研究者詳細 - 齋藤　竜太

論文 - 齋藤　竜太

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Favorable seizure and developmental outcomes without preoperative intracranial electroencephalography in pediatric patients following epilepsy surgery: A single epilepsy center retrospective study 国際誌

Okumura, T; Usui, N; Kondo, A; Ogawa, H; Hashiguchi, M; Kuromi, Y; Yamaguchi, T; Otani, H; Imai, K; Ishizaki, T; Tanei, T; Maesawa, S; Saito, R

EPILEPSIA 66 巻 ( 4 ) 頁： 1084 - 1096 2025年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Epilepsia

Objective: At our institute, most pediatric patients undergo epilepsy surgery following a thorough presurgical evaluation without intracranial electroencephalography (EEG). We conducted an initial validation of our noninvasive presurgical strategy by assessing the seizure and developmental outcomes of 135 children. Methods: All 135 pediatric patients were <15 years old, had undergone curative surgery, and were followed for at least 2 years postoperatively. Presurgical evaluations and postoperative seizure and developmental outcomes were investigated. Thorough noninvasive evaluation included 3-T magnetic resonance imaging (MRI) and fluorodeoxyglucose positron emission tomography (FDG-PET) in all patients. Intracranial EEG was mainly indicated for patients whose MRIs were negative or subtle. We defined Engel class I as favorable and Engel classes II–IV as unfavorable seizure outcomes. Intelligence quotient (IQ) and developmental quotient (DQ) before and 2 years after surgery were used to assess developmental/neuropsychological outcomes. Results: MRI was positive in 130 of 135 patients (96.3%), including 39 of 40 with focal cortical dysplasia (FCD) type II and 30 of 33 with FCD type I. FDG-PET revealed concordant localizing findings in 119 of 132 patients (90.2%). Ictal single photon emission computed tomography provided concordant localizing information in 85 of 91 patients (93.4%). Intracranial EEG was performed in only 10 of 135 patients (7.4%). Ninety-seven of 135 patients (71.9%) were seizure-free 2 years after surgery. The final seizure-free rate was 99 of 135 (73.3%). Temporal lobe surgery predicted a favorable seizure outcome by multivariate analysis, whereas FCD type I and preoperative IQ/DQ < 70 predicted an unfavorable outcome. The mean IQ change was +1.3 points, and the mean DQ change was +1.0 points. Mean DQ significantly improved following extratemporal surgery (multivariate regression, p <.05), and mean DQ significantly decreased in patients with epileptic spasms (multivariate regression, p <.01). Significance: Thorough noninvasive presurgical evaluation enables detection of subtle MRI lesions and curative epilepsy surgery without intracranial EEG in most patients, including those with FCD type II and type I, and leads to favorable seizure and developmental/neuropsychological outcomes.

DOI： 10.1111/epi.18249

Spontaneous Shrinkage of isocitrate dehydrogenase (IDH)-mutant astrocytoma caused by intra-tumoural cyst rupture: a case report 査読有り国際誌

Suzuki, R; Kanamori, M; Saito, R; Shimoda, Y; Watanabe, M; Tominaga, T

BRITISH JOURNAL OF NEUROSURGERY 39 巻 ( 2 ) 頁： 246 - 250 2025年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：British Journal of Neurosurgery

Background: T2-fluid-attenuated inversion recovery (FLAIR) mismatch sign is a specific imaging finding of isocitrate dehydrogenase (IDH)-mutant astrocytomas. Histologically, a hypointense area on FLAIR images indicates the presence of microcysts. Here we report a case of IDH-mutant astrocytoma that shrunk spontaneously. Case description: A 26-year-old woman presented with a complaint of headache. Her magnetic resonance (MR) images revealed a lesion mass with a T2-FLAIR mismatch sign in the left frontal lobe. Subsequently, after 1 month, she was referred to our department, and we found that the lesion had unexpectedly shrunk; however, no further shrinkage was observed in the next 3 months. Furthermore, a biopsy was performed, and the results indicated a diagnosis of astrocytoma, IDH-mutant CNS WHO grade 3. Thus, she underwent subtotal resection. We found no neurological deficits in the patient, and she received 60 Gy of radiotherapy at the local site and chemotherapy with nimustine hydrochloride (ACNU), followed by the administration of ACNU every 8 weeks for 2 years. Overall, after 36 months of tumour resection, she was in good health and exhibited no recurrence. Notably, her histological and MR image findings suggested that the macroscopic cyst was formed by the fusion of microcysts, which is a characteristic feature of IDH-mutant astrocytoma with a T2-FLAIR mismatch sign, and that the tumour shrunk because of the rupture of the cyst in the Sylvian cistern. Conclusion: The present case report suggests that IDH-mutant astrocytoma cannot be ruled out even when the lesion shrinks spontaneously.

