Faculty Profiles - ABE Hiroshi

Papers - ABE Hiroshi

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Intracellular Delivery of Antisense DNA and siRNA with Amino Groups Masked with Disulfide Units Reviewed

Shu Zhaoma, Ota Azumi, Takayama Yukiya, Katsurada Yuri, Kusamori Kosuke, Abe Naoko, Nakamoto Kosuke, Tomoike Fumiaki, Tada Seiichi, Ito Yoshihiro, Nishikawa Makiya, Kimura Yasuaki, Abe Hiroshi

CHEMICAL & PHARMACEUTICAL BULLETIN Vol. 68 ( 2 ) page： 129 - 132 2020.2

Intracellular build-up RNAi with single-strand circular RNAs as siRNA precursors Reviewed

Kimura Yasuaki, Shu Zhaoma, Ito Mika, Abe Naoko, Nakamoto Kosuke, Tomoike Fumiaki, Shuto Satoshi, Ito Yoshihiro, Abe Hiroshi

CHEMICAL COMMUNICATIONS Vol. 56 ( 3 ) page： 466 - 469 2020.1

SYNTHESIS AND BIOLOGICAL EVALUATION OF NMDI14 DERIVATIVES AS ANTI-MESOTHELIOMA AGENTS Reviewed

Hong Nhung Nguyen, Suzuki Koya, Kimura Yasuaki, Hirokawa Takatsugu, Murakami-Tonami Yuko, Abe Hiroshi

Heterocycles Vol. 100 ( 2 ) page： 253 - 266 2020.1

Intracellular delivery of Antisense DNA and siRNA with amino groups masked with disulfide units Reviewed

Zhaoma Shu, Azumi Ota, Yukiya Takayama, Yuri Katsurada, Kosuke Kusamori, Naoko Abe, Kosuke Nakamoto, Fumiaki Tomoike, Seiichi Tada, Yoshihiro Ito, Makiya Nishikawa, Yasuaki Kimura, Hiroshi Abe

Chemical and Pharmaceutical Bulletins 2020

Intracellular Build-up RNAi with Single-Strand Circular RNAs as siRNA Precursors Reviewed

Yasuaki Kimura, Zhaoma Shu, Mika Ito, Naoko Abe, Kosuke Nakamoto, Fumiaki Tomoike, Satoshi Shuto, Yoshihiro Ito, Hiroshi Abe

Chemical Communications 2020

Quantification of native mRNA dynamics in living neurons using fluorescence correlation spectroscopy and reduction-triggered fluorescent probes Reviewed International journal

Hirotaka Fujita, Ryota Oikawa, Mayu Hayakawa, Fumiaki Tomoike, Yasuaki Kimura, Hiroyuki Okuno, Yoshiki Hatashita, Carolina Fiallos Oliveros, Haruhiko Bito, Toshio Ohshima, Satoshi Tsuneda, Hiroshi Abe, Takafumi Inoue

Journal of Biological Chemistry Vol. in press 2020

Intracellular Delivery of Antisense DNA and siRNA with Amino Groups Masked with Disulfide Units. Reviewed

Vol. 68 ( 2 ) page： 129 - 132 2020

Synthesis of 1,1,2-trisubstituted cyclopropane nucleosides in enantiomerically pure forms. Reviewed International journal

Daichi Fushihara, Hayato Fukuda, Hiroshi Abe, Satoshi Shuto

Nucleosides, nucleotides & nucleic acids Vol. 38 ( 12 ) page： 921 - 941 2019.12

Language：English Publishing type：Research paper (scientific journal)

Due to the unique rigid and small steric feature of cyclopropane, cyclopropane nucleosides (CPNs) in which the ribose (deoxyribose) of nucleosides are replaced by a hydroxy-substituted cyclopropane, are of great biological interest. Novel 1,1,2-trisubstituted cyclopropane nucleosides were synthesized in enantiomerically pure forms as potential antiviral agents. In the synthesis, two cyclopropane tosylates, which were prepared from chiral cyclopropane lactones previously reported by us, were used effectively as common intermediates for the CPNs. These CPNs are also potentially useful as nucleoside units to incorporate into oligonucleotides in nucleic acids chemotherapy studies.

