Faculty Profiles - HASHIKAWA Kazunobu

Blowing time ratio and high-resolution manometry to evaluate swallowing function of patients with oral and oropharyngeal cancer Reviewed

Komatsu Hirokazu, Furukawa Tatsuya, Iritani Keisuke, Tatehara Shun, Takahashi Miki, Iwaki Shinobu, Kakei Yasumasa, Hasegawa Takumi, Teshima Masanori, Shinomiya Hirotaka, Otsuki Naoki, Hashikawa Kazunobu, Kiyota Naomi, Sasaki Ryohei, Akashi Masaya, Nibu Ken-ichi

AURIS NASUS LARYNX Vol. 49 ( 3 ) page： 477 - 483 2022.6

Analysis of Orbital Blowout Fracture Location and Hess Area Ratio Reviewed

Osaki Takeo, Tamura Ryosuke, Sakakibara Shunsuke, Nomura Tadashi, Hashikawa Kazunobu, Terashi Hiroto

JOURNAL OF CRANIOFACIAL SURGERY Vol. 33 ( 4 ) page： 1042 - 1045 2022.6

A Case of a Rare Branching Pattern in the Carotid Artery Reviewed International journal

Sakai A, Hashikawa K, Sakakibara A, Murai N, Nomura T, Akashi M, Terashi H

Eplasty Vol. 22 2022.2

Roles of skull base surgery and particle radiotherapy for orbital malignant tumors involving the skull base Reviewed International journal

Teshima Masanori, Shinomiya Hirotaka, Kimura Hidehito, Hashikawa Kazunobu, Kiyota Naomi, Miyawaki Daisuke, Sasaki Ryohei, Kohmura Eiji, Nibu Ken-ichi

LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY Vol. 6 ( 6 ) page： 1347 - 1352 2021.12

Language：English Publishing type：Research paper (scientific journal) Publisher：Laryngoscope Investigative Otolaryngology

Purpose: To investigate the oncological outcomes of orbital malignant tumors invading the skull base. Methods: A retrospective analysis was conducted on 16 patients with orbital malignant tumors invading the skull base. Eleven patients were treated with skull base surgery, four patients were treated with particle therapies, and one patient was treated with chemoradiotherapy (CRT) as initial treatment. Results: The most frequent histological type was adenoid cystic carcinoma in seven patients, followed by squamous cell carcinoma in two patients. Local recurrence occurred in two of the six surgically treated patients who did not receive postoperative radiotherapy (RT) or CRT. One of them was successfully salvaged by RT, and the other died of disease. With a median follow-up of 24 months, the 2-year overall, local control, and disease-free survival rates of all patients were 82.5%, 87.5%, and 59%, respectively. Conclusions: Patients with positive surgical margins were at risk of local recurrence. Postoperative RT should be considered for all surgically treated patients. Level of Evidence: 4.

DOI： 10.1002/lio2.687

Experimental study on the efficacy of a hybrid artificial nerve: The hot dog method Reviewed International journal

Tamura Ryosuke, Hashikawa Kazunobu, Sakakibara Shunsuke, Osaki Takeo, Kitano Daiki, Maruguchi Hayato, Nomura Tadashi, Sugiyama Daisuke, Terashi Hiroto

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS Vol. 44 ( 10 ) page： 711 - 717 2021.10

Language：English Publishing type：Research paper (scientific journal) Publisher：International Journal of Artificial Organs

Introduction: We hypothesized that hybrid artificial nerves might overcome the limitations of a nerve conduit by isolating nerve fascicles from autologous nerves. Nerve sacrifice during harvest, a drawback of conventional autologous nerve transplantation, may be reduced by the hot dog method. The hot dog method (based on the morphology of hybrid artificial nerves) adds nerve conduits to autologous nerve fascicles. Methods: Forty-eight rats with a 10-mm sciatic nerve defect were divided into six groups (n = 8 per group) according to the neural reconstruction method: autologous nerve transplantation, the hot dog method, nerve conduit, nerve fascicle transplantation, sham control, and nerve fascicle isolation were classified as Groups I, II, III, IV, V, and VI, respectively. The sciatic nerve function was assessed in these groups, a histological evaluation was performed, and statistical analyses were conducted based on these data. Results: Group III (nerve conduit) and Group IV (nerve fascicle transplantation) showed the lowest functional and axonal regenerative effects, followed by Group II (hot dog method) and Group I (autologous nerve transplantation). Group VI (nerve fascicle isolation) tended to achieve better recovery in motor function and axonal regeneration than Group I (autologous nerve transplantation). Conclusions: The hot dog method is simple, safe, and easy to execute. This method can serve as a new neural reconstruction method that uses artificial nerves.

