada J, Ito Y.

Nagoya J Med Sci Vol. 75 page： 169-79 2013

A pediatric case of hepatitis B virus subgenotype A2 in Japan. Reviewed

Hayashi K, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Itoh A, Hirooka Y, Ishikawa T, Nakano I, Ito Y, Kimura H, Katano Y, Goto H.

Clin J Gastroenterol Vol. 6 page： 383-5 2013

A probable identical Epstein-Barr virus clone-positive composite lymphoma with aggressive natural killer-cell leukemia and cytotoxic T-cell lymphoma. Reviewed

Sugimoto KJ, Shimada A, Wakabayashi M, Imai H, Sekiguchi Y, Nakamura N, Sawada T, Ota Y, Takeuchi K, Ito Y, Kimura H, Komatsu N, Noguchi M.

Int J Clin Exp Pathol Vol. 15 page： 411-7 2013

Epstein-Barr virus-positive cytotoxic T-cell lymphoma followed by chronic active Epstein-Barr virus infection-associated T/NK-cell lymphoproliferative disorder: a case report. Reviewed

Kato S, Miyata T, Takata K, Shimada S, Ito Y, Tomita A, Elsayed AA, Takahashi E, Asano N, Kinoshita T, Kimura H, Nakamura S.

Hum Pathol Vol. 44 page： 2849-52 2013

HLA-A*26 and HLA-B*52 are associated with a risk of developing EBV-associated T/NK lymphoproliferative disease. Reviewed

Ito Y, Suzuki R, Torii Y, Kawa K, Kikuta A, Kojima S, Kimura H.

Blood e-Letter page： 8085 2013

Immunogenicity of inactivated seasonal influenza vaccine in adult and pediatric liver transplant recipients over two seasons. Reviewed

Suzuki M, Torii Y, Kawada J, Kimura H, Kamei H, Onishi Y, Kaneko K, Ando H, Kiuchi T, Ito Y.

Microbiol Immunol Vol. 57 page： 715-22 2013

Risk factors for poor outcome in congenital cytomegalovirus infection and neonatal herpes on the basis of a nationwide survey in Japan. Reviewed

Ito Y, Kimura H, Torii Y, Hayakawa M, Tanaka T, Tajiri H, Yoto Y, Tanaka-Taya K, Kanegane H, Nariai A, Sakata H, Tsutsumi H, Oda M, Yokota S, Morishima T, Moriuchi H.

Pediatr Int Vol. 55 page： 566-571 2013

Heat shock protein 90 inhibitors repress latent membrane protein 1 (LMP1) expression and proliferation of Epstein-Barr virus-positive natural killer cell lymphoma. Reviewed

Murata T, Iwata S, Siddiquey NA, Kanazawa T, Goshima F, Kimura H, Tsurumi T.

PLoS One Vol. 8 page： e63566 2013

Different Distributions of Epstein-Barr virus early and late gene transcripts within viral replication compartments. Reviewed

Sugimoto A, Sato Y, Kanda T, Murata T, Narita Y, Kawashima D, Kimura H, Tsurumi T.

J Virol Vol. 87 page： 6693-9 2013

Plasma viral MicroRNA profiles reveal potential biomarkers for chronic active Epstein-Barr virus infection. Reviewed

Kawano Y, Iwata S, Kawada J, Gotoh K, Suzuki M, Torii Y, Kojima S, Kimura H, Ito Y.

J Infect Dis Vol. 208 page： 771-9 2013

Clinico-epidemiological states of mother-to-child infections: a nationwide survey in Japan. Reviewed

Torii Y, Kimura H, Ito Y, Hayakawa M, Tanaka T, Tajiri H, Yoto Y, Tanaka-Taya K, Kanegane H, Nariai A, Sakata H, Tsutsumi H, Oda M, Yokota S, Morishima T, Moriuchi H.

Pediatr Infect Dis J Vol. 32 page： 699-701 2013

Interleukin-17A-producing T lymphocytes in chronic active Epstein-Barr virus infection. Reviewed

Ohta R, Imai M, Kawada J, Kimura H, Ito Y.

Microbiol Immunol Vol. 57 page： 139-44 2013

A monoclonal expansion of Epstein-Barr virus-infected natural killer cells after allogeneic peripheral blood stem cell transplantation. Reviewed

Isobe Y, Hamano Y, Ito Y, Kimura H, Tsukada N, Sugimoto K, Komatsu N.

J Clin Virol Vol. 56 page： 150-2 2013

Pin1 interacts with the Epstein-Barr virus DNA polymerase catalytic subunit and regulates viral DNA replication. Reviewed

Narita Y, Murata T, Ryo A, Kawashima D, Sugimoto A, Kanda T, Kimura H, Tsurumi T.

J Virol Vol. 87 page： 2020-7 2013

Causes of vertical transmission of hepatitis B virus under the at-risk prevention strategy in Japan. Reviewed

Torii Y, Kimura H, Hayashi K, Suzuki M, Kawada J, Kojima S, Katano Y, Goto H, Ito Y.

Microbiol Immunol Vol. 57 page： 118-21 2013

Enhanced antitumoral activitiy of oncolytic herpes simplex virus with gemcitabine using colorectal tumor models. Reviewed

Esaki S, Goshima F, Kimura H, Murakami S, Nishiyama Y

Int J Cancer Vol. 132 page： 1592-601 2013

Demonstration of type II latency in T lymphocytes of Epstein-Barr Virus -associated hemophagocytic lymphohistiocytosis. Reviewed

Ito Y, Kawamura Y, Iwata S, Kawada J, Yoshikawa T, Kimura H.

Pediatr Blood Cancer Vol. 60 page： 326-328 2013

Human herpesvirus 6-associated encephalopathy in a child with Dravet syndrome. Reviewed

Hiraiwa-Sofue A, Ito Y, Ohta R, Kimura H, Okumura A.

Neuropediatrics Vol. 44 page： 155-8 2013

Remission of juvenile idiopathic arthritis with primary Epstein-Barr virus infection. Reviewed

Kawada J, Ito Y, Torii Y, Kimura H, Iwata N

Rheumatol Vol. 52 page： 956-8 2013

Prospective Monitoring of Epstein-Barr virus and other Herpesviruses in Patients with Juvenile Idiopathic Arthritis Treated with Methotrexate and Tocilizuma Reviewed

Kawada J, Iwata N, Kitagawa Y, Kimura H, Ito Y

Mod Rheumatol 2012

Hydroa vacciniforme is associated with increased numbers of Epstein-Barr virus-infected γδ T-cells. Reviewed

Hirai Y, Yamamoto T, Kimura H, Ito Y, Tsuji K, Miyake T, Morizane S, Suzuki D, Fujii K, Keiji Iwatsuki K.

J Invest Dermatol Vol. 132 page： 1401-8 2012

Herpes simplex virus requires PARP activity for efficient replication and induces ERK-dependent phosphorylation and ICP0-dependent nuclear localization of tankyrase 1 Reviewed

Li Z, Yamauchi Y, Kamakura M, Murayama T, Goshima F, Kimura H, Nishiyama Y.

Vol. 86 page： 492-503 2012

EBV-associated T/NK lymphoproliferative diseases in non-immunocompromised hosts:prospective analysis of 108 cases Reviewed

Kimura H, Ito Y, Kawabe S, Gotoh K, Takahashi Y, Kojima S, Naoe T, Esaki S, Kikura A, Sawada A, Kawa K, Ohshima K, Nakamura S.

