Faculty Profiles - OGURA Atsushi

Papers - OGURA Atsushi

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骨盤内巨大Solitary fibrous tumorの2例

神原祐一, 上原圭, 小倉淳司, 村田悠記, 三品拓也, 小池佳勇, 西村元伸, 伊神剛, 水野隆史, 山口淳平, 宮田一志, 尾上俊介, 渡辺伸元, 横山幸浩, 江畑智希

日本臨床外科学会雑誌 Vol. 82 ( 増刊 ) page： S673 - S673 2021.10

進行直腸癌に対する集学的治療 Total Neoadjuvant Therapyを見据えた、進行直腸癌に対する術前化学療法の治療奏効予測因子の検討

三品拓也, 上原圭, 小倉淳司, 村田悠記, 小池佳勇, 神原祐一, 西村元伸, 伊神剛, 水野隆史, 山口淳平, 宮田一志, 尾上俊介, 渡辺伸元, 横山幸浩, 江畑智希

日本臨床外科学会雑誌 Vol. 82 ( 増刊 ) page： S343 - S343 2021.10

腹腔鏡下仙骨合併腫瘍切除を施行した骨盤内巨大神経鞘腫の一例

西村元伸, 上原圭, 小倉淳司, 服部憲史, 中山吾郎, 國料俊男, 伊神剛, 水野隆史, 山口淳平, 宮田一志, 尾上俊介, 渡辺伸元, 横山幸浩, 小寺泰弘, 江畑智希

日本臨床外科学会雑誌 Vol. 82 ( 増刊 ) page： S932 - S932 2021.10

胆道癌肝切除における門脈切除・再建

江畑智希, 水野隆史, 尾上俊介, 渡辺伸元, 伊神剛, 山口淳平, 上原圭, 宮田一志, 砂川真輝, 小倉淳司, 國料俊男, 横山幸浩

日本臨床外科学会雑誌 Vol. 82 ( 増刊 ) page： S503 - S503 2021.10

肝門部領域胆管癌における膵内胆管の切除法 PDを避ける工夫

渡辺伸元, 水野隆史, 尾上俊介, 横山幸浩, 國料俊男, 伊神剛, 上原圭, 山口淳平, 宮田一志, 砂川真輝, 小倉淳司, 江畑智希

日本臨床外科学会雑誌 Vol. 82 ( 増刊 ) page： S503 - S503 2021.10

肝十二指腸間膜の定型的リンパ節郭清

水野隆史, 尾上俊介, 渡辺伸元, 横山幸浩, 伊神剛, 山口淳平, 砂川正輝, 國料敏男, 上原圭, 宮田一志, 小倉淳司, 江畑智希

日本臨床外科学会雑誌 Vol. 82 ( 増刊 ) page： S502 - S502 2021.10

Local recurrences in western low rectal cancer patients treated with or without lateral lymph node dissection after neoadjuvant (chemo)radiotherapy: An international multi-centre comparative study. International journal

Hidde M Kroon, Songphol Malakorn, Nagendra N Dudi-Venkata, Sergei Bedrikovetski, Jianliang Liu, Tim Kenyon-Smith, Brian K Bednarski, Atsushi Ogura, Cornelis J H van de Velde, Harm J T Rutten, Geerard L Beets, Michelle L Thomas, Miranda Kusters, George J Chang, Tarik Sammour

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology Vol. 47 ( 9 ) page： 2441 - 2449 2021.9

