研究者詳細 - 齋藤　竜太

論文 - 齋藤　竜太

分割表示 412 件中 361 - 380 件目／全件表示 >>

H3K27M and TERT promoter mutations are poor prognostic factors in surgical cases of adult thalamic high-grade glioma. 国際誌 Open Access

Osada Y, Saito R, Shibahara I, Sasaki K, Shoji T, Kanamori M, Sonoda Y, Kumabe T, Watanabe M, Tominaga T

Neuro-oncology advances 3 巻 ( 1 ) 頁： vdab038 2021年1月

覚醒下手術中痙攣発作コントロールにおけるレベチラセタム・ペランパネル併用療法の有効性について

本村和也, 齋藤竜太

神経治療学 38 巻 ( 6 ) 頁： S211 - S211 2021年

アクセス困難な硬膜動静脈瘻症例における，対側上錐体静脈洞を経由する上錐体静脈洞へのアプローチ Open Access

鈴木啓太, 西堀正洋, 泉孝嗣, 鈴木宰, 武藤学, 荒木芳生, 宇田憲司, 横山欣也, 齋藤竜太

脳血管内治療 6 巻 ( 3 ) 頁： 161 - 168 2021年

記述言語：日本語出版者・発行元：特定非営利活動法人日本脳神経血管内治療学会

【目的】多発硬膜動静脈瘻（dural arteriovenous fistula: DAVF）の症例において，左上錐体静脈洞部（superior petrosal sinus: SPS）のシャントを右 SPS 経由で塞栓した症例を報告する．【症例】60 歳女性，意識障害の精査にて深部静脈逆流を伴う多発 DAVF を認めた．逆流に最も関与する左横静脈洞部 DAVF に対して経静脈的塞栓術を施行した．術後症状改善が乏しく，再度DSA を行うと，左 SPS へのシャントと深部静脈への逆流が明らかとなった．左横静脈洞と両側下錐体静脈洞は閉塞していたため，右 SPS と両側海綿静脈洞を経由してマイクロカテーテルをシャント部へ誘導し，左 SPS を塞栓し，逆流の消失を得た．【結論】対側 SPS を経由した SPS へのアクセスは，同側からのアクセスが困難な症例において，有効な選択肢になり得る．

DOI： 10.20626/nkc.tn.2021-0009

Open Access

CiNii Research

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Corpus Callosum Swelling after Resection of Intraventricular Central Neurocytoma.

Aburakawa D, Kanamori M, Akashi T, Sato S, Saito R, Tominaga T

NMC case report journal 8 巻 ( 1 ) 頁： 535 - 543 2021年

Survival Benefit of Supratotal Resection in a Long-term Survivor of IDH-wildtype Glioblastoma: A Case Report and Literature Review. Open Access

Yamaguchi J, Motomura K, Ohka F, Aoki K, Tanahashi K, Hirano M, Chalise L, Nishikawa T, Shimizu H, Natsume A, Wakabayashi T, Saito R

NMC case report journal 8 巻 ( 1 ) 頁： 747 - 753 2021年

Management of Asymptomatic Vertebral Artery Injury Caused by a Cervical Pedicle Screw Malposition: Two Case Reports. Open Access

Otsuka T, Izumi T, Nishihori M, Tsukada T, Araki Y, Yokoyama K, Uda K, Goto S, Ikezawa M, Kato N, Nakano M, Saito R

NMC case report journal 8 巻 ( 1 ) 頁： 713 - 717 2021年

Postoperative Cervicothoracic Kyphosis Following Infantile Intramedullary Tumor Resection Accelerates Neurological Deterioration. Open Access

Gonda T, Nagashima Y, Nishimura Y, Ito H, Nisii T, Oyama T, Hara M, Saito R

NMC case report journal 8 巻 ( 1 ) 頁： 705 - 711 2021年

TERT promoter mutation confers favorable prognosis regardless of 1p/19q status in adult diffuse gliomas with IDH1/2 mutations 国際誌 Open Access

Hideyuki Arita, Yuko Matsushita, Ryunosuke Machida, Kai Yamasaki, Nobuhiro Hata, Makoto Ohno, Shigeru Yamaguchi, Takashi Sasayama, Shota Tanaka, Fumi Higuchi, Toshihiko Iuchi, Kuniaki Saito, Masayuki Kanamori, Ken ichiro Matsuda, Yohei Miyake, Kaoru Tamura, Sho Tamai, Taishi Nakamura, Takehiro Uda, Yoshiko Okita, Junya Fukai, Daisuke Sakamoto, Yasuhiko Hattori, Eriel Sandika Pareira, Ryusuke Hatae, Yukitomo Ishi, Yasuji Miyakita, Kazuhiro Tanaka, Shunsaku Takayanagi, Ryohei Otani, Tsukasa Sakaida, Keiichi Kobayashi, Ryuta Saito, Kazuhiko Kurozumi, Tomoko Shofuda, Masahiro Nonaka, Hiroyoshi Suzuki, Makoto Shibuya, Takashi Komori, Hikaru Sasaki, Masahiro Mizoguchi, Haruhiko Kishima, Mitsutoshi Nakada, Yukihiko Sonoda, Teiji Tominaga, Motoo Nagane, Ryo Nishikawa, Yonehiro Kanemura, Aya Kuchiba, Yoshitaka Narita, Koichi Ichimura

