研究者詳細 - 中川　優

論文 - 中川　優

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Molecular Basis of Mannose Recognition by Pradimicins and their Application to Microbial Cell Surface Imaging 査読有り国際誌

Nakagawa Yu, Doi Takashi, Takegoshi K., Sugahara Takahiro, Akase Dai, Aida Misako, Tsuzuki Kazue, Watanabe Yasunori, Tomura Tomohiko, Ojika Makoto, Igarashi Yasuhiro, Hashizume Daisuke, Ito Yukishige

CELL CHEMICAL BIOLOGY 26 巻 ( 7 ) 頁： 950 - + 2019年7月

Molecular basis of N-glycan recognition by pradimicin A and its potential as a SARS-CoV-2 entry inhibitor 査読有り

Yu Nakagawa, Masato Fujii, Nanaka Ito, Makoto Ojika, Dai Akase, Misako Aida, Takaaki Kinoshita, Yasuteru Sakurai, Jiro Yasuda, Yasuhiro Igarashi, Yukishige Ito

Bioorganic & Medicinal Chemistry 105 巻頁： 117732 2024年4月

レクチンミミックの開発と応用研究の最前線査読有り

中川　優

35 巻 ( 203 ) 頁： E6 - E10 2023年1月

Chemical modification of pradimicin A to suppress aggregation without impairing D-mannose-binding and antifungal activities 査読有り国際誌

Nakagawa Yu, Oya Yuzuka, Ojika Makoto, Igarashi Yasuhiro, Ito Yukishige

TETRAHEDRON 121 巻 2022年8月

D-Mannose binding, aggregation property, and antifungal activity of amide derivatives of pradimicin A 査読有り国際誌

Miyanishi Wataru, Ojika Makoto, Akase Dai, Aida Misako, Igarashi Yasuhiro, Ito Yukishige, Nakagawa Yu

BIOORGANIC & MEDICINAL CHEMISTRY 55 巻頁： 116590 2022年2月

Mannose-binding analysis and biological application of pradimicins 招待有り査読有り国際誌

Nakagawa Yu, To Yukishige

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES 98 巻 ( 1 ) 頁： 15 - 29 2022年1月

A Pradimicin-Based Staining Dye for Glycoprotein Detection 査読有り国際誌

Nakagawa Yu, Kakihara Shintaro, Tsuzuki Kazue, Ojika Makoto, Igarashi Yasuhiro, Ito Yukishige

JOURNAL OF NATURAL PRODUCTS 84 巻 ( 9 ) 頁： 2496 - 2501 2021年9月

Binding Evaluation of Pradimicins for Oligomannose Motifs from Fungal Mannans 査読有り国際誌

Nakagawa Yu, Yamaji Fumiya, Miyanishi Wataru, Ojika Makoto, Igarashi Yasuhiro, Ito Yukishige

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN 94 巻 ( 3 ) 頁： 732 - 754 2021年3月

Paving the Way for Practical Use of Sugar-Binding Natural Products as Lectin Mimics in Glycobiological Research 査読有り国際誌

Nakagawa Yu

CHEMBIOCHEM 21 巻 ( 11 ) 頁： 1567 - 1572 2020年6月

The endocyclic oxygen atom of D-mannopyranose is involved in its binding to pradimicins 査読有り国際誌

Watanabe Yasunori, Yamaji Fumiya, Ojika Makoto, Sugawara Takahiro, Akase Dai, Aida Misako, Igarashi Yasuhiro, Ito Yukishige, Nakagawa Yu

TETRAHEDRON LETTERS 61 巻 ( 9 ) 2020年2月

Relationship among structure, cytotoxicity, and Michael acceptor reactivity of quinocidin 査読有り国際誌

Nakagawa Yu, Sawaki Yuki, Miyanishi Wataru, Shimomura Sayako, Shibata Takahiro, Ojika Makoto

