Faculty Profiles - OHIRA, Hideki

Papers - OHIRA, Hideki

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*Polymorphism of the serotonin transporter gene modulates brain and physiological responses to acute stress in Japanese men Reviewed

Ohira H, Matsunaga M, Isowa T, Nomura M, Ichikawa N, Kimura K, Kanayama N, Murakami H, Osumi T, Konagaya T, Nogimori T, Fukuyama S, Shinoda J, Yamada J.

Stress Vol. in press. 2009.8

Inhibitory effect of oxytocin on accelerated colonic motility induced by water-avoidance stress in rats

Matsunaga M., Konagaya T., Nogimori T., Yoneda M., Kasugai K., Ohira H., Kaneko H.

NEUROGASTROENTEROLOGY AND MOTILITY Vol. 21 ( 8 ) page： 856 - + 2009.8

Language：English Publishing type：Research paper (scientific journal) Publisher：Neurogastroenterology and Motility

Recent studies have indicated that brain and gut activities are interrelated and exposure to several stressors, such as water-avoidance stress, stimulates the motor function of the gut through corticotropin-releasing factor (CRF)-signalling pathways in the brain. Central oxytocin is known to attenuate stress responses, including CRF expression in the brain. Here, we examined whether central oxytocin attenuated the acceleration of colonic motility induced by water-avoidance stress. A force transducer was attached to the distal colon of male rat, and the colonic motility and faecal pellet output were recorded while the rats were exposed to water-avoidance stress. Intracerebroventricular (i.c.v.) injections of oxytocin (5, 50 and 500 pmol) and the oxytocin receptor antagonist tocinoic acid (25 μg) were administered before exposure to water-avoidance stress, and the effect of oxytocin on colonic motor function was determined. Centrally administered oxytocin inhibited the accelerated colonic motility induced by water-avoidance stress. The effective dose ranged between 5 and 50 pmol on i.c.v. injection. Oxytocin also decreased the number of CRF-positive cells in the paraventricular nucleus and corticosterone release. The inhibitory effect of oxytocin on accelerated colonic motility was blocked by pretreatment with oxytocin receptor antagonist. Furthermore, centrally administered tocinoic acid enhanced the acceleration of colonic motility. These results suggested that endogenous central oxytocin may contribute to the regulation of colonic function and inhibit the brain CRF-signalling pathways targeting the gut, resulting in the inhibition of stress-induced colonic contractions. © 2009 Blackwell Publishing Ltd.

DOI： 10.1111/j.1365-2982.2009.01286.x

Web of Science

Scopus

Neural bases of behavior selection without an objective correct answer

Nakao Takashi, Osumi Takahiro, Ohira Hideki, Kasuya Yukinori, Shinoda Jun, Yamada Jitsuhiro

NEUROSCIENCE LETTERS Vol. 459 ( 1 ) page： 30 - 34 2009.7

Neural bases of behavior selection without an objective correct answer

Nakao T., Osumi T., Ohira H., Kasuya Y., Shinoda J., Yamada J.

Neuroscience Letters Vol. 459 ( 1 ) page： 30 - 34 2009.7

Language：English Publishing type：Research paper (scientific journal) Publisher：Neuroscience Letters

Life choice (e.g. occupation choice) often includes situations with two or more possible answers. How does the brain respond to such conflict-ridden situations? We investigated whether the dorsal anterior cingulate cortex (dACC) evaluates the degree of conflict between possible answers. Additionally, we investigated whether the medial prefrontal cortex (MPFC) or the medial temporal lobe (MTL) has a function in behavior selection with plural possible answers. We used an occupational choice task (e.g. which occupation do you think you could do better?-dancer or chemist) with two possible answers and a word-length task (e.g. which word is longer?-dentist or comedian) that has a correct answer. The conflicts in each task were manipulated. Results showed that the dACC and the MTL were activated when the conflict during occupational choice was large, and that the MPFC and posterior cingulate cortex were activated more in the occupational choice task than in the word-length task. Our results show that the dACC evaluates the degree of conflict between possible answers, and that the MTL, MPFC, and posterior cingulate cortex have a function in behavior selection without an objective correct answer. It is thought that the MTL functions to reduce conflict when a large-conflict is detected in the dACC. Furthermore, the MPFC and posterior cingulate are thought to have a function of biasing any of the plural answers in behavior selection without an objective answer. © 2009 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.neulet.2009.04.056

Scopus

Neural bases of behavior selection without an objective correct answer. Reviewed

Nakao T, Osumi T, Ohira H, Kasuya Y, Shinoda J, Yamada J.

Neuroscience Letters Vol. 459 ( 1 ) page： 30-34 2009.7

*Brain and autonomic association accompanying stochastic decision-making Reviewed

Ohira H, Ichikawa N, Nomura M, Isowa T, Kimura K, Kanayama N, Fukuyama S, Shinoda J, Yamada J.

Neuroimage Vol. 49 ( 1 ) page： 1024-1037 2009.7

Human Visual System Automatically Encodes Sequential Regularities of Discrete Events Reviewed

Kimura M, Schröger E, Czigler I, Ohira H.

