Faculty Profiles - SAITO Ryuta

Papers - SAITO Ryuta

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Clinical significance of cerebral microbleeds in patients with germinoma who underwent long-term follow-up. Reviewed International journal Open Access

Masayuki Kanamori, Shunji Mugikura, Osamu Iizuka, Naoko Mori, Yoshiteru Shimoda, Ichiyo Shibahara, Rei Umezawa, Keiichi Jingu, Ryuta Saito, Yukihiko Sonoda, Toshihiro Kumabe, Kyoko Suzuki, Hidenori Endo

Journal of neuro-oncology Vol. 170 ( 1 ) page： 173 - 184 2024.10

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: This study identified the factors affecting cerebral microbleed (CMBs) development. Moreover, their effects on intelligence and memory and association with stroke in patients with germinoma who had long-term follow-up were evaluated. METHODS: This study included 64 patients with germinoma who were histologically and clinically diagnosed with and treated for germinoma. These patients were evaluated cross-sectionally, with a focus on CMBs on susceptibility-weighted magnetic resonance imaging (SWI), brain atrophy assessed through volumetric analysis, and intelligence and memory. RESULTS: The follow-up period was from 32 to 412 (median: 175.5) months. In total, 43 (67%) patients had 509 CMBs and 21 did not have CMBs. Moderate correlations were observed between the number of CMBs and time from initial treatments and recurrence was found to be a risk factor for CMB development. Increased temporal CMBs had a marginal effect on the processing speed and visual memory, whereas brain atrophy had a statistically significant effect on verbal, visual, and general memory and a marginal effect on processing speed. Before SWI acquisition and during the follow-up periods, eight strokes occurred in four patients. All of these patients had ≥ 15 CMBs on SWI before stroke onset. Meanwhile, 33 patients with < 14 CMBs or 21 patients without CMBs did not experience stroke. CONCLUSION: Patients with a longer time from treatment initiation had a higher number of CMBs, and recurrence was a significant risk factor for CMB development. Furthermore, brain atrophy had a stronger effect on memory than CMBs. Increased CMBs predict the stroke onset.

DOI： 10.1007/s11060-024-04753-9

Epileptic foci and networks in children with epilepsy after acute encephalopathy with biphasic seizures and late reduced diffusion. Reviewed International journal Open Access

Takamasa Mitsumatsu, Yuji Ito, Yuki Maki, Hiroyuki Yamamoto, Fumi Sawamura, Tomotaka Ishizaki, Satoshi Maesawa, Epifanio Bagarinao, Tomohiko Nakata, Hiroyuki Kidokoro, Ryuta Saito, Jun Natsume

Brain & development Vol. 46 ( 9 ) page： 302 - 307 2024.10

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) develops along with status epilepticus and widespread subcortical white matter edema. We aimed to evaluate the epileptic foci and networks in two patients with epilepsy after AESD using simultaneous electroencephalography and functional magnetic resonance imaging (EEG-fMRI). METHODS: Statistically significant blood oxygen level-dependent (BOLD) responses related to interictal epileptiform discharges (IEDs) were analyzed using an event-related design of hemodynamic response functions with multiple peaks. RESULTS: Patient 1 developed focal seizures at age 10 years, one year after AESD onset. Positive BOLD changes were observed in the bilateral frontotemporal lobes, left parietal lobe, and left insula. BOLD changes were also observed in the subcortical structures. Patient 2 developed epileptic spasms at age two years, one month after AESD onset. Following total corpus callosotomy (CC) at age three years, the epileptic spasms resolved, and neurodevelopmental improvement was observed. Before CC, positive BOLD changes were observed bilaterally in the frontotemporal lobes. BOLD changes were also observed in the subcortical structures. After CC, the positive BOLD changes were localized in the temporal lobe ipsilateral to the IEDs, and the negative BOLD changes were mainly in the cortex and subcortical structures of the hemisphere ipsilateral to IEDs. CONCLUSION: EEG-fMRI revealed multiple epileptic foci and extensive epileptic networks, including subcortical structures in two cases with post-AESD epilepsy. CC may be effective in disconnecting the bilaterally synchronous epileptic networks of epileptic spasms after AESD, and pre-and post-operative changes in EEG-fMRI may reflect improvements in epileptic symptoms.