BIOORGANIC & MEDICINAL CHEMISTRY 28 巻 ( 4 ) 頁： 115308 2020年2月

SYNTHESIS AND BIOLOGICAL ACTIVITIES OF ACETAL ANALOGS AT POSITION 3 OF 10-METHYL-APLOG-1, A POTENTIAL ANTI-CANCER LEAD DERIVED FROM DEBROMOAPLYSIATOXIN 査読有り国際誌

Hayakawa Koutaro, Hanaki Yusuke, Tokuda Harukuni, Yanagita Ryo C., Nakagawa Yu, Okamura Mutsumi, Dan Shingo, Irie Kazuhiro

HETEROCYCLES 97 巻 ( 1 ) 頁： 478 - 492 2018年9月

Quinocidin, a Cytotoxic Antibiotic with an Unusual 3,4-Dihydroquinolizinium Ring and Michael Acceptor Reactivity toward Thiols 査読有り

Nakagawa Yu, Sawaki Yuki, Kimura Takahiro, Tomura Tomohiko, Igarashi Yasuhiro, Ojika Makoto

CHEMISTRY-A EUROPEAN JOURNAL 23 巻 ( 71 ) 頁： 17894-17897 2017年12月

Solid-State Nuclear Magnetic Resonance Analysis Reveals a Possible Calcium Binding Site of Pradimicin A 査読有り

Doi Takashi, Nakagawa Yu, Takegoshi K.

BIOCHEMISTRY 56 巻 ( 3 ) 頁： 468-472 2017年1月

Solid-State NMR Analysis of Mannose Recognition by Pradimicin A

Nakagawa Yu, Ito Yukishige

NMR IN GLYCOSCIENCE AND GLYCOTECHNOLOGY 10 巻頁： 269-289 2017年

Inhibition of Chikungunya Virus-Induced Cell Death by Salicylate-Derived Bryostatin Analogues Provides Additional Evidence for a PKC-Independent Pathway 査読有り

Staveness, D., Abdelnabi, R., Near, K. E., Nakagawa, Y., Neyts, J., Delang, L., Leyssen, P., Wender, P. A.

Journal of Natural Products 頁： 10.1021/acs.jnatprod.5b01017 2016年2月

Pradimicin A, a D-mannose-binding antibiotic, binds pyranosides of L-fucose and L-galactose in a calcium-sensitive manner 査読有り

Nakagawa, Y., Watanabe, Y., Igarashi, Y., Ito, Y., Ojika, M.

Bioorg. Med. Chem. Lett. 25 巻 ( 15 ) 頁： 2963-2966 2015年5月

天然物の構造単純化による有用分子の創製：天然プロテインキナーゼC活性化剤のアナログ設計査読有り

中川優

有機合成化学協会誌 73 巻 ( 4 ) 頁： 316-327 2015年4月

Computer-guided design, synthesis, and protein kinase C affinity of a new salicylate-based class of bryostatin analogs 査読有り

Wender, P. A., Nakagawa, Y., Near, K. E., Staveness, D.

Org. Lett. 16 巻頁： 5136-5139 2014年

第3の生命鎖・糖鎖に結合する低分子化合物に関する現状と展望招待有り査読有り

中川　優

ファルマシア 50 巻 ( 11 ) 頁： 1117-1122 2014年

Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity 査読有り

Kamachi, H., Tanaka, K., Yanagita, R. C., Murakami, A., Murakami, K., Tokuda, H., Suzuki, N., Nakagawa, Y., and Irie, K.

Bioorg. Med. Chem. 21 巻頁： 2695-2702 2013年

Mannose binding geometry of pradimicin A 査読有り

Nakagawa, Y., Doi, T., Taketani, T., Takegoshi, K., Igarashi, Y., and Ito, Y.

Chem. Eur. J. 19 巻頁： 10516-10525 2013年

Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues 査読有り

Sato, M., Murakami, K., Uno, M., Ikubo, H., Nakagawa, Y., Katayama, S., Akagi, H., Masuda, Y., Takegoshi, K. and Irie, K.

