Faculty Profiles - SAITO Ryuta

Papers - SAITO Ryuta

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Clinical Efficiency of an Artificial Intelligence-Based 3D-Angiography for Visualization of Cerebral Aneurysm: Comparison with the Conventional Method. Reviewed International journal

Kojiro Ishikawa, Takashi Izumi, Masahiro Nishihori, Takahiro Imaizumi, Shunsaku Goto, Keita Suzuki, Kinya Yokoyama, Fumiaki Kanamori, Kenji Uda, Yoshio Araki, Ryuta Saito

Clinical neuroradiology Vol. 33 ( 4 ) page： 1143 - 1150 2023.12

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: Artificial intelligence (AI)-based three-dimensional angiography (3D-A) was reported to demonstrate visualization of cerebral vasculature equivalent to that of three-dimensional digital subtraction angiography (3D-DSA). However, the applicability and efficacy of the AI-based 3D‑A algorithm have not yet been investigated for 3D-DSA micro imaging. In this study, we evaluated the usefulness of the AI-based 3D‑A in 3D-DSA micro imaging. MATERIALS AND METHODS: The 3D-DSA micro datasets of 20 consecutive patients with cerebral aneurysm (CA) were reconstructed with 3D-DSA and 3D‑A. Three reviewers compared 3D-DSA and 3D‑A in terms of qualitative parameters (degrees of visualization of CA and the anterior choroidal artery [AChA]) and quantitative parameters (aneurysm diameter, neck diameter, parent vessel diameter, and visible length of AChA). RESULTS: Qualitative evaluation of diagnostic potential revealed that visualization of CA and the proximal to middle parts of the AChA with 3D‑A was equal to that with conventional 3D-DSA; in contrast, visualization of the distal part of the AChA was lower with 3D‑A than with 3D-DSA. Further, regarding quantitative evaluation, the aneurysm diameter, neck diameter, and parent vessel diameter were comparable between 3D‑A and 3D-DSA; in contrast, the visible length of the AChA was lower with 3D‑A than with 3D-DSA. CONCLUSIONS: The AI-based 3D‑A technique is feasible and evaluable visualization of cerebral vasculature with respect to quantitative and qualitative parameters in 3D-DSA micro imaging. However, the 3D‑A technique offers lower visualization of such as the distal portion of the AChA than 3D-DSA.

DOI： 10.1007/s00062-023-01325-8

Lateral Lumbar Interbody Fusion within Three-level for Patients with Neurological Symptoms due to Vertebral Fragility Fractures in the Lumbar Spine Reviewed Open Access

Nagashima, Y, Nishimura, Y, Kanemura, T, Hata, N, Satake, K, Akahori, S, Ishii, M, Tanei, T, Takayasu, M, Saito, R

Neurologia Medico-Chirurgica Vol. 63 ( 12 ) page： 548 - 554 2023.12

Language：English Publishing type：Research paper (scientific journal) Publisher：The Japan Neurosurgical Society

There is a lack of agreement on whether minimally invasive lateral lumbar intervertebral fusion (LLIF) is a suitable treatment option for vertebral fragility fractures (VFFs). Hence, we sought to evaluate the efficacy and safety of LLIF in the management of VFF with neurological deficits in the lumbar spine. Between April 2015 and March 2020, we conducted a retrospective observational study of patients with VFF treated with three-level or less LLIF. The participants had previously received conservative treatment but had not been able to control their neurological symptoms. To assess the outcomes of the LLIF procedures, the patients were followed up for a minimum of 1 year. Clinical and radiological results, which include the timing and location of the bony fusion, were analyzed. The study involved 19 patients with 23 vertebral fracture levels. The residual height of the fractured vertebra was found to be 57.0 ± 12.3% of the height of the adjacent level. The mean Japanese Orthopedic Association score significantly improved postoperatively. Postoperative radiological parameters were significantly maintained at 1 year, and lumbar lordosis was maintained at the last follow-up (45.0 ± 26.7). In total 31 LLIF levels, bone fusion was observed in four levels at 6 months postoperatively, in 16 levels at 1 year, and in 23 levels at the last follow-up. The facet joint had the highest bony fusion location. LLIF within three levels can be safely performed in certain VFF cases with sufficient residual vertebral height.