Vol. 119 page： 673-86 2012

Antitumor activities of valproic acid on Epstein-Barr virus-associated T and natural killer lymphoma cells. Reviewed

Iwata S, Saito T, Ito Y, Kamakura M, Gotoh K, Kawada J, Nishiyama Y, Kimura H

Vol. 103 page： 375-8 2012

Pretreatment EBV-DNA copy number is predictive of response and toxicities to SMILE chemotherapy for extranodal NK/T-cell lymphoma, nasal type. Reviewed

Ito Y, Kimura H, Maeda Y, Hashimoto C, Ishida F, Izutsu K, Sueoka E, Isobe Y, Takizawa J, Hasegawa Y, Kobayashi H, Okamura S, Kobayashi H, Yamaguchi M, Suzumiya J, Hyo R, Nakamura S, Kawa K, Oshimi K, Suzuki R.

Clin Cancer Res Vol. 18 page： 4183-4190 2012

Application of flow cytometric in situ hybridization assay to Epstein-Barr virus-associated T-NK lymphoproliferative diseases. Reviewed

Kawabe S, Ito Y, Gotoh K, Kojima S, Matsumoto K, Kinoshita T, Iwata S, Nishiyama Y, Kimura H.

Cancer Sci Vol. 103 page： 1481-8 2012

Diabetic mice show an aggravated course of herpes-simplex-virus-induced facial nerve paralysis. Reviewed

Esaki S, Yamano K, Kiguchi J, Katsumi S, Keceli S, Okamoto H, Goshima F, Kimura H, Nishiyama Y, Murakami S.

Otol Neurotol Vol. 33 page： 1452-7 2012

Perinatal cytomegalovirus-associated bullae in an immunocompetent infant. Arch Dermatol Reviewed

Yasuda K, Sugiura K, Ishikawa R, Kihira M, Negishi Y, Iwayama H, Ito K, Kimura H, Kosugi I, Akiyama M.

Arch Dermatol Vol. 148 page： 770-2 2012

Immunization with a highly attenuated replication-competent herpes simplex virus type 1 mutant, HF10, protects mice from genital disease caused by herpes simplex virus type 2. Reviewed

Luo C, Goshima F, Kamakura M, Mutoh Y, Iwata S, Kimura H, Nishiyama Y.

Front Microbiol Vol. 3 page： 158 2012

T/NK-cell type chronic active Epstein-Barr virus (EBV) disease in adults: an underlying condition for EBV-associated T/NK-cell lymphoma. Reviewed

Isobe Y, Aritaka N, Setoguchi Y, Ito Y, Kimura H, Hamano Y, Sugimoto K, Komatsu N.

J Clin Pathol Vol. 65 page： 278-82 2012

Generation and characterization of UL21-null herpes simplex virus type 1 Reviewed

Muto Y, Goshima F, Ushijima Y, Kimura H, Nishiyama Y

Front Microbiol Vol. 3 page： 394 2012

EBV-associated T and NK cell lymphoproliferative disorders: Consensus report of the 4th Asian Hematopathology Workshop. Reviewed

Ko Y-H, Kim H-J, Oh Y-H, Park G, Lee S-S, Huh J, Kim C-W, Kim I, Ng S-B, Tan S-Y, Chuang S-S, Nakamura N, Yoshino T, Nakamura S, Kimura H, Ohshima K.

J Hematopathol Vol. 5 page： 319-324 2012

Chronological changes in Epstein-Barr virus genome and subsets of peripheral mononuclear cells in a case of HLH. Reviewed

Ukeba-Terashita Y, Saita Y, Ito Y, Kanegane H, Kimura H, Kobayashi I.

Open Journal of Pediatrics page： in press 2011

Phase II study of SMILE chemotherapy for newly-diagnosed stage IV, relapsed or refractory extranodal NK/T-cell lymphoma, nasal type: the NK-cell Tumor Study Group (NKTSG) study. Reviewed

Yamaguchi M, Kwong YL, Kim WS, Maeda Y, Hashimoto C, Suh C, Izutsu K, Ishida F, Isobe Y, Suzumiya J, Kodama T, Kimura H, Hyo R, Nakamura S, Oshimi K, Suzuki R.

J Clin Oncol Vol. 29 page： 4410-4416 2011

Increased levels of cytokines and high-mobility group box 1 are associated with the development of severe pneumonia, but not acute encephalopathy, in 2009 H1N1 influenza-infected children. Reviewed

Ito Y, Torii Y, Ohta R, Imai M, Hara S, Kawano Y, Matsubayashi T, Inui A, Yoshikawa T, Nishimura N, Ozaki T, Morishima T, Kimura H.

Cytokine page： in press 2011

Clinicopathological analysis of the age-related differences in patients with Epstein-Barr virus-associated extranasal NK/T-cell lymphoma with reference to the relationship with aggressive NK cell leukemia and chronic active Epstein-Barr virus infection-associated lymphoproliferative disorder. Reviewed

Takahashi E, Ohshima K, Kimura H, Hara K, Suzuki R, Kawa K, Eimoto T, Nakamura S.

Histopathology Vol. 59 page： 660-67 2011

Relationship between lower respiratory tract infections caused by respiratory syncytial virus and the subsequent development of asthma in Japanese children. Reviewed

Narita A, Nishimura N, Arakawa Y, Suzuki M, Sakamoto K, Sakamoto M, Hosono H, Yamamoto Y, Kimura H, Ozaki T.

Jap J Infect Dis page： in press 2011

Herpes simplex virus type 1 UL14 tegument protein regulates intracellular compartmentalization of major tegument protein VP16. Reviewed

Ohta A, Yamauchi Y, Muto Y, Kimura H, Nishiyama Y.

Virology J Vol. 26 page： 365 2011

Identification of Epstein-Barr virus-infected CD27+ memory B cells in patients after transplantation. Reviewed

Ito Y, Kawabe S, Kojima S, Nakamura F, Nishiyama Y, Kaneko K, Kiuchi K, Ando H, Kimura H.

J Gen Virol Vol. 192 page： 2590-5 2011

Elevated expression of activation-induced cytidine deaminase in T and NK cells from patients with chronic active Epstein-Barr virus infection. Reviewed

Nakamura M, Iwata S, Kimura H, TokuraY.

Eur J Dermatol Vol. 21 page： 780-2 2011

Replication of Epstein-Barr virus primary infection in human tonsil tissue explants Reviewed

Gotoh K, Ito Y, Maruo S, Takada K, Mizuno T, Teranishi M, Nakata S, Nakashima T, Iwata S, Goshima F, Nakamura S, Kimura H

PLoS One Vol. 6 page： e25490 2011

Kinetics of Epstein-Barr Virus Load and Virus-Specific CD8+ T Cells in Acute Infectious Mononucleosis. Reviewed

Hoshino Y, Nishikawa K, Ito Y, Kuzushima K, Kimura H.

J Clin Virol Vol. 50 page： 244-246 2011

Immunogenicity of inactivated 2009 H1N1 influenza vaccine in pediatric liver transplant recipients. Reviewed

Torii Y, Kimura H, Gotoh K, Ochi N, Kaneko K, Ando H, Kiuchi T, Ito Y.

Vaccine Vol. 29 page： 4187-4189 2011

Serum concentrations of complement anaphylatoxins and proinflammatory mediators in patients with 2009 H1N1 influenza. Reviewed

Ohta R, Torii Y, Imai M, Kimura H, Okada N, Ito Y.