J. Biol. Chem. 288 巻頁： 23212-23224 2013年

Structure-activity relationship for (+)-taxifolin isolated from silymarin as an inhibitor of amyloid beta aggregation 査読有り

Sato, M., Murakami, K., Uno, M., Ikubo, H., Nakagawa, Y., Katayama, S., Akagi, H., and Irie, K.

Biosci. Biotechnol. Biochem. 77 巻頁： 1100-1103 2013年

Solid-state NMR analysis of calcium and D-mannose binding of BMY-28864, a water-soluble analogue of pradimicin A 査読有り

Nakagawa, Y., Doi, T., Takegoshi, K., Igarashi, Y., and Ito, Y.

Bioorg. Med. Chem. Lett. 22 巻頁： 1040-1043 2012年

Molecular architecture and therapeutic potential of lectin mimics 招待有り査読有り

Nakagawa, Y. and Ito, Y.

Advances in Carbohydrate Chemistry and Biochemistry 頁： 1-58 2012年

Artificial analogs of naturally occurring tumor promoters as biochemical tools and therapeutic leads 招待有り査読有り

Nakagawa, Y.

Biosci. Biotechnol. Biochem. 76 巻頁： 1262-1274 2012年

Carbohydrate-binding molecules with non-peptidic skeletons 招待有り査読有り

Nakagawa, Y. and Ito, Y.

Trends Glycosci. Glycotechnol. 24 巻頁： 1-12 2012年

Synthesis and structure-activity studies of simplified analogues of aplysiatoxin with antiproliferative activity like bryostatin-1 招待有り査読有り

Irie, K., Kikumori, M., Kamachi, H., Tanaka, K., Murakami, A., Yanagita, R. C., Tokuda, H., Suzuki, N., Nagai, H., Suenaga, K., and Nakagawa, Y.

Pure Appl. Chem. 84 巻頁： 1341-1351 2012年

Challenges to the Development of Bryostatin-type Anticancer Drugs Based on the Activation Mechanism of Protein Kinase Cδ 招待有り査読有り

Irie, K., Yanagita, R. C., and Nakagawa, Y.

Med. Res. Rev. 32 巻頁： 518-535 2012年

Synthesis and Biological Evaluation of the 12,12-Dimethyl Derivative of Aplog-1, an Anti-Proliferative Analog of Tumor-Promoting Aplysiatoxin 査読有り

Nakagawa, Y., Kikumori, M., Yanagita, R. C., Murakami, A., Tokuda, H., Nagai, H. and Irie, K.

Biosci. Biotechnol. Biochem. 75 巻頁： 1167-1173 2011年

Mapping of the Primary Mannose-Binding Site of Pradimicin A 査読有り

Nakagawa, Y., Doi, T., Masuda, Y., Takegoshi, K., Igarashi, Y., and Ito, Y.

J. Am. Chem. Soc. 133 巻頁： 17485-17493 2011年

Solid-state NMR Spectroscopic Analysis of the Ca2+-dependent Mannose Binding of Pradimicin A 査読有り

Nakagawa, Y., Masuda, Y., Yamada, K., Doi, T., Takegoshi, K., Igarashi, Y., and Ito, Y.

Angew. Chem. Int. Ed. 50 巻頁： 6084-6088 2011年

Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity 査読有り

Yanagita, R. C., Kamachi, H., Tanaka, K., Murakami, A., Nakagawa, Y., Tokuda, H., Nagai, H., and Irie, K.

Bioorg. Med. Chem. Lett. 20 巻頁： 6064-6066 2010年

A Simple Analog of Tumor-promoting Aplysiatoxin Is an Antineoplastic Agent Rather Than a Tumor Promoter: Development of a Synthetically Accessible PKC Activator with Bryostatin-like Activity 査読有り

Nakagawa, Y., Yanagita, R. C., Hamada, N., Murakami, A., Takahashi, H., Saito, N., Nagai, H. and Irie, K.

