Papers - NAKAGAWA Yu
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Molecular Basis of Mannose Recognition by Pradimicins and their Application to Microbial Cell Surface Imaging Reviewed International journal
Nakagawa Yu, Doi Takashi, Takegoshi K., Sugahara Takahiro, Akase Dai, Aida Misako, Tsuzuki Kazue, Watanabe Yasunori, Tomura Tomohiko, Ojika Makoto, Igarashi Yasuhiro, Hashizume Daisuke, Ito Yukishige
CELL CHEMICAL BIOLOGY Vol. 26 ( 7 ) page： 950 - + 2019.7
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Molecular basis of N-glycan recognition by pradimicin A and its potential as a SARS-CoV-2 entry inhibitor Reviewed
Yu Nakagawa, Masato Fujii, Nanaka Ito, Makoto Ojika, Dai Akase, Misako Aida, Takaaki Kinoshita, Yasuteru Sakurai, Jiro Yasuda, Yasuhiro Igarashi, Yukishige Ito
Bioorganic & Medicinal Chemistry Vol. 105 page： 117732 2024.4
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Recent progress in the development and application of lectin mimics Reviewed
Yu Nakagawa
Trends in Glycoscience and Glycotechnology Vol. 35 ( 203 ) page： E6 - E10 2023.1
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Chemical modification of pradimicin A to suppress aggregation without impairing D-mannose-binding and antifungal activities Reviewed International journal
Nakagawa Yu, Oya Yuzuka, Ojika Makoto, Igarashi Yasuhiro, Ito Yukishige
TETRAHEDRON Vol. 121 2022.8
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D-Mannose binding, aggregation property, and antifungal activity of amide derivatives of pradimicin A Reviewed International journal
Miyanishi Wataru, Ojika Makoto, Akase Dai, Aida Misako, Igarashi Yasuhiro, Ito Yukishige, Nakagawa Yu
BIOORGANIC & MEDICINAL CHEMISTRY Vol. 55 page： 116590 2022.2
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Mannose-binding analysis and biological application of pradimicins Invited Reviewed International journal
Nakagawa Yu, To Yukishige
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES Vol. 98 ( 1 ) page： 15 - 29 2022.1
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A Pradimicin-Based Staining Dye for Glycoprotein Detection Reviewed International journal
Nakagawa Yu, Kakihara Shintaro, Tsuzuki Kazue, Ojika Makoto, Igarashi Yasuhiro, Ito Yukishige
JOURNAL OF NATURAL PRODUCTS Vol. 84 ( 9 ) page： 2496 - 2501 2021.9
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Binding Evaluation of Pradimicins for Oligomannose Motifs from Fungal Mannans Reviewed International journal
Nakagawa Yu, Yamaji Fumiya, Miyanishi Wataru, Ojika Makoto, Igarashi Yasuhiro, Ito Yukishige
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN Vol. 94 ( 3 ) page： 732 - 754 2021.3
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Paving the Way for Practical Use of Sugar-Binding Natural Products as Lectin Mimics in Glycobiological Research Reviewed International journal
Nakagawa Yu
CHEMBIOCHEM Vol. 21 ( 11 ) page： 1567 - 1572 2020.6
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The endocyclic oxygen atom of D-mannopyranose is involved in its binding to pradimicins Reviewed International journal
Watanabe Yasunori, Yamaji Fumiya, Ojika Makoto, Sugawara Takahiro, Akase Dai, Aida Misako, Igarashi Yasuhiro, Ito Yukishige, Nakagawa Yu
TETRAHEDRON LETTERS Vol. 61 ( 9 ) 2020.2
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Relationship among structure, cytotoxicity, and Michael acceptor reactivity of quinocidin Reviewed International journal