Journal of Cognitive Neuroscience Vol. in press. 2009.7

Neural bases of behavior selection without an objective correct answer Reviewed

Takashi Nakao, Takahiro Osumi, Hideki Ohira, Yukinori Kasuya, Jun Shinoda, Jitsuhiro Yamada

NEUROSCIENCE LETTERS Vol. 459 ( 1 ) page： 30 - 34 2009.7

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER IRELAND LTD

DOI： 10.1016/j.neulet.2009.04.056

Web of Science

Human Visual System Automatically Encodes Sequential Regularities of Discrete Events Reviewed

Kimura M, Schr&ouml, ger E, Czigler I, Ohira H

Journal of Cognitive Neuroscience Vol. in press. 2009.7

*Brain and autonomic association accompanying stochastic decision-making Reviewed

Ohira H, Ichikawa N, Nomura M, Isowa T, Kimura K, Kanayama N, Fukuyama S, Shinoda J, Yamada J

Neuroimage Vol. 49 ( 1 ) page： 1024-1037 2009.7

主観的幸福感と急性ストレス負荷時の免疫系の活性化との関連

松永昌宏, 金子宏, 坪井宏仁, 山本紘子, 大平英樹, 山川香織, 磯和勅子

心身医学 Vol. 49 ( 6 ) page： 534 - 534 2009.6

MEDIAL PREFRONTAL CORTEX AND COGNITIVE REGULATION

NAKAO Takashi, TAKEZAWA Tomohiro, MIYATANI Makoto, OHIRA Hideki

PSYCHOLOGIA Vol. 52 ( 2 ) page： 93 - 109 2009.6

Language：English Publishing type：Research paper (scientific journal) Publisher：Psychologia Society

Medial prefrontal cortex (MPFC) activation has been observed in studies of many types related to emotion regulation, self and familiar other-knowledge, mentalizing, morality, reward, and uncertainty. Furthermore, the anterior cingulate cortex (ACC) and the lateral prefrontal cortex (LPFC), which have reciprocal connections with MPFC, are considered necessary for cognitive regulation. Based on these findings, Nakao, Takezawa, and Miyatani (2006) proposed an integrative explanation for MPFC function: MPFC has a function of representing a benchmark that reduces conflict among many possible answers by biasing either choice of behavior. In this article, we review studies related to MPFC function and the benchmark hypothesis with recent new findings. Additionally, we discuss emotion regulation, which was not described in Nakao et al. (2006), in relation to the benchmark hypothesis.<br>

DOI： 10.2117/psysoc.2009.93

Web of Science

Scopus

CiNii Research

MEDIAL PREFRONTAL CORTEX AND COGNITIVE REGULATION Reviewed

Takashi Nakao, Tomohiro Takezawa, Makoto Miyatani, Hideki Ohira

PSYCHOLOGIA Vol. 52 ( 2 ) page： 93 - 109 2009.6

Language：English Publishing type：Research paper (scientific journal) Publisher：PSYCHOLOGIA SOC

Web of Science

*Regulation of natural killer cell redistribution by prefrontal cortex during stochastic learning. Reviewed

Ohira H, Fukuyama S, Kimura K, Nomura M, Isowa T, Ichikawa N, Matsunaga M, Shinoda J, Yamada J.

Neuroimage Vol. 47 ( 3 ) page： 897-907 2009.5

Transient responses of inflammatory cytokines in acute stress. Reviewed

Yamakawa K, Matsunaga M, Isowa T, Kimura K, Kasugai K, Yoneda M, Kaneko H, Ohira H.

Biological Psychology Vol. 82 page： 25-32 2009.5

Transient responses of inflammatory cytokines in acute stress. Reviewed

Yamakawa K, Matsunaga M, Isowa T, Kimura K, Kasugai K, Yoneda M, Kaneko H, Ohira H

Biological Psychology Vol. 82 page： 25-32 2009.5

*Regulation of natural killer cell redistribution by prefrontal cortex during stochastic learning. Reviewed

Ohira H, Fukuyama S, Kimura K, Nomura M, Isowa T, Ichikawa N, Matsunaga M, Shinoda J, Yamada J

Neuroimage Vol. 47 ( 3 ) page： 897-907 2009.5

Influence of attention to somatic information on emotional and autonomic responses Reviewed

Murakami H, Ohira H, Matsunaga M, Kimura K.

Percepteptual and Motor Skills Vol. 108 ( 2 ) page： 531-539 2009.4

Molecular analysis of mitochondrial hypervariable region 1 in 394 Japanese individuals

Kato H., Maeno Y., Ohira H., Yamada Y., Nagao M.

Legal Medicine Vol. 11 ( SUPPL. 1 ) 2009.4

Language：English Publishing type：Research paper (scientific journal) Publisher：Legal Medicine

Mitochondrial DNA (mtDNA) is a powerful tool for forensic casework when the resource is highly putrefied or very limited. It is important that mtDNA sequence databases continue to be generated and published, to extend mtDNA typing capability to additional populations and to increase the size of existing databases. The aim of this study was to analyze hypervariable region 1 (HV1) of mtDNA and establish a new database of mtDNA in Japanese population. Three hundred and ninety-four unrelated Japanese individuals were investigated. They were classified into 193 haplotypes based on HV1 sequence. Nucleotide substitutions were clustered in several positions and were 79% at 16,223, 50% at 16,362, and 29% at 16,189. Transition accounts for 81% of all the mutations and especially transition from cytosine to thymine (33%) was the most frequent substitution. 16,223-16,362 was observed in 34 individuals, following 16,129-16,223-16,362 in 29 individuals, and haplotype 16,223-16,278-16,362 in 14 individuals. Genetic diversity and random match probability in this population were estimated to 0.987% and 1.95%, respectively. In conclusion, HV1 of mitochondria sequence has a high discrimination power, but in addition to HV1, analysis of other region such as HV2 and HV3 are required in certain cases. © 2009 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.legalmed.2009.01.069

Scopus

INFLUENCE OF ATTENTION TO SOMATIC INFORMATION ON EMOTIONAL AND AUTONOMIC RESPONSES

Murakami Hiroki, Ohira Hideki, Matsunaga Masahiro, Kimura Kenta

PERCEPTUAL AND MOTOR SKILLS Vol. 108 ( 2 ) page： 531 - 539 2009.4

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Papers - OHIRA, Hideki