J. Am. Chem. Soc. 131 巻頁： 7573-7579 2009年

Synthesis, Conformational Analysis, and Biological Evaluation of 1-Hexyl-indolactam-V10 as a Selective Activator for Novel Protein Kinase C Isozymes 査読有り

Yanagita, R. C., Nakagawa, Y., Yamanaka, N., Kashiwagi, K., Saito, N. and Irie, K.

J. Med. Chem. 51 巻頁： 46-56 2008年

Binding selectivity of 1- or 12-substituted indolactam derivatives for protein kinase C isozymes 査読有り

Yanagita, R. C., Torii, K., Nakagawa, Y. and Irie, K.

Heterocycles 73 巻頁： 289-302 2007年

Design and Synthesis of 8-Octyl-benzolactam-V9, the selective activator for PKCε and η 査読有り

Nakagawa, Y., Irie, K., Yanagita, R. C., Ohigashi, H., Tsuda, K., Kashiwagi, K. and Saito, N.

J. Med. Chem. 49 巻頁： 2681-2688 2006年

Indolactam-V is involved in the CH/π Interaction with Pro-11 of PKCδ C1B domain: Application to Structural Optimization for PKCδ Ligand 査読有り

Nakagawa, Y., Irie, K., Yanagita, C. R., Ohigashi, H. and Tsuda, K.

J. Am. Chem. Soc. 127 巻頁： 5746-5747 2005年

Toward the Development of New Medicinal Leads with Selectivity for Protein Kinase C Isozymes 招待有り査読有り

Irie, K., Nakagawa, Y. and Ohigashi, H.

Chem. Rec. 5 巻頁： 185-195 2005年

Synthesis, Conformation and PKC isozyme Surrogate Binding of Indolinelactam-Vs, New Conformationally-Restricted Analogues of (-)-Indolactam-V 査読有り

Nakagawa, Y., Irie, K., Komiya, Y., Ohigashi, H. and Tsuda, K.

Tetrahedron 60 巻頁： 7077-7084 2004年

Indolactam and Benzolactam Compounds as New Medical Leads with Binding Selectivity for C1 Domains of Protein Kinase C Isozymes 招待有り査読有り

Irie, K., Nakagawa, Y. and Ohigashi, H.

Curr. Pharm. Design 10 巻頁： 1371-1385 2004年

Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s 査読有り

Irie, K., Masuda, A., Shindo, M., Nakagawa, Y. and Ohigashi, H.

Bioorg. Med. Chem. Lett. 12 巻頁： 4547-4583 2004年

Synthesis and Binding Selectivity of 7- and 15-Decylbenzolactone-V8 for the C1 Domains of Protein Kinase C Isozymes 査読有り

Nakagawa, Y., Irie, K., Yamanaka, N., Ohigashi, H. and Tsuda, K.

Bioorg. Med. Chem. Lett. 13 巻頁： 3015-3019 2003年

Synthesis and PKC Isozyme Surrogate Binding of Lactone Analogues of Benzolactam-V8's 査読有り

Nakagawa, Y., Irie, K., Masuda, A. and Ohigashi, H.

Tetrahedron 58 巻頁： 2101-2115 2002年

Establishment of a binding assay for new medicinal leads with protein kinase C isozyme and C1 domain selectivity 招待有り査読有り

Irie, K., Nakahara, A., Nakagawa, Y., Ohigashi, H., Shindo, M., Fukuda, H., Konishi, H., Kikkawa, U., Kashiwagi, K. and Saito, N.

Pharmacol. Ther. 93 巻頁： 271-281 2002年

Binding Selectivity of Conformationally Restricted Analogues of (-)-Indolactam-V to the C1 Domains of Protein Kinase C Isozymes 査読有り

Masuda, A., Irie, K., Nakagawa, Y. and Ohigashi, H.