Microbiol Immunol Vol. 55 page： 191-198 2011

Unrelated bone marrow transplantation induced long-term remission in a patient with life-threatening epstein-barr virus-associated hemophagocytic lymphohistiocytosis. Reviewed

Kunitomi A, Kimura H, Ito Y, Naitoh K, Noda N, Iida H, Sao H.

J Clin Exp Hematop Vol. 51 page： 57-61 2011

Herpes simplex virus induces the marked up-regulation of the zinc finger transcriptional factor INSM1, which modulates the expression and localization of the immediate early protein ICP0. Reviewed

Kamakura M, Goshima F, Luo C, Kimura H, Nishiyama Y.

Virology J Vol. 8 page： 257 2011

Auditory and Vestibular Defects Induced by Experimental Labyrinthitis Following Herpes Simplex Virus in Mice. Reviewed

Esaki S, Goshima F, Kimura H, Ikeda S, Katsumi S, Kabaya K, Watanabe M, Hashiba M, Nishiyama Y, Murakami S.

Acta Oto-Laryngologica Vol. 131 page： 684-691 2011

Bortezomib Induces Apoptosis in T Lymphoma Cells and Natural Killer Lymphoma Cells Independent of Epstein-Barr Virus Infection. Reviewed

Iwata S, Yano S, Ito Y, Ushijima Y, Gotoh K, Kawada J, Fujiwara S, Sugimoto K, Isobe Y, Nishiyama Y, Kimura H.

Int J Cancer Vol. 129 page： 2263-2273 2011

Hepatocyte growth factor incorporated into herpes simplex virus vector accelerates facial nerve regeneration after crush injury. Reviewed

Esaki S, Kitoh J, Katsumi S, Goshima F, Kimura H, Safwat M, Yamano K, Watanabe N, Nonoguchi N, Nakamura T, Coffin RS, Miyatake S, Nishiyama Y, Murakami S.

Gene Therapy page： in press 2011

Quantitative Analysis of Epstein-Barr Virus (EBV)-Related Gene Expression in Patients with Chronic Active EBV infection. Invited Reviewed

Iwata, S., Wada, K., Tobita, S., Gotoh, K., Ito, Y., Demachi-Okamura, A., Shimizu, N., Nishiyama, Y. and Kimura, H.

J Gen Virol Vol. 90 page： 42-50 2010

Transmission of cytomegalovirus via breast milk in extremely premature infants. Invited Reviewed

Hayashi S, Kimura H, Oshiro M, Kato Y, Yasuda A, Suzuki C, Watanabe Y, Morishima T, Hayakawa M.

J Perinatol page： in press 2010

Effectiveness and safety of inactivated influenza vaccination in pediatric liver transplant recipients over three influenza seasons. Invited Reviewed

Gotoh K, Ito Y, Suzuki E, Kaneko K, Kiuchi T, Ando H, Kimura H.

Pediatr Transplant page： in press 2010

Detection of EBV genomes in plasmablasts/plasma cells and non-B cells in the blood of most patients with EBV lymphoproliferative disorders using Immuno-FISH. Invited Reviewed

Calatini S, Sereti I, Scheinberg P, Kimura H, Childs R, Cohen JI.

Blood page： in press 2010

Multicenter evaluation of prototype real-time PCR assays for Epstein-Barr virus and cytomegalovirus DNA in whole blood samples from transplant recipients" in its current form for publication in Microbiology and Immunology. Invited Reviewed

Ito Y, Takakura S, Ichiyama S, Ueda M, Ando Y, Matsuda K, Hidaka E, Nakatani A, ishioka J, Nobori T, Sasaki M, Kimura H.

Microbiol Immunol Vol. 54 page： 516-522 2010

Herpes simplex virus UL56 interacts with and regulates the Nedd4-family ubiquitin ligase Itch. Invited Reviewed

Ushijima Y, Luo C, Kamakura M, Goshima F, Kimura H, Nishiyama Y.

Virology J Vol. 7 page： 179 2010

Comparison of the cerebrospinal fluid levels and serum concentrations of human herpesvirus 6 (HHV-6) DNA and cytokines in children with HHV-6 encephalopathy. Invited Reviewed

Kawabe S, Ito Y, Ohta R, Sofue A, Gotoh K, Morishima T, Kimura H.

J Med Virol Vol. 82 page： 1410-1415 2010

Immunologic and Virologic Analyses in Pediatric Liver Transplant Recipients with Chronic High Epstein-Barr Viral Loads Reviewed

Gotoh K, Ito Y, Ohta R, Iwata S, Nishiyama Y, Nakamura T, Kaneko K, Kiuchi T, Ando H, Kimura H.

J Infect Dis Vol. 202 page： 461-469 2010

Multiplex Real-time PCR Assay for Quantifying BK Polyomavirus, JC Polyomavirus, and Adenovirus DNA Simultaneously Reviewed

Funahashi Y, Iwata S, Ito Y, Kojima, Yoshikawa T, Hattor R, Gotoh M, Nishiyama Y, Kimura H.

J Clin Microbiol Vol. 48 page： 825-830 2010

Multiplex real-time PCR for the simultaneous detection of herpes simplex virus, human herpesvirus 6, and human herpesvirus 7. Invited Reviewed

Wada K, Mizoguchi S, Ito Y, Kawada J, Yamauchi Y, Morishima T, Nishiyama Y, Kimura H.

Microbiol Immunol Vol. 53 ( 1 ) page： 22-29 2009

Epstein-Barr virus Associated Lymphoproliferative Disease in Non-Immunocompromised Hosts. Reviewed

Cohen JI, Kimura H, Nakamura S, Ko Y-H, Jaffe ES.

Ann Oncol Vol. 20 page： 1472-82 2009

Hepatocellular apoptosis associated with cytotoxic T/naturalkiller-cell infiltration in chronic active EBV infection. Reviewed

Nomura Y, Kimura H, Karube K, Yoshida S, Sugita Y, Niino D, Shimizu K, Kimura Y, Aoki R, Kiyasu J, Takeuchi M, Hashikawa K, Hirose S, Ohshima K.

Pathol Int Vol. 59 page： 438–442 2009

Cytomegalovirus and Epstein–Barr virus coinfection in three toddlers with prolonged illness. Reviewed

Ito Y, Shibata-Watanabe Y, Kawada J, Maruyama K, Yagasaki H, Kojima S, Kimura H.

J Med Virol Vol. 81 page： 1399-1402 2009

Acute retinal necrosis caused by herpes simplex virus type 2 in a 3- year-old Japanese boy. Reviewed

Tanaka-Kitajima N, Iwata N, Ando Y, Sakurai H, Iwami M, Tsuzuki K, Kondo M, Ito Y, Kimura H.

Eur J Pediatr Vol. 168 page： 1125-28 2009

UL56 relocalizes ubiquitin ligase Nedd4 and has a role in transport and/or release of virions Reviewed

Ushijima Y, Goshima F, Kimura H, Nishiyama Y.

Virology J Vol. 6 page： 168 2009

*Identification of Epstein-Barr Virus (EBV)-Infected Lymphocyte Subtypes by Flow Cytometric In Situ Hybridization in EBV-Associated Lymphoproliferative Diseases. Reviewed

Kimura H, Miyake K, Yamauchi Y, Nishiyama K, Iwata S, Iwatsuki K, Gotoh K, Kojima S, Ito Y, Nishiyama Y.

J Infect Dis Vol. 200 ( 7 ) page： 1078-1087 2009

Detection of cytomegalovirus DNA in preserved umbilical cords from patients with sensorineural hearing loss. Invited Reviewed

Mizuno T, Sugiura S, Kimura H, Ando Y, Sone M, Nishiyama Y, Nakashima T.

