Faculty Profiles - HASHIKAWA Kazunobu

Literature Review of Criteria for Defining Recipient-Site Infection after Oral Oncologic Surgery with Simultaneous Reconstruction

Masaya Akashi, Junya Kusumoto, Akiko Sakakibara, Kazunobu Hashikawa, Shungo Furudoi, Takahide Komori

SURGICAL INFECTIONS Vol. 18 ( 7 ) page： 755 - 764 2017.10

Language：English Publisher：MARY ANN LIEBERT, INC

Background: The lack of uniformity of criteria for defining recipient-site infection after oral oncologic surgery with simultaneous reconstruction is problematic despite numerous studies on this issue. This study aimed to investigate the difference in the criteria for defining recipient-site infection after oral oncologic surgery with reconstruction.
Methods: A Medline search was performed via PUBMED using the following combinations of key terms that were tagged in the title, abstract, or both: "surgical site infectionhead neck," "surgical site infectionoral cancer," "antibiotic prophylaxishead neck," and "surgical site infectionoral carcinoma." Search results were filtered between 2005 and 2017. Articles in which there was no mention of the criteria for definition of surgical-site infection were excluded.
Results: The number of articles that met the inclusion criteria was 24. The lack of uniformity in the criteria for defining recipient-site infection in each article appeared to be attributable mainly to differences in whether an orocutaneous fistula and superficial incisional infection were regarded as recipient-site infection.
Conclusion: Reconsideration of the categorization of orocutaneous fistula as infection, regardless of the etiology, and differentiation of superficial and deep incisional infections are necessary for correct assessment of recipient-site infection in oral oncologic surgery.

DOI： 10.1089/sur.2017.101

Rhinoplasty via the midface degloving approach for nasal deformity due to nasal polyps: A case report of Woakes’ syndrome Reviewed

色素レーザー照射後に潰瘍を生じた乳児血管腫症例の検討 Reviewed

Nomura Tadashi, 江尻浩隆, 森脇綾, 岩山隆憲, 榊原俊介, 高須啓之, 石椛寛芳, 長谷川泰子, 橋川和信, 寺師浩人

日本レーザー医学会誌 Vol. 38 ( 3号 ) page： 315 2017.10

Misato Ueda, Kazunobu Hashikawa, Takanori Iwayama, Hiroto Terashi

Oral and Maxillofacial Surgery Cases Vol. 3 ( 3 ) page： 64 - 69 2017.9

Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier Inc

Nasal polyps are inflammatory proliferative tumors arising from the mucosa of the nasal cavity and paranasal sinuses. Although many cases concerning nasal polyps have been reported, those involving external nasal deformities are rare. We report a case of nasal polyposis filling the nasal cavity and paranasal sinuses, leading to external nasal and facial deformities. The condition above is known as Woakes’ syndrome, which is characterized by severe recurrent nasal polyps with deformity of the nasal pyramid, leading to broadening of the nose. We performed nasal osteotomy and facial bone-shaving via the midface degloving approach, which improved the patient's facial appearance.

DOI： 10.1016/j.omsc.2017.05.001

Upregulated Expression of Transient Receptor Potential Cation Channel Subfamily V Receptors in Mucosae of Patients with Oral Squamous Cell Carcinoma and Patients with a History of Alcohol Consumption or Smoking Reviewed

Computed Tomographic Evaluation of Posttreatment Soft-Tissue Changes by Using a Lymphedema Scoring System in Patients with Oral Cancer Reviewed

Akashi Masaya, TeraokaS, KakeiY, KusumotoJ, Hasegawa Takumi, MinamikawaT, Hashikawa Kazunobu, Komori Takahide

Lymphat Res Biol 2017.7

【頭頸部動静脈奇形の最新治療】動静脈奇形に対する手術療法 nidusを見極めるわれわれの試み Reviewed

Nomura Tadashi, 江尻浩隆, 櫻井敦, 川北育子, Hashikawa Kazunobu, 寺師浩人

形成外科 Vol. 60 ( 6号 ) page： 649 - 660 2017.6

膝窩リンパ節転移を認めた母趾悪性黒色腫の1例 Reviewed

北川敬之, Nomura Tadashi, Hashikawa Kazunobu, Fujiwara Susumu, 田島翔子, Nishigori Chikako, Terashi Hiroto

Skin Cancer Vol. 31 ( 3号 ) page： 233 - 237 2017.3

Akiko Sakakibara, Shunsuke Sakakibara, Junya Kusumoto, Daisuke Takeda, Takumi Hasegawa, Masaya Akashi, Tsutomu Minamikawa, Kazunobu Hashikawa, Hiroto Terashi, Takahide Komori