DOI： 10.1016/j.braindev.2024.07.003

がん診療ガイドライン作成・改訂に関する問題点と対応について脳腫瘍診療ガイドラインの現状と課題

園田順彦, 中田光俊, 田中將太, 篠山隆司, 吉本幸司, 成田善孝, 荒川芳輝, 山崎文之, 齋藤竜太, 阿部竜也, 黒住和彦, 市川智継, 永根基雄

日本癌治療学会学術集会抄録集 Vol. 62回 page： GL - 4 2024.10

Fact-finding survey of gynecologic oncologist on appearance care for cancer patients in Japan

Kuji, S; Nozawa, K; Toma, S; Arao, H; Imoto, S; Kajiyama, H; Kitano, A; Kodera, Y; Saito, R; Sakai, R; Taketomi, A; Nakayama, R; Hiyama, E; Futamura, M; Matsui, M; Yonemura, M; Oya, M; Suzuki, N

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER Vol. 34 ( SUPPL_3 ) page： A328 - A328 2024.10

下垂体腫瘍に対する治療

竹内和人, 永田雄一, 齋藤竜太

日本内分泌学会雑誌 Vol. 100 ( 2 ) page： 565 - 565 2024.10

がん診療ガイドライン作成・改訂に関する問題点と対応について脳腫瘍診療ガイドラインの現状と課題

園田順彦, 中田光俊, 田中將太, 篠山隆司, 吉本幸司, 成田善孝, 荒川芳輝, 山崎文之, 齋藤竜太, 阿部竜也, 黒住和彦, 市川智継, 永根基雄

日本癌治療学会学術集会抄録集 Vol. 62回 page： GL - 4 2024.10

悪性神経膠腫に対してペムブロリズマブを使用した3例の臨床経過

清水大輝, 大岡史治, 本村和也, 出口彰一, 山口純矢, 芝良樹, 前田紗知, 滝戸悠平, 山本諒, 伊藤翔平, 中村旭宏, 齋藤竜太

日本癌治療学会学術集会抄録集 Vol. 62回 page： ICCJ1 - 6 2024.10

脳腫瘍の術中迅速遺伝子解析法の樹立

大岡史治, 前田紗知, 山口純矢, 清水大輝, 本村和也, 出口彰一, 芝良樹, 竹内和人, 永田雄一, 滝戸悠平, 齋藤竜太

日本癌治療学会学術集会抄録集 Vol. 62回 page： O88 - 2 2024.10

最適なグリオーマ治療に向けた手術システムの開発

齋藤竜太, 本村和也, 大岡史治, 出口彰一, 西川知秀, 山口純矢, 木部祐士, 清水大輝, 前田紗知

日本癌治療学会学術集会抄録集 Vol. 62回 page： P65 - 3 2024.10

Cost of medical care for malignant brain tumors at hospitals in the Japan Clinical Oncology Group brain-tumor study group Reviewed Open Access

Kazuya Motomura, Keita Sasaki, Narushi Sugii, Shigeru Yamaguchi, Hirotaka Inoue, Akito Oshima, Kazuhiro Tanaka, Yoshihiro Otani, Mitsuaki Shirahata, Ichiyo Shibahara, Motoo Nagane, Shunsuke Tsuzuki, Tomoo Matsutani, Yoshihiro Tsukamoto, Noriyuki Kijima, Kenichiro Asano, Makoto Ohno, Akihiro Inoue, Yohei Mineharu, Keisuke Miyake, Yuta Mitobe, Mitsuto Hanihara, Yu Kawanishi, Shoichi Deguchi, Masato Saito, Ryosuke Matsuda, Kenta Ujifuku, Hideyuki Arita, Yuichi Sato, Shinji Yamashita, Ushio Yonezawa, Junya Yamaguchi, Yasutomo Momii, Takahiro Ogawa, Atsushi Kambe, Shigeo Ohba, Junya Fukai, Norihiko Saito, Masashi Kinoshita, Koichiro Sumi, Ryohei Otani, Takeo Uzuka, Noriyoshi Takebe, Shinichiro Koizumi, Ryuta Saito, Yoshiki Arakawa, Yoshitaka Narita

