Faculty Profiles - ASANUMA, Hiroyuki

Papers - ASANUMA, Hiroyuki

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Signal Amplification Circuit Composed of Serinol Nucleic Acid for RNA Detection Reviewed

Chen, Y.; Murayama, K.; Asanuma, H.

Chem. Lett. Vol. 51 page： 330 - 333 2022.1

Renewable DNA proportional-integral controller with photoresponsive molecules Invited Reviewed

Tamba, M.; Murayama, K.; Asanuma, H.; Nakakuki, T.

Micromachines Vol. 13 page： 193 2022.1

Unexpected Dissociation of Photoresponsive UV-ON DNA Carrying p-tert-Butyl Azobenzene under UV Light Irradiation Reviewed

Ishii, S.; Murayama, K.; Sada, K.; Asanuma, H.; Kakugo, A.

Chemistry Letters Vol. 51 page： 292 - 295 2022.1

Pseudo Base Pairs that Exhibit High Duplex Stability and Orthogonality through Covalent and Non-covalent Interactions Invited

Kashida Hiromu, Asanuma Hiroyuki

Journal of Synthetic Organic Chemistry, Japan Vol. 79 ( 11 ) page： 1013 - 1019 2021.11

Language：English Publishing type：Research paper (scientific journal) Publisher：The Society of Synthetic Organic Chemistry, Japan

<p>Natural base pairs stabilize nucleic acid duplexes via hydrogen bonding and stacking interactions, and efforts have been made to identify artificial base pairs that stabilize duplexes through different interactions. Herein, we describe our attempts to prepare pseudo base pairs that exhibit high stability and orthogonality. Pairs of azobenzene derivatives showed unexpectedly high stability and orthogonality due to intermolecular stacking interactions. Pairs of cationic molecules showed even higher stability than natural G-C pairs through both electrostatic and stacking interactions. Duplexes can be crosslinked via [2+2] photocycloaddition between stilbene derivatives, and pairs of non-planar cyclohexane derivatives can stabilize duplexes by hydrophobic interactions rather than stacking interactions. Hetero-selective pairing can be achieved using electron donor-acceptor interactions. These pseudo base pairs would work well as building blocks in nanotechnology and biotechnology due to their unique functionalities.</p>

DOI： 10.5059/yukigoseikyokaishi.79.1013

Scopus

CiNii Research

光駆動型DNAナノマシン Invited Reviewed

浅沼浩之, 村山恵司, 神谷由紀子, 樫田　啓

高分子 Vol. 70 page： 550 - 552 2021.10

Preparation of artificial hexaplex composed of non-natural nucleic acid Invited Reviewed

Current Protocols Vol. 1 ( 4 ) page： e106 2021.4

Microheater-integrated zinc oxide nanowire microfluidic device for hybridization-based detection of target single-stranded DNA Reviewed

Nanotechnology 2021.3

Development of pre-miRNAs modification with FRET dye pair for intracellular visualization of processing intermediates generated in cells Reviewed

Kamiya, Y.; Kamimoto, H.; Zhu, H. ; Asanuma, H.

Sensors Vol. 21 page： 1785 2021.3

Development and modification of pre-mirnas with a fret dye pair for the intracellular visualization of processing intermediates that are generated in cells Invited Reviewed

Kamiya Y., Kamimoto H., Zhu H., Asanuma H.

Sensors Vol. 21 ( 5 ) page： 1 - 14 2021.3

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Sensors

microRNAs (miRNAs) are small non-coding ribonucleic acids (RNAs), which regulate gene expression via the RNA interference (RNAi) system. miRNAs have attracted enormous interest because of their biological significance and disease relationship. In cell systems, the generation of miRNA is regulated by multiple steps: the transfer of primary miRNA from the nucleus to the cy-tosol, the generation of the precursor-miRNA (pre-miRNA), the production of double-stranded RNA from pre-miRNA by the Dicer, the interaction with protein argonaute-2 (AGO2), and the sub-sequent release of one strand to form miRISC with AGO2. In this study, we attempt to visualize the intermediates that were generated in the miRNA-maturation step in the cells to acquire a detailed understanding of the maturation process of miRNA. To achieve this, we developed pre-miRNAs labeling with a Dicer-or AGO2-responsible fluorescence resonance energy transfer (FRET) dye pair. We observed that modifications with the dye at suitable positions did not interfere with the biological activities of pre-miRNAs. Further, imaging analyses employing these pre-miRNAs demon-strated that the processing of pre-miRNA promoted the accumulation of miRNA at the specific foci in the cytosol. The FRET-labeled pre-miRNA would further elucidate the mechanisms of the RNAi process and provide the basis for development of nucleic acid drugs working in the RNAi system.