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: In the West, low rectal cancer patients with abnormal lateral lymph nodes (LLNs) are commonly treated with neoadjuvant (chemo)radiotherapy (nCRT) followed by total mesorectal excision (TME). Additionally, some perform a lateral lymph node dissection (LLND). To date, no comparative data (nCRT vs. nCRT + LLND) are available in Western patients. METHODS: An international multi-centre cohort study was conducted at six centres from the Netherlands, US and Australia. Patients with low rectal cancers from the Netherlands and Australia with abnormal LLNs (≥5 mm short-axis in the obturator, internal iliac, external iliac and/or common iliac basin) who underwent nCRT and TME (LLND-group) were compared to similarly staged patients from the US who underwent a LLND in addition to nCRT and TME (LLND + group). RESULTS: LLND + patients (n = 44) were younger with higher ASA-classifications and ypN-stages compared to LLND-patients (n = 115). LLND + patients had larger median LLNs short-axes and received more adjuvant chemotherapy (100 vs. 30%; p < 0.0001). Between groups, the local recurrence rate (LRR) was 3% for LLND + vs. 11% for LLND- (p = 0.13). Disease-free survival (DFS, p = 0.94) and overall survival (OS, p = 0.42) were similar. On multivariable analysis, LLND was an independent significant factor for local recurrences (p = 0.01). Sub-analysis of patients who underwent long-course nCRT and had adjuvant chemotherapy (LLND-n = 30, LLND + n = 44) demonstrated a lower LRR for LLND + patients (3% vs. 16% for LLND-; p = 0.04). DFS (p = 0.10) and OS (p = 0.11) were similar between groups. CONCLUSION: A LLND in addition to nCRT may improve loco-regional control in Western patients with low rectal cancer and abnormal LLNs. Larger studies in Western patients are required to evaluate its contribution.

DOI： 10.1016/j.ejso.2021.06.004

Web of Science

Scopus

PubMed

会陰部に広範に自壊した局所再発直腸粘液癌に対し、仙骨合併骨盤内臓全摘術+複数の筋皮弁再建を施行し、R0切除を達成し得た一例

神原祐一, 上原圭, 小倉淳司, 村田悠記, 三品拓也, 小池佳勇, 鈴木優美, 西村元伸, 伊神剛, 水野隆史, 山口淳平, 宮田一志, 尾上俊介, 渡辺伸元, 佐藤雄介, 服部憲史, 中山吾郎, 横山幸浩, 小寺泰弘, 江畑智希

日本大腸肛門病学会雑誌 Vol. 74 ( 9 ) page： A204 - A204 2021.9

当科におけるBRAF V600E変異陽性大腸癌に対するBRAF阻害剤併用療法の使用経験

神野孝徳, 上原圭, 小倉淳司, 村田悠記, 三品拓也, 小池佳勇, 神原祐一, 鈴木優美, 西村元伸, 伊神剛, 水野隆史, 山口淳平, 宮田一志, 尾上俊介, 渡辺伸元, 服部憲史, 中山吾郎, 横山幸浩, 小寺泰弘, 江畑智希

日本大腸肛門病学会雑誌 Vol. 74 ( 9 ) page： A208 - A208 2021.9

結腸癌腹膜播種に対する外科切除の意義

三品拓也, 上原圭, 小倉淳司, 村田悠記, 小池佳勇, 鈴木優美, 神原祐一, 西村元伸, 伊神剛, 水野隆史, 山口淳平, 宮田一志, 尾上俊介, 渡辺伸元, 佐藤雄介, 服部憲史, 中山吾郎, 横山幸浩, 小寺泰弘, 江畑智希

日本大腸肛門病学会雑誌 Vol. 74 ( 9 ) page： A209 - A209 2021.9

当科における局所進行結腸癌に対する術前化学療法の臨床経験

小倉淳司, 上原圭, 小池佳勇, 村田悠記, 神野孝徳, 鈴木優美, 三品拓也, 神原祐一, 西村元伸, 伊神剛, 水野隆史, 山口淳平, 宮田一志, 尾上俊介, 渡辺伸元, 服部憲史, 中山吾郎, 横山幸浩, 小寺泰弘, 江畑智希

日本大腸肛門病学会雑誌 Vol. 74 ( 9 ) page： A200 - A200 2021.9

The carcinoembryonic antigen ratio is a potential predictor of survival in recurrent colorectal cancer.

