Papers - NAKAGAWA Yu
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Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity Reviewed
Kamachi, H., Tanaka, K., Yanagita, R. C., Murakami, A., Murakami, K., Tokuda, H., Suzuki, N., Nakagawa, Y., and Irie, K.
Bioorg. Med. Chem. Vol. 21 page： 2695-2702 2013
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Mannose binding geometry of pradimicin A Reviewed
Nakagawa, Y., Doi, T., Taketani, T., Takegoshi, K., Igarashi, Y., and Ito, Y.
Chem. Eur. J. Vol. 19 page： 10516-10525 2013
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Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues Reviewed
Sato, M., Murakami, K., Uno, M., Ikubo, H., Nakagawa, Y., Katayama, S., Akagi, H., Masuda, Y., Takegoshi, K. and Irie, K.
J. Biol. Chem. Vol. 288 page： 23212-23224 2013
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Structure-activity relationship for (+)-taxifolin isolated from silymarin as an inhibitor of amyloid beta aggregation Reviewed
Sato, M., Murakami, K., Uno, M., Ikubo, H., Nakagawa, Y., Katayama, S., Akagi, H., and Irie, K.
Biosci. Biotechnol. Biochem. Vol. 77 page： 1100-1103 2013
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Solid-state NMR analysis of calcium and D-mannose binding of BMY-28864, a water-soluble analogue of pradimicin A Reviewed
Nakagawa, Y., Doi, T., Takegoshi, K., Igarashi, Y., and Ito, Y.
Bioorg. Med. Chem. Lett. Vol. 22 page： 1040-1043 2012
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Molecular architecture and therapeutic potential of lectin mimics Invited Reviewed
Nakagawa, Y. and Ito, Y.
Advances in Carbohydrate Chemistry and Biochemistry page： 1-58 2012
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Artificial analogs of naturally occurring tumor promoters as biochemical tools and therapeutic leads Invited Reviewed
Nakagawa, Y.
Biosci. Biotechnol. Biochem. Vol. 76 page： 1262-1274 2012
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Carbohydrate-binding molecules with non-peptidic skeletons Invited Reviewed
Nakagawa, Y. and Ito, Y.
Trends Glycosci. Glycotechnol. Vol. 24 page： 1-12 2012
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Synthesis and structure-activity studies of simplified analogues of aplysiatoxin with antiproliferative activity like bryostatin-1 Invited Reviewed
Irie, K., Kikumori, M., Kamachi, H., Tanaka, K., Murakami, A., Yanagita, R. C., Tokuda, H., Suzuki, N., Nagai, H., Suenaga, K., and Nakagawa, Y.
Pure Appl. Chem. Vol. 84 page： 1341-1351 2012
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Challenges to the Development of Bryostatin-type Anticancer Drugs Based on the Activation Mechanism of Protein Kinase Cδ Invited Reviewed
Irie, K., Yanagita, R. C., and Nakagawa, Y.
Med. Res. Rev. Vol. 32 page： 518-535 2012
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Synthesis and Biological Evaluation of the 12,12-Dimethyl Derivative of Aplog-1, an Anti-Proliferative Analog of Tumor-Promoting Aplysiatoxin Reviewed
Nakagawa, Y., Kikumori, M., Yanagita, R. C., Murakami, A., Tokuda, H., Nagai, H. and Irie, K.
Biosci. Biotechnol. Biochem. Vol. 75 page： 1167-1173 2011
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Mapping of the Primary Mannose-Binding Site of Pradimicin A Reviewed
Nakagawa, Y., Doi, T., Masuda, Y., Takegoshi, K., Igarashi, Y., and Ito, Y.
J. Am. Chem. Soc. Vol. 133 page： 17485-17493 2011
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Solid-state NMR Spectroscopic Analysis of the Ca2+-dependent Mannose Binding of Pradimicin A Reviewed
Nakagawa, Y., Masuda, Y., Yamada, K., Doi, T., Takegoshi, K., Igarashi, Y., and Ito, Y.
Angew. Chem. Int. Ed. Vol. 50 page： 6084-6088 2011
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Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity Reviewed
Yanagita, R. C., Kamachi, H., Tanaka, K., Murakami, A., Nakagawa, Y., Tokuda, H., Nagai, H., and Irie, K.
Bioorg. Med. Chem. Lett. Vol. 20 page： 6064-6066 2010
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A Simple Analog of Tumor-promoting Aplysiatoxin Is an Antineoplastic Agent Rather Than a Tumor Promoter: Development of a Synthetically Accessible PKC Activator with Bryostatin-like Activity Reviewed
Nakagawa, Y., Yanagita, R. C., Hamada, N., Murakami, A., Takahashi, H., Saito, N., Nagai, H. and Irie, K.
J. Am. Chem. Soc. Vol. 131 page： 7573-7579 2009
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Synthesis, Conformational Analysis, and Biological Evaluation of 1-Hexyl-indolactam-V10 as a Selective Activator for Novel Protein Kinase C Isozymes Reviewed
Yanagita, R. C., Nakagawa, Y., Yamanaka, N., Kashiwagi, K., Saito, N. and Irie, K.
J. Med. Chem. Vol. 51 page： 46-56 2008
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Binding selectivity of 1- or 12-substituted indolactam derivatives for protein kinase C isozymes Reviewed
Yanagita, R. C., Torii, K., Nakagawa, Y. and Irie, K.
Heterocycles Vol. 73 page： 289-302 2007
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Design and Synthesis of 8-Octyl-benzolactam-V9, the selective activator for PKCε and η Reviewed
Nakagawa, Y., Irie, K., Yanagita, R. C., Ohigashi, H., Tsuda, K., Kashiwagi, K. and Saito, N.
J. Med. Chem. Vol. 49 page： 2681-2688 2006
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Indolactam-V is involved in the CH/π Interaction with Pro-11 of PKCδ C1B domain: Application to Structural Optimization for PKCδ Ligand Reviewed
Nakagawa, Y., Irie, K., Yanagita, C. R., Ohigashi, H. and Tsuda, K.
J. Am. Chem. Soc. Vol. 127 page： 5746-5747 2005
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Toward the Development of New Medicinal Leads with Selectivity for Protein Kinase C Isozymes Invited Reviewed
Irie, K., Nakagawa, Y. and Ohigashi, H.
Chem. Rec. Vol. 5 page： 185-195 2005