Nakagawa Yu, Sawaki Yuki, Miyanishi Wataru, Shimomura Sayako, Shibata Takahiro, Ojika Makoto
BIOORGANIC & MEDICINAL CHEMISTRY Vol. 28 ( 4 ) page： 115308 2020.2
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SYNTHESIS AND BIOLOGICAL ACTIVITIES OF ACETAL ANALOGS AT POSITION 3 OF 10-METHYL-APLOG-1, A POTENTIAL ANTI-CANCER LEAD DERIVED FROM DEBROMOAPLYSIATOXIN Reviewed International journal
Hayakawa Koutaro, Hanaki Yusuke, Tokuda Harukuni, Yanagita Ryo C., Nakagawa Yu, Okamura Mutsumi, Dan Shingo, Irie Kazuhiro
HETEROCYCLES Vol. 97 ( 1 ) page： 478 - 492 2018.9
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Quinocidin, a Cytotoxic Antibiotic with an Unusual 3,4-Dihydroquinolizinium Ring and Michael Acceptor Reactivity toward Thiols Reviewed
Nakagawa Yu, Sawaki Yuki, Kimura Takahiro, Tomura Tomohiko, Igarashi Yasuhiro, Ojika Makoto
CHEMISTRY-A EUROPEAN JOURNAL Vol. 23 ( 71 ) page： 17894-17897 2017.12
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Solid-State Nuclear Magnetic Resonance Analysis Reveals a Possible Calcium Binding Site of Pradimicin A Reviewed
Doi Takashi, Nakagawa Yu, Takegoshi K.
BIOCHEMISTRY Vol. 56 ( 3 ) page： 468-472 2017.1
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Solid-State NMR Analysis of Mannose Recognition by Pradimicin A
Nakagawa Yu, Ito Yukishige
NMR IN GLYCOSCIENCE AND GLYCOTECHNOLOGY Vol. 10 page： 269-289 2017
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Inhibition of Chikungunya Virus-Induced Cell Death by Salicylate-Derived Bryostatin Analogues Provides Additional Evidence for a PKC-Independent Pathway Reviewed
Staveness, D., Abdelnabi, R., Near, K. E., Nakagawa, Y., Neyts, J., Delang, L., Leyssen, P., Wender, P. A.
Journal of Natural Products page： 10.1021/acs.jnatprod.5b01017 2016.2
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Pradimicin A, a D-mannose-binding antibiotic, binds pyranosides of L-fucose and L-galactose in a calcium-sensitive manner Reviewed
Nakagawa, Y., Watanabe, Y., Igarashi, Y., Ito, Y., Ojika, M.
Bioorg. Med. Chem. Lett. Vol. 25 ( 15 ) page： 2963-2966 2015.5
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天然物の構造単純化による有用分子の創製：天然プロテインキナーゼC活性化剤のアナログ設計 Reviewed
中川 優
有機合成化学協会誌 Vol. 73 ( 4 ) page： 316-327 2015.4
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第3の生命鎖・糖鎖に結合する低分子化合物に関する現状と展望 Invited Reviewed
中川 優
ファルマシア Vol. 50 ( 11 ) page： 1117-1122 2014
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Computer-guided design, synthesis, and protein kinase C affinity of a new salicylate-based class of bryostatin analogs Reviewed
Wender, P. A., Nakagawa, Y., Near, K. E., Staveness, D.
Org. Lett. Vol. 16 page： 5136-5139 2014
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Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity Reviewed
Kamachi, H., Tanaka, K., Yanagita, R. C., Murakami, A., Murakami, K., Tokuda, H., Suzuki, N., Nakagawa, Y., and Irie, K.
Bioorg. Med. Chem. Vol. 21 page： 2695-2702 2013
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Mannose binding geometry of pradimicin A Reviewed
Nakagawa, Y., Doi, T., Taketani, T., Takegoshi, K., Igarashi, Y., and Ito, Y.
Chem. Eur. J. Vol. 19 page： 10516-10525 2013
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Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues Reviewed
Sato, M., Murakami, K., Uno, M., Ikubo, H., Nakagawa, Y., Katayama, S., Akagi, H., Masuda, Y., Takegoshi, K. and Irie, K.