Yumi Suzuki, Atsushi Ogura, Kay Uehara, Toshisada Aiba, Noriaki Ohara, Yuki Murata, Takanori Jinno, Takuya Mishina, Yusuke Sato, Norifumi Hattori, Goro Nakayama, Yasuhiro Kodera, Tomoki Ebata

International journal of clinical oncology Vol. 26 ( 7 ) page： 1264 - 1271 2021.7

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The carcinoembryonic antigen (CEA) "value" itself is often useless in patients with a normal CEA level at initial presentation and those with tumor-irrelevant elevated CEA. Although the unified marker using CEA has been desirable for recurrent tumor staging as well as for primary tumor staging, little is known concerning its relationship with the survival of patients with recurrent colorectal cancer in particular. METHODS: This retrospective historical study included patients who experienced disease relapse after curative surgery for stage I-III colorectal cancer between 2006 and 2018. A total of 129 patients with recurrent disease after curative surgery for colorectal cancer were included. We focused on the CEA "ratio" (CEA-R: the ratio of the CEA level at the time of recurrence to that measured 3 months before recurrence) and aimed to evaluate the correlation between CEA-R and survival in recurrent colorectal cancer. RESULTS: Patients with a high CEA-R (≥ 2) exhibited significantly worse 2 year survival than those with a low CEA-R (< 2) (88.1% vs. 44.9%, P < 0.001), irrespective of the CEA value before primary resection. Multivariate analyses demonstrated that the CEA-R (HR; 3.270, 95% CI 1.646-6.497, P = 0.001) was a significant prognostic factor. CONCLUSION: The CEA-R is a potential marker stratifying the survival of patients with disease relapse who exhibit aggressive biology at recurrent disease foci. As a novel marker, the CEA-R would serve as a clinical guide for tailoring treatment strategies at the time of disease relapse in patients with colorectal cancer.

DOI： 10.1007/s10147-021-01919-7

Web of Science

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PubMed

Transanal lateral pelvic lymph node dissection

Vol. 76 ( 5 ) page： 596 - 602 2021.5

特集専門医必携新外科手術書-新しい手術手技のエッセンス IV. 大腸 5.剝離層を意識した腹腔鏡下低位前方切除術の手術手技

小倉淳司, 上原圭, 相場利貞, 村田悠記, 江畑智希

外科 Vol. 83 ( 5 ) page： 506 - 512 2021.4

Laparoscopic surgery for sigmoid colon cancer with complicated communication between the superior and inferior mesenteric arteries. Reviewed

Ryutaro Kobayashi, Atsushi Ogura, Satoru Kawai, Kenji Takagi, Kiyotaka Kawai, Takashi Maeda, Masanori Sando, Konosuke Yogo, Natsuki Nagano, Satoaki Kamiya

Asian journal of endoscopic surgery Vol. 14 ( 2 ) page： 267 - 270 2021.4

Language：English Publishing type：Research paper (scientific journal)

To perform complete mesocolic excision with central vessel ligation, it is important to recognize the vessel anomaly and the location of the tumor. For left-sided colon cancer, the variations in the course of the left colic artery and accessary middle colic artery must be recognized preoperatively. Here, we describe our experience with a 57-year-old man who was diagnosed with sigmoid colon cancer with complicated inter-mesenteric connections between the inferior mesenteric artery (IMA) and superior mesenteric artery (SMA), possibly due to median arcuate ligament syndrome. We performed laparoscopic sigmoidectomy with low ligation of the IMA to preserve the extremely enlarged left colic artery. The total operative time was 155 minutes, and the estimated total blood loss was 10 mL. The patient was discharged on postoperative day 9 without any postoperative complications. For patients with vascular anomalies in the left-sided mesocolon, preoperatively ruling out SMA stenosis by using angiography and 3-D CT might be important.

