研究者詳細 - 齋藤　竜太

論文 - 齋藤　竜太

分割表示 412 件中 21 - 40 件目／全件表示 >>

DIAGNOSIS AND TREATMENT OF BRAIN TUMORS USING METHIONINE PET

Shiba, Y; Maeda, S; Yamaguchi, J; Deguchi, S; Ohka, F; Saito, R

NEURO-ONCOLOGY 26 巻 2024年11月

INTRA-OPERATIVE GENETIC ANALYSES FOR DECISION-MAKING DURING TUMOR REMOVAL OF ADULT-TYPE DIFFUSE GLIOMA USING RAPID QUANTITATIVE PCR DEVICE Open Access

Ohka, F; Maeda, S; Shimizu, H; Motomura, K; Takeuchi, K; Nagata, Y; Deguchi, S; Shiba, Y; Yamaguchi, J; Takido, Y; Nakamura, A; Ito, S; Saito, R

NEURO-ONCOLOGY 26 巻 2024年11月

ESTABLISHMENT OF PITUITARY NEUROENDOCRINE TUMOR (PITNET) ORGANOID MODELS

Maeda, S; Ohka, F; Kanamori, F; Okumura, Y; Takeuchi, K; Nagata, Y; Yamaguchi, J; Harada, H; Shimizu, H; Takido, Y; Saito, R

NEURO-ONCOLOGY 26 巻 2024年11月

ESTABLISHMENT OF AN APPROPRIATE GLIOMA SURGERY SYSTEM CONSIDERING MOLECULAR AND FUNCTIONAL BOUNDARIES Open Access

Saito, R; Motomura, K; Ohka, F; Deguchi, S; Shiba, Y; Yamaguchi, J; Nishikawa, T; Kibe, Y; Shimizu, H; Maeda, S

NEURO-ONCOLOGY 26 巻 2024年11月

DISTANT PARENCHYMAL RECURRENCE DURING LONG-TERM USE OF TTFIELDS TREATMENT FOR GLIOBLASTOMA

Takido, Y; Ohka, F; Deguchi, S; Motomura, K; Mitsuya, K; Shiba, Y; Takeuchi, K; Nagata, Y; Yamaguchi, J; Kibe, Y; Fuse, Y; Maeda, S; Shimizu, H; Nohira, S; Yamamoto, R; Ito, S; Nakamura, A; Saito, R

NEURO-ONCOLOGY 26 巻 2024年11月

Comparison of the inter-laminar approach and laminotomy open approach for filum terminale lipoma: A retrospective analysis 査読有り国際誌

Nawashiro, T; Kurimoto, M; Nagakura, M; Kato, M; Aoki, K; Saito, R

CHILDS NERVOUS SYSTEM 40 巻 ( 11 ) 頁： 3801 - 3810 2024年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Child S Nervous System

Purpose: Filum terminale lipoma (FTL) causes spinal-cord tethering and is associated with tethered-cord syndrome, which is treated by dissection of the entrapment. The conventional treatment for FTL involves dissection of the spinal cord through a laminotomy open approach (LOA). However, in recent years, the interlaminar approach (ILA) has gained popularity as a minimally invasive surgery. This study compares the effectiveness of the minimally invasive ILA with the conventional LOA in treating FTL. Methods: We retrospectively evaluated data on the ILA and LOA for FTL at our center. In total, 103 participants were enrolled, including 55 in the ILA group and 48 in the LOA group. Results: The ILA required significantly less surgical time and resulted in less blood loss. The improvement rate of symptoms in symptomatic patients was 84%, and for urinary symptoms and abnormal urodynamic study findings, it was 77%. The postoperative maintenance rate for asymptomatic patients was 100%. Postoperative complications of ILA included delayed wound healing in two patients (3.6%). Conclusion: Compared with LOA, ILA offers advantages in terms of shorter operative time and less blood loss, with no significant difference in long-term symptom-improvement rates between the groups.

