Faculty Profiles - OGURA Atsushi

Papers - OGURA Atsushi

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困難症例に対する大腸癌手術:手技の工夫と成績他臓器浸潤結腸癌に対する腹腔鏡手術の実際と工夫

小倉淳司, 上原圭, 村田悠記, 鳥居直矢, 小林龍太朗, 深田浩志, 野中有紀子, 伊神剛, 水野隆史, 宮田一志, 尾上俊介, 中山吾郎, 服部憲史, 梅田晋一, 江畑智希

日本内視鏡外科学会雑誌 Vol. 27 ( 7 ) page： 1875 - 1875 2022.12

切除不能肺転移を有する直腸癌同時性切除可能肝転移に対する腹腔鏡下rescue liver resection

水野隆史, 小倉淳司, 尾上俊介, 村田悠記, 川勝章司, 伊神剛, 宮田一志, 杉田静紀, 上原圭, 江畑智希

日本内視鏡外科学会雑誌 Vol. 27 ( 7 ) page： 2508 - 2508 2022.12

イマチニブ投与後に経肛門アプローチを併用して前方臓器温存し得た直腸巨大GISTの1例

神原祐一, 上原圭, 小倉淳司, 村田悠記, 小林龍太朗, 伊神剛, 水野隆史, 宮田一志, 尾上俊介, 砂川真輝, 杉田静紀, 梅田晋一, 服部憲史, 中山吾郎, 江畑智希

日本内視鏡外科学会雑誌 Vol. 27 ( 7 ) page： 659 - 659 2022.12

進行再発直腸癌に対する腹腔鏡拡大手術:手技の工夫と成績当科における局所再発直腸癌に対する腹腔鏡下拡大手術の治療成績

深田浩志, 上原圭, 小倉淳司, 村田悠記, 鳥居直矢, 小林龍太朗, 伊神剛, 水野隆史, 宮田一志, 尾上俊介, 砂川真輝, 杉田静紀, 服部憲史, 中山吾郎, 江畑智希

日本内視鏡外科学会雑誌 Vol. 27 ( 7 ) page： 933 - 933 2022.12

骨盤外科手術に必要な外科解剖-拡大手術、他臓器合併切除を安全に行うために- 局所進行・再発直腸癌に対する腹腔鏡下骨盤内臓全摘術の安全な導入に向けた取り組み umbilical 1stアプローチの有用性

村田悠記, 上原圭, 小倉淳司, 小林龍太朗, 鳥居直矢, 深田浩志, 野中有紀子, 伊神剛, 水野隆史, 宮田一志, 尾上俊介, 中山吾郎, 服部憲史, 梅田晋一, 江畑智希

日本内視鏡外科学会雑誌 Vol. 27 ( 7 ) page： 908 - 908 2022.12

Early volume loss of skeletal muscle after esophagectomy: a risk for late-onset postoperative pneumonia. International journal

Koudai Nishimura, Kazushi Miyata, Masahide Fukaya, Yukihiro Yokoyama, Kay Uehara, Junpei Yamaguchi, Takashi Mizuno, Shunsuke Onoe, Atsushi Ogura, Tomoki Ebata

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus Vol. 35 ( 11 ) 2022.11

Language：English Publishing type：Research paper (scientific journal)

Late-onset postoperative pneumonia (LOPP) after esophagectomy is poorly understood. This study was designed to clarify the features and risk factors for this event. Patients who underwent esophagectomy for esophageal cancer between 2006 and 2016 were included. LOPP was defined as radiologically proven pneumonia that occurred over 3 months after surgery, and clinically relevant late-onset postoperative pneumonia (CR-LOPP) was defined as LOPP that required administration of oxygen and antibiotics in the hospital and/or more intensive treatment. The total psoas muscle area (TPA) was measured using preoperative and postoperative (at 3 months after surgery) computed tomography scan images. Potential risk factors for CR-LOPP were investigated. Among 175 study patients, 46 (26.3%) had LOPP, 29 (16.6%) of whom exhibited CR-LOPP with a cumulative incidence of 15.6% at 3 years and 22.4% at 5 years. Four (13.8%) of these patients died of LOPP. Univariable analysis showed that clinical stage ≥III (P = 0.005), preoperative prognostic nutritional index (PNI) <45 (P = 0.035), arrhythmia (P = 0.014), postoperative hospital stay ≥40 days (P = 0.003), and percent decrease of TPA more than 5% (P < 0.001) were associated with CR-LOPP but not early onset postoperative pneumonia. Multivariable analysis revealed that clinical stage ≥III (hazard ratio [HR] 3.01, P = 0.004), postoperative hospital stay ≥40 days (HR 2.51, P = 0.015), and percent decrease of TPA >5% (HR 9.93, P < 0.001) were independent risk factors for CR-LOPP. CR-LOPP occurred in over 20% of patients at 5 years, and early postoperative loss of TPA was a potential trigger for this delayed complication.

