Faculty Profiles - OGURA Atsushi

Papers - OGURA Atsushi

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Recurrent colorectal cancer after endoscopic resection when additional surgery was recommended. Reviewed

Takatsu Y, Fukunaga Y, Hamasaki S, Ogura A, Nagata J, Nagasaki T, Akiyoshi T, Konishi T, Fujimoto Y, Nagayama S, Ueno M

World Journal of Gastroenterology Vol. 22 ( 7 ) page： 2336-2341 2016.2

Recurrent colorectal cancer after endoscopic resection when additional surgery was recommended. International journal

Yukiko Takatsu, Yosuke Fukunaga, Shunsuke Hamasaki, Atsushi Ogura, Jun Nagata, Toshiya Nagasaki, Takashi Akiyoshi, Tsuyoshi Konishi, Yoshiya Fujimoto, Satoshi Nagayama, Masashi Ueno

World journal of gastroenterology Vol. 22 ( 7 ) page： 2336 - 41 2016.2

Language：English Publishing type：Research paper (scientific journal)

AIM: To evaluate the type of recurrence after endoscopic resection in colorectal cancer patients and whether rescue was possible by salvage operation. METHODS: Among 4972 patients who underwent surgical resection at our institution for primary or recurrent colorectal cancers from January 2005 to February 2015, we experienced eight recurrent colorectal cancers after endoscopic resection when additional surgical resection was recommended. RESULTS: The recurrence patterns were: intramural local recurrence (five cases), regional lymph node recurrence (three cases), and associated with simultaneous distant metastasis (three cases). Among five cases with lymphatic invasion observed histologically in endoscopic resected specimens, four cases recurred with lymph node metastasis or distant metastasis. All cases were treated laparoscopically and curative surgery was achieved in six cases. Among four cases located in the rectum, three cases achieved preservation of the anus. Postoperative complications occurred in two cases (enteritis). CONCLUSION: For high-risk submucosal invasive colorectal cancers after endoscopic resection, additional surgical resection with lymphadenectomy is recommended, particularly in cases with lymphovascular invasion.

DOI： 10.3748/wjg.v22.i7.2336

Scopus

PubMed

Laparoscopic anterior pelvic exenteration for advanced sigmoid colon cancer--a video vignette.

Akiyoshi T, Ogura A, Sakura M, Ueno M

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland Vol. 17 ( 5 ) page： 454 - 454 2015.5

Endoscopic evaluation of clinical response after preoperative chemoradiotherapy for lower rectal cancer: the significance of endoscopic complete response. Reviewed

Ogura A, Chino A, Konishi T, Akiyoshi T, Kishihara T, Tamegai Y, Ueno M, Igarashi M.

International Journal of Colorectal Disease Vol. 30 ( 3 ) page： 367-373 2015.3

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

PURPOSE:
The management of rectal cancer is a significant oncologic challenge because rectal cancer has a poor prognosis among the various types of colorectal cancer. There have been several recent reports on a nonoperative approach for advanced lower rectal cancer, and this may be best for local disease control. However, objective evaluation of tumor response after preoperative chemoradiotherapy has not been standardized. The purpose of this study is to evaluate our method of endoscopic evaluation of complete response.

METHODS:
This is a retrospective chart review. All patients received a long course of preoperative chemoradiotherapy (5-fluorouracil-based chemotherapy and 45-50.4 Gy) followed by radical surgical resection from May 2005 to March 2012 in The Cancer Institute Hospital of Japanese Foundation for Cancer Research. One hundred fifty-seven patients were reviewed consecutively. Criteria for endoscopic complete response were defined with a focus on the degree of ulcer healing and pit pattern without magnification.

RESULTS:
Endoscopic CR (E-CR) evaluation with our definitions reflected histopathologic response evaluation with an accuracy of 91.7 %, sensitivity of 27.8 %, specificity of 100 %, positive predictive value (PPV) of 100 %, and negative predictive value (NPV) of 91.4 % (p < 0.001). Our criteria of E-CR led all cases of y-clinical CR (ycCR) to pathological CR.

CONCLUSIONS:
Endoscopic evaluation focused on the degree of ulcer healing, and pit pattern without magnification is useful for judging ycCR.

Endoscopic evaluation of clinical response after preoperative chemoradiotherapy for lower rectal cancer: the significance of endoscopic complete response. International journal

Atsushi Ogura, Akiko Chino, Tsuyoshi Konishi, Takashi Akiyoshi, Teruhito Kishihara, Yoshiro Tamegai, Masashi Ueno, Masahiro Igarashi

International journal of colorectal disease Vol. 30 ( 3 ) page： 367 - 73 2015.3

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: The management of rectal cancer is a significant oncologic challenge because rectal cancer has a poor prognosis among the various types of colorectal cancer. There have been several recent reports on a nonoperative approach for advanced lower rectal cancer, and this may be best for local disease control. However, objective evaluation of tumor response after preoperative chemoradiotherapy has not been standardized. The purpose of this study is to evaluate our method of endoscopic evaluation of complete response. METHODS: This is a retrospective chart review. All patients received a long course of preoperative chemoradiotherapy (5-fluorouracil-based chemotherapy and 45-50.4 Gy) followed by radical surgical resection from May 2005 to March 2012 in The Cancer Institute Hospital of Japanese Foundation for Cancer Research. One hundred fifty-seven patients were reviewed consecutively. Criteria for endoscopic complete response were defined with a focus on the degree of ulcer healing and pit pattern without magnification. RESULTS: Endoscopic CR (E-CR) evaluation with our definitions reflected histopathologic response evaluation with an accuracy of 91.7 %, sensitivity of 27.8 %, specificity of 100 %, positive predictive value (PPV) of 100 %, and negative predictive value (NPV) of 91.4 % (p < 0.001). Our criteria of E-CR led all cases of y-clinical CR (ycCR) to pathological CR. CONCLUSIONS: Endoscopic evaluation focused on the degree of ulcer healing, and pit pattern without magnification is useful for judging ycCR.

DOI： 10.1007/s00384-014-2105-6

Scopus

PubMed

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