DOI： 10.2176/jns-nmc.2023-0064

Endoscopic debulking canalization for optic pathway glioma with obstructive hydrocephalus. Reviewed International journal

Kazuhito Takeuchi, Fumiharu Ohka, Yuichi Nagata, Eiji Ito, Hideyuki Harada, Ryuta Saito

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery Vol. 39 ( 12 ) page： 3421 - 3425 2023.12

Language：English Publishing type：Research paper (scientific journal)

Optic pathway gliomas (OPGs) are benign tumors that can stop growing or even shrink. In recent years, surgical resection has not been considered the first-line treatment because of its high risk of complications. Chemotherapy is the mainstay of treatment for growing OPGs. Surgical treatment for OPGs with obstructive hydrocephalus is required. Ventriculoperitoneal shunting is effective for all types of hydrocephalus. However, long-term management is required, especially in pediatric cases, and there is a risk of shunt-related complications over a long lifespan. Debulking surgery for OPGs allows us to avoid shunt placement by creating a waterway and releasing the hydrocephalus. To reduce the surgical risk and invasiveness, we used an endoscopic canalization technique with a small-diameter cylinder. In this article, we present a case of endoscopic canalization of an obstructive hydrocephalus caused by OPGs in a 14-year-old female to illustrate our surgical technique.(Trial registration Registry name and number: Efficacy and safety of the neuro-endoscopic treatment for brain tumors (2019-0254)).

DOI： 10.1007/s00381-023-06053-5

Deep learning based identification of pituitary adenoma on surgical endoscopic images: a pilot study Reviewed

Yutaro Fuse, Kazuhito Takeuchi, Noriaki Hashimoto, Yuichi Nagata, Yusuke Takagi, Tetsuya Nagatani, Ichiro Takeuchi, Ryuta Saito

Neurosurgical Review Vol. 46 ( 1 ) page： 291 2023.11

Difference of coil distribution made by finishing coils in large size aneurysm model with radiolucent coils. Reviewed

Hiroki Matsuno, Takashi Izumi, Masahiro Nishihori, Shunsaku Goto, Yoshio Araki, Kinya Yokoyama, Kenji Uda, Ryuta Saito

Nagoya journal of medical science Vol. 85 ( 4 ) page： 725 - 732 2023.11

Language：English Publishing type：Research paper (scientific journal)

We conducted a study to understand the characteristics of the finishing coils to select the appropriate coil for the final stage of embolization. Consequently, experimental embolization was performed on a 10 mm spherical silicone aneurysm filled with radiolucent coils, which simulated a volume embolization ratio of 20%. Nine different coils (i-ED complex ∞ SilkySoft, SilkySoft, ExtraSoft, V-Trak HyperSoft helical, Barricade 10 complex finishing, Optima complex 10 soft, Target 360 Ultra, Galaxy G3 mini, and Axium prime 3D ExtraSoft) were analyzed six times at random. After each coil insertion, indices that include area, Feret diameter, circularity, and centroid center of mass were calculated using biplane x-ray images. Furthermore, these data were analyzed using the spring constant k, which represents the stiffness of the coil. In multiple comparisons, a significant difference was observed in the area analysis. The i-ED complex ∞ SilkySoft was more widespread than Target 360 Ultra (p < 0.05). However, no significant differences were observed in the other indices. The spring constant k value of Target 360 Ultra was 2.5 times larger than that of the i-ED complex ∞ SilkySoft, and it negatively correlated with the area index rather than with the other indices. Notably, it was suggested that the smaller the spring constant k, the wider the distribution of the finishing coils. Although there was little difference between the coils, some coils had characteristics suggesting that good embolization could be expected using appropriate finishing coils.

DOI： 10.18999/nagjms.85.4.725

DISSECTING THE INTRA- AND INTER-TUMORAL HETEROGENEITY UNDERLYING GLIOBLASTOMA PATHOGENESIS UTILIZING MULTI-OMICS ANALYSIS

Nakashima, T; Funakoshi, Y; Yajima, H; Yamamoto, R; Sugihara, Y; Nambu, S; Arakawa, Y; Tanaka, S; Ishida, J; Saito, R; Hanaya, R; Yoshimoto, K; Narita, Y; Suzuki, H

NEURO-ONCOLOGY Vol. 25 2023.11

INTRA-OPERATIVE ANALYSES OF GENETIC ALTERATIONS IN THE CENTRAL NERVOUS SYSTEM TUMORS USING RAPID QUANTITATIVE PCR DEVICE

Ohka, F, Maeda, S, Yamaguchi, J, Shimizu, H, Motomura, K, Takeuchi, K, Nagata, Y, Nishikawa, T, Kibe, Y, Takido, Y, Saito, R

NEURO-ONCOLOGY Vol. 25 2023.11

DISSECTING THE INTRA- AND INTER-TUMORAL HETEROGENEITY UNDERLYING GLIOBLASTOMA PATHOGENESIS UTILIZING MULTI-OMICS ANALYSIS

Nakashima, T, Funakoshi, Y, Yajima, H, Yamamoto, R, Sugihara, Y, Nambu, S, Arakawa, Y, Tanaka, S, Ishida, J, Saito, R, Hanaya, R, Yoshimoto, K, Narita, Y, Suzuki, H