DOI： 10.1007/s00381-024-06507-4

Three-dimensional spiral-shaping method of microcatheter for paraclinoid aneurysms: assessment using silicone models

Imaoka, E; Nishihori, M; Izumi, T; Goto, S; Araki, Y; Yokoyama, K; Uda, K; Kanamori, F; Saito, R

NAGOYA JOURNAL OF MEDICAL SCIENCE 86 巻 ( 4 ) 頁： 655 - 664 2024年11月

記述言語：英語出版者・発行元：Nagoya Journal of Medical Science

Selecting an appropriate microcatheter tip shape for paraclinoid aneurysms is difficult. Therefore, we devised an original simple and uniform three-dimensional (3D) spiral-shaping method of microcatheter and validated the characteristics and usefulness of this method for coil embolization of paraclinoid aneurysms using patient-specific silicone models. These silicone models were produced based on clinical data from four patients with four paraclinoid aneurysms that underwent endovascular treatment using the 3D spiral-shaping method. These models were classified into four types: superior, medial, inferior, and lateral corresponding to the aneurysm protrusion and locations (C3 or C2 segments by Fisher’s classification). Employing a pulsatile pump setup, two operators assessed the following items: navigation methods (pull and wire guiding), catheterization times, microcatheter tip position in the aneurysm, and the feasibility of inserting a framing coil by simple technique compared with three other shapes (straight, 90, pigtail). Three-dimensional spiral-shaped microcatheter could be placed in the medial and inferior type models of C3 segments and superior type model of C2 segment by the pullback method. Catheterization times using a 3D spiral-shaped catheter were significantly shorter than other shaped ones in the superior type models. No significant difference was found in another silicone model. Three-dimensional spiral- and pigtail-shaped catheters tended to position the tip at the center of the aneurysm. In conclusion, 3D spiral-shaped microcatheter was especially effective for the superior projected aneurysm at the C2 segment. The 3D spiral-shaping method can provide easy and secure navigation of the microcatheter into the paraclinoid aneurysms, ensuring optimal positioning for coil insertion.

DOI： 10.18999/nagjms.86.4.655

Web of Science

Scopus

PubMed

Efficacy and safety of endovascular coil embolization for unruptured middle cerebral artery aneurysms: middle-term clinical and imaging outcomes with 3 years mean follow-up periods, a 16-year experience

Hanyu, T; Izumi, T; Tanei, T; Nishihori, M; Goto, S; Araki, Y; Yokoyama, K; Miyachi, S; Saito, R

NAGOYA JOURNAL OF MEDICAL SCIENCE 86 巻 ( 4 ) 頁： 596 - 607 2024年11月

記述言語：英語出版者・発行元：Nagoya Journal of Medical Science

The anatomical characteristics of middle cerebral artery aneurysms make endovascular treatment difficult. This study evaluated the efficacy and safety of endovascular treatment of unruptured middle cerebral artery aneurysm in preventing rupture. A retrospective review of patients who underwent coil embolization for unruptured middle cerebral artery aneurysm between 2006 and 2022 at Nagoya University Hospital with at least 12 months followed up was conducted. Imaging and clinical outcomes were described using the Raymond classification and the modified Rankin Scale, respectively. Good imaging outcome was defined as complete occlusion or neck remnant and clinical outcome as modified Rankin Scale score of 0–2. Patients were divided into initial and recurrent group based on the number of treatments, pre- and post-stent groups based on when stents became available in Japan. A total of 77 patients (80 with aneurysms) were included in the final analysis. Their average age was 60.3 years, and their average follow-up period was 38 months. Favorable clinical outcomes were achieved for 96.2% among 66 (97.0%) initial and 11 (91.7%) recurrent aneurysms. Furthermore, good imaging outcomes were obtained in 90.0 %, and 5% had permanent symptomatic ischemic complications. The pre-stent group had a significantly higher proportion of patients with narrow-neck aneurysms than the post-stent group. There were no significant differences in terms of imaging and clinical outcomes or complication rates. The present study demonstrated that endovascular treatment of unruptured middle cerebral artery aneurysm was safe and effective in preventing rupture. The wide-neck aneurysm was also well embolized by using adjunctive technique.