J. Biol. Chem. Vol. 288 page： 23212-23224 2013
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Structure-activity relationship for (+)-taxifolin isolated from silymarin as an inhibitor of amyloid beta aggregation Reviewed
Sato, M., Murakami, K., Uno, M., Ikubo, H., Nakagawa, Y., Katayama, S., Akagi, H., and Irie, K.
Biosci. Biotechnol. Biochem. Vol. 77 page： 1100-1103 2013
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Solid-state NMR analysis of calcium and D-mannose binding of BMY-28864, a water-soluble analogue of pradimicin A Reviewed
Nakagawa, Y., Doi, T., Takegoshi, K., Igarashi, Y., and Ito, Y.
Bioorg. Med. Chem. Lett. Vol. 22 page： 1040-1043 2012
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Molecular architecture and therapeutic potential of lectin mimics Invited Reviewed
Nakagawa, Y. and Ito, Y.
Advances in Carbohydrate Chemistry and Biochemistry page： 1-58 2012
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Artificial analogs of naturally occurring tumor promoters as biochemical tools and therapeutic leads Invited Reviewed
Nakagawa, Y.
Biosci. Biotechnol. Biochem. Vol. 76 page： 1262-1274 2012
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Carbohydrate-binding molecules with non-peptidic skeletons Invited Reviewed
Nakagawa, Y. and Ito, Y.
Trends Glycosci. Glycotechnol. Vol. 24 page： 1-12 2012
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Synthesis and structure-activity studies of simplified analogues of aplysiatoxin with antiproliferative activity like bryostatin-1 Invited Reviewed
Irie, K., Kikumori, M., Kamachi, H., Tanaka, K., Murakami, A., Yanagita, R. C., Tokuda, H., Suzuki, N., Nagai, H., Suenaga, K., and Nakagawa, Y.
Pure Appl. Chem. Vol. 84 page： 1341-1351 2012
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Challenges to the Development of Bryostatin-type Anticancer Drugs Based on the Activation Mechanism of Protein Kinase Cδ Invited Reviewed
Irie, K., Yanagita, R. C., and Nakagawa, Y.
Med. Res. Rev. Vol. 32 page： 518-535 2012
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Synthesis and Biological Evaluation of the 12,12-Dimethyl Derivative of Aplog-1, an Anti-Proliferative Analog of Tumor-Promoting Aplysiatoxin Reviewed
Nakagawa, Y., Kikumori, M., Yanagita, R. C., Murakami, A., Tokuda, H., Nagai, H. and Irie, K.
Biosci. Biotechnol. Biochem. Vol. 75 page： 1167-1173 2011
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Mapping of the Primary Mannose-Binding Site of Pradimicin A Reviewed
Nakagawa, Y., Doi, T., Masuda, Y., Takegoshi, K., Igarashi, Y., and Ito, Y.
J. Am. Chem. Soc. Vol. 133 page： 17485-17493 2011
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Solid-state NMR Spectroscopic Analysis of the Ca2+-dependent Mannose Binding of Pradimicin A Reviewed
Nakagawa, Y., Masuda, Y., Yamada, K., Doi, T., Takegoshi, K., Igarashi, Y., and Ito, Y.
Angew. Chem. Int. Ed. Vol. 50 page： 6084-6088 2011
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Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity Reviewed
Yanagita, R. C., Kamachi, H., Tanaka, K., Murakami, A., Nakagawa, Y., Tokuda, H., Nagai, H., and Irie, K.
Bioorg. Med. Chem. Lett. Vol. 20 page： 6064-6066 2010
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A Simple Analog of Tumor-promoting Aplysiatoxin Is an Antineoplastic Agent Rather Than a Tumor Promoter: Development of a Synthetically Accessible PKC Activator with Bryostatin-like Activity Reviewed
Nakagawa, Y., Yanagita, R. C., Hamada, N., Murakami, A., Takahashi, H., Saito, N., Nagai, H. and Irie, K.
