Faculty Profiles - OHIRA, Hideki

Papers - OHIRA, Hideki

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Insular neural system controls decision-making in healthy and methamphetamine-treated rats Reviewed

Hiroyuki Mizoguchi, Kentaro Katahira, Ayumu Inutsuka, Kazuya Fukumoto, Akihiro Nakamura, Tian Wang, Taku Nagai, Jun Sato, Makoto Sawada, Hideki Ohira, Akihiro Yamanaka, Kiyofumi Yamada

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 112 ( 29 ) page： E3930 - E3939 2015.7

Language：English Publishing type：Research paper (scientific journal) Publisher：NATL ACAD SCIENCES

Patients suffering from neuropsychiatric disorders such as substance-related and addictive disorders exhibit altered decision-making patterns, which may be associated with their behavioral abnormalities. However, the neuronal mechanisms underlying such impairments are largely unknown. Using a gambling test, we demonstrated that methamphetamine (METH)-treated rats chose a high-risk/high-reward option more frequently and assigned higher value to high returns than control rats, suggestive of changes in decision-making choice strategy. Immunohistochemical analysis following the gambling test revealed aberrant activation of the insular cortex (INS) and nucleus accumbens in METH-treated animals. Pharmacological studies, together with in vivo microdialysis, showed that the insular neural system played a crucial role in decision-making. Moreover, manipulation of INS activation using designer receptor exclusively activated by designer drug technology resulted in alterations to decision-making. Our findings suggest that the INS is a critical region involved in decision-making and that insular neural dysfunction results in risk-taking behaviors associated with altered decision-making.

DOI： 10.1073/pnas.1418014112

Web of Science

Diabetes Mellitus is Associated With Low Secretion Rates of Immunoglobulin A in Saliva. Reviewed

Oikawa J, Ukawa S, Ohira H, Kawamura T, Wakai K, Ando M, Hata A, Tamakoshi A

Journal of epidemiology Vol. 25 ( 7 ) page： 470 - 474 2015.7

Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Epidemiological Association

Background: The association between diabetes mellitus (DM) and low secretory immunoglobulin A (s-IgA) secretion rates is one mechanism suspected of influencing susceptibility to infections among DM patients. However, several studies have shown contradictory results. We examined these two factors to seek evidence of an association among older people. Methods: We analyzed a prospective cohort of 2306 subjects (1209 men and 1097 women) around 64 years old from the New Integrated Suburban Seniority Investigation (NISSIN) Project in Nisshin, Japan. DM statuses were ascertained from levels of fasting plasma glucose and HbA1c, and s-IgA secretion rates were obtained from 5-min saliva samples. We used an analysis of covariance adjusted for possible confounders to compare s-IgA secretion rates according to DM status. Results: s-IgA secretion rates in DM participants were lower than in those classified as normal (18.6 µg/min vs 15.0 µg/min, P = 0.03), even after elimination of the effects of possible confounders. Conclusions: DM was associated with lower s-IgA secretion rates. This suggests that lower s-IgA levels may be a mechanism of susceptibility to infection in individuals with DM.

DOI： 10.2188/jea.JE20140088

社会経済地位とこころの健康の関連性ストレスマーカー炎症性サイトカインを用いて

山川香織, 松永昌宏, 大平英樹

東海学園大学研究紀要(人文科学研究編) ( 20 ) page： 85 - 91 2015.3

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：東海学園大学

近年、主観的に社会経済地位(subjective Social Economics Status:sSES)を低く評価している人は精神的健康のトラブルを引き起こしやすいということが報告されている。その背景には社会心理的ストレスが関係しているとし、ストレスマーカーによる知見が蓄積されているが、未だ不明な点が多い。本研究ではストレスマーカーとして炎症性サイトカインを用い、主観的社会経済地位と精神的健康の関連性について検討を行った。この結果、低い社会経済的地位の評価が高い炎症性サイトカイン値を示すことが明らかとなった。さらに、男性においてのみ社会経済地位と炎症性サイトカインとの間に負の相関が認められた。本研究によって、男性における社会経済地位の健康問題に炎症性サイトカインが寄与する可能性が示唆された。(著者抄録)

Do the letters F, A and S represent Indonesian letter fluency stimuli?