DOI： 10.18999/nagjms.86.4.596

Web of Science

Scopus

PubMed

1st passとしてのADAPTとステント併用テクニックの治療成績比較傾向スコアマッチングを用いたNagoya AIS registryの解析

後藤峻作, 西堀正洋, 石川晃司郎, 泉孝嗣, 村岡真輔, 鈴木啓太, 羽生健人, 高柳海, 川嵜裕一, 竹内一生, 齋藤竜太

日本脳神経血管内治療学会学術集会抄録集 40回巻頁： 945 - 945 2024年11月

小児・AYA世代脳腫瘍治療の最前線を知る小児・AYA世代脳腫瘍に対する外科治療

隈部俊宏, 柴原一陽, 金森政之, 齋藤竜太, 園田順彦, 遠藤英徳

日本小児血液・がん学会雑誌 61 巻 ( 3 ) 頁： 238 - 244 2024年11月

中枢性脳卒中後疼痛に対する脊髄刺激療法刺激法と治療効果の検討

種井隆文, 前澤聡, 西村由介, 永島吉孝, 石崎友崇, 武藤学, 伊藤芳記, 橋田美紀, 鈴木崇宏, 山本俊, 齋藤竜太

PAIN RESEARCH 39 巻 ( Suppl. ) 頁： S81 - S81 2024年11月

クラゾセンタンを軸とした脳動脈瘤破裂によるくも膜下出血の周術期管理に対するシロスタゾール上乗せ効果多施設後向き観察研究

竹内一生, 村岡真輔, 泉孝嗣, 西堀正洋, 後藤峻作, 羽生健人, 鈴木啓太, 高柳海, 川嵜裕一, 齋藤竜太

日本脳神経血管内治療学会学術集会抄録集 40回巻頁： 874 - 874 2024年11月

急性期脳主幹動脈閉塞症におけるRNF213迅速検査の有効性の検証

川嵜裕一, 泉孝嗣, 西堀正洋, 大岡史治, 金森史哲, 前田紗知, 後藤峻作, 鈴木啓太, 高柳海, 羽生健人, 竹内一生, 齋藤竜太

日本脳神経血管内治療学会学術集会抄録集 40回巻頁： 312 - 312 2024年11月

頭皮動静脈瘻に対して血管内治療を行った3例の報告

鈴木啓太, 泉孝嗣, 西堀正洋, 後藤峻作, 村岡真輔, 羽生健人, 川嵜裕一, 竹内一生, 齋藤竜太

日本脳神経血管内治療学会学術集会抄録集 40回巻頁： 988 - 988 2024年11月

術中破裂を回避する解離性椎骨動脈瘤における逆行性撮影法

西堀正洋, 一ノ瀬花奈, 中村匡徳, 泉孝嗣, 後藤峻作, 羽生健人, 鈴木啓太, 高柳海, 川嵜裕一, 竹内一生, 村岡真輔, 齋藤竜太

日本脳神経血管内治療学会学術集会抄録集 40回巻頁： 906 - 906 2024年11月

Dual phenotypes in recurrent astrocytoma, IDH-mutant; coexistence of IDH-mutant and IDH-wildtype components: a case report with genetic and epigenetic analysis 国際誌 Open Access

Yamaguchi, J; Ohka, F; Seki, M; Motomura, K; Deguchi, S; Shiba, Y; Okumura, Y; Kibe, Y; Shimizu, H; Maeda, S; Takido, Y; Yamamoto, R; Nakamura, A; Karube, K; Saito, R

ACTA NEUROPATHOLOGICA COMMUNICATIONS 12 巻 ( 1 ) 頁： 169 - 169 2024年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Acta Neuropathologica Communications