Eur Arch Otorhinolaryngol. Vol. 266 ( 3 ) page： 351-355 2009

One-step multiplex real-time PCR assay to analyse the latency patterns of Epstein-Barr virus infection. Reviewed

Kubota, N., Wada, K., Ito, Y., Shimoyama, Y., Nakamura, S., Nishiyama, Y., and Kimura, H.

Journal of Virological Methods Vol. 147 page： 26-36 2008

The UL14 Tegument Protein of Herpes Simplex Virus Type 1 (HSV-1) is Required for Efficient Nuclear Transport of the Alpha Transinducing Factor VP16 and Viral Capsids. Reviewed

Yamauchi Y, Kiriyama K, Kubota N, Kimura H, Usukura J, Nishiyama Y.

Journal of Virology Vol. 82 page： 1094-1106 2008

Clinical and virologic characteristics of 15 patients with chronic active Epstein-Barr virus infection treated with hematopoietic stem cell transplantation Reviewed

Gotoh K, Ito Y, Shibata-Watanabe Y, Kawada J, Takahashi Y, Yagasaki H, Kojima S, Nishiyama Y, Kimura H.

Clinical Infectious Disease Vol. 46 page： 1525-1534 2008

Oligonucleotide Microarray Analysis of Gene Expression Profiles followed by a Real-time RT-PCR Assay in Chronic Active Epstein-Barr Virus Infection. Reviewed

Ito Y, Shibata-Watanabe Y, Ushijima Y, Kawada J, Nishiyama Y, Kojima S, Kimura H.

Journal of Infectious Disease Vol. 197 page： 663-666 2008

Measles Outbreak in Adolescent. Invited

Kimura, H. and Nishiyama, Y.

JMA Journal page： in press 2008

Herpes Simplex Virus Type 2 UL56 Interacts with the Ubiquitin Ligase Nedd4 and Increases its Ubiquitination. Reviewed

Ushijima Y, Koshizuka T, Goshima F, Kimura H, Nishiyama Y.

J Virol Vol. 82 page： 5220-5233 2008

Herpes Simplex Virus Induces Extensive Modification and Dynamic Relocalisation of the Nuclear Mitotic Apparatus Protein (NuMA) in Interphase Cells Reviewed

Yamauchi, Y., Kiriyama, K., Kimura, H. and Nishiyama, Y.

Journal of Cell Science Vol. 121 page： 2087-2096 2008

Detection of cytomegalovirus DNA in preserved umbilical cords from patients with sensorineural hearing loss. Reviewed

Mizuno T, Sugiura S, Kimura H, Ando Y, Sone M, Nishiyama Y, Nakashima T.

Eur Arch Otorhinolaryngol page： in press 2008

Measuring Epstein-Barr virus (EBV) load: the significance and application for each EBV-associated disease. Reviewed

Kimura H, Ito Y, Suzuki R, Nishiyama Y.

Rev Med Virol Vol. 18 page： 305-319 2008

Prognostic Factors in Influenza-Associated Encephalopathyモ Reviewed

Nagao T, Morishima T, Kimura H, Yokota S, Yamashita N, Ichiyama T, Kurihara M, Miyazaki C, Okabe N.

Pediat Infect Dis J Vol. 27 page： 384-389 2008

Conversion From Mycophenolate Mofetil to Mizoribine for Patients With Positive Polyomavirus Type BK in Urine. Reviewed

Funahashi Y, Hattori R, Kinukawa T, Kimura H, Nishiyama Y, Gotoh M.

Transplant Proc Vol. 40 page： 2268-2270 2008

Simultaneous monitoring by real-time PCR of Epstein-Barr virus, human cytomegalovirus, and human herpesvirus 6 in juvenile and adult liver transplant recipients. Reviewed

OnoY, Ito Y, Kaneko K, Shibata-Watanabe Y, Tainaka T, Sumida W, Nakamura T, Kamei H, Kiuchi T, Ando H, Kimura H.

Transplant Proc Vol. 40 page： 3578-82 2008

Replication-competent, oncolytic herpes simplex virus type 1 mutants induce a bystander effect following gancyclovir treatment. Reviewed

Luo C, Mori I, Ushijima Y, Nawa A, Kimura H, Nishiyama Y.

J Gene Med Vol. 9 page： 875-883 2007

Association of human herpesvirus 6 reactivation with the flaring and severity of drug-induced hypersensitivity syndrome. Reviewed

Tohyama M, Hashimoto K, Yasukawa M, Kimura H, Horikawa T, Nakajima K, Urano Y, Matsumoto K, Iijima M, Shear NH.

Br J Dermatol Vol. 157 page： 934-940 2007

Association of transforming growth factor-b1 gene polymorphism in the development of Epstein-Barr virus-related hematologic diseases. Reviewed

Hatta K, Morimoto A, Ishii E, Kimura H, Ueda I, Hibi S, Todo S, Sugimoto T, Imashuku S.

Haematologica Vol. 92 page： 1470-1474 2007

Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus. Reviewed

Ushijima Y, Luo C, Goshima F, Yamauchi Y, Kimura H, Nishiyama Y.

Microbes and Infection Vol. 9 page： 142-149 2007

Simultaneous quantification of Epstein-Barr virus, Cytomegalovirus, and human Herpesvirus 6 DNA in transplant recipients by multiplex real-time PCR assay. Reviewed

Wada, K., Kubota, N., Ito, Y., Yagasaki, H., Kato, K., Yoshikawa, T., Ono, Y., Ando, H., Fujimoto, Y., Kiuchi, T., Kojima, S., Nishiyama, Y. and Kimura H.

Journal of Clinical Microbiology Vol. 45 page： 1426-1432 2007

Fatal Varicella Infection in a Girl with Systemic Lupus Erythematosus after Oral Acyclovir Prophylaxis. Reviewed

Hirose I, Ymamaguchi H, Inagaguma D, Ono K, Shimada S, Kawada J, Shiraki K, Kimura H.

Eur J Pediatr Vol. 165 page： 280-1 2006

Analysis of Gene Expression Profiles byOligonucleotide Microarray in Children with Influenza. Reviewed

Kawada J,Kimura H , Kamachi Y, Nishikawa K, Taniguchi M, Nagaoka K, Kurahashi H, Kojima S, Morishima T.

J Gen Virol Vol. 87 page： 1677-1683 2006

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

インフルエンザに対する宿主反応のメカニズムを明らかにするために,マイクロアレイを用い,インフルエンザ罹患小児末梢血中の遺伝子発現を網羅的解析した.発現亢進していた遺伝子群は,免疫反応遺伝子群に属するものが多く,インターフェロン制御遺伝子が強く発現亢進していた.熱性痙攣群では,痙攣の無かった群に比べ,22遺伝子の発現が亢進し5つの遺伝子が発現減弱していた.

Association of virus infected-T cell in severe hepatitis caused by primary Epstein-Barr virus infection. Reviewed

Hara S, Hoshino Y, Naitou T, Nagano K, Iwai M, Suzuki K, Yamamoto K, Nagasaka T, Morishima T, Kimura H.

J Clinical Virol Vol. 35 page： 250-256 2006

Chronic Active Epstein-Barr Virus Infection Invited

Kimura H

New Development in Epstein-Barr Virus Research page： 55-70 2006

Chronic active Epstein-Barr virus infection with dilatation of the Valsalva sinus. Reviewed

Sato Y, Tsuboi T, Mikami T, Kurosawa H, Kanou K, Sugita K, Kimura H , Nagasaka T, Imashyuku S, Eguchi M.