DOI： 10.1093/dote/doac019

Web of Science

Scopus

PubMed

BRAF V600E変異陽性進行再発大腸癌の治療成績から考える転移巣切除の至適適応

神野孝徳, 上原圭, 小倉淳司, 村田悠記, 三品拓也, 神原祐一, 小林龍太朗, 尾上俊介, 宮田一志, 山口淳平, 水野隆史, 伊神剛, 國料俊男, 横山幸浩, 江畑智希

日本癌治療学会学術集会抄録集 Vol. 60回 page： OF - 3 2022.10

肝門部領域胆管癌術後のComprehensive Complication Indexの至適な算出期間は?

川勝章司, 水野隆史, 山口淳平, 尾上俊介, 砂川真輝, 渡辺伸元, 伊神剛, 上原圭, 宮田一志, 小倉淳司, 村田悠記, 國料俊男, 横山幸浩, 江畑智希

日本消化器外科学会雑誌 Vol. 55 ( Suppl.2 ) page： 241 - 241 2022.10

膵癌における栄養評価およびCA19-9に基づく術前予後層別化非解剖学的バイオマーカーによるアプローチ

尾上俊介, 横山幸浩, 伊神剛, 上原圭, 水野隆史, 山口淳平, 宮田一志, 砂川真輝, 渡辺伸元, 小倉淳司, 杉田静紀, 村田悠記, 川勝章司

日本消化器外科学会雑誌 Vol. 55 ( Suppl.2 ) page： 163 - 163 2022.10

高齢者に対する大腸がん治療の個別化を考える術前CRP/Alb比高値と術後内臓脂肪面積減少は高齢者大腸癌患者の予後不良因子である

神原祐一, 上原圭, 小倉淳司, 村田悠記, 小林龍太朗, 伊神剛, 水野隆史, 山口淳平, 宮田一志, 尾上俊介, 砂川真輝, 渡辺伸元, 杉田静紀, 横山幸浩, 江畑智希

日本癌治療学会学術集会抄録集 Vol. 60回 page： OWS9 - 2 2022.10

困難な状況下でも良いストーマを造設する手技腸管粘膜反転が困難な場合の対処法煙突状ストーマ造設術の有用性について

村田悠記, 上原圭, 小倉淳司, 神原祐一, 小林龍太朗, 鳥居直矢, 深田浩志, 國料俊男, 伊神剛, 水野隆史, 山口淳平, 宮田一志, 尾上俊介, 砂川真輝, 渡辺伸元, 杉田静紀, 横山幸浩, 江畑智希

日本大腸肛門病学会雑誌 Vol. 75 ( 9 ) page： A69 - A69 2022.9

直腸癌術後異時性肝・肺転移に対して化学療法開始後1年7ヵ月でconversion切除し得た1例

深田浩志, 上原圭, 小倉淳司, 村田悠記, 國料俊男, 伊神剛, 水野隆史, 山口淳平, 宮田一志, 尾上俊介, 砂川真輝, 渡辺伸元, 杉田静紀, 服部憲史, 中山吾郎, 横山幸浩, 小寺泰弘, 江畑智希

日本大腸肛門病学会雑誌 Vol. 75 ( 9 ) page： A221 - A221 2022.9

直腸癌術前集学的治療の成績:Watch & Waitを含めて局所進行直腸癌に対する術前化学療法を基本とした治療戦略Tripletレジメンの臨床経験とWatch and Wait strategyの安全な導入

小倉淳司, 上原圭, 村田悠記, 鳥居直矢, 小林龍太朗, 深田浩志, 國料俊男, 伊神剛, 水野隆史, 山口淳平, 宮田一志, 尾上俊介, 砂川真輝, 渡辺伸元, 杉田静紀, 服部憲史, 中山吾郎, 横山幸浩, 小寺泰弘, 江畑智希

日本大腸肛門病学会雑誌 Vol. 75 ( 9 ) page： A54 - A54 2022.9

当院におけるMSI-High大腸癌に対する免疫チェックポイント阻害薬の臨床経験

小林龍太朗, 上原圭, 小倉淳司, 村田悠記, 神原祐一, 伊神剛, 水野隆史, 山口淳平, 宮田一志, 尾上俊介, 砂川真輝, 渡辺伸元, 杉田静紀, 横山幸浩, 江畑智希

日本大腸肛門病学会雑誌 Vol. 75 ( 9 ) page： A149 - A149 2022.9

Role of resection for extrahepatopulmonary metastases of colon cancer. International journal

Takuya Mishina, Kay Uehara, Atsushi Ogura, Yuki Murata, Toshisada Aiba, Takashi Mizuno, Yukihiro Yokoyama, Tomoki Ebata