NEURO-ONCOLOGY Vol. 25 2023.11

ESTABLISHMENT OF ORGANOID MODELS OF PATIENT-DERIVED GH-PRODUCING PITUITARY ADENOMA

Maeda, S, Ohka, F, Kanamori, F, Okumura, Y, Takeuchi, K, Nagata, Y, Motomura, K, Yamaguchi, J, Kibe, Y, Harada, H, Shimizu, H, Takido, Y, Saito, R

NEURO-ONCOLOGY Vol. 25 2023.11

GLIOBLASTOMA, IDH-WILDTYPE WITHOUT KEY MOLECULAR FEATURES

Saito, R, Motomura, K, Ohka, F, Yamaguchi, J, Maeda, S, Nishikawa, T, Mizutani, K, Kibe, Y, Shimizu, H, Takido, Y

NEURO-ONCOLOGY Vol. 25 2023.11

IMAGING FEATURES AND CONSIDERATION OF PROGRESSION PATTERN OF DIFFUSE HEMISPHERIC GLIOMAS, H3 G34-MUTANT

Kibe, Y, Ohka, F, Motomura, K, Aoki, K, Maeda, S, Yamaguchi, J, Shimizu, H, Saito, R

NEURO-ONCOLOGY Vol. 25 2023.11

Epileptogenic zone in Broca's area is resectable under awake surgery in accordance with the hodotopic framework: A case report Reviewed

Suzuki, T, Ishizaki, T, Maesawa, S, Hashida, M, Mutoh, M, Ito, Y, Tanei, T, Saito, R

Seizure Vol. 112 page： 84 - 87 2023.11

Minor Suture Fusion is Associated With Chiari Malformation in Nonsyndromic Craniosynostosis. Reviewed International journal Open Access

Kosuke Mizutani, Michihiro Kurimoto, Masamune Nagakura, Tomoki Nawashiro, Toshiya Nagai, Kosuke Aoki, Mihoko Kato, Ryuta Saito

The Journal of craniofacial surgery Vol. 34 ( 8 ) page： 2308 - 2312 2023.11

Language：English Publishing type：Research paper (scientific journal)

Here, we focused on the association between minor suture fusion and Chiari malformation (CM) occurrence in nonsyndromic craniosynostosis (NSC), and evaluated how the minor suture affects the posterior cranial fossa by measuring the posterior fossa deflection angle (PFA). In this retrospective study, the clinical records of 137 patients who underwent surgery for NSC at Aichi Children's Health and Medical Center between April 2010 and May 2022 were analyzed. Clinical data from Aichi Developmental Disability Center Central Hospital was collected for 23 patients as the external validation set. Among the 137 patients, 123 were diagnosed with NSC and the remaining 14 with syndromic craniosynostosis. Of the 123 NSC patients, 23 patients presented with CM. Multivariate analysis showed that occipito-mastoid fusion was the only significant risk factor for CM (P=0.0218). Within the NSC group, CM patients had a significantly increased PFA (6.33±8.10 deg) compared with those without CM (2.76±3.29 deg, P=0.0487). Nonsyndromic craniosynostosis patients with occipito-mastoid suture fusion had a significantly increased PFA (6.50±7.60 deg) compared with those without occipito-mastoid fusion (2.60±3.23 deg, P=0.0164). In the validation cohort, occipito-mastoid suture fusion was validated as an independent risk factor for CM in univariate analysis. Minor suture fusion may cause CM associated with NSC. Chiari malformation could develop due to an increased PFA due to minor suture fusion, which causes growth disturbance in the affected side and compensatory dilation in the contralateral side within the posterior cranial fossa.

DOI： 10.1097/SCS.0000000000009552

Local Delivery of Nimustine Hydrochloride against Brain Tumors: Basic Characterization Study Open Access

Xiaodong Shao, Ryuta Saito, Aya Sato, Saori Okuno, Daisuke Saigusa, Ritsumi Saito, Akira Uruno, Yoshinari Osada, Masayuki Kanamori, Teiji Tominaga

The Tohoku Journal of Experimental Medicine Vol. 261 ( 3 ) page： 187 - 194 2023.11

Language：English Publishing type：Research paper (scientific journal) Publisher：Tohoku University Medical Press