Pediatr Int Vol. 48 page： 643-645 2006

Rapid detection of Epstein-Barr virus DNA by loop-mediated isothermal amplification method. Reviewed

Iwata S, Shibata Y , Kawada J, Hara S, Nishiyama Y, Morishima T, Ihira M, Yoshikawa T, Asano Y, Kimura H .

J Clin Virol Vol. 37 page： 128-133 2006

Pathogenesis of chronic active Epstein-Barr virus infection: Is this an infectious disease, lymphoproliferative disorder, or immunodeficiency? Reviewed

Kimura H.

Rev Med Virol Vol. 16 page： 251-261 2006

Quantitative analysis of herpesvirus load in the lymph nodes of patients with histiocytic necrotizing lymphadenitis using a real-time PCR assay. Reviewed

Maeda N et al,

Diagnostic Molecular Pathology Vol. 15 page： 49-55 2006

Clonality Analysis by Sequence Variation of the Latent Membrane Protein 1 Gene in Patients with Chronic Active Epstein ?Barr Virus Infection. Reviewed

Shibata Y,Hoshino Y, Hara S, Yagasaki H, Kojima S, Nishiyama Y, Morishima M, Kimura H .

J Med Virol Vol. 78 page： 770-779 2006

Evaluation of Apoptosis in Epstein-Barr Virus-Associated Haemophagocytic Lymphohistiocytosis. Reviewed

Kawada J, Kimura H , Shibata Y, Hara S, Hoshino Y, Kojima S, Nishikawa K, Morishima T.

J Mel Virol Vol. 17 ( 78 ) page： 400-407 2006

*Differences between T cell-type and natural killer cell-type chronic active Epstein-Barr virus infection. Reviewed

Kimura H, Hoshino Y, Hara S, Sugaya N, Kawada J, Shibata Y, Kojima S, Nagasaka T, Kuzushima K, Morishima T.

J Infect Dis Vol. 191 page： 531-539 2005

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

慢性活動性EBウイルス感染症はEBウイルスがT細胞もしくはNK細胞に感染することによって生じる難治性疾患である.本疾患の発症病理を解明するために,T細胞感染群,NK細胞感染群について,ウイルス学・免疫学的な解析を行った.

Virological aspects of Epstein-Barr virus infections. Reviewed

Yamashita N, Kimura H, Morishima T.

Acta Med Okayama. Vol. 59 page： 239-46 2005

Proposed guidelines for diagnosing chronic active epstein-barr virus infection Reviewed

Okano M, Kawa K, Kimura H, Yachie A, Wakiguchi H, Ohga S, Maeda M, Kanegane H, Imai S, Tsuchiya S, Morio T, Mori M, Yokota S, Imashuku S.

Am J Hematol Vol. 80 page： 64-9 2005

Drug-Induced Hypersensitivity Syndrome due to Mexiletine Associated with Human Herpes Virus 6 and Cytomegalovirus Reactivation. Reviewed

Sekiguchi A, Kashiwagi T, Ishida-Yamamoto A, Takahahi H, Hashimoto Y, Kimura H, Tohyama M, Hashimoto K, Iizuka H.

J Dermatol Vol. 32 page： 278-281 2005

Fatal natural killer cell lymphoma arising in a patient with a crop of Epstein-Barr virus-associated disorders. Reviewed

Nitta Y, Iwatsuki K, Kimura H, Kojima S, Morishima T, Tsuji K, Oono T.

Eur J Dermatol Vol. 15 page： 503-506 2005

Ganciclovir therapy in congenital cytomegalovirus infection in six infants. Reviewed

Tanaka-Kitajima N, Sugaya N, Futatani T, Kanegane H, Suzuki C, Oshiro M, Hayakawa M, Futamura M, Morishima T, Kimura H.

Pediatr Infect Dis J Vol. 24 page： 782-785 2005

Rapid detection of herpes simplex virus DNA in cerebrospinal fluid: comparison between loop-mediated isothermal amplification and real-time PCR. Reviewed

Kimura H, Ihira M, Enomoto Y, Kawada J, Ito Y, Morishima T, Yoshikawa T, Asano Y.

Med Microbiol Immunol Vol. 194 page： 181-185 2005

Association of cytomegalovirus with infantile hepatitis. Reviewed

Shibata Y, Kitajima N, Kawada J, Sugaya N, Nishikawa K, T Morishima T, Kimura H.

Microbiol Immunol Vol. 49 page： 771-777 2005

Congenital Cytomegalovirus Infection Diagnosed by Polymerase Chain Reaction With the Use of Preserved Umbilical Cord. Reviewed

Kakizawa H, Okumura A, Suzuki Y, Natsume J, Kimura H, Negoro T, Watanabe K.

Pediatr Infect Dis J Vol. 24 page： 653-654 2005

Herpes simplex virus type 1 UL51 protein is involved in maturation and egress of virus particles. Reviewed

Nozawa N, Kawaguchi Y, Tanaka M, Kato A, Kimura H, Nishiyama Y.

J Virol Vol. 79 page： 6947-6956 2005

Chronic active Epstein-Barr virus infection associated with mutations in Perforin that impair its maturation. Reviewed

Katano H, Ali MA, Patera AC, Catalfamo M, Henkart PA, Jaffe ES, Kimura H, Dale JK, Straus SE, Cohen JI.

Blood Vol. 103 page： 1244-1252 2004

Language：English Publishing type：Research paper (scientific journal)

近年,Perforin遺伝子は家族性血球貪食性リンパ増殖症の責任遺伝子として同定されている.本研究は,EBウイルス感染により重症・慢性化した児にPerforin遺伝子欠損を見出し,Fasが関与しないPerforinによる細胞障害能の低下により慢性のEBウイルス感染が生じている可能性を示した.

Pharmacokinetics and Effects of Ribavirin following Intraventricular Administration for Treatment of Subacute Sclerosing Panencephalitis. Reviewed

Hosoya M. Mori S. Tomoda A. Mori K. Sawaishi Y. Kimura H. Shigeta S. Suzuki H.

Antimicrob Agents Ch Vol. 48 page： 4631-4635 2004

Quantitative analysis of Epstein-Barr virus (EBV)-specific CD8+ T cells in chronic active EBV infection. Reviewed

Sugaya N, Kimura H, Hara S, Hoshino Y, Kojima S, Morishima T, Tsurumi T, Kuzushima K.

J Infect Dis Vol. 190 page： 985-988 2004

Evaluation of systemic inflammatory responses in neonates with herpes simplex virus infection. Reviewed

Kawada J, Kimura H, Ito Y, Ando Y, Tanaka-Kitajima N, Hayakawa M, Nunoi H, Endo F, MD, Morishima T.

J Infect Dis Vol. 190 page： 494-498 2004

Himiconvulsion-hemiplegia syndrome and primary human herpesvirus 7 infection. Reviewed

Kawada J, Kimura H, Yoshikawa T, Ihira M, Okumura A, Morishima T, Hayakawa F.

Brain Dev Vol. 6 page： 412-414 2004

Comparison of real-time and nested PCR assays for detection of herpes simplex virus DNA. Reviewed

Kawada J, Kimura H, Ito Y, Hoshino Y, Tanaka-Kitajima N, Ando Y, Futamura M, Morishima T.

