研究者詳細 - 宮田　聖子

論文 - 宮田　聖子

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Effects of age and sex on eye movement characteristics. Open Access

Takahashi J, Miura K, Morita K, Fujimoto M, Miyata S, Okazaki K, Matsumoto J, Hasegawa N, Hirano Y, Yamamori H, Yasuda Y, Makinodan M, Kasai K, Ozaki N, Onitsuka T, Hashimoto R

Neuropsychopharmacology reports 41 巻 ( 2 ) 頁： 152 - 158 2021年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Neuropsychopharmacology Reports

Abnormal eye movements are often associated with psychiatric disorders. Eye