Faculty Profiles - SAITO Ryuta

Papers - SAITO Ryuta

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てんかんのDBS治療てんかんに対する視床DBS治療のエビデンス

前澤聡, 石崎友崇, 齋藤竜太

てんかん研究 Vol. 42 ( 2 ) page： 353 - 354 2024.9

SEEG合併症対策出血症例から学ぶ安全なプランニングルールの検討

鈴木崇宏, 石崎友崇, 前澤聡, 種井隆文, 武藤学, 伊藤芳記, 橋田美紀, 齋藤竜太

てんかん研究 Vol. 42 ( 2 ) page： 571 - 571 2024.9

難治てんかんに対するニューロモデュレーションの現在名古屋大学の治療戦略

石崎友崇, 前澤聡, 齋藤竜太

てんかん研究 Vol. 42 ( 2 ) page： 450 - 450 2024.9

脳腫瘍に対する全ゲノム解析(Whole-genome sequencing analysis of brain tumors)

鈴木啓道, 中島拓真, 舟越勇介, 金森政之, 柴原一陽, 鈴木智成, 木下学, 園田順彦, 荒川芳輝, 永根基雄, 田中將太, 石田穣治, 齋藤竜太, 花谷亮典, 吉本幸司, 成田善孝

日本癌学会総会記事 Vol. 83回 page： S08 - 3 2024.9

死亡後画像診断センターに搬送されたてんかん関連異状死の特徴(Characteristics of deceased subjects transported to a postmortem imaging center due to unusual death related to epilepsy)

伊藤芳記, 秦誠宏, 前澤聡, 種井隆文, 石崎友崇, 武藤学, 橋田美紀, 鈴木崇宏, 小林豊, 齋藤竜太

てんかん研究 Vol. 42 ( 2 ) page： 579 - 579 2024.9

定位手術用ロボットアームNeuromateによる視床前核脳深部刺激療法(ANT-DBS)の導入経験

石崎友崇, 前澤聡, 鈴木崇宏, 橋田美紀, 伊藤芳記, 武藤学, 種井隆文, 齋藤竜太

てんかん研究 Vol. 42 ( 2 ) page： 523 - 523 2024.9

側頭葉外術中皮質脳波が示唆するtemporal plus epilepsyについての検討

橋田美紀, 石崎友崇, 鈴木崇宏, 伊藤芳記, 武藤学, 種井隆文, 前澤聡, 齋藤竜太

てんかん研究 Vol. 42 ( 2 ) page： 570 - 570 2024.9

ニューロメートで切り拓く定位的てんかん外科手術の未来

石崎友崇, 前澤聡, 齋藤竜太

てんかん研究 Vol. 42 ( 2 ) page： 446 - 446 2024.9

Intracranial Myeloid Sarcoma Arising Intraaxially From Acute Myeloid Leukemia: A Case Report and Literature Review Reviewed

Kageyama, A; Motomura, K; Motomura, A; Nakajima, Y; Tsujiuchi, T; Matsuo, M; Akahori, S; Watarai, M; Kojima, I; Saito, R

CUREUS JOURNAL OF MEDICAL SCIENCE Vol. 16 ( 8 ) page： e67884 2024.8

神経内視鏡画像における機能性下垂体腫瘍を含めた手術支援AIシステムの構築

布施佑太郎, 竹内和人, 橋本典明, 永田雄一, 永谷哲也, 竹内一郎, 齋藤竜太

日本内分泌学会雑誌 Vol. 100 ( S.HPT ) page： 19 - 21 2024.8

The indication of palliative whole-brain radiotherapy for patients with brain metastases: a simple prognostic scoring system in the era of stereotactic radiosurgery Reviewed Open Access

Hirose, T; Deguchi, S; Yasui, K; Inoue, M; Onoe, T; Ogawa, H; Asakura, H; Mitsuya, K; Harada, H; Murayama, S; Hayashi, N; Nishimura, T; Saito, R