Microbiol Immunol Vol. 48 page： 411-415 2004

Monitoring herpesvirus DNA in three cases of acute retinal necrosis by real-time PCR. Reviewed

Asano S, Yoshikawa T, Kimura H, Enomoto Y, Ohashi M, Terasaki H, Nishiyama Y.

J Clin Virol Vol. 29 page： 206-209 2004

A case of a long-time survivor with chronic active Epstein-Barr virus infection. Reviewed

3) Takeoka Y, Nakao Y, Ueda M, Koh KR, Aoyama Y, Nakamae H, Yamamura R, Ohta K, Takubo T, Yamane T, Hino M, Tokura Y, Ishihara S, Oshima K, Kimura H, Imashuku S.

Eur J Haematol Vol. 72 page： 73-76 2004

Influenza Virus and Febrile Convulsions. Reviewed

Kawada J, Kimura H, Morishima T.

J Infect Dis Vol. 189 page： 564-565 2004

Prognostic factors for chronic active Epstein-Barr virus infection. Reviewed

Kimura H, Morishima T, Kanegane H, Ohga S, Hoshino Y, Maeda A, Imai S, Okano M, Morio T, Yokota S, Tsuchiya S, Yachie A, Imashuku S, Kawa K, Wakiguchi H.

J Infect Dis Vol. 187 page： 527-533 2003

Absence of Associations between Influenza-Associated Encephalopathy and Human Herpesvirus 6 or Human Herpesvirus 7. Reviewed

Kawada J, Kimura H, Ito Y, Hara S, Kawashima H, Okuno T, Morishima T.

Pediatr Infect Dis J Vol. 22 page： 115-119 2003

Possibility of preventive treatment for EBV-associated NK cell-lineage proliferative disorders. Reviewed

Ishii M, Yamaguchi N, Oshima S, Ishii T, Mori KL, Kimura H, Morishima T, Kawase I, Saeki Y.

Intern Med Vol. 3 page： 250-254 2003

Evaluation of cytomegalovirus infections transmitted via breast milk in preterm infants with a real-time polymerase chain reaction assay. Reviewed

Yasuda A, Kimura H, Hayakawa M, Oshiro M, Kato Y, Matsuura O, Suzuki C, Morishima T.

Pediatr Vol. 111 page： 1333-1336 2003

Epstein-Barr virus (EBV)-associated post-transplantation lymphoproliferative disorder simultaneously affecting both B and T cells after allogeneic bone marrow transplantation. Reviewed

Chuhjo T, Yachie A, Kanegane H, Kimura H, Siobara S, Nakao S.

Am J Hematol Vol. 72 page： 255-258 2003

Varicella Exposure in the neonatal medicine: control measurements by prophylactic acyclovir administration. Reviewed

Hayakawa M, Ohshiro M, Kato Y, Fukami E, yasuda A, Okumura A, Kimura H, Morishima T.

J Hospital Infect Vol. 54 page： 212-215 2003

Combination therapy with intraventricular interferon-a and ribavirin for subacute sclerosing panencephalitis and monitoring measles virus RNA by quantitative PCR assay. Reviewed

Hara S, Kimura H, Hoshino Y, Hayashi N, Negoro T, Okumura A, Kajita Y, Sakuma T, Nakayama T, Hosoya M, Tomoda A, Morishima T.

Brain Dev Vol. 25 page： 367-369 2003

Trial of Intraventricular Ribavirin Therapy for Subacute Sclerosing Panencephalitis in Japan. Reviewed

Tomoda A, Nomura K, Shiraishi S, Hamada A, Ohmura T, Hosoya M, Miike T, Sawaishi Y, Kimura H, Takashima H, Tohda Y, Mori K, Kato Z, Fukushima A, Nishio H, Nezu A, Nihei K.

Brain Dev Vol. 25 page： 514-517 2003

Relapse of Neonatal Herpes Simplex Virus Infection. Reviewed

Kimura H, Futamura M, Ito Y, Ando Y, Hara S, Sobajima H, Nishiyama Y, Morishima T.

Arch Dis Child Fetal Neonatal Ed Vol. 88 page： 483-486 2003

Flow cytometoric analysis of cytomegalovirus-specific cell-mediated immunity in the congenital infection. Reviewed

Hayashi N, Kimura H, Morishima T, Tanaka N, Tsurumi T, Kuzushima K.

J Med Virol Vol. 71 page： 251-258 2003

Systemic Cytokine Responses in Patients with Influenza-Associated Encephalopathy.

Kawada J, Kimura H, Ito Y, Hara S, Iriyama I, Yoshikawa T, Morishima T.

J Infect Dis Vol. 188 page： 690-698 2003

Quantitation of viral load in neonatal herpes simplex virus infection and comparison between type 1 and type 2. Reviewed

Kimura H, Ito Y, Futamura M, Ando Y, Yabuta Y, Hoshino Y, Nishiyama Y, Morishima T.

J Med Virol Vol. 67 page： 349-353 2002

Fatal adult case with severe lymphocytopenia associated with reactivation of human herpesvirus 6. Reviewed

Yoshikawa T, Ihira M, Asano Y, Tomitaka A, Suzuki K, Matsunaga K, Kato Y, Hiramitsu S, Nagai T, Tanaka N, Kimura H, Nishiyama Y.

J Med Virol Vol. 66 page： 82-85 2002

Detection of herpesvirus DNA in the serum of immunocompetent children. Reviewed

Hara S, Kimura H, Hoshino Y, Tanaka N, Nishikawa K, Ihira M, Yoshikawa T, Morishima T.

Microbiol Immunol Vol. 46 page： 177-180 2002

Helicobacter pylori infection in patients with idiopathic short stature. Reviewed

Takahashi M, Kimura H, Watanabe K.

Pediatrics International Vol. 44 page： 277-280 2002

Epstein-Barr virus specific T cell cytotoxicity is mediated through the perforin pathway in patients with lymphoproliferative disorders after allogeneic bone marrow transplantation. Reviewed

Yoshimi A, Tsuge I, Namizaki H, Hoshino Y, Kimura H, Takahashi Y, Watanabe N, Kuzushima K, Kojima S.

Br J Heamatol Vol. 116 page： 710-715 2002

Natural Killer Cell Proliferation and Circulating Cytokines in Patients with Bilateral Basal Ganglia Calcification, Reviewed

Morishima T, Morita M, Kato T, Hoshino Y, Kimura H.

Eur J Neurol Vol. 9 page： 521-525 2002

Viral Load in Epsten-Barr Virus-Associated Hemophagocytic syndrome, Reviewed

Kimura H, Hoshino Y, Hara S, Nishikawa K, Sako M, Hirayama M, Komada Y, Morishima T.

Microbiol Immunol Vol. 46 page： 579-582 2002

Expression of tegment protein pp65 of Human cytomegalovirus (CMV) and its application for the analysis of viral-specific cellular immunity in CMV-infected individuals, Reviewed

Tanaka N, Kimura H, Hoshino Y, Nishikawa K, Kojima S, Morishima T.

Arch Virol Vol. 147 ( 12 ) page： 2405-2417 2002

Monitoring of active HHV-6 infection in bone marrow transplant recipients by real time PCR; comparison to detection of viral DNA in plasma by qualitative PCR. Reviewed

Ihira M, Yoshikawa T, Suzuki K, Ohashi M, Suga S, Horibe K, Tanaka N, Kimura H, Kojima S, Kato K, Matsuyama T, Nishiyama Y, Asano Y.

Microbiol Immunol Vol. 46 page： 701-705 2002

Decreasing the Epstein-Barr virus load by adjusting the FK506 blood level. Reviewed

Orii T, Ohkohchi N, Satomi S, Hoshino Y, Kimura H.