Biosci. Biotechnol. Biochem. 66 巻頁： 1615-1617 2002年

The C4 Hydroxyl Group of Phorbol Esters is Not Necessary for Protein Kinase C Binding 査読有り

Tanaka, M., Irie, K., Nakagawa, Y., Nakamura, Y., Ohigashi, H. and Wender, P. A.

Bioorg. Med. Chem. Lett. 11 巻頁： 719-722 2001年

The Amide Hydrogen of (-)-Indolactam-V and Benzolactam-V8's Plays a Critical Role in Protein Kinase C Binding and Tumor-promoting Activities 査読有り

Nakagawa, Y., Irie, K., Nakamura, Y. and Ohigashi, H.

Bioorg. Med. Chem. Lett. 11 巻頁： 723-728 2001年

Synthesis and Tumor-promoting Activities of 12-Epi-phorbol-12,13-dibutyrate 査読有り

Irie, K., Nakahara, A., Ikawa, Y., Tanaka, M., Nakagawa, Y., Nakamura, Y., Ohigashi, H. and Wender, P. A.

Biosci. Biotechnol. Biochem. 64 巻頁： 2429-2436 2000年

Selective Binding of Tumor Promoters to the Novel PKC C1B Domains 招待有り査読有り

Irie, K., Nakahara, A., Nakagawa, Y., Ohigashi, H., Shindo, M., Fukuda, H., Konishi, H. and Kikkawa, U.

Peptide Science 2000 頁： 197-200 2000年

Selective Binding to the nPKC C1B Domains by Tumor Promoters

Nakagawa, Y. and Irie, K.

Bioscience & Industry 58 巻頁： 570-571 2000年

Synthesis and PKC Isozyme Surrogate Binding of Indothiolactam-V, a New Thioamide Analogue of Tumor Promoting Indolactam-V 査読有り

Nakagawa, Y., Irie, K., Ohigashi, H., Hayashi, H. and Wender, P. A.

Bioorg. Med. Chem. Lett. 10 巻頁： 2087-2090 2000年

Isolation of (-)-14-O-Malonylindolactam-V as a Possible Precursor of (-)-Indolactam-V and (-)-14-O-Acetylindolactam-V from Streptomyces blastmyceticum 査読有り

Irie, K., Tomimatsu, S., Nakagawa, Y., Ohigashi, H. and Hayashi, H.

Biosci. Biotechnol. Biochem. 63 巻頁： 1669-1670 1999年

Synthesis and Biological Activities of (-)-6-n-Octyl-indolactam-V, a New Potent Analogue of the Tumor Promoter (-)-Indolactam-V 査読有り

Nakagawa, Y., Irie, K., Nakamura, Y. and Ohigashi, H.

Biosci. Biotechnol. Biochem. 62 巻頁： 1568-1573 1998年

Biosynthesis of Monoterpenoid Moiety of Teleocidins via the Non-mevalonate Pathway in Streptomyces 査読有り

Irie, K., Nakagawa, Y., Tomimatsu, S. and Ohigashi, H.

Tetrahedron Lett. 39 巻頁： 7929-7930 1998年

Synthesis and Biological Activities of Indolactone-V, the Lactone Analogue of the Tumor Promoter (-)-Indolactam-V 査読有り

Nakagawa, Y., Irie, K., Nakamura, Y., Ohigashi, H. and Hayashi, H.

Biosci. Biotech. Biochem. 61 巻頁： 1415-1417 1997年

Comparison of Chemical Characteristics of the First and Second Cystein-Rich Domains of Protein Kinase Cγ 査読有り

Irie, K., Yanai, Y., Oie, K., Ishizawa, J., Nakagawa, Y., Ohigashi, H., Wender, P. A. and Kikkawa, U.

Bioorg. Med. Chem. 5 巻頁： 1725-1737 1997年

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