BMC CANCER Vol. 24 ( 1 ) page： 940 2024.8

Language：English Publisher：BMC Cancer

Background: Stereotactic irradiation has become the mainstay treatment for brain metastases (BM), and whole-brain radiotherapy (WBRT) is often used for symptom palliation. However, the survival time of patients with BM undergoing palliative WBRT (pWBRT) is limited, making it difficult to select patients who should receive treatment. Methods: We collected patient data from 2016 to 2022 at the Shizuoka Cancer Center and retrospectively analyzed the factors related to survival time. Overall survival (OS) was defined as the survival time after WBRT. Results: A total of 301 patients (median age, 66 years) who underwent pWBRT were included. The primary cancers were lung, breast, gastrointestinal tract, and other cancers in 203 (67%), 38 (13%), 33 (11%), and 27 (9%) patients, respectively. Median OS of all patients was 4.1 months. In the multivariate analysis, male sex (hazard ratio [HR]:1.4), Karnofsky Performance Status (KPS) ≤ 60 (HR:1.7), presence of extracranial metastasis (ECM) (HR:1.6), neutrophil-lymphocyte ratio (NLR) ≥ 5 (HR:1.6), and lactate dehydrogenase (LDH) ≥ upper limit of normal (ULN) (HR:1.3) were significantly associated with shorter OS (all P < 0.05). To predict the OS, we created a prognostic scoring system (PSS). We gave one point to each independent prognostic factor. Median OS for patients with scores of 0–2, 3, and 4–5 were 9.0, 3.5 and 1.7 months, respectively (P < 0.001). Conclusions: Male sex, KPS ≤ 60, presence of ECM, NLR ≥ 5, and LDH ≥ ULN were poor prognostic factors for patients with BM undergoing pWBRT. By PSS combining these factors, it may be possible to select patients who should undergo pWBRT.

DOI： 10.1186/s12885-024-12729-1

Tertiary Lymphoid Structures in Brain Metastases of Lung Cancer: Prognostic Significance and Correlation With Clinical Outcomes. Reviewed International journal Open Access

Shota Nohira, Shunichiro Kuramitsu, Masasuke Ohno, Mitsugu Fujita, Kimihiro Yamashita, Toru Nagasaka, Shoichi Haimoto, Noriaki Sakakura, Hirokazu Matsushita, Ryuta Saito

Anticancer research Vol. 44 ( 8 ) page： 3615 - 3621 2024.8

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND/AIM: The prognosis of patients with brain metastases (BMs) originating from lung cancer remains poor, despite advancements in treatment strategies. The role of tertiary lymphoid structures (TLSs) within the tumor immune microenvironment of BMs has not been extensively explored. PATIENTS AND METHODS: This study utilized patient-derived clinical samples from 17 patients with histologically confirmed BMs of lung cancer, undergoing surgical resection. Immunohistochemistry was employed to analyze the presence and characteristics of TLS and tumor-infiltrating lymphocytes (TILs) within BM tissues, correlating these with clinical outcomes. RESULTS: TLSs, albeit in their immature form, were identified within BM tissues, distinguishing them from their mature counterparts in primary lung cancer tissues. A significant correlation between TLS density (but not TIL density) and improved postoperative survival was observed, underscoring the potential of TLS density as an independent prognostic marker. Furthermore, TLS density did not correlate with the Graded Prognostic Assessment (GPA) index, suggesting its unique prognostic value beyond conventional predictors. CONCLUSION: Our findings reveal the presence of TLSs in lung cancer-derived BMs and highlight their prognostic significance, independent of the GPA index. The identification of TLS within the unique central nervous system tumor microenvironment offers new insights into the immune landscape of BMs and suggests potential avenues for immunotherapeutic interventions targeting these structures to improve patient outcomes.

DOI： 10.21873/anticanres.17184

Clinical and molecular features of patients with IDH1 wild-type primary glioblastoma presenting unexpected short-term survival after gross total resection Reviewed

Mariko Toyoda, Ichiyo Shibahara, Ryota Shigeeda, Kazuko Fujitani, Yoko Tanihata, Yuri Hyakutake, Hajime Handa, Hideto Komai, Sumito Sato, Madoka Inukai, Takuichiro Hide, Yoshiteru Shimoda, Masayuki Kanamori, Hidenori Endo, Ryuta Saito, Ken-Ichiro Matsuda, Yukihiko Sonoda, Toshihiro Kumabe

Journal of Neuro-Oncology Vol. 169 ( 1 ) page： 39 - 50 2024.8

Microsurgical Management of Craniocervical Dural Arteriovenous Fistula: A Case Report and Literature Review Reviewed

Araki, Y; Putra, MB; Tsukada, T; Niryana, IW; Saito, R

CUREUS JOURNAL OF MEDICAL SCIENCE Vol. 16 ( 7 ) page： e65547 2024.7

The potential role of preoperative posterior cerebral artery involvement in predicting postoperative transient neurological deficits and ischemic stroke after indirect revascularization in patients with moyamoya disease. Reviewed International journal