Transpl Int Vol. 15 page： 529-534 2002

Diagnostic testing in Epstein-Barr virus infection. Reviewed

Kudo T, Egawa H, Kuzushima K, Kimura H, Morishima T, Ichiyama S.

Clin Chem Lab Med Vol. 39 page： 789-94 2001

SH2D1A mutations in Japanese males with severe Epstein-barr virus associated illness. Reviewed

Sumazaki R, Kanegane H, Osaki M, Fukushima T, Tsutida M, Matsukura H, Shinozaki K, Kimura H, Matsui A, Miyamwaki T.

Blood. Vol. 98 page： 1268-1270 2001

Investigation of Varicella-Zoster Virus DNA in Lymphocyte Subpopulations by Quantitative PCR Assay. Reviewed

Ito Y, Kimura H, Hara S, Kido S, Ozaki T, Nishiyama Y, Morishima T.

Microbiol Immunol Vol. 45 page： 267-269 2001

Impaired Cytotoxic T Lymphocyte Response to Epstein-Barr Virus-infected NK Cells in Patients with Severe Chronic Active EBV Infection. Reviewed

Tsuge I, Morishima T, Morita M, Kimura H, Kuzushima K, Matsuoka H

J Med Virol Vol. 64 page： 141-148 2001

Vidarabine Therapy for Severe Chronic Active Epstein-Barr Virus Infection. Reviewed

Kimura H, Morita M, Tsuge I, Hoshino Y, Tanaka N, Ito Y, Morishima T.

Am J Pediatr Hematol Oncol Vol. 23 page： 294-299 2001

Severe Hepatitis caused by Epstein-Barr Virus without infection of hepatocytes Reviewed

Kimura H, Nagasaka T, Hoshino Y, Hayashi N, Tanaka N, Jing Lan Xu, Kuzushima K, Morishima T.

Human pathology Vol. 32 page： 757-762 2001

*Clinical and Virological Characteristics of Chronic Active Epstein-Barr Virus Infection. Reviewed

Kimura H, Hoshino Y, Kanegane H, Tsuge I, Okamura T, Kawa K, Morishim T.

Blood Vol. 98 page： 280-286 2001

Prospective Monitoring of the Epstein-Barr virus DNA by a real-time quantitative PCR after allogeneic stem cell transplantation. Reviewed

Hoshino Y, Kimura H, Tanaka N, Tsuge I, Kudo K, Horibe K, Kato K, Matsuyama T, Kikuta A, Kojima S, Morishima T.

Br J Heamatol Vol. 115 page： 105-111 2001

Efficient identification of HLA A*2402-restricted cytomegalovirus-specific CD8+ T cell epitopes by a computer algorithm and an enzyme-linked immunospot assay.

Kuzushima K, Hayashi H, Kimura H, Tsurumi T.

Blood Vol. 98 page： 1872-1881 2001

Monitoring of four herpesviruses in unrelated cord blood transplantation. Reviewed

Tanaka N, Kimura H, Hoshino Y, Yoshikawa T, Asano Y, Horibe K, Kojima S, Morishima T.

Bone Marrow Transplant Vol. 26 page： 1193-1197 2000

Exacerbation of herpes simplex encephalitis after successful treatment with acyclovir. Reviewed

Ito Y, Kimura H, Yabuta Y, Ando Y, Murakami T, Shiomi M, Morishima T.

Clin Infect Dis Vol. 30 page： 185-187 2000

Quantitative analysis of cytomegalovirus load using a real-time PCR assay. Reviewed

Tanaka N, Kimura H, Iida K, Saito Y, Tsuge I, Yoshimi A, Matsuyama T, Morishima T.

J Med Virol Vol. 60 page： 455-462 2000

Monitoring of Cell-Free Viral DNA in Primary Epstein-Barr virus infection. Reviewed

Kimura H, Nishikawa K, Hoshino Y, Sofue A, Nishiyama Y, and Morishima T.

Med Microbiol Immunol Vol. 188 page： 197-202 2000

Comparison of quantitations of viral load in varicella and zoster. Reviewed

Kimura H, Kido S, Ozaki T, Tanaka N, Ito Y, Williams RK, Morishima T.

J Clin Microbiol Vol. 38 page： 2447-2449 2000

Large deletion of the X-linked lymphoproliferative disease gene detected by fluorescence in situ hybridization. Reviewed

Honda K, Kanegane H, Eguchi M, Kimura H, Morishima T, Masaki K, Tosato G, Miyawaki T, Ishii E.

Am J Hematol Vol. 64 page： 128-132 2000

Early intervention in post-transplant lymphoproliferative disorders based on epstein-barr viral load. Reviewed

Hoshino Y, Kimura H, Kuzushima K, Tsurumi T, Nemoto K, Kikuta A, Nishiyama Y, Kojima S, Matsuyama T, Morishima T.

Bone Marrow Transplant Vol. 26 page： 199-201 2000

Usefulness of quantitative real-time polymerase chain reaction in following up patients with Epstein-Barr virus infection after liver transplantation. Reviewed

Orii T, Ohkohchi N, Kikuchi H, Koyamada N, Chubachi S, Satomi S, Kimura H, Hoshino Y, Morita M.

Clin Transplant Vol. 14 page： 308-317 2000

Longitudinal Dynamics of Epstein-Barr Virus-Specific Cytotoxic T Lymphocytes during Posttransplant Lymphoproliferative Disorder. Reviewed

Kuzushima K, Kimura H, Hoshino Y, Yoshimi A, Tsuge I, Horibe K, Morishima T, Tsurumi T, Kojima S.

J Infect Dis Vol. 182 page： 937-940 2000

Real-time quantitative reverse transcription-polymerase chain reaction for the detection of AML1-MTG8 fusion transcripts in t(8;21)-positive acute myelogenous leukemia. Reviewed

Kondo K, Kudo K, Kimura H, Inaba J, Kato K, Kojima S, Matsuyama T, Horibe K.

Leukemia Research Vol. 24 page： 951-956 2000

The prevalence of TT virus (TTV) infection and its relationship to hepatitis in children. Reviewed

Iriyama M, Kimura H, Nishikawa K, Yoshioka K, Wakita T,Nishimura N, Shibata M, Ozaki T, Morishima T

Med Microbiol Immunol Vol. 188 page： 83-89 1999

Characterization of Epstein-Bar virus (EBV)-infected natural killer (NK) cell proliferation in patients with severe mosquito allergy; establishment of an IL-2-dependent NK-like cell line. Reviewed

Tsuge I, Morishima T, Morita M, Kimura H, Kuzushima K, Matsuoka H.

Clin Exp Immunol. Vol. 115 page： 385-392 1999

CD4- and CD56-positive T-cell line, MTA, established from natural killer-like T-cell leukemia/lymphoma. Reviewed

Emi N, Abe A, Kasai M, Kohno A, Tanimoto M, Kimura H, Kawashima K, Ito M, Mori N, Saito H.

Int J Hematol Vol. 69 page： 180-185 1999

Detection of influenza virus RNA by reverse transcription-PCR and proinflammatorycytokines in influenza-virus-associated encephalopathy. Reviewed

Ito Y, Ichiyama T, Kimura H, Shibata M, Ishiwada N, Kuroki H, Furukawa S, Morishima T

J Med Virol Vol. 58 page： 420-425 1999

Prevalence of maternal cytomegalovirus (CMV) antibody and detection of CMV DNA in amniotic fluid. Reviewed

Nishimura N, Kimura H, Yabuta Y, Tanaka N, Ito Y, Ishikawa K, Suzuki C, Morishima T.