DOI： 10.1080/02688697.2023.2170328

Superselective Angiography of Vasa Vasorum Within Partially Thrombosed Vertebral Aneurysm: A Case Report. 査読有り国際誌

Kawasaki Y, Izumi T, Nishihori M, Goto S, Araki Y, Yokoyama K, Saito R

Neurosurgery 96 巻 ( 3 ) 頁： e52 - e57 2025年3月

Comparison of Early-onset Efficacy of Anti-calcitonin Gene-related Peptide Monoclonal Antibodies for Patients with Migraine in Real-world Clinical Practice: Study Protocol for an Exploratory Clinical Trial

Tanei, T; Maesawa, S; Nishimura, Y; Ishizaki, T; Nagashima, Y; Hashida, M; Yamamoto, S; Ando, M; Kuwatsuka, Y; Hashizume, A; Wakabayashi, T; Saito, R

NEUROLOGIA MEDICO-CHIRURGICA 65 巻 ( 2 ) 頁： 71 - 80 2025年2月

Postoperative fragmentation and distal migration of Carotid Stent in vascular Eagle Syndrome☆

Nishihori, M; Izumi, T; Goto, S; Muraoka, S; Kogame, H; Saito, R

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES 34 巻 ( 2 ) 頁： 108202 2025年2月

Hemorrhagic complication due to vascular side branch injury from a distant site in stereoelectroencephalography: A case report and proposed rules for safer electrode implantation.

Suzuki T, Ishizaki T, Maesawa S, Hashida M, Ito Y, Tanei T, Saito R

Seizure 125 巻頁： 50 - 53 2025年2月

Evaluation of mild cognitive impairment in older patients with essential tremor 国際誌

Hashida, M; Maesawa, S; Mizuno, S; Kato, S; Ito, Y; Mutoh, M; Suzuki, T; Ishizaki, T; Tanei, T; Tsuboi, T; Suzuki, M; Nakatsubo, D; Tsugawa, T; Bagarinao, E; Wakabayashi, T; Katsuno, M; Saito, R

PARKINSONISM & RELATED DISORDERS 131 巻頁： 107228 - 107228 2025年2月

Residual Pattern of the Hyperintense Area on T2-Weighted Magnetic Resonance Imaging After Initial Treatment Predicts the Pattern and Location of Recurrence in Patients with Newly Diagnosed Glioblastoma 査読有り国際誌

Shimoda, Y; Kanamori, M; Yamashita, S; Shibahara, I; Umezawa, R; Mugikura, S; Jingu, K; Saito, R; Sonoda, Y; Kumabe, T; Endo, H

WORLD NEUROSURGERY 193 巻頁： 517 - 532 2025年1月

Endoscopic Cystoventricular Stenting in Awake Patients with Electrical Stimulation Mapping for Convexity Cysts: Three Case Reports and a Systematic Review 査読有り国際誌

Okumura, E; Takeuchi, K; Nagata, Y; Iwami, K; Motomura, K; Ohka, F; Sato, Y; Hirose, T; Saito, R

WORLD NEUROSURGERY 193 巻頁： 108 - 118 2025年1月

Efficacy and safety of carmustine wafers, followed by radiation, temozolomide, and bevacizumab therapy, for newly diagnosed glioblastoma with maximal resection

Kanamori, M; Shibahara, I; Shimoda, Y; Akiyama, Y; Beppu, T; Ohba, S; Enomoto, T; Ono, T; Mitobe, Y; Hanihara, M; Mineharu, Y; Ishida, J; Asano, K; Yoshida, Y; Natsumeda, M; Nomura, S; Abe, T; Yonezawa, H; Katakura, R; Shibui, S; Kuroiwa, T; Suzuki, H; Takei, H; Matsushita, H; Saito, R; Arakawa, Y; Sonoda, Y; Hirose, Y; Kumabe, T; Yamaguchi, T; Endo, H; Tominaga, T