Acta Neuropathologica Communications 8 巻 ( 1 ) 頁： 201 - 201 2020年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

TERT promoter mutations are commonly associated with 1p/19q codeletion in IDH-mutated gliomas. However, whether these mutations have an impact on patient survival independent of 1p/19q codeletion is unknown. In this study, we investigated the impact of TERT promoter mutations on survival in IDH-mutated glioma cases. Detailed clinical information and molecular status data were collected for a cohort of 560 adult patients with IDH-mutated gliomas. Among these patients, 279 had both TERT promoter mutation and 1p/19q codeletion, while 30 had either TERT promoter mutation (n = 24) or 1p/19q codeletion (n = 6) alone. A univariable Cox proportional hazard analysis for survival using clinical and genetic factors indicated that a Karnofsky performance status score (KPS) of 90 or 100, WHO grade II or III, TERT promoter mutation, 1p/19q codeletion, radiation therapy, and extent of resection (90–100%) were associated with favorable prognosis (p < 0.05). A multivariable Cox regression model revealed that TERT promoter mutation had a significantly favorable prognostic impact (hazard ratio = 0.421, p = 0.049), while 1p/19q codeletion did not have a significant impact (hazard ratio = 0.648, p = 0.349). Analyses incorporating patient clinical and genetic information were further conducted to identify subgroups showing the favorable prognostic impact of TERT promoter mutation. Among the grade II-III glioma patients with a KPS score of 90 or 100, those with IDH-TERT co-mutation and intact 1p/19q (n = 17) showed significantly longer survival than those with IDH mutation, wild-type TERT, and intact 1p/19q (n = 185) (5-year overall survival, 94% and 77%, respectively; p = 0.032). Our results demonstrate that TERT promoter mutation predicts favorable prognosis independent of 1p/19q codeletion in IDH-mutated gliomas. Combined with its adverse effect on survival among IDH-wild glioma cases, the bivalent prognostic impact of TERT promoter mutation may help further refine the molecular diagnosis and prognostication of diffuse gliomas.

DOI： 10.1186/s40478-020-01078-2

A multinodular and vacuolating neuronal tumor in the right temporal lobe with positive methionine uptake: A case report Open Access

Taketo Nishizawa, Ryuta Saito, Masashi Chonan, Masayuki Kanamori, Kentaro Takanami, Mika Watanabe, Teiji Tominaga

Interdisciplinary Neurosurgery: Advanced Techniques and Case Management 22 巻 2020年12月

掲載種別：研究論文（学術雑誌）

Multinodular and vacuolating neuronal tumor (MVNT) is a recently recognized type of neural tumor that was first documented in 2013. This tumor type is characterized by multiple nodules of neuronal cells with vacuolar degeneration localized in the subcortical white matter. Here, we report a case of MVNT in the right temporal lobe of a 26-year-old female. Magnetic resonance imaging (MRI) revealed a high-intensity lesion on a T2- weighted image of the right temporal lobe without contrast enhancement. Positron emission tomography revealed increased 11C-methionine uptake in the lesion, which was pathologically diagnosed as MVNT.

DOI： 10.1016/j.inat.2020.100861

Open Access

Scopus

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がん遺伝子パネル検査でSMARCB1変異を認め、INI-1蛋白陽性のAT/RTと考えられた一例(Clinical sequencing revealed two distinct mutations in SMARCB1, in an INI-1 positive AT/RT)

Kaino Akira, Niizuma Hidetaka, Moriya Kunihiko, Katayama Saori, Irie Masahiro, Rikiishi Takeshi, Saito Ryuta, Kanamori Masayuki, Sasahara Yoji, Kure Shigeo

日本小児血液・がん学会雑誌 57 巻 ( 4 ) 頁： 245 - 245 2020年10月

Orengedokuto and shosaikoto for intractable intracranial carmustine implant-induced fever in a patient with brain tumor: A case report. 国際誌 Open Access

Suzuki S, Takayama S, Kikuchi A, Arita R, Abe M, Saito R, Kanamori M, Tominaga T, Ishii T