Japanese journal of clinical oncology Vol. 52 ( 7 ) page： 727 - 733 2022.7

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Although surgical resection for liver or lung metastases of colorectal cancer has been widely accepted, the use of this approach for extrahepatopulmonary metastases remains debatable due to the systemic nature of the disease. The aim of this study was to clarify the utility of resection along with perioperative chemotherapy for patients with extrahepatopulmonary metastases of colon cancer. METHODS: This is a retrospective single-arm study at a single institution. Forty-two patients with resectable extrahepatopulmonary metastases who underwent metastasectomy with curative intent between 2009 and 2018 at Nagoya University Hospital were retrospectively analyzed. The primary outcomes measured were overall and relapse-free survival. RESULTS: The most common metastatic site was the peritoneum (n = 31), followed by the distant lymph nodes (n = 10), ovary (n = 1) and spleen (n = 1), with overlaps. Preoperative and postoperative chemotherapies were administered to 22 and 8 patients, respectively; the remaining 14 patients received surgery alone. R0 resection was achieved in 36 patients (85.7%). The 5-year overall survival and 3-year relapse-free survival rates were 58.6% and 33.8%, respectively. In the univariate analysis, R1 resection was associated with a poor relapse-free survival rate (P = 0.02). In the multivariate analysis, the absence of perioperative chemotherapy was an independent risk factor for poor overall survival rates (P = 0.02). CONCLUSIONS: Surgical resection benefited selected patients with extrahepatopulmonary metastases with favorable long-term survival outcomes. Surgery alone without systemic chemotherapy is likely to bring poor outcome; therefore, preoperative induction might be promising to keep up with chemotherapy.

DOI： 10.1093/jjco/hyac045

Web of Science

PubMed

切除可能同時性大腸癌肝転移症例に対する肝実質温存肝切除が生存率に与える影響

村田悠記, 水野隆史, 上原圭, 小倉淳司, 宮田一志, 山口淳平, 伊神剛, 國料俊男, 横山幸浩, 江畑智希

日本消化器外科学会総会 Vol. 77回 page： P093 - 4 2022.7

術前CAR(CRP/albumin ratio)は高齢者大腸癌術後症例の予後予測因子である

神原祐一, 上原圭, 小倉淳司, 村田悠記, 宮田一志, 山口淳平, 水野隆史, 伊神剛, 横山幸浩, 江畑智希

日本消化器外科学会総会 Vol. 77回 page： P119 - 6 2022.7

Stoma creation is associated with a low incidence of midline incisional hernia after colorectal surgery: the "fighting over the fascia" theory concerning the incision and stoma hole.

Noriaki Ohara, Kay Uehara, Atsushi Ogura, Masanori Sando, Toshisada Aiba, Yuki Murata, Takashi Mizuno, Kokuryo Toshio, Yukihiro Yokoyama, Satoko Ishigaki, Yuanying Li, Hiroshi Yatsuya, Tomoki Ebata

Surgery today Vol. 52 ( 6 ) page： 953 - 963 2022.6

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: Parastomal hernia (PH) develops more frequently than incisional hernia (IH) after colorectal surgery with stoma. This study evaluated our hypothesis that inward traction of the fascia when closing a midline incision widens the stoma hole and increases the incidence of PH. METHODS: A total of 795 patients who underwent colorectal resection between 2006 and 2016 were retrospectively analyzed. The risk classification was constructed from IH risk factors extracted from the non-stoma group. Then, the classification was extrapolated to the stoma group for predicting midline IH and PH. RESULTS: The incidence of IH was 5.3% in the stoma group and 12.5% in the non-stoma group (p = 0.005). PH developed in 19.6% of 97 patients with permanent stoma. The risk classification was able to predict PH without a significant difference but was well balanced in patients with permanent stoma; however, it failed to predict IH in the stoma group. CONCLUSION: The risk classification constructed from the non-stoma group was useful for predicting not midline IH but PH, suggesting that the stoma site was the most vulnerable for herniation. The "fighting over the fascia" theory between the midline incision and stoma hole may explain the causal relationship between the midline IH and PH.

DOI： 10.1007/s00595-021-02434-y

Web of Science

Scopus

PubMed

村田悠記, 上原圭, 小倉淳司, 杉田静紀, 渡辺伸元, 砂川真輝, 尾上俊介, 宮田一志, 山口淳平, 水野隆史, 伊神剛, 國料俊男, 横山幸浩, 江畑智希

臨床外科 Vol. 77 ( 5 ) page： 514 - 519 2022.5

特集内視鏡手術からみえる新しい解剖学 II. 下部消化管 6.左側結腸癌に対する腹腔鏡下大動脈周囲リンパ節郭清

相場利貞, 上原圭, 小倉淳司, 村田悠記, 水野隆史, 横山幸浩, 江畑智希

外科 Vol. 84 ( 5 ) page： 484 - 488 2022.5

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Papers - OGURA Atsushi