J. Am. Chem. Soc. Vol. 131 page： 7573-7579 2009
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Synthesis, Conformational Analysis, and Biological Evaluation of 1-Hexyl-indolactam-V10 as a Selective Activator for Novel Protein Kinase C Isozymes Reviewed
Yanagita, R. C., Nakagawa, Y., Yamanaka, N., Kashiwagi, K., Saito, N. and Irie, K.
J. Med. Chem. Vol. 51 page： 46-56 2008
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Binding selectivity of 1- or 12-substituted indolactam derivatives for protein kinase C isozymes Reviewed
Yanagita, R. C., Torii, K., Nakagawa, Y. and Irie, K.
Heterocycles Vol. 73 page： 289-302 2007
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Design and Synthesis of 8-Octyl-benzolactam-V9, the selective activator for PKCε and η Reviewed
Nakagawa, Y., Irie, K., Yanagita, R. C., Ohigashi, H., Tsuda, K., Kashiwagi, K. and Saito, N.
J. Med. Chem. Vol. 49 page： 2681-2688 2006
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Indolactam-V is involved in the CH/π Interaction with Pro-11 of PKCδ C1B domain: Application to Structural Optimization for PKCδ Ligand Reviewed
Nakagawa, Y., Irie, K., Yanagita, C. R., Ohigashi, H. and Tsuda, K.
J. Am. Chem. Soc. Vol. 127 page： 5746-5747 2005
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Toward the Development of New Medicinal Leads with Selectivity for Protein Kinase C Isozymes Invited Reviewed
Irie, K., Nakagawa, Y. and Ohigashi, H.
Chem. Rec. Vol. 5 page： 185-195 2005
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Synthesis, Conformation and PKC isozyme Surrogate Binding of Indolinelactam-Vs, New Conformationally-Restricted Analogues of (-)-Indolactam-V Reviewed
Nakagawa, Y., Irie, K., Komiya, Y., Ohigashi, H. and Tsuda, K.
Tetrahedron Vol. 60 page： 7077-7084 2004
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Indolactam and Benzolactam Compounds as New Medical Leads with Binding Selectivity for C1 Domains of Protein Kinase C Isozymes Invited Reviewed
Irie, K., Nakagawa, Y. and Ohigashi, H.
Curr. Pharm. Design Vol. 10 page： 1371-1385 2004
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Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s Reviewed
Irie, K., Masuda, A., Shindo, M., Nakagawa, Y. and Ohigashi, H.
Bioorg. Med. Chem. Lett. Vol. 12 page： 4547-4583 2004
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Synthesis and Binding Selectivity of 7- and 15-Decylbenzolactone-V8 for the C1 Domains of Protein Kinase C Isozymes Reviewed
Nakagawa, Y., Irie, K., Yamanaka, N., Ohigashi, H. and Tsuda, K.
Bioorg. Med. Chem. Lett. Vol. 13 page： 3015-3019 2003
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Synthesis and PKC Isozyme Surrogate Binding of Lactone Analogues of Benzolactam-V8's Reviewed
Nakagawa, Y., Irie, K., Masuda, A. and Ohigashi, H.
Tetrahedron Vol. 58 page： 2101-2115 2002
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Establishment of a binding assay for new medicinal leads with protein kinase C isozyme and C1 domain selectivity Invited Reviewed
Irie, K., Nakahara, A., Nakagawa, Y., Ohigashi, H., Shindo, M., Fukuda, H., Konishi, H., Kikkawa, U., Kashiwagi, K. and Saito, N.
Pharmacol. Ther. Vol. 93 page： 271-281 2002
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Binding Selectivity of Conformationally Restricted Analogues of (-)-Indolactam-V to the C1 Domains of Protein Kinase C Isozymes Reviewed
Masuda, A., Irie, K., Nakagawa, Y. and Ohigashi, H.