Japanese Journal of Clinical Oncology Vol. 54 ( 10 ) page： 1123 - 1131 2024.9

Language：English Publishing type：Research paper (scientific journal) Publisher：Oxford University Press (OUP)

Abstract

Background

This study aimed to investigate what treatment are selected for malignant brain tumors, particularly glioblastoma (GBM) and primary central nervous system lymphoma (PCNSL), in real-world Japan and the costs involved.

Methods

We conducted a questionnaire survey regarding treatment selections for newly diagnosed GBM and PCNSL treated between July 2021 and June 2022 among 47 institutions in the Japan Clinical Oncology Group-Brain Tumor Study Group. We calculated the total cost and cost per month of the initial therapy for newly diagnosed GBM or PCNSL.

Results

The most used regimen (46.8%) for GBM in patients aged ≤74 years was ‘Surgery + radiotherapy concomitant with temozolomide’. This regimen’s total cost was 7.50 million JPY (Japanese yen). Adding carmustine wafer implantation (used in 15.0%), TTFields (used in 14.1%), and bevacizumab (BEV) (used in 14.5%) to the standard treatment of GBM increased the cost by 1.24 million JPY for initial treatment, and 1.44 and 0.22 million JPY per month, respectively. Regarding PCNSL, ‘Surgery (biopsy) + rituximab, methotrexate, procarbazine, and vincristine (R-MPV) therapy’ was the most used regimen (42.5%) for patients of all ages. This regimen incurred 1.07 million JPY per month. The three PCNSL regimens based on R-MPV therapy were in ultra-high-cost medical care (exceeding 1 million JPY per month).

Conclusions

Treatment of malignant brain tumors is generally expensive, and cost-ineffective treatments such as BEV are frequently used. We believe that the results of this study can be used to design future economic health studies examining the cost-effectiveness of malignant brain tumors.

DOI： 10.1093/jjco/hyae116

Isolation of ependymal cilia from mouse brain. Reviewed International journal Open Access

Akihiro Mizuno, Kazuhito Takeuchi, Yuichi Nagata, Hideyuki Harada, Taiki Yamamoto, Takayuki Ishikawa, Sachi Maeda, Fumiharu Ohka, Hironori Ueno, Ryuta Saito

Journal of neuroscience methods Vol. 409 page： 110198 - 110198 2024.9

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Ependymal cilia play a major role in the circulation of cerebrospinal fluid. Although isolation of cilia is an essential technique for investigating ciliary structure, to the best of our knowledge, no report on the isolation and structural analysis of ependymal cilia from mouse brain is available. NEW METHOD: We developed a novel method for isolating ependymal cilia from mouse brain ventricles. We isolated ependymal cilia by partially opening the lateral ventricles and gently applying shear stress, followed by pipetting and ultracentrifugation. RESULTS: Using this new method, we were able to observe cilia separately. The results demonstrated that our method successfully isolated intact ependymal cilia with preserved morphology and ultrastructure. In this procedure, the ventricular ependymal cell layer was partially detached. COMPARISON WITH EXISTING METHODS: Compared to existing methods for isolating cilia from other tissues, our method is meticulously tailored for extracting ependymal cilia from the mouse brain. Designed with a keen understanding of the fragility of the ventricular ependyma, our method prioritizes minimizing tissue damage during the isolation procedure. CONCLUSIONS: We isolated ependymal cilia from mouse brain by applying shear stress selectively to the ventricles. Our method can be used to conduct more detailed studies on the structure of ependymal cilia.