DOI： 10.3390/s21051785

Scopus

PubMed

Pyrene modified serinol nucleic acid nanostructure converts chirality of threoninol nucleic acids into circularly polarized luminescence signals Invited Reviewed

Kashida, H.; Nishikawa, K.; Ito Y.; Murayama, K.; Hayashi, I.; Kakuta, T.; Ogoshi, T.; Asanuma, H.

2021.1

Microheater-integrated zinc oxide nanowire microfluidic device for hybridization-based detection of target single-stranded DNA Reviewed

Takahashi, H.; Yasui, T.; Kashida, H.; Makino, K.; Shinjo, K.; Liu, Q.; Shimada, T.; Rahong, S.; Kaji, N.; Asanuma, H.; Baba, Y.

Nanotechnology Vol. 32 page： 255301 2021

核酸医薬の創製に向けた人工核酸の開発 Invited Reviewed

樫田啓、村山恵司、浅沼浩之

バイオマテリアル Vol. 38 ( 2 ) page： 124 - 129 2020.4

The Use of Serinol Nucleic Acids as Ultrasensitive Molecular Beacons Invited Reviewed

Murayama Keiji, Kashida Hiromu, Asanuma Hiroyuki

NON-NATURAL NUCLEIC ACIDS: METHODS AND PROTOCOLS Vol. 1973 page： 261-279 2019

Development of Visible-Light-Responsive RNA Scissors Based on a 10-23 DNAzyme Reviewed

Kamiya Yukiko, Arimura Yu, Ooi Hideaki, Kato Kenjiro, Liang Xing-Guo, Asanuma Hiroyuki

CHEMBIOCHEM Vol. 19 ( 12 ) page： 1305 - 1311 2018.6

DNA Microcapsule for Photo-Triggered Drug Release Systems

Kamiya Yukiko, Yamada Yoshinobu, Muro Takahiro, Matsuura Kazunori, Asanuma Hiroyuki

CHEMMEDCHEM Vol. 12 ( 24 ) page： 2016-2021 2017.12

Introduction of 2,6-Diaminopurines into Serinol Nucleic Acid Improves Anti-miRNA Performance Reviewed

Kamiya Yukiko, Donoshita Yuka, Kamimoto Hiroshi, Murayama Keiji, Ariyoshi Jumpei, Asanuma Hiroyuki

CHEMBIOCHEM Vol. 18 ( 19 ) page： 1917-1922 2017.10

Chaperone-Polymer-Assisted, Photodriven DNA Strand Displacement

Cheng Bohao, Kashida Hiromu, Shimada Naohiko, Maruyama Atsushi, Asanuma Hiroyuki

CHEMBIOCHEM Vol. 18 ( 16 ) page： 1568-1572 2017.8

D-aTNA Circuit Orthogonal to DNA Can Be Operated by RNA Input via SNA

Murayama Keiji, Nagao Ryuya, Asanuma Hiroyuki

CHEMISTRYSELECT Vol. 2 ( 20 ) page： 5624-5627 2017.7

Antisense oligonucleotide modified with serinol nucleic acid (SNA) induces exon skipping in mdx myotubes Reviewed

Le, B. T.; Murayama, K.; Shabanpoor, F.; Asanuma, H.; Veedu, R. N.

RSC Advances Vol. 7 page： 34049-34052 2017.7

光応答性DNAの開発―ナノ環境を汚染しない分子マシンへの応用― Invited

浅沼浩之

現代化学 Vol. 556 ( 7 ) page： 50-55 2017.7

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Papers - ASANUMA, Hiroyuki