論文 - 中川 優
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Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity 査読有り
Kamachi, H., Tanaka, K., Yanagita, R. C., Murakami, A., Murakami, K., Tokuda, H., Suzuki, N., Nakagawa, Y., and Irie, K.
Bioorg. Med. Chem. 21 巻 頁： 2695-2702 2013年
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Mannose binding geometry of pradimicin A 査読有り
Nakagawa, Y., Doi, T., Taketani, T., Takegoshi, K., Igarashi, Y., and Ito, Y.
Chem. Eur. J. 19 巻 頁： 10516-10525 2013年
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Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues 査読有り
Sato, M., Murakami, K., Uno, M., Ikubo, H., Nakagawa, Y., Katayama, S., Akagi, H., Masuda, Y., Takegoshi, K. and Irie, K.
J. Biol. Chem. 288 巻 頁： 23212-23224 2013年
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Structure-activity relationship for (+)-taxifolin isolated from silymarin as an inhibitor of amyloid beta aggregation 査読有り
Sato, M., Murakami, K., Uno, M., Ikubo, H., Nakagawa, Y., Katayama, S., Akagi, H., and Irie, K.
Biosci. Biotechnol. Biochem. 77 巻 頁： 1100-1103 2013年
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Solid-state NMR analysis of calcium and D-mannose binding of BMY-28864, a water-soluble analogue of pradimicin A 査読有り
Nakagawa, Y., Doi, T., Takegoshi, K., Igarashi, Y., and Ito, Y.
Bioorg. Med. Chem. Lett. 22 巻 頁： 1040-1043 2012年
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Molecular architecture and therapeutic potential of lectin mimics 招待有り 査読有り
Nakagawa, Y. and Ito, Y.
Advances in Carbohydrate Chemistry and Biochemistry 頁： 1-58 2012年
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Artificial analogs of naturally occurring tumor promoters as biochemical tools and therapeutic leads 招待有り 査読有り
Nakagawa, Y.
Biosci. Biotechnol. Biochem. 76 巻 頁： 1262-1274 2012年
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Carbohydrate-binding molecules with non-peptidic skeletons 招待有り 査読有り
Nakagawa, Y. and Ito, Y.
Trends Glycosci. Glycotechnol. 24 巻 頁： 1-12 2012年
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Synthesis and structure-activity studies of simplified analogues of aplysiatoxin with antiproliferative activity like bryostatin-1 招待有り 査読有り
Irie, K., Kikumori, M., Kamachi, H., Tanaka, K., Murakami, A., Yanagita, R. C., Tokuda, H., Suzuki, N., Nagai, H., Suenaga, K., and Nakagawa, Y.
Pure Appl. Chem. 84 巻 頁： 1341-1351 2012年
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Challenges to the Development of Bryostatin-type Anticancer Drugs Based on the Activation Mechanism of Protein Kinase Cδ 招待有り 査読有り
Irie, K., Yanagita, R. C., and Nakagawa, Y.
Med. Res. Rev. 32 巻 頁： 518-535 2012年
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Synthesis and Biological Evaluation of the 12,12-Dimethyl Derivative of Aplog-1, an Anti-Proliferative Analog of Tumor-Promoting Aplysiatoxin 査読有り
Nakagawa, Y., Kikumori, M., Yanagita, R. C., Murakami, A., Tokuda, H., Nagai, H. and Irie, K.
Biosci. Biotechnol. Biochem. 75 巻 頁： 1167-1173 2011年
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Mapping of the Primary Mannose-Binding Site of Pradimicin A 査読有り
Nakagawa, Y., Doi, T., Masuda, Y., Takegoshi, K., Igarashi, Y., and Ito, Y.
J. Am. Chem. Soc. 133 巻 頁： 17485-17493 2011年
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Solid-state NMR Spectroscopic Analysis of the Ca2+-dependent Mannose Binding of Pradimicin A 査読有り
Nakagawa, Y., Masuda, Y., Yamada, K., Doi, T., Takegoshi, K., Igarashi, Y., and Ito, Y.
Angew. Chem. Int. Ed. 50 巻 頁： 6084-6088 2011年
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Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity 査読有り
Yanagita, R. C., Kamachi, H., Tanaka, K., Murakami, A., Nakagawa, Y., Tokuda, H., Nagai, H., and Irie, K.
Bioorg. Med. Chem. Lett. 20 巻 頁： 6064-6066 2010年
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A Simple Analog of Tumor-promoting Aplysiatoxin Is an Antineoplastic Agent Rather Than a Tumor Promoter: Development of a Synthetically Accessible PKC Activator with Bryostatin-like Activity 査読有り
Nakagawa, Y., Yanagita, R. C., Hamada, N., Murakami, A., Takahashi, H., Saito, N., Nagai, H. and Irie, K.
J. Am. Chem. Soc. 131 巻 頁： 7573-7579 2009年
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Synthesis, Conformational Analysis, and Biological Evaluation of 1-Hexyl-indolactam-V10 as a Selective Activator for Novel Protein Kinase C Isozymes 査読有り
Yanagita, R. C., Nakagawa, Y., Yamanaka, N., Kashiwagi, K., Saito, N. and Irie, K.
J. Med. Chem. 51 巻 頁： 46-56 2008年
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Binding selectivity of 1- or 12-substituted indolactam derivatives for protein kinase C isozymes 査読有り
Yanagita, R. C., Torii, K., Nakagawa, Y. and Irie, K.
Heterocycles 73 巻 頁： 289-302 2007年
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Design and Synthesis of 8-Octyl-benzolactam-V9, the selective activator for PKCε and η 査読有り
Nakagawa, Y., Irie, K., Yanagita, R. C., Ohigashi, H., Tsuda, K., Kashiwagi, K. and Saito, N.
J. Med. Chem. 49 巻 頁： 2681-2688 2006年
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Indolactam-V is involved in the CH/π Interaction with Pro-11 of PKCδ C1B domain: Application to Structural Optimization for PKCδ Ligand 査読有り
Nakagawa, Y., Irie, K., Yanagita, C. R., Ohigashi, H. and Tsuda, K.
J. Am. Chem. Soc. 127 巻 頁： 5746-5747 2005年
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Toward the Development of New Medicinal Leads with Selectivity for Protein Kinase C Isozymes 招待有り 査読有り
Irie, K., Nakagawa, Y. and Ohigashi, H.
Chem. Rec. 5 巻 頁： 185-195 2005年