Convection-enhanced delivery (CED) delivers agents directly into tumors and the surrounding parenchyma. Although a promising concept, clinical applications are often hampered by insufficient treatment efficacy. Toward developing an effective CED-based strategy for delivering drugs with proven clinical efficacy, we performed a basic characterization study to explore the locally delivered characteristics of the water soluble nitrosourea nimustine hydrochloride (ACNU). First, ACNU distribution after CED in rodent brain was studied using mass spectrometry imaging. Clearance of 14C-labeled ACNU after CED in striatum was also studied. ACNU was robustly distributed in rodent brain similar to the distribution of the hydrophilic dye Evans blue after CED, and locally delivered ACNU was observed for over 24 h at the delivery site. Subsequently, to investigate the potential of ACNU to induce an immunostimulative microenvironment, Fas and transforming growth factor-β1 (TGF-β1) was assessed in vitro. We found that ACNU significantly inhibited TGF-β1 secretion and reduced Fas expression. Further, after CED of ACNU in 9L-derived intracranial tumors, the infiltration of CD4/CD8 lymphocytes in tumors was evaluated by immunofluorescence.CED of ACNU in xenografted intracranial tumors induced tumor infiltration of CD4/CD8 lymphocytes. ACNU has a robust distribution in rodent brain by CED, and delayed clearance of the drug was observed at the local infusion site. Further, local delivery of ACNU affects the tumor microenvironment and induces immune cell migration in tumor. These characteristics make ACNU a promising agent for CED.

DOI： 10.1620/tjem.2023.J069

INTRA-OPERATIVE ANALYSES OF GENETIC ALTERATIONS IN THE CENTRAL NERVOUS SYSTEM TUMORS USING RAPID QUANTITATIVE PCR DEVICE

Ohka, F; Maeda, S; Yamaguchi, J; Shimizu, H; Motomura, K; Takeuchi, K; Nagata, Y; Nishikawa, T; Kibe, Y; Takido, Y; Saito, R

NEURO-ONCOLOGY Vol. 25 2023.11

IMAGING FEATURES AND CONSIDERATION OF PROGRESSION PATTERN OF DIFFUSE HEMISPHERIC GLIOMAS, H3 G34-MUTANT

Kibe, Y; Ohka, F; Motomura, K; Aoki, K; Maeda, S; Yamaguchi, J; Shimizu, H; Saito, R

NEURO-ONCOLOGY Vol. 25 2023.11

GLIOBLASTOMA, IDH-WILDTYPE WITHOUT KEY MOLECULAR FEATURES

Saito, R; Motomura, K; Ohka, F; Yamaguchi, J; Maeda, S; Nishikawa, T; Mizutani, K; Kibe, Y; Shimizu, H; Takido, Y

NEURO-ONCOLOGY Vol. 25 2023.11

ESTABLISHMENT OF ORGANOID MODELS OF PATIENT-DERIVED GH-PRODUCING PITUITARY ADENOMA

Maeda, S; Ohka, F; Kanamori, F; Okumura, Y; Takeuchi, K; Nagata, Y; Motomura, K; Yamaguchi, J; Kibe, Y; Harada, H; Shimizu, H; Takido, Y; Saito, R

NEURO-ONCOLOGY Vol. 25 2023.11

Higher abundance of Campylobacter in the oral microbiome of Japanese patients with moyamoya disease Reviewed Open Access

Takayanagi, K, Kanamori, F, Ishii, K, Yokoyama, K, Araki, Y, Sumitomo, M, Maeda, S, Goto, S, Ota, S, Nagata, Y, Nishihori, M, Maesawa, S, Izumi, T, Takasu, S, Saito, R

Scientific Reports Vol. 13 ( 1 ) page： 18545 2023.10

Development of machine learning models for predicting unfavorable functional outcomes from preoperative data in patients with chronic subdural hematomas Reviewed Open Access

Fuse, Y; Nagashima, Y; Nishiwaki, H; Ohka, F; Muramatsu, Y; Araki, Y; Nishimura, Y; Ienaga, J; Nagatani, T; Seki, Y; Watanabe, K; Ohno, K; Saito, R

SCIENTIFIC REPORTS Vol. 13 ( 1 ) page： 16997 2023.10

Language：English Publishing type：Research paper (scientific journal) Publisher：Scientific Reports

Chronic subdural hematoma (CSDH) often causes neurological deterioration and is treated with hematoma evacuation. This study aimed to assess the feasibility of various machine learning models to preoperatively predict the functional outcome of patients with CSDH. Data were retrospectively collected from patients who underwent CSDH surgery at two institutions: one for internal validation and the other for external validation. The poor functional outcome was defined as a modified Rankin scale score of 3–6 upon hospital discharge. The unfavorable outcome was predicted using four machine learning algorithms on an internal held-out cohort (n = 188): logistic regression, support vector machine (SVM), random forest, and light gradient boosting machine. The prediction performance of these models was also validated in an external cohort (n = 99). The area under the curve of the receiver operating characteristic curve (ROC-AUC) of each machine learning-based model was found to be high in both validations (internal: 0.906–0.925, external: 0.833–0.860). In external validation, the SVM model demonstrated the highest ROC-AUC of 0.860 and accuracy of 0.919. This study revealed the potential of machine learning algorithms in predicting unfavorable outcomes at discharge among patients with CSDH undergoing burr hole surgery.

DOI： 10.1038/s41598-023-44029-2

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Papers - SAITO Ryuta