PLOS ONE Vol. 12 ( 1 ) page： e0169723 2017.1

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：PUBLIC LIBRARY SCIENCE

Objectives
Transient receptor potential cation channel (subfamily V, members 1-4) (TRPV1-4) are expressed in skin and neurons and activated by external stimuli in normal mucosae of all oral cavity sites. The oral cavity is exposed to various stimuli, including temperature, mechanical stimuli, chemical substances, and changes in pH, and, notably, the risk factors for oncogenic transformation in oral squamous epithelium are the same as the external stimuli received by TRPV1-4 receptors. Hence, we examined the relationship between oral squamous cell carcinoma (SCC) and TRPV1-4 expression.
Materials and Methods
Oral SCC patients (n = 37) who underwent surgical resection were included in this study. We investigated the expression of TRPV1-4 by immunohistochemical staining and quantification of TRPV1-4 mRNA in human oral mucosa. In addition, we compared the TRPV1-4 levels in mucosa from patients with SCC to those in normal oral mucosa.
Results
The receptors were expressed in oral mucosa at all sites (tongue, buccal mucosa, gingiva, and oral floor) and the expression was stronger in epithelia from patients with SCC than in normal epithelia. Furthermore, alcohol consumption and tobacco use were strongly associated with the occurrence of oral cancer and were found to have a remarkable influence on TRPV1-4 receptor expression in normal oral mucosa. In particular, patients with a history of alcohol consumption demonstrated significantly higher expression levels.
Conclusion
Various external stimuli may influence the behavior of cancer cells. Overexpression of TRPV1-4 is likely to be a factor in enhanced sensitivity to external stimuli. These findings could contribute to the establishment of novel strategies for cancer therapy or prevention.

DOI： 10.1371/journal.pone.0169723

A Novel Method of Noninvasive Monitoring of Free Flaps With Near-Infrared Spectroscopy.

Takasu H, Hashikawa K, Nomura T, Sakakibara S, Osaki T, Terashi H

Eplasty Vol. 17 page： e37 2017

Low-Grade Myxofibrosarcoma of the Rectus Abdominus Muscle Infiltrating into Abdominal Cavity: A Case Report. Reviewed International journal

Tadashi Nomura, Shunsuke Sakakibara, Aya Moriwaki, Teruya Kawamoto, Satoshi Suzuki, Takeshi Ishimura, Kazunobu Hashikawa, Hiroto Terashi

Eplasty Vol. 17 ( 2 ) page： e6 2017

Language：English Publishing type：Research paper (scientific journal)

Objective: Myxofibrosarcoma (MFS) is a relatively rare tumor that is histologically characterized by myxoid stroma and spindle cell proliferation. This tumor most commonly arises as a slow growing, enlarging painless mass in the extremities of elderly patients. Methods: We report a case of a primary, low-grade MFS in the rectus abdominis muscle infiltrating the abdominal cavity of a 75-year-old man. Results: The patient underwent a wide excision of the right abdominal wall mass with a 3-cm surgical margin from the scar due to a biopsy. The tumor infiltrated the urinary bladder, peritoneum, and external iliac vessels. Twenty-six months after the initial operation, he had recurrences in his abdominal wall, urinary bladder, and right iliac vessels. Conclusions: To our knowledge, primary MFS of the muscle in the abdomen has not been documented previously. Although this case was histopathologically classified as a low-grade tumor, it infiltrated the abdominal cavity. The tumor is suspected to have penetrated the abdominal cavity below the linea arcuata, which lacks the posterior sheath of the rectus abdominis muscle; from there, it could easily spread without being blocked by any biological barriers.

Heterogeneity of Necrotic Changes between Cortical and Cancellous Bone in Mandibular Osteoradionecrosis: A Histopathological Analysis of Resection Margin after Segmental Mandibulectomy Reviewed

Low-Grade Myxofibrosarcoma of the Rectus Abdominus Muscle Infiltrating into Abdominal Cavity: A Case Report.

Nomura T, Sakakibara S, Moriwaki A, Kawamoto T, Suzuki S, Ishimura T, Hashikawa K, Terashi H

Eplasty Vol. 17 page： e6 2017

Masaya Akashi, Kazunobu Hashikawa, Satoshi Wanifuchi, Junya Kusumoto, Manabu Shigeoka, Shungo Furudoi, Hiroto Terashi, Takahide Komori

BIOMED RESEARCH INTERNATIONAL Vol. 2017 page： 3125842 2017

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：HINDAWI LTD

Background. This study aimed to analyze differences in necrotic changes between cortical and cancellous bone in resection margins after segmental mandibulectomy for advanced mandibular osteoradionecrosis. Methods. Anteroposterior bone specimens from eleven patients who underwent segmental mandibulectomy with simultaneous free fibula flap reconstruction for advanced osteoradionecrosis were analyzed histopathologically for the presence of necrotic bone based on the presence of blood vessels within Haversian canals. Results. Ten of eleven (91%) cortices near the inferior border of the mandible at the anterior margins were necrotic. All cancellous bones at the anterior margins were viable. Seven of eleven (64%) cortices near the inferior border of the mandible at the posterior margins were necrotic. Three of eleven (27%) cancellous bones at the posterior margins were necrotic. Conclusion. Necrotic changes are more prevalent in cortices than in cancellous bones in mandibular osteoradionecrosis, probably due to a decrease of periosteal blood supply caused by radiotherapy.

DOI： 10.1155/2017/3125842