DOI： 10.1111/ases.12844

Web of Science

Scopus

PubMed

下部直腸癌術後患者の長期腎機能へ影響を与える因子の検討

山東雅紀, 上原圭, 相場利貞, 小倉淳司, 大原規彰, 村田悠記, 三品拓也, 服部憲史, 中山吾郎, 横山幸浩, 伊神剛, 深谷昌秀, 水野隆, 山口淳平, 宮田一志, 尾上俊介, 渡辺伸元, 川井覚, 小寺泰弘, 江畑智希

日本外科学会定期学術集会抄録集 Vol. 121回 page： SF - 5 2021.4

再発大腸癌における予後予測マーカーとしてのCEA比の有用性

鈴木優美, 小倉淳司, 上原圭, 相場利貞, 大原規彰, 村田悠記, 神野孝徳, 三品拓也, 服部憲史, 中山吾郎, 横山幸浩, 伊神剛, 深谷昌秀, 水野隆史, 山口淳平, 宮田一志, 尾上俊介, 渡辺伸元, 小寺泰弘, 江畑智希

日本外科学会定期学術集会抄録集 Vol. 121回 page： PS - 1 2021.4

大腸癌術後ストマ造設症例における腹壁瘢痕および傍ストマヘルニアの因果関係

大原規彰, 上原圭, 相場利貞, 小倉淳司, 村田悠記, 神野孝徳, 三品拓也, 佐藤雄介, 服部憲史, 中山吾郎, 横山幸浩, 伊神剛, 深谷昌秀, 水野隆史, 山口淳平, 宮田一志, 尾上俊介, 渡辺伸元, 小寺泰弘, 江畑智希

日本外科学会定期学術集会抄録集 Vol. 121回 page： SF - 8 2021.4

骨盤内臓全摘術後のサルコペニア内腸骨動脈血管処理に着目して

村田悠記, 上原圭, 相場利貞, 小倉淳司, 大原規彰, 神野孝徳, 三品拓也, 鈴木優美, 服部憲史, 中山吾郎, 横山幸浩, 伊神剛, 深谷昌秀, 水野隆史, 山口淳平, 宮田一志, 尾上俊介, 渡辺伸元, 小寺泰弘, 江畑智希

日本外科学会定期学術集会抄録集 Vol. 121回 page： SF - 4 2021.4

頸部リンパ節転移再発に対し二次治療が著効し病理学的完全奏効を得たRAS/BRAF V600E変異型横行結腸癌の1例

村田悠記, 上原圭, 相場利貞, 小倉淳司, 深谷昌秀, 宮田一志, 田中綾, 大原規彰, 神野孝徳, 江畑智希

日本消化器外科学会雑誌 Vol. 54 ( 4 ) page： 278 - 284 2021.4

Language：Japanese Publisher：(一社)日本消化器外科学会

今日,進行再発大腸癌治療において遺伝子検査は必要不可欠なものとなっている.中でもBRAF V600E変異症例の予後は極めて不良と報告され,その治療選択に悩むことは少なくない.今回,オキサリプラチンベースの術後補助化学療法が終了した直後の術後9ヵ月の早期に,頸部リンパ節再発を来し,BRAF V600E変異型で予後不良が予測された症例に対し,二次治療としてのFOLFIRI+aflibercept療法が著効し,切除により病理学的完全奏効を確認した1例を経験した.術後経過観察期間は9ヵ月とまだ短いが,外来で無再発,無治療で経過観察中である.予後不良とされるBRAF V600E変異型であっても野生型と同様に一定の全身コントロールが可能であれば,転移巣切除を考慮する意義はあると考えられた.(著者抄録)

Other Link： https://search.jamas.or.jp/default/link?pub_year=2021&ichushi_jid=J01117&link_issn=&doc_id=20210519510007&doc_link_id=10.5833%2Fjjgs.2020.0057&url=https%3A%2F%2Fdoi.org%2F10.5833%2Fjjgs.2020.0057&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

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Papers - OGURA Atsushi