Hendrawan, D; Hatta, T; Ohira, H

ASIA-PACIFIC PSYCHIATRY Vol. 7 ( 1 ) page： 64 - 71 2015.3

Language：English Publishing type：Research paper (scientific journal) Publisher：Asia-Pacific Psychiatry

Introduction: The letters F, A and S, originally used in the English letter fluency stimuli test, have been frequently adopted to assess executive function in many languages. However, few studies reported the significance of FAS testing employed in different languages. The current study explored whether FAS could be widely applied to the Indonesian language. Methods: A total of 211 undergraduate students from state and private universities who participated in this study were randomly assigned into four groups. Each group was exposed to six different letter fluency stimuli. The total number of words the participants produced for each letter stimulus were averaged and ranked to determine the degree of difficulty in generating words. Furthermore, the normal distribution and equal ratio comparison were examined to verify the representative letter fluency stimuli. In addition, the effect of sex and university affiliation on letter fluency performance was also analyzed. Results: The letters A and S were among the easiest letters used to generate words; however, the letter F was regarded as a difficult stimulus. Furthermore, only the number of words beginning the letter S was distributed according to a normal curve. The number of words starting with the letters F and A were not normally distributed. Although sex difference was not associated with letter fluency performance, difference in university affiliation showed a significant effect on performance. Discussion: Our findings suggest that consideration of several stimuli factors is required to accurately measure performance in the letter fluency task in a specific language.

DOI： 10.1111/appy.12082

Web of Science

Scopus

PubMed

Valence-separated representation of reward prediction error in feedback-related negativity and positivity. Reviewed

Bai, Y., Katahira, K., & Ohira, H.

Neuroreport Vol. 26 ( 3 ) page： 157-162 2015.2

Valence-separated representation of reward prediction error in feedback-related negativity and positivity.

Bai Y, Katahira K, Ohira H

Neuroreport Vol. 26 ( 3 ) page： 157 - 62 2015.2

Valence-separated representation of reward prediction error in feedback-related negativity and positivity

Bai Yu, Katahira Kentaro, Ohira Hideki

NEUROREPORT Vol. 26 ( 3 ) page： 157 - 162 2015.2

Analysis of skin conductance response during evaluation of preferences for cosmetic products

Ohira Hideki, Hirao Naoyasu

FRONTIERS IN PSYCHOLOGY Vol. 6 2015.2

Interoception and decision-making

Ohira H.

Japanese Journal of Neuropsychopharmacology Vol. 35 ( 1 ) page： 11 - 18 2015.2

Language：English Publishing type：Research paper (scientific journal) Publisher：Japanese Journal of Neuropsychopharmacology

We sometimes make decisions relying not necessarily on deliberative thoughts but on intuitive and emotional processes in uncertain situations. The somatic marker hypothesis proposed by Damasio argued that interoception, which means bodily responses such as sympathetic activity, can be represented in the insula and anterior cingulate cortex and can play critical roles in decision-making. Though this hypothesis has been criticized in its theoretical and empirical aspects, recent studies are expanding the hypothesis to elucidate multiple bodily responses including autonomic, endocrine, and immune activities that affect decision-making. In addition, cumulative findings suggest that the anterior insula where the inner model of interoception is represented can act as an interface between the brain and body in decision-making. This article aims to survey recent findings on the brain-body interplays underlying decision-making, and to propose hypotheses on the significance of the body in decision-making.