Mutations in the isocitrate dehydrogenase (IDH) gene are recognized as the key drivers in the oncogenesis of astrocytoma and oligodendroglioma. However, the significance of IDH mutation in tumor maintenance and malignant transformation has not been elucidated. We encountered a unique case of IDH-mutant astrocytoma that, upon malignant transformation, presented two distinct intratumoral components: one IDH-wildtype and one IDH-mutant. The IDH-wild-type component exhibited histological findings similar to those of small cell-type glioblastoma with a higher Ki-67 index than the IDH-mutant component. Despite their genetic divergence, both components exhibited similar comprehensive methylation profiles within the CpG island and were classified into methylation class of “Astrocytoma, IDH-mutant; High Grade” by the German Cancer Center (DKFZ) classifier v11.4. Phylogenetic analysis demonstrated that the IDH-wildtype component emerged as a subclonal component of the primary tumor. Detailed molecular analyses revealed that the loss of the IDH mutation was induced by the hemizygous loss of the entire arm of chromosome 2, on which IDH1 gene is located. Notably, the IDH-wild-type subclones uniquely acquired CDKN2A/B homozygous deletion and PDGFRA amplification, which is a marker of the aggressive phenotype of astrocytoma, IDH-mutant. Because these genetic abnormalities can drive oncogenic pathways, such as the PI3K/AKT/mTOR and RB signaling pathway, IDH-mutant gliomas that acquired these mutations were no longer dependent on the initial driver mutation, the IDH mutation. Molecular analysis of this unique case provides insight that in a subset of astrocytoma, IDH-mutant that acquired these genetic abnormalities, IDH mutation may not play a pivotal role in tumor growth and acquisition of these genetic abnormalities may contribute to the acquisition of resistance to IDH inhibitors.

DOI： 10.1186/s40478-024-01879-9

Recurrent symptomatic intracranial hemorrhage in high-grade astrocytoma with piloid features: illustrative case 査読有り国際誌 Open Access

Niwa, H; Kato, T; Hasegawa, T; Kuwabara, K; Ohka, F; Hirato, J; Sasaki, S; Ichimura, K; Yoshioka, T; Naito, T; Mizuno, A; Kageyama, A; Oishi, H; Saito, R

JOURNAL OF NEUROSURGERY-CASE LESSONS 8 巻 ( 15 ) 2024年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Neurosurgery Case Lessons

BACKGROUND High-grade astrocytoma with piloid features (HGAP) is a novel condition introduced in the 2021 World Health Organization classification. Given that it has been recently classified, reports clarifying its clinical features or diagnostic criteria are lacking, especially in cases of atypical presentation. Herein, the authors present a rare case of HGAP with repeated symptomatic hemorrhages. OBSERVATIONS A woman in her 20s presented with an acute headache and vertigo. Computed tomography and magnetic resonance imaging revealed a 2.5 × 2.8 × 2.3–cm hemorrhagic cerebellar mass with calcifications. After moderate improvement of her symptoms, she developed recurrent hemorrhage, and the tumor size increased (3.0 × 3.6 × 4.0 cm) 18 days later, necessitating resection. Pathological and molecular analyses confirmed the diagnosis of HGAP with an FGFR1-TACC1 fusion, MTAP/CDKN2A/B deletion, and SETD2 rearrangement. Radiologically, the presence of calcification and cystic components and the absence of perilesional edema were atypical features of previously reported HGAP. LESSONS Although recurrent symptomatic intracranial hemorrhages are rare in HGAP, enhancing lesions on magnetic resonance imaging suggest the need for resection to obtain tissue for molecular diagnosis and guide adjuvant treatment strategies.

DOI： 10.3171/CASE24395

Exo- and endoscopic two-step approach for meningeal tumours invading the lateral wall of large dural venous sinuses: how I do it 査読有り国際誌 Open Access

Iwami, K; Watanabe, T; Takeuchi, K; Saito, R

ACTA NEUROCHIRURGICA 166 巻 ( 1 ) 頁： 397 - 397 2024年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Acta Neurochirurgica

Background: Treating meningeal tumours invading the large dural venous sinuses is a subject of debate regarding the approach for removing the intra-sinus components. Additionally, directly observing the invasion site of tumours invading the lateral wall of the sinus is difficult. Method: We describe our exo- and endoscopic two-step approach (EETA): an exoscope is used to remove the extra-sinus component, while an endoscope is used to observe the invaded lateral wall and remove the intra-sinus component. Conclusion: EETA can be a viable option for treating meningeal tumours invading the venous sinus owing to its high resection rate and low invasiveness.