Yoshio Araki, Kinya Yokoyama, Kenji Uda, Fumiaki Kanamori, Kai Takayanagi, Kazuki Ishii, Masahiro Nishihori, Shunsaku Goto, Tetsuya Tsukada, Kazuhito Takeuchi, Kuniaki Tanahashi, Yuichi Nagata, Yusuke Nishimura, Takafumi Tanei, Yoshitaka Nagashima, Shinsuke Muraoka, Takashi Izumi, Yukio Seki, Ryuta Saito

World neurosurgery Vol. 187 page： E610 - E619 2024.7

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: Transient neurological deficits (TNDs) are known to develop after direct bypass for moyamoya disease (MMD) and may be risk factors for subsequent stroke. However, the factors involved in the development of TNDs and stroke after indirect revascularization alone, including their association with subsequent stroke, remain unclear. The purpose of this study was to investigate this issue. METHODS: The subjects of the study were 30 patients with MMD who underwent a total of 40 indirect revascularization procedures at our institution. Clinical and radiological data were collected retrospectively. To examine factors associated with the development of postoperative TND/stroke/asymptomatic disease, the clinical characteristics of each group were statistically compared. RESULTS: The mean age at surgery was 7 years (range 1-63). TNDs developed after surgery in 9 out of 40 patients (22.5%). Stroke in the acute postoperative period occurred in 3 patients (7.5%), all of whom experienced cerebral infarctions. Demographic data and preoperative clinical information were not different between the groups. However, posterior cerebral artery (PCA) involvement on preoperative imaging was significantly associated with the development of TNDs and stroke (p=0.006). Furthermore, postoperative stroke was associated with unfavorable outcomes (p=0.025). CONCLUSIONS: PCA involvement is significantly associated with the occurrence of TNDs. In contrast, TNDs after indirect revascularization have little relationship with the subsequent development of stroke. TNDs usually resolve without new strokes, and a better understanding of this particular pathology could help establish an optimal treatment regimen.

DOI： 10.1016/j.wneu.2024.04.135

[Prediction of the Natural Course of Meningioma Using CT and MR Images]. Reviewed

Deguchi S, Mitsuya K, Saito R

No shinkei geka. Neurological surgery Vol. 52 ( 4 ) page： 699 - 704 2024.7

Decreased heart rate variability in sympathetic dominant states in Parkinson's disease and isolated REM sleep behavior disorder Reviewed

Suzuki, M; Nakamura, T; Ohba, C; Hatanaka, M; Tsuboi, T; Hirayama, M; Nakatsubo, D; Maesawa, S; Saito, R; Katsuno, M

PARKINSONISM & RELATED DISORDERS Vol. 124 page： 107020 2024.7

Language：English Publisher：Parkinsonism and Related Disorders

Introduction: Parkinson's disease (PD) presents with decreased heart rate variability (HRV) from its early stages. However, most of its evidence originates from HRV measurements in parasympathetic dominant states. In this study, we aimed to examine whether HRV in sympathetic dominant states during the head-up tilt table test (HUT) serves as a marker of autonomic dysfunction in PD and isolated REM sleep behavior disorder (iRBD). Methods: We retrospectively assessed 102 patients with PD, 10 patients with iRBD, and 43 healthy controls. We then measured the coefficient of variation of RR intervals as an HRV parameter in sympathetic dominant states (CVRR-S) and parasympathetic dominant states (CVRR-P). Furthermore, we evaluated parameters of cardiac autonomic function, including HUT and the heart-to-mediastinum (H/M) ratio of cardiac metaiodobenzylguanidine scintigraphy. Results: Patients with iRBD and PD at Hoehn and Yahr stage I exhibited a significantly decreased CVRR-S compared to healthy controls (controls vs. iRBD vs. PD; 1.82 ± 0.64 % vs. 1.13 ± 0.41 % vs. 1.15 ± 0.51 %, p < 0.001), although no further deterioration was observed in PD at more severe Hoehn and Yahr stages. CVRR-S showed a significant correlation with the H/M ratio in PD (r = 0.51, p < 0.001). Additionally, receiver operating characteristic (ROC) analysis revealed a larger area under the ROC curve in CVRR-S compared to that in CVRR-P for discriminating PD or iRBD from healthy controls. Conclusion: HRV in sympathetic dominant states shows the potential to be a marker of autonomic dysfunction in iRBD and early-stage PD, aiding in early diagnosis and patient stratification.