Scopus

Valence-separated representation of reward prediction error in feedback-related negativity and positivity Reviewed

Yu Bai, Kentaro Katahira, Hideki Ohira

NEUROREPORT Vol. 26 ( 3 ) page： 157 - 162 2015.2

Language：English Publishing type：Research paper (scientific journal) Publisher：LIPPINCOTT WILLIAMS & WILKINS

Feedback-related negativity (FRN) is an event-related brain potential (ERP) component elicited by errors and negative outcomes. Previous studies proposed that FRN reflects the activity of a general error-processing system that incorporates reward prediction error (RPE). However, other studies reported inconsistent results on this issue - namely, that FRN only reflects the valence of feedback and that the magnitude of RPE is reflected by the other ERP component called P300. The present study focused on the relationship between the FRN amplitude and RPE. ERPs were recorded during a reversal learning task performed by the participants, and a computational model was used to estimate trial-by-trial RPEs, which we correlated with the ERPs. The results indicated that FRN and P300 reflected the magnitude of RPE in negative outcomes and positive outcomes, respectively. In addition, the correlation between RPE and the P300 amplitude was stronger than the correlation between RPE and the FRN amplitude. These differences in the correlation between ERP and RPE components may explain the inconsistent results reported by previous studies; the asymmetry in the correlations might make it difficult to detect the effect of the RPE magnitude on the FRN and makes it appear that the FRN only reflects the valence of feedback. Copyright (c) 2015 Wolters Kluwer Health, Inc. All rights reserved.

DOI： 10.1097/WNR.0000000000000318

Web of Science

Interoception and decision-making

Ohira Hideki

JAPANESE JOURNAL OF NEUROPSYCHOPHARMACOLOGY Vol. 35 ( 1 ) page： 11 - 18 2015.2

Analysis of skin conductance response during evaluation of preferences for cosmetic products Reviewed

Hideki Ohira, Naoyasu Hirao

FRONTIERS IN PSYCHOLOGY Vol. 6 2015.2

Language：English Publishing type：Research paper (scientific journal) Publisher：FRONTIERS RESEARCH FOUNDATION

We analyzed skin conductance response (SCR) as a psychophysiological index to evaluate affective aspects of consumer preferences for cosmetic products. To examine the test-retest reliability of association between preferences and SCR, we asked 33 female volunteers to complete two experimental sessions approximately 1 year apart. The participants indicated their preferences in a typical paired comparison task by choosing the better option from a combination of two products among four products. We measured anticipatory SCR prior to expressions of the preferences. We found that the mean amplitude of the SCR elicited by the preferred products was significantly larger than that elicited by the non-preferred products. The participants' preferences and corresponding SCR patterns were well preserved at the second session 1 year later. Our results supported cumulating findings that SCR is a useful index of consumer preferences that has future potential, both in laboratory and marketing settings.

DOI： 10.3389/fpsyg.2015.00103

Web of Science

DNA Barcoding of Japanese Click Beetles (Coleoptera, Elateridae)

Oba, Y; Ohira, H; Murase, Y; Moriyama, A; Kumazawa, Y

PLOS ONE Vol. 10 ( 1 ) page： e0116612 2015.1

Language：English Publishing type：Research paper (scientific journal) Publisher：PLoS ONE

Click beetles (Coleoptera: Elateridae) represent one of the largest groups of beetle insects. Some click beetles in larval form, known as wireworms, are destructive agricultural pests. Morphological identification of click beetles is generally difficult and requires taxonomic expertise. This study reports on the DNA barcoding of Japanese click beetles to enable their rapid and accurate identification. We collected and assembled 762 cytochrome oxidase subunit I barcode sequences from 275 species, which cover approximately 75% of the common species found on the Japanese main island, Honshu. This barcode library also contains 20 out of the 21 potential pest species recorded in Japan. Our analysis shows that most morphologically identified species form distinct phylogenetic clusters separated from each other by large molecular distances. This supports the general usefulness of the DNA barcoding approach for quick and reliable identification of Japanese elaterid species for environmental impact assessment, agricultural pest control, and biodiversity analysis. On the other hand, the taxonomic boundary in dozens of species did not agree with the boundary of barcode index numbers (a criterion for sequence-based species delimitation). These findings urge taxonomic reinvestigation of these mismatched taxa.

DOI： 10.1371/journal.pone.0116612

Web of Science

Scopus

PubMed

内受容感覚と意思決定 Reviewed

大平英樹

日本神経精神薬理学雑誌 Vol. 35 page： 11-18 2015

ストレスと認知機能：脳と身体の機能的相関 Reviewed

大平英樹

ストレス科学 Vol. 29 page： 13-23 2015