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY 30 巻 ( 1 ) 頁： 51 - 61 2025年1月

特集頸椎神経根症再考頸椎神経根症に対する頸椎前方固定術

西村由介, 永島吉孝, 齋藤竜太

脊椎脊髄ジャーナル 37 巻 ( 11 ) 頁： 993 - 1000 2024年12月

脳内血腫を生じた外傷性中硬膜動脈仮性動脈瘤の１例

石川晃司郎, 若林健一, 大人正人, 水野翔平, 家永惇平, 川口知己, 中村茂和, 種井隆文, 齋藤竜太

神経外傷 47 巻 ( 2 ) 頁： 94 - 100 2024年12月

A multi-center, open-label, randomized clinical trial evaluating the preventive effect of perampanel on craniotomy-induced epileptogenesis in seizure-naive patients with supratentorial brain tumors: study protocol for a GRAMPAS trial 国際誌 Open Access

Yamaguchi, J; Ohka, F; Motomura, K; Ishizaki, T; Nakahara, N; Fujitani, S; Nagatani, T; Ohno, M; Ando, M; Kuwatsuka, Y; Nishida, K; Saito, R

TRIALS 25 巻 ( 1 ) 頁： 849 - 849 2024年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Trials

Background: Early seizures after craniotomy are significant perioperative complications that can adversely impact patient outcomes. Despite current guidelines advising against the routine use of antiseizure drugs for seizure after craniotomy prevention due to limited efficacy data, many clinicians continue prescribing them. This discrepancy highlights the need for robust evidence to guide clinical practice. This multi-center, randomized clinical trial was designed to investigate the efficacy of perampanel in preventing early seizures after craniotomy. Method: This multi-center, open-label, randomized clinical trial will be conducted across five hospitals in Nagoya, Japan, from February 2024 to December 2026. A total of 142 seizure-naive patients with supratentorial brain tumors will be recruited and randomized (1:1) into the treatment and control groups. The treatment group will receive 2 mg of perampanel starting 2 days preoperatively and continuing for 28 days postoperatively, while the control group will receive no antiseizure drugs. The primary outcome is the incidence of seizures within 28 days after craniotomy. Secondary outcomes are length of hospital and intensive care unit stays and postoperative complications. Discussion: This study addresses the critical need for evidence-based recommendations regarding antiseizure drug use for preventing early seizures after craniotomy. As the first multi-center, randomized trial evaluating perampanel’s efficacy in this setting, the findings may significantly influence clinical guidelines and perioperative practices. Trial registration: This trial was registered with the Japan Registry of Clinical Trials (approval number: jRCTs041230117) on December 18, 2023, a member of the Primary Registry Network of the World Health Organization’s International Clinical Trials Registry Platform.

DOI： 10.1186/s13063-024-08693-7

Isolation of ependymal cilia from mouse brain( vol 409, 110198, 2024) 査読有り

Mizuno, A; Takeuchi, K; Nagata, Y; Harada, H; Yamamoto, T; Ishikawa, T; Maeda, S; Ohka, F; Ueno, H; Saito, R

JOURNAL OF NEUROSCIENCE METHODS 412 巻頁： 110293 2024年12月

記述言語：英語出版者・発行元：Journal of Neuroscience Methods

The authors regret that the affiliation information was incomplete in the original article. The correct and complete affiliation information should be as follows: Akihiro Mizunoa,b a Department of Neurosurgery, Komaki City Hospital, Aichi, Japan b Department of Neurosurgery, Nagoya University, Nagoya, Japan This research was conducted while the author was affiliated with Nagoya University. The addition of this affiliation is important for accurately reflecting the research context. The authors would like to apologize for any inconvenience caused.

DOI： 10.1016/j.jneumeth.2024.110293

Web of Science

Scopus

PubMed

Femoral Nerve Injury After Prone-Position Lumbar Discectomy: A Case Report Highlighting the Role of Ultrasound in Recovery Monitoring.