Microbiol Immunol Vol. 43 page： 781-784 1999

Rapid determination of Epstein-Barr virus specific CD8+T cell frequencies by flow cytometry. Reviewed

Kuzushima K, Hoshino Y, Fujii K, Yokoyama N, Fujita M, Kiyono T, Kimura H, Morishima T, Trurumi T.

Blood Vol. 94 page： 3094-3100 1999

*Quantitative analysis of the Epstein-Barr virus load using a real-time PCR assay. Reviewed

J. Clin. Microbiol. Vol. 37 page： 132-136 1999

Antigen-driven expansion and contraction of CD8+-activated T cells in primary EBV infection. Reviewed

Hoshino Y, Morishima T, Kimura H, Nishikawa K, Tsurumi T, Kuzushima K.

J Immunol Vol. 163 page： 5735-5740 1999

Baculovirus expression, purification, and properties of VZV gE, gI, and the complex they form. Reviewed

Kimura H, Straus SE, and Williams RK.

J Infect Dis Vol. 178 page： 513-515 1998

Polymerase chain reaction-proven herpes simplex encephalitis in children. Reviewed

Ito Y, Ando Y, Kimura H, Kuzushima K, Morishima T.

Pediatr Infect Dis J Vol. 17 page： 29-32 1998

Recombinant Varicella-Zoster virus glycoprotein E and I : immunologic response and clearance of virus in a guinea pig model of chronic uveitis(共著) Reviewed

Journal of Infectious Deseases Vol. 178 page： 310 1998

Varicella-zoster virus glycoproteins E and I expressed in insect cells form a heterodimer that requires the N-terminal domain of glycoprotein I. Reviewed

Kimura H, Straus SE, and Williams RK.

Virology. Vol. 233 page： 382-391 1997

Establishment of anti-Epstein-Barr virus (EBV) cellular immunity by adoptive transfer of virus-specific cytotoxic T lymphocytes from an HLA-matched sibling to a patient with severe chronic active EBV infection. Reviewed

Kuzushima K, Yamamoto M, Kimura H, Ando T, Kudo T, Tsuge I, Morishima T.

Clin Exp Immunol Vol. 103 page： 192-198 1996

Epstein-Barr virus (EBV)-carrying and -expressing T-cell lines established from severe chronic active EBV infection. Reviewed

Imai S, Sugiura M, Oikawa O, Koizumi S, Hirao M, Kimura H, Hayashibara H, Terai N, Tsutsumi H, Oda T, Chiba s, Osato T.

Blood Vol. 87 page： 1446-1457 1996

Detection and quantification of virus DNA in plasma of patients with Epstein-Barr virus-associated diseases. Reviewed

Yamamoto M. Kimura H. Hironaka T. Hirai K. Hasegawa S. Kuzushima K. Shibata M. Morishima T.

J Clin Microbiol Vol. 33 page： 1765-1768 1995

Intact antigen presentation for Epstein-Barr virus (EBV)-specific CTL by a lynphoblastoid cell line established from a patient with severe chronic active EBV intection

Medical Microbiology and Immunology Vol. 184 page： 63 1995

T-cell receptor V α region usage in the cerebrospinal fluid of patients with mumps meningitis. Reviewed

Kimura H, Ando Y, Shibata M, Abe T and Morishima T.

J Med Virol Vol. 41 page： 306-311 1993

Quantitative analysis of herpes simplex virus DNA in cerebrospinal fluid of children with herpes simplex encephalitis. Reviewed

Ando Y, Kimura H, Miwata H, Kudo T, Shibata M and Morishima T.

J Med Virol Vol. 41 page： 170-173 1993

Serum amyloid A protein in acute viral infections. Reviewed

Miwata H, Yamada T, Okada M, Kudo T, Kimura H and Morishima T.

Arch Dis Child Vol. 68 page： 210-214 1993

Relapse of Herpes simplex encephalitis in children. Reviewed

Kimura H, Aso K, Kuzushima K, Hanada N, Shibata M and Morishima T.

Pediatr Vol. 89 page： 891-894 1992

Human herpesvirus-6 DNA in cerebrospinal fluid of a child with exanthem subitum and meningoencephalitis. Reviewed

Yoshikawa T, Nakashima T, Suga S, Asano Y, Yazaki T, Kimura H, Morishima T, Kondo K and Yamanishi K.

Pediatr Vol. 89 page： 888-890 1992

Quantitation of cytomegalovirus DNA in lung tissue of bone marrow transplant recipients. Reviewed

Shibata M, Terashima M, Kimura H, Kuzushima K, Yoshida J, Horibe K, Morishima T.

Hum Pathol Vol. 23 page： 911-915 1992

Prophylactic oral acyclovir in outbreaks of primary herpes simplex virus type 1 Infection in a closed community. Reviewed

Kuzushima K, Kudo T, Kimura H, Kido S, Hanada N, Shibata M, Nishikawa K and Morishima T.

Pediatr Vol. 89 page： 379-383 1992

Detction of viral DNA in neonatal herpes simplex virus infuctions: Frequent and prolonged presence in serum and cerebrospinal fluid. Reviewed

Kimura H, Futamura M, Kito H, Ando T, Goto M, Kuzushima K, Shibata M, Morishima T.

J Infect Dis Vol. 164 page： 289-293 1991

Minus strand RNA of hepatitis C virus in liver tissues. Reviewed

Shibata M, Takeda S, Kudo T, Kimura H, Kuzushima K, Morishima T, Nagai Y.

J Hepatol Vol. 13 page： 379-380 1991

The pathogenecity of ribonucleotide reductase-null mutant of herpes simplex virus type 1 in mice. Reviewed

Yamada Y, Kimura H, Morishima T, Daikoku T, Maeno K, Nishiyama Y.

J Infect Dis Vol. 164 page： 1091-1097 1991

Complementary lethal invasion of the central nervous system by nonneuroinvasive herpes simplex virus type 1 and 2. Reviewed

Nishiyama Y, Kimura H, Daikoku T.

J Virol Vol. 65 page： 4520-4524 1991

Clinical manifestations of primary herpes simplex Virus type I infection in a closed community. Reviewed

Kuzushima K, Kimura H, Kino Y, Kido S, Hanada N, Shibata M, Morishima T.

Pediatr Vol. 87 page： 152-158 1991

Human cytomegalovirus infection during childhood: Detection of viral DNA in peripheral blood by means of polymerase chain reaction. Reviewed

Shibata M, Morishima T, Terashima T, Kimura H, Kuzushima K, Hanada N, Nishikawa K and Watanabe K.

Med Microbiol Immunol Vol. 179 page： 245-253 1990

Detection and direct typing of herpes simplex virus by polymerase chain raction. Reviewed

Kimura H, Shibata M, Kuzushima K, Nishiyama Y. Morishima T.

Med Microbiol Immunol Vol. 179 page： 177-184 1990

SHepatitis C viral sepuences in sera during the acute phase of infection. Reviewed

hibata M, Kudo T, Kajiyama M, Takahashi T, Matsushima S, Kimura H, Kuzushima K, and Morishima T.

Am J Med Vol. 89 page： 830-832 1990

Prophylactic oral acyclovir in outbreaks of primary herpes simplex virus 1 infection. Reviewed

Kuzushima K, Kimura H, Shibata M, Nishikawa K, Morishima T.

Lancet Vol. 335 page： 1043 1990

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