DOI： 10.1007/s00701-024-06298-2

Four-dimensional digital subtraction angiography for the vascular anatomical diagnosis of dural arteriovenous malformation: Comparison with the conventional method 国際誌 Open Access

Ishikawa, K; Nishihori, M; Izumi, T; Oshima, R; Uemura, T; Kanamori, F; Uda, K; Yokoyama, K; Araki, Y; Saito, R

INTERVENTIONAL NEURORADIOLOGY 30 巻 ( 5 ) 頁： 738 - 745 2024年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Interventional Neuroradiology

Background: Two-dimensional digital subtraction angiography (2D-DSA) and conventional three-dimensional digital subtraction angiography (3D-DSA) are used for the detailed analysis of dural arteriovenous fistula (DAVF). Recently, four-dimensional digital subtraction angiography (4D-DSA), a novel technology, has been attracting attention. The current study aimed to evaluate the capability of 4D-DSA in assessing anatomical angioarchitecture in DAVF. Methods: In total, 10 consecutive patients with DAVF who underwent 3D-DSA and 4D-DSA at a single institution were included in the analysis. Initially, one-slice multiplanar reconstruction (MPR) images obtained via 4D-DSA and 3D-DSA were compared to investigate the visibility of the feeding artery, fistulous point, and draining vein. Next, 4D-DSA images alone were compared and evaluated with and the MPR images of conventional 3D-DSA in terms of diagnosis of the angioarchitecture. Results: In total, six men and four women (with a mean age of 65.6 ± 10.0 years) were included in the study. The MPR image obtained via 3D-DSA had a significantly better visibility of the feeding artery and fistulous point than that acquired via 4D-DSA (p < 0.05). As for the draining vein, the score was equivalent and not significant. The diagnosis of the vascular architecture of only 4D-DSA images was nearly equivalent to that of MPR images of 3D-DSA. There were no inter-rater differences. Conclusion: The MPR images obtained via 4D-DSA may be slightly inferior to those acquired via 3D-DSA in identifying fine angioarchitecture in DAVF. However, they were comparable in terms of diagnostic accuracy.

DOI： 10.1177/15910199221145526

Novel case of ependymoma-like tumor with mesenchymal differentiation harboring <i>ZFTA</i>::<i>RELA</i> fusion in an adult 査読有り

Yajima, H; Takayanagi, S; Takami, H; Tanaka, S; Nomura, M; Satomi, K; Ikemura, M; Nobusawa, S; Saito, R; Kondo, A; Saito, N

BRAIN TUMOR PATHOLOGY 41 巻 ( 3-4 ) 頁： 139 - 144 2024年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Brain Tumor Pathology

High-grade supratentorial tumors harboring ZFTA::NCOA1/2 fusion in infants presenting with mixed histology of embryonal-appearing components resembling ependymoma and mesenchymal sarcomatous components have recently been reported as ependymoma-like tumors with mesenchymal differentiation (ELTMDs). In contrast, we describe herein a pathologically similar case with a novel ZFTA::RELA fusion in an adult. A frontal lobe lesion was resected from a 30-year-old woman and displayed mixed components on pathological examination, showing ependymoma-like and sarcomatous parts. The absence of perivascular pseudorosettes was inconsistent with a diagnosis of ependymoma. Fluorescence in situ hybridization analysis confirmed ZFTA::RELA fusion. The DKFZ methylation classifier (v12.8) did not categorize this case among established methylation classes. In addition, t-distributed stochastic neighbor embedding analysis using DNA methylation data revealed that the present case was distant from ependymomas but close to two previously reported cases of ELTMD involving ZFTA::NCOA1/2 fusion. Taken together, we concluded that this tumor should be considered under the entity of ELTMD. This represents the first description of an adult patient with ELTMD harboring ZFTA::RELA fusion analyzed by DNA methylation profiling, supporting the establishment of ELTMD as a possible new tumor type.

DOI： 10.1007/s10014-024-00489-6

<齋藤 竜太>

論文 - 齋藤 竜太

<齋藤　竜太>

論文 - 齋藤　竜太