Papers - NAKAGAWA Yu
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Synthesis, Conformation and PKC isozyme Surrogate Binding of Indolinelactam-Vs, New Conformationally-Restricted Analogues of (-)-Indolactam-V Reviewed
Nakagawa, Y., Irie, K., Komiya, Y., Ohigashi, H. and Tsuda, K.
Tetrahedron Vol. 60 page： 7077-7084 2004
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Indolactam and Benzolactam Compounds as New Medical Leads with Binding Selectivity for C1 Domains of Protein Kinase C Isozymes Invited Reviewed
Irie, K., Nakagawa, Y. and Ohigashi, H.
Curr. Pharm. Design Vol. 10 page： 1371-1385 2004
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Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s Reviewed
Irie, K., Masuda, A., Shindo, M., Nakagawa, Y. and Ohigashi, H.
Bioorg. Med. Chem. Lett. Vol. 12 page： 4547-4583 2004
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Synthesis and Binding Selectivity of 7- and 15-Decylbenzolactone-V8 for the C1 Domains of Protein Kinase C Isozymes Reviewed
Nakagawa, Y., Irie, K., Yamanaka, N., Ohigashi, H. and Tsuda, K.
Bioorg. Med. Chem. Lett. Vol. 13 page： 3015-3019 2003
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Synthesis and PKC Isozyme Surrogate Binding of Lactone Analogues of Benzolactam-V8's Reviewed
Nakagawa, Y., Irie, K., Masuda, A. and Ohigashi, H.
Tetrahedron Vol. 58 page： 2101-2115 2002
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Establishment of a binding assay for new medicinal leads with protein kinase C isozyme and C1 domain selectivity Invited Reviewed
Irie, K., Nakahara, A., Nakagawa, Y., Ohigashi, H., Shindo, M., Fukuda, H., Konishi, H., Kikkawa, U., Kashiwagi, K. and Saito, N.
Pharmacol. Ther. Vol. 93 page： 271-281 2002
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Binding Selectivity of Conformationally Restricted Analogues of (-)-Indolactam-V to the C1 Domains of Protein Kinase C Isozymes Reviewed
Masuda, A., Irie, K., Nakagawa, Y. and Ohigashi, H.
Biosci. Biotechnol. Biochem. Vol. 66 page： 1615-1617 2002
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The C4 Hydroxyl Group of Phorbol Esters is Not Necessary for Protein Kinase C Binding Reviewed
Tanaka, M., Irie, K., Nakagawa, Y., Nakamura, Y., Ohigashi, H. and Wender, P. A.
Bioorg. Med. Chem. Lett. Vol. 11 page： 719-722 2001
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The Amide Hydrogen of (-)-Indolactam-V and Benzolactam-V8's Plays a Critical Role in Protein Kinase C Binding and Tumor-promoting Activities Reviewed
Nakagawa, Y., Irie, K., Nakamura, Y. and Ohigashi, H.
Bioorg. Med. Chem. Lett. Vol. 11 page： 723-728 2001
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Synthesis and Tumor-promoting Activities of 12-Epi-phorbol-12,13-dibutyrate Reviewed
Irie, K., Nakahara, A., Ikawa, Y., Tanaka, M., Nakagawa, Y., Nakamura, Y., Ohigashi, H. and Wender, P. A.
Biosci. Biotechnol. Biochem. Vol. 64 page： 2429-2436 2000
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Selective Binding of Tumor Promoters to the Novel PKC C1B Domains Invited Reviewed
Irie, K., Nakahara, A., Nakagawa, Y., Ohigashi, H., Shindo, M., Fukuda, H., Konishi, H. and Kikkawa, U.
Peptide Science 2000 page： 197-200 2000
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Selective Binding to the nPKC C1B Domains by Tumor Promoters
Nakagawa, Y. and Irie, K.
Bioscience & Industry Vol. 58 page： 570-571 2000
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Synthesis and PKC Isozyme Surrogate Binding of Indothiolactam-V, a New Thioamide Analogue of Tumor Promoting Indolactam-V Reviewed
Nakagawa, Y., Irie, K., Ohigashi, H., Hayashi, H. and Wender, P. A.
Bioorg. Med. Chem. Lett. Vol. 10 page： 2087-2090 2000
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Isolation of (-)-14-O-Malonylindolactam-V as a Possible Precursor of (-)-Indolactam-V and (-)-14-O-Acetylindolactam-V from Streptomyces blastmyceticum Reviewed
Irie, K., Tomimatsu, S., Nakagawa, Y., Ohigashi, H. and Hayashi, H.
Biosci. Biotechnol. Biochem. Vol. 63 page： 1669-1670 1999
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Synthesis and Biological Activities of (-)-6-n-Octyl-indolactam-V, a New Potent Analogue of the Tumor Promoter (-)-Indolactam-V Reviewed
Nakagawa, Y., Irie, K., Nakamura, Y. and Ohigashi, H.
Biosci. Biotechnol. Biochem. Vol. 62 page： 1568-1573 1998
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Biosynthesis of Monoterpenoid Moiety of Teleocidins via the Non-mevalonate Pathway in Streptomyces Reviewed
Irie, K., Nakagawa, Y., Tomimatsu, S. and Ohigashi, H.
Tetrahedron Lett. Vol. 39 page： 7929-7930 1998
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Synthesis and Biological Activities of Indolactone-V, the Lactone Analogue of the Tumor Promoter (-)-Indolactam-V Reviewed
Nakagawa, Y., Irie, K., Nakamura, Y., Ohigashi, H. and Hayashi, H.
Biosci. Biotech. Biochem. Vol. 61 page： 1415-1417 1997
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Comparison of Chemical Characteristics of the First and Second Cystein-Rich Domains of Protein Kinase Cγ Reviewed
Irie, K., Yanai, Y., Oie, K., Ishizawa, J., Nakagawa, Y., Ohigashi, H., Wender, P. A. and Kikkawa, U.
Bioorg. Med. Chem. Vol. 5 page： 1725-1737 1997