Explore (New York, N.Y.) 17 巻 ( 3 ) 頁： 236 - 238 2020年8月

視床高悪性度神経膠腫におけるヒストン変異と予後についての検討

長田佳整, 齋藤竜太, 庄司拓大, 長南雅志, 柴原一陽, 金森政之, 園田順彦, 隈部俊宏, 渡邉みか, 冨永悌二

Brain Tumor Pathology 37 巻 ( Suppl. ) 頁： 130 - 130 2020年8月

IDH変異型膠芽腫自験連続9例の検討

齋藤竜太, 長田佳整, 柴原一陽, 金森政之, 園田順彦, 隈部俊宏, 渡辺みか, 冨永悌二

Brain Tumor Pathology 37 巻 ( Suppl. ) 頁： 092 - 092 2020年8月

Frequent Clinical and Radiological Progression of Optic Pathway/Hypothalamic Pilocytic Astrocytoma in Adolescents and Young Adults. 査読有り Open Access

Shoji T, Kanamori M, Saito R, Watanabe Y, Watanabe M, Fujimura M, Ogawa Y, Sonoda Y, Kumabe T, Kure S, Tominaga T

Neurologia medico-chirurgica 60 巻 ( 6 ) 頁： 277 - 285 2020年5月

Regression of Recurrent Spinal Cord High-Grade Glioma After Convection-Enhanced Delivery of Nimustine Hydrochloride: Case Reports and Literature Review. 国際誌

Endo T, Inoue T, Sugiyama S, Saito R, Tominaga T

Operative neurosurgery (Hagerstown, Md.) 18 巻 ( 4 ) 頁： 451 - 459 2020年4月

髄芽腫の放射線療法中に合併した難治性ITPに対し,rituximabが奏功した一例

戒能明, 新妻秀剛, 入江正寛, 片山紗乙莉, 森谷邦彦, 力石健, 齋藤竜太, 金森政之, 笹原洋二, 呉繁夫

日本小児科学会雑誌 124 巻 ( 2 ) 頁： 321 - 321 2020年2月

髄芽腫の放射線療法中に合併した難治性ITPに対し,rituximabが奏功した一例

戒能明, 新妻秀剛, 入江正寛, 片山紗乙莉, 森谷邦彦, 力石健, 齋藤竜太, 金森政之, 笹原洋二, 呉繁夫

日本小児科学会雑誌 124 巻 ( 2 ) 頁： 321 - 321 2020年2月

Phase I trial of convection-enhanced delivery of nimustine hydrochloride (ACNU) for brainstem recurrent glioma. 国際誌 Open Access

Saito R, Kanamori M, Sonoda Y, Yamashita Y, Nagamatsu K, Murata T, Mugikura S, Kumabe T, Wembacher-Schröder E, Thomson R, Tominaga T

Neuro-oncology advances 2 巻 ( 1 ) 頁： vdaa033 2020年1月

TERT promoter mutation associated with multifocal phenotype and poor prognosis in patients with IDH wild-type glioblastoma. 国際誌 Open Access

Kikuchi Z, Shibahara I, Yamaki T, Yoshioka E, Shofuda T, Ohe R, Matsuda KI, Saito R, Kanamori M, Kanemura Y, Kumabe T, Tominaga T, Sonoda Y

Neuro-oncology advances 2 巻 ( 1 ) 頁： vdaa114 2020年1月

Cystic Glioblastoma Rupturing into the Ventricle.

Yoshimichi Sato, Ryuta Saito, Masayuki Kanamori, Teiji Tominaga

NMC case report journal 7 巻 ( 1 ) 頁： 39 - 41 2020年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

Cystic tumors, such as craniopharyngiomas and Rathke's cleft cysts, as well as arachnoid cysts have been reported to rupture occasionally. Approximately 8-10% of glioblastomas (GBMs) are known to have a significant cystic component; however, to the best of our knowledge, no studies have reported cystic rupturing of GBMs. Here, we describe a unique case of cystic GBM rupturing and penetrating into the cerebral ventricle. A 77-year-old man with a right frontal lobe lesion suspected as GBM with a large cyst was referred to our hospital. At admission, disorientation and left facial weakness were detected. Consciousness disturbance worsened on the 8th day of hospitalization. Computed tomography (CT) revealed prominent shrinkage of the tumor and intratumoral cyst. Signs of meningeal irritation were observed, and chemical meningitis due to cystic tumor rupture and leakage of necrotic components into the ventricle was highly suspected. Surgical resection of the right frontal lobe tumor was performed on the 10th day of hospitalization. During the surgery, clear and colorless cerebrospinal fluid was obtained upon penetration of the tumoral cyst, suggesting traffic of tumor cysts and cerebral ventricle. Adjuvant chemoradiation therapy was initiated postoperatively. Local recurrence was noted at the corpus callosum 7 months postoperatively and was treated with a gamma knife. Further therapy was performed after this recurrence. However, his condition gradually deteriorated 15 months postoperatively, and he was subjected to terminal care. To the best of our knowledge, this is the first report on a cystic GBM rupture.

DOI： 10.2176/nmccrj.cr.2019-0043

PubMed

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