DOI： 10.1016/j.parkreldis.2024.107020

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Scopus

PubMed

Epilepsy in Patients with Gliomas Open Access

EHARA Takuro, OHKA Fumiharu, MOTOMURA Kazuya, SAITO Ryuta

Neurologia medico-chirurgica Vol. 64 ( 7 ) page： 253 - 260 2024.7

Language：English Publisher：The Japan Neurosurgical Society

<p>Brain tumor-related epilepsy (BTRE) is a complication that significantly impairs the quality of life and course of treatment of patients with brain tumors. Several recent studies have shed further light on the mechanisms and pathways by which genes and biological molecules in the tumor microenvironment can cause epilepsy. Moreover, epileptic seizures have been found to promote the growth of brain tumors, making the control of epilepsy a critical factor in treating brain tumors. In this study, we summarize the previous research and recent findings concerning BTRE. Expectedly, a deeper understanding of the underlying genetic and molecular mechanisms leads to safer and more effective treatments for suppressing epileptic symptoms and tumor growth.</p>

DOI： 10.2176/jns-nmc.2023-0299

Navigation-assisted occipitocervical fixation and decompression in a patient with polyostotic fibrous dysplasia Reviewed Open Access

Nagashima, Y; Nishimura, Y; Abe, T; Saito, R

JOURNAL OF CRANIOVERTEBRAL JUNCTION AND SPINE Vol. 15 ( 3 ) page： 380 - 383 2024.7

Language：English Publisher：Journal of Craniovertebral Junction and Spine

Fibrous dysplasia (FD) is a rare skeletal disorder characterized by the replacement of normal bone with fibrous connective tissue, leading to abnormal bone formation. This case report details the successful treatment of a 61-year-old woman with FD at the craniovertebral junction (CVJ). The patient, who had a history of intracranial meningioma and had already been diagnosed with FD, experienced worsening gait disturbance and muscle weakness following a fall. Imaging studies revealed extensive polyostotic FD lesions in the skull and cervical spine, along with a C2 odontoid fracture causing spinal cord compression. The patient underwent occipitocervical fixation and decompression surgery. Intraoperative O-arm navigation was used to ensure accurate screw placement and effective decompression. This procedure allowed for proper positioning of the C2 and C3 pedicle screws, resection of the hyperplastic occipital bone and C1 posterior arch, and placement of the occipital plate with avoiding the cyst components. At a 2-year follow-up, there were no signs of screw loosening, and the patient showed marked clinical improvement. This case emphasizes the importance of tailored surgical strategies and the use of advanced navigational technologies in managing complex FD cases, particularly those involving the CVJ. It also highlights the challenges of treating polyostotic FD, where complete resection is often unfeasible. The successful outcome in this case supports the use of decompressive surgery combined with stabilization to relieve symptoms and prevent further complications.

DOI： 10.4103/jcvjs.jcvjs_104_24

Case report: Endoscopic endonasal transposterior clinoid approach for resection of posterior clinoid process meningioma: technical notes and literature review. Reviewed International journal Open Access

Steven Awyono, Kazuhito Takeuchi, Eiji Ito, Yuichi Nagata, Nyoman Golden, Tjokorda Gde Bagus Mahadewa, Ryuta Saito

Frontiers in oncology Vol. 14 page： 1368277 - 1368277 2024.6

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Posterior clinoid process (PCP) meningioma is an exceedingly rare entity. It remains the most challenging skull base lesion for neurosurgeons due to its treacherous location that insinuates amongst critical neurovascular structures. This article will describe the technical notes using the endoscopic endonasal approach that provide the earliest devascularization and detachment of the tumor PCP meningioma. METHODS: We are introducing the surgical implementation of an endoscopic endonasal approach to removing PCP meningioma. Furthermore, we perform a literature review of posterior clinoid process meningioma that undergoes surgical intervention, then summarize the benefits and limitations of each approach. RESULTS: We present a case of right PCP meningioma that was removed using an endoscopic endonasal approach through the transposterior clinoid corridor in a 52-year-old-woman. We describe the technical notes in performing this approach to have the earliest devascularization and detachment of the tumor by performing posterior clinoidectomy. Safe tumor removal is performed with a wide and clear view of the surrounding neurovascular structure. Based on our database search, we found nine articles reported on the surgical management of PCP meningiomas, with a total number of 15 cases. All of the reported cases performed the tumor removal using the transcranial approach. CONCLUSION: The endoscopic endonasal transposterior clinoid approach circumvents all disadvantages faced by the traditional transcranial approach, providing the earliest approach to devascularized and detaching the tumor from its attachment at PCP. This approach demonstrates safety and efficacy, making it an acceptable alternative for PCP meningioma resections.

DOI： 10.3389/fonc.2024.1368277

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Papers - SAITO Ryuta