Biosci. Biotechnol. Biochem. Vol. 66 page： 1615-1617 2002
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The C4 Hydroxyl Group of Phorbol Esters is Not Necessary for Protein Kinase C Binding Reviewed
Tanaka, M., Irie, K., Nakagawa, Y., Nakamura, Y., Ohigashi, H. and Wender, P. A.
Bioorg. Med. Chem. Lett. Vol. 11 page： 719-722 2001
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The Amide Hydrogen of (-)-Indolactam-V and Benzolactam-V8's Plays a Critical Role in Protein Kinase C Binding and Tumor-promoting Activities Reviewed
Nakagawa, Y., Irie, K., Nakamura, Y. and Ohigashi, H.
Bioorg. Med. Chem. Lett. Vol. 11 page： 723-728 2001
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Synthesis and Tumor-promoting Activities of 12-Epi-phorbol-12,13-dibutyrate Reviewed
Irie, K., Nakahara, A., Ikawa, Y., Tanaka, M., Nakagawa, Y., Nakamura, Y., Ohigashi, H. and Wender, P. A.
Biosci. Biotechnol. Biochem. Vol. 64 page： 2429-2436 2000
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Selective Binding of Tumor Promoters to the Novel PKC C1B Domains Invited Reviewed
Irie, K., Nakahara, A., Nakagawa, Y., Ohigashi, H., Shindo, M., Fukuda, H., Konishi, H. and Kikkawa, U.
Peptide Science 2000 page： 197-200 2000
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Selective Binding to the nPKC C1B Domains by Tumor Promoters
Nakagawa, Y. and Irie, K.
Bioscience & Industry Vol. 58 page： 570-571 2000
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Synthesis and PKC Isozyme Surrogate Binding of Indothiolactam-V, a New Thioamide Analogue of Tumor Promoting Indolactam-V Reviewed
Nakagawa, Y., Irie, K., Ohigashi, H., Hayashi, H. and Wender, P. A.
Bioorg. Med. Chem. Lett. Vol. 10 page： 2087-2090 2000
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Isolation of (-)-14-O-Malonylindolactam-V as a Possible Precursor of (-)-Indolactam-V and (-)-14-O-Acetylindolactam-V from Streptomyces blastmyceticum Reviewed
Irie, K., Tomimatsu, S., Nakagawa, Y., Ohigashi, H. and Hayashi, H.
Biosci. Biotechnol. Biochem. Vol. 63 page： 1669-1670 1999
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Synthesis and Biological Activities of (-)-6-n-Octyl-indolactam-V, a New Potent Analogue of the Tumor Promoter (-)-Indolactam-V Reviewed
Nakagawa, Y., Irie, K., Nakamura, Y. and Ohigashi, H.
Biosci. Biotechnol. Biochem. Vol. 62 page： 1568-1573 1998
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Biosynthesis of Monoterpenoid Moiety of Teleocidins via the Non-mevalonate Pathway in Streptomyces Reviewed
Irie, K., Nakagawa, Y., Tomimatsu, S. and Ohigashi, H.
Tetrahedron Lett. Vol. 39 page： 7929-7930 1998
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Synthesis and Biological Activities of Indolactone-V, the Lactone Analogue of the Tumor Promoter (-)-Indolactam-V Reviewed
Nakagawa, Y., Irie, K., Nakamura, Y., Ohigashi, H. and Hayashi, H.
Biosci. Biotech. Biochem. Vol. 61 page： 1415-1417 1997
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Comparison of Chemical Characteristics of the First and Second Cystein-Rich Domains of Protein Kinase Cγ Reviewed
Irie, K., Yanai, Y., Oie, K., Ishizawa, J., Nakagawa, Y., Ohigashi, H., Wender, P. A. and Kikkawa, U.
Bioorg. Med. Chem. Vol. 5 page： 1725-1737 1997