Matsuo M, Nagashima Y, Nishimura Y, Saito R

Cureus 16 巻 ( 12 ) 頁： e76653 2024年12月

Regression of bilateral persistent primitive ophthalmic artery: a case report

Takeuchi, I; Izumi, T; Nishihori, M; Goto, S; Hanyu, T; Suzuki, K; Takayanagi, K; Kawasaki, Y; Saito, R

SURGICAL AND RADIOLOGIC ANATOMY 47 巻 ( 1 ) 頁： 42 2024年12月

Prognosis and Treatment Effectiveness of Austrian Syndrome: A Case Report and Systematic Review.

Fukui T, Muraoka S, Asai T, Nisizawa T, Araki Y, Saito R

Cureus 16 巻 ( 12 ) 頁： e74971 2024年12月

Real-world clinical results of CGRP monoclonal antibody treatment for medication overuse headache of migraine without abrupt drug discontinuation and no hospitalization. 国際誌 Open Access

Tanei T, Fuse Y, Maesawa S, Nishimura Y, Ishizaki T, Nagashima Y, Mutoh M, Ito Y, Hashida M, Suzuki T, Yamamoto S, Wakabayashi T, Saito R

Heliyon 10 巻 ( 22 ) 頁： e40190 2024年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Heliyon

Background: Abrupt discontinuation of overused medications is standard treatment for medication overuse headache (MOH), but discontinuation is difficult to maintain. The aim was to evaluate the real-world clinical results of anti-calcitonin gene-related peptide monoclonal antibody (CGRP-mAb) treatment for migraine with MOH without abrupt drug discontinuation and no hospitalization. Methods: Data were collected before starting CGRP-mAb injections (baseline) and 1 month after each injection. The following items were compared between baseline and after the first, second, and third CGRP-mAb injections, monthly headache days (MHD), monthly migraine days (MMD), monthly acute medication use (AMU) days, monthly total amount of AMU tablets, headache impact test-6 (HIT-6), and the migraine-specific quality of life questionnaire (MSQ). Achieving reduction rates ≥50 % in the frequency of each headache and migraine was defined as a good response. Achieving reduction rates of both AMU days and tablets ≥50 % was defined as effective in reducing AMU. Results: This study included 33 patients with migraine with MOH. After the third CGRP-mAb injection, MHD and MMD were significantly decreased from median 30.0 to 9.5 days, and 10.0 to 1.5 days, respectively. In addition, monthly AMU days and tablets were significantly decreased from median 28.0 to 8.0 days, and 30.0 to 9.5 tablets, respectively. After the third CGRP-mAb injection, the good MHD and MMD responder rates were 75.0 % and 85.7 %, respectively. The rate of reducing AMU was 78.6 %. HIT-6 and MSQ scores decreased significantly from baseline to after each CGRP-mAb injection. Conclusions: When CGRP-mAb was administered to migraine with MOH, frequency of headache symptoms and AMU were reduced without abrupt drug discontinuation and no hospitalization.

DOI： 10.1016/j.heliyon.2024.e40190

Image-based Re-evaluation of the JCOG0911 Study Focusing on Tumor Volume and Survival, Disease Progression Diagnosis, and Radiomic Prognostication for Newly Diagnosed Glioblastoma

Kinoshita, M; Fushimi, Y; Masumoto, T; Sasaki, K; Sekita, T; Natsume, A; Wakabashi, T; Komori, T; Tsuzuki, S; Muragaki, Y; Motomura, K; Saito, R; Sato, K; Beppu, T; Takahashi, M; Kuroda, JI; Sonoda, Y; Kobayashi, K; Mishima, K; Mitsuya, K; Yamasaki, F; Inoue, A; Matsutani, T; Nakamura, H; Yamaguchi, S; Ishikawa, E; Nakaya, M; Tanaka, S; Ujifuku, K; Uchida, H; Kanamori, M; Otani, R; Kijima, N; Nishida, N; Yoshino, A; Mineharu, Y; Arakawa, Y; Fukuda, H; Narita, Y

MAGNETIC RESONANCE IN MEDICAL SCIENCES advpub 巻 ( 0 ) 2024年11月

DIAGNOSIS AND TREATMENT OF BRAIN TUMORS USING METHIONINE PET

Shiba, Y; Maeda, S; Yamaguchi, J; Deguchi, S; Ohka, F; Saito, R

NEURO-ONCOLOGY 26 巻 2024年11月

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