DOI： 10.1080/15257770.2019.1625380

N-6-methyl adenosine in siRNA evades immune response without reducing RNAi activity Reviewed

Imaeda Akihiro, Tomoike Fumiaki, Hayakawa Mayu, Nakamoto Kosuke, Kimura Yasuaki, Abe Naoko, Abe Hiroshi

Vol. 38 ( 12 ) page： 972 - 979 2019.12

Translational contro by secondary-structure formation in mRNA in eukaryotic system Reviewed

Daisuke Kawaguchi, Saaya Shimizu, Naoko Abe, Fumitaka Hashiya, Tomoike Fumiaki, Yasuaki Kimura, Hiroshi Abe

Nucleosides, Nucleotides and Nucleic Acids page： 1 - 9 2019.9

RNA imaging by chemical probes Invited Reviewed

TOMOIKE Fumiaki, ABE Hiroshi

Advanced Drug Delivery Reviews Vol. 147 page： 44 - 58 2019.7

Disulfide-Unit Conjugation Enables Ultrafast Cytosolic Internalization of Antisense DNA and siRNA Reviewed

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION Vol. 58 ( 20 ) page： 6611 - 6615 2019.5

Disulfide‐Unit Conjugation Enables Ultrafast Cytosolic Internalization of Antisense DNA and siRNA Reviewed

Zhaoma Shu, Iku Tanaka, Azumi Ota, Daichi Fushihara, Naoko Abe, Saki Kawaguchi, Kosuke Nakamoto, Fumiaki Tomoike, Seiichi Tada, Yoshihiro Ito, Yasuaki Kimura, Hiroshi Abe

Angewandte Chemie Vol. 131 ( 20 ) page： 6683 2019.5

A Covalent Inhibitor for Glutathione S-Transferase Pi (GSTP(1-1)) in Human Cells Reviewed

Shishido Yuko, Tomoike Fumiaki, Kuwata Keiko, Fujikawa Haruka, Sekido Yoshitaka, Murakami-Tonami Yuko, Kameda Tomoshi, Abe Naoko, Kimura Yasuaki, Shuto Satoshi, Abe Hiroshi

CHEMBIOCHEM Vol. 20 ( 7 ) page： 900 - 905 2019.4

膜透過性を有するGST共有結合性阻害剤の開発

友池史明, 宍戸裕子, 藤川遥加, 木村康明, 桑田啓子, 村上優子, 福井健二, 関戸好孝, 矢野貴人, 亀田倫史, 周東智, 阿部洋

日本薬学会年会要旨集 Vol. 139年会 ( 2 ) page： 80 - 80 2019.3

ウイルスタンパク質の活性をトリガーとした新規不可逆阻害剤の開発 Reviewed

福井竜介, 新美結士, 片倉秀雄, 鈴木哲郎, 村上努, 児玉栄一, 木村康明, 阿部洋

日本薬学会年会要旨集 Vol. 139年会 ( 2 ) page： 103 - 103 2019.3

Disulfide‐unit conjugation enables ultrafast cytosolic internalization of antisense DNA and siRNA Reviewed

Zhaoma Shu, Iku Tanaka, Azumi Ota, Daichi Fushihara, Naoko Abe, Saki Kawaguchi, Kosuke Nakamoto, Fumiaki Tomoike, Seiichi Tada, Yoshihiro Ito, Yasuaki Kimura, Hiroshi Abe

Angewandte Chemie International Edition Vol. 58 page： 6611 - 6615 2019

A Covalent Inhibitor for Glutathione S‐Transferase Pi (GSTP1‐1) in Human Cells Reviewed

Yuko Shishido, Fumiaki Tomoike, Keiko Kuwata, Haruka Fujikawa, Yoshitaka Sekido, Yuko Murakami-Tonami, Tomoshi Kameda, Naoko Abe, Yasuaki Kimura, Satoshi Shuto, Hiroshi Abe

ChemBioChem Vol. 20 page： 900 - 905 2019

N6-methyl adenosine in siRNA evades immune response without reducing RNAi activity Reviewed

Akihiro Imaeda, Fumiaki Tomoike, Mayu Hayakawa, Kosuke Nakamoto, Yasuaki Kimura, Naoko Abe, Hiroshi Abe

Nucleosides, Nucleotides and Nucleic Acids Vol. 38 page： 6611 - 6615 2019

Nearest-neighbor parameter for inosine-cytosine pairs through a combined experimental and computational approach Reviewed

Shun Sakuraba, Junichi Iwakiri, Michiaki Hamada, Tomoshi Kameda, Genichiro Tsuji, Yasuaki Kimura, Hiroshi Abe, Kiyoshi Asai

2018.10

Publisher：Cold Spring Harbor Laboratory

<title>Abstract</title>In RNA secondary structure prediction, nearest-neighbor parameters are used to determine the stability of a given structure. We derived the nearest-neighbor parameters for RNAs containing inosine-cytosine pairs. For parameter derivation, we developed a method that combines UV adsorption measurement experiments with free-energy calculations using molecular dynamics simulations. The method provides fast drop-in parameters for modified bases. Derived parameters were compared and found to be consistent with existing parameters for canonical RNAs. A duplex with an internal inosine-cytosine pair is 0.9 kcal/mol more unstable than the same duplex with an internal guanine-cytosine pair, and is as stable as the one with an internal adenine-uracil pair (only 0.1 kcal/mol more stable) on average.

DOI： 10.1101/454124

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Papers - ABE Hiroshi