Faculty Profiles - ASANUMA, Hiroyuki

Papers - ASANUMA, Hiroyuki

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Acceleration of influenza virus clearance by Th1 cells in the nasal site of mice immunized intranasally with adjuvant-combined recombinant nucleoprotein

Tamura S.I., Miyata K., Matsuo K., Asanuma H., Takahashi H., Nakajima K., Suzuki Y., Aizawa C., Kurata T.

Journal of Immunology Vol. 156 ( 10 ) page： 3892 - 3900 1996.5

Language：Japanese Publisher：Journal of Immunology

The protective roles of influenza viral nucleoprotein (NP), together with the cellular mechanism of the protection in the nasal site, were examined in BALB/c mice immunized intranasally with an adjuvant (cholera toxin B subunit containing 0.2% of the whole toxin)-combined A or B virus recombinant NP. The NP-immune mice, when challenged intranasally with a sublethal dose of the virus 3 wk after immunization, had accelerated virus clearance from the nasal site in both an influenza type-specific and a nonspecific manner, as shown by the protection from high morbidity from the second day after challenge. Both type-specific and nonspecific acceleration of recovery was confirmed by the increased survival rate after challenge with a lethal dose of virus in mice immunized and boosted with adjuvant-combined NP. The acceleration of nasal virus clearance was accompanied with acceleration of type-specific systemic delayed-type hypersensitivity (DTH) and with IFN-γ production by nasal lymphocytes. The nasal lymphocytes from the immunized and challenged mice generated a significantly high level of DTH when transferred locally, but no class I MHC-restricted CTL response. Moreover, nasal CD4+ T cells, induced by NP immunization and increased in number by the subsequent challenge, were involved in the accelerated IFN-γ production. These results suggest that nasal Th1 cells, capable of producing IFN-γ and mediating DTH, are involved in the type-specific acceleration of recovery from influenza after challenge in mice immunized intranasally with adjuvant-combined NP, although the nonspecific mechanism of accelerated recovery remains to be solved.

Scopus

Reversible Optical Control of Receptor Tyrosine Kinase Activity and ERK Dynamics Using Azobenzene-Carrying DNA Aptamer Agonist Reviewed

Wakano, M.; Tsunoda, M.; Murayama, K.; Morimoto, J.; Ueki, R.; Aoyama-Ishiwatari, S.; Hirabayashi, Y.; Asanuma, H.; Sando, S.

J. Am. Chem. Soc. Vol. 147 2025.3

Protocol for controlling the strand selectivity of siRNA using acyclic artificial nucleic acids Invited Reviewed

Current protocols Vol. 5 page： e70103 2025.3

Reaction and interaction dynamics of azobenzene-tethered DNA with T7 RNA polymerase Reviewed

Takekawa, G.; Nakasone, Y.; Kamiya, Y.; Asanuma, H.; Terazima, M.

Phys. Chem. Chem. Phys. Vol. 27 page： 3302 - 3312 2025.1

Localized Control of the Swarming of Kinesin-Driven Microtubules Using Light Reviewed International coauthorship

Akter, M.; Kabir, A.M.R.; Keya, J.J.; Sada, K.; Asanuma, H.; Kakugo, A.

ACS Omega Vol. 9 page： 377348 - 37753 2024.8

Photosensitization of TiO2 Electrodes Immobilized with Chiral Plasmonic Au Nanocolloids by Circularly Polarized Light Irradiation Invited Reviewed

Kameyama, T.; Isogawa, S.; Akiyoshi, K.; Kashida, H.; Asanuma, H.; Torimoto, T.

The Journal of Chemical Physics Vol. 160 page： 094709 2024.3

DNA reaction system that acquires classical conditioning Invited Reviewed

ACS Synthetic Biology page： 521 - 529 2024.1

Highly Functional Acyclic Xeno Nucleic Acids Invited Reviewed

Murayama, K.; Okita, H.; Asanuma, H.

Bull. Chem. Soc. Jpn. Vol. 96 page： 1179 - 1187 2023.11

Illuminating miRNA inhibition: Visualizing the interaction between anti-miRNA oligonucleotide and target miRNA using FRET Reviewed

Zhu, H.; Kamiya, Y.; Asanuma, H.

ACS Chemical Biology Vol. 18 page： 2281 - 2289 2023.10

Functionalization of Acyclic Xenonucleic Acid with Modified Nucleobases Invited Reviewed

Murayama, K.; Yamano, Y.; Asanuma, H.

Polym. J. Vol. 55 page： 743 - 752 2023.4

Orientational control of circularly polarized luminescence from pyrene clusters using a DNA scaffold Reviewed

Chemistry - A European Journal 2023.2

Orientational control of circularly polarized luminescence from pyrene clusters using a DNA scaffold Reviewed

Kashida, H.; Ito, Y.; Kakuta, T.; Ogoshi, T.; Asanuma, H.

Chemistry - A European Journal 2023.2

DNA二重鎖を利用したFRET配向依存性の検討 Invited Reviewed

樫田　啓, 浅沼浩之

光化学 Vol. 53 ( 3 ) page： 148 - 153 2022.12

DNA Concentration Regulator That can be Driven for a Long Time Reviewed

Nakakuki, T.; Murayama, K.; Asanuma, H.

New Gener. Comput. Vol. 40 page： 681 - 702 2022.9

RNA以前の世界を妄想する Invited Reviewed

浅沼浩之, 村山恵司

化学と工業 Vol. 75 ( 8 ) page： 552 - 554 2022.8

Kinesin motors driven microtubule swarming triggered by UV light Reviewed

Ishii, S.; Akter, M.; Murayama, K.; Kabir, A. M. R.; Asanuma, H.; Sada, K.; Kakugo, A.

Polym. J. Vol. 54 page： 1501 - 1507 2022.7

Methyl group configuration on acyclic threoninol nucleic acids (aTNAs) impacts supramolecular properties Reviewed

Murayama, K.; Kashida, H.; Asanuma, H.

Org. Biomol. Chem. Vol. 20 page： 4115 - 4122 2022.3

Renewable DNA proportional-integral controller with photoresponsive molecules Invited Reviewed

Tamba, M.; Murayama, K.; Asanuma, H.; Nakakuki, T.

Micromachines Vol. 13 page： 193 2022.2

Signal Amplification Circuit Composed of Serinol Nucleic Acid for RNA Detection Reviewed

Chen, Y.; Murayama, K.; Asanuma, H.

Chemistry Letters Vol. 51 page： 330 - 333 2022.2

Unexpected Dissociation of Photoresponsive UV-ON DNA Carrying p-tert-Butyl Azobenzene under UV Light Irradiation Reviewed

Ishii, S.; Murayama, K.; Sada, K.; Asanuma, H.; Kakugo, A.

Chem. Lett. Vol. 51 page： 292 - 295 2022.1

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Papers - ASANUMA, Hiroyuki