DOI： 10.1177/03913988211026000

Clinical Evaluation of Unsintered Hydroxyapatite Particles/Poly L-Lactide Composite Device in Craniofacial Surgery Reviewed International journal

Osawa Sayuri, Hashikawa Kazunobu, Naruse Hidemi, Terashi Hiroto

JOURNAL OF CRANIOFACIAL SURGERY Vol. 32 ( 6 ) page： 2148 - 2151 2021.9

Language：English Publishing type：Research paper (scientific journal) Publisher：The Journal of craniofacial surgery

ABSTRACT: A total of 47 patients who underwent the craniofacial implantation of unsintered hydroxyapatite particles and a poly-L-lactide device were evaluated for clinical local findings and computed tomography (CT) images after about 6 months. Long-term follow-up of 3 patients was done from 5 to 11 years. The patients underwent CT imaging pre- and postoperatively, while local clinical examination was done upon follow-up. For the 3 patients who were followed up for more than 5 years, implant changes were evaluated by using CT. Computed tomography revealed 3 patients of dislocation, 2 patients of insufficient bone union, and 3 patients of implant breakage. All patients healed well with no complications requiring a secondary operation. The CT findings of the long-term cases revealed the following: a plate and screw were still present 5 years postsurgery (patient 1), mesh implants were completely resorbed after 9 years and 6 months (patient 2), and plates were almost resorbed after 11 years but some of their shapes remained (patient 3).The unsintered hydroxyapatite/poly-L-lactide device is useful in the maxillofacial region in terms of strength and radiographic contrast. However, since the absorption rate is slow, it is necessary to keep in mind its long-term radiographic detectability and the possibility of late-onset granuloma.

DOI： 10.1097/SCS.0000000000007491

Wire Myography for Continuous Estimation of the Optimal Concentration of Topical Lidocaine as a Vasodilator in Microsurgery Reviewed International journal

Ogawa Haruo, Kusumoto Junya, Nomura Tadashi, Hashikawa Kazunobu, Terashi Hiroto, Sakakibara Shunsuke

JOURNAL OF RECONSTRUCTIVE MICROSURGERY Vol. 37 ( 06 ) page： 541 - 550 2021.7

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Reconstructive Microsurgery

Background Intraoperative vasospasm during reconstructive microvascular surgery is often unpredictable and may lead to devastating flap loss. Therefore, various vasodilators are used in reconstructive microsurgery to prevent and relieve vasospasm. Lidocaine is a vasodilator commonly used in microvascular surgery. Although many reports have described its in vitro and in vivo concentration-dependent vasodilatory effects, limited studies have examined the pharmacological effects of lidocaine on blood vessels in terms of persistence and titer. Methods In this study, the vasodilatory effect of lidocaine was examined by using the wire myograph system. Abdominal aortas were harvested from female rats, sliced into rings of 1-mm thickness, and mounted in the wire myograph system. Next, 10, 5, 2, and 1% lidocaine solutions were applied to the artery, and the change in vasodilation force, persistence of the force, and time required to reach equilibrium were measured. Results The vasodilatory effect was confirmed in all groups following lidocaine treatment. Although strong vasodilation was observed in the 10% lidocaine group, it was accompanied by irreversible degeneration of the artery. Vasodilation in the 1% lidocaine group was weaker than that in the other groups 500 seconds after lidocaine addition (p < 0.05). Between the 5 and 2% lidocaine groups, 5% lidocaine showed a stronger vasodilatory effect 400 to 600 seconds after lidocaine addition (p < 0.01); however, there was no significant difference in these groups after 700 seconds. Additionally, there was no difference in the time required for the relaxation force to reach equilibrium among the 5, 2, and 1% lidocaine groups. Conclusion Although our study confirmed the dose-dependent vasodilatory effect of lidocaine, 5% lidocaine showed the best vasodilatory effect and continuity with minimal irreversible changes in the arterial tissue.

DOI： 10.1055/s-0040-1722759

Occurrence and Treatment Outcome of Late Complications After Free Fibula Flap Reconstruction for Mandibular Osteoradionecrosis Reviewed International journal

Yamashita Junya, Akashi Masaya, Takeda Daisuke, Kusumoto Junya, Hasegawa Takumi, Hashikawa Kazunobu

CUREUS JOURNAL OF MEDICAL SCIENCE Vol. 13 ( 3 ) page： e13833 2021.3

Language：English Publishing type：Research paper (scientific journal)

Purpose: This study aimed to evaluate the occurrence and treatment outcome of late complications after free fibula osteocutaneous flap reconstruction for mandibular osteoradionecrosis (ORN).

Methods: We enrolled 15 consecutive patients (14 men, one woman; median age 65 years, range 57-80 years) who underwent free fibula reconstruction for advanced mandibular ORN during 2013-2017 with two or more years of follow-up. Late complications included infection, plate exposure, and recurrence at the resection margin. The effect of perioperative antibiotic administration on late complications was also assessed.

Results: Late complications occurred in 33.3% (5/15) of patients, including two infections (local and distant), two plate exposures, and two recurrences (plate exposure and recurrence occurred in one patient). Perioperative antibiotic administration duration did not significantly affect the occurrence of postoperative late complications. All late complications were treated without problems.

Conclusions: Late complications after ORN reconstructive surgery are not uncommon, but can be treated properly.

DOI： 10.7759/cureus.13833