DOI： 10.1016/j.jneumeth.2024.110198

A Combination Technique of N-butyl-2-cyanoacrylate and Minimal Coils with Flow Control for Parent Artery Occlusion of a Giant Internal Carotid Artery Aneurysm: A Technical Note Open Access

HANYU Taketo, IZUMI Takashi, TANEI Takafumi, NISHIHORI Masahiro, GOTOH Shunsaku, ARAKI Yoshio, YOKOYAMA Kinya, SAITO Ryuta

Neurologia medico-chirurgica Vol. 64 ( 9 ) page： 347 - 351 2024.9

Language：English Publisher：The Japan Neurosurgical Society

<p>Parent artery occlusion for large or giant internal carotid artery aneurysms remains a necessary procedure in the era of flow diverters. Endovascular parent artery occlusion is currently performed using detachable balloons or coils, which are difficult to obtain or costly. At our institution, we have devised a technique for combining n-butyl-2-cyanoacrylate and coils with flow control to solve this problem. Patients who underwent parent artery occlusion for large or giant internal carotid artery aneurysms with a follow-up period of more than 12 months were included. Imaging outcomes were evaluated for complete or incomplete aneurysmal occlusion and with or without aneurysmal shrinkage. The clinical outcome was based on changes in the modified Rankin Scale. Ten patients (ten aneurysms) were included. Their average age and average follow-up period were 68.4 years and 36 months, respectively. Complete occlusion and favorable clinical outcome were observed in all cases. The parent artery occlusion using a combination of coils and n-butyl-2-cyanoacrylate with flow control technique is effective for both imaging and clinical outcomes.</p>

DOI： 10.2176/jns-nmc.2024-0046

てんかんのDBS治療てんかんに対する視床DBS治療のエビデンス

前澤聡, 石崎友崇, 齋藤竜太

てんかん研究 Vol. 42 ( 2 ) page： 353 - 354 2024.9

ニューロメートで切り拓く定位的てんかん外科手術の未来

石崎友崇, 前澤聡, 齋藤竜太

てんかん研究 Vol. 42 ( 2 ) page： 446 - 446 2024.9

SEEG合併症対策出血症例から学ぶ安全なプランニングルールの検討

鈴木崇宏, 石崎友崇, 前澤聡, 種井隆文, 武藤学, 伊藤芳記, 橋田美紀, 齋藤竜太

てんかん研究 Vol. 42 ( 2 ) page： 571 - 571 2024.9

難治てんかんに対するニューロモデュレーションの現在名古屋大学の治療戦略

石崎友崇, 前澤聡, 齋藤竜太

てんかん研究 Vol. 42 ( 2 ) page： 450 - 450 2024.9

脳腫瘍に対する全ゲノム解析(Whole-genome sequencing analysis of brain tumors)

鈴木啓道, 中島拓真, 舟越勇介, 金森政之, 柴原一陽, 鈴木智成, 木下学, 園田順彦, 荒川芳輝, 永根基雄, 田中將太, 石田穣治, 齋藤竜太, 花谷亮典, 吉本幸司, 成田善孝

日本癌学会総会記事 Vol. 83回 page： S08 - 3 2024.9

死亡後画像診断センターに搬送されたてんかん関連異状死の特徴(Characteristics of deceased subjects transported to a postmortem imaging center due to unusual death related to epilepsy)

伊藤芳記, 秦誠宏, 前澤聡, 種井隆文, 石崎友崇, 武藤学, 橋田美紀, 鈴木崇宏, 小林豊, 齋藤竜太

てんかん研究 Vol. 42 ( 2 ) page： 579 - 579 2024.9

定位手術用ロボットアームNeuromateによる視床前核脳深部刺激療法(ANT-DBS)の導入経験

石崎友崇, 前澤聡, 鈴木崇宏, 橋田美紀, 伊藤芳記, 武藤学, 種井隆文, 齋藤竜太

てんかん研究 Vol. 42 ( 2 ) page： 523 - 523 2024.9

側頭葉外術中皮質脳波が示唆するtemporal plus epilepsyについての検討

橋田美紀, 石崎友崇, 鈴木崇宏, 伊藤芳記, 武藤学, 種井隆文, 前澤聡, 齋藤竜太

てんかん研究 Vol. 42 ( 2 ) page： 570 - 570 2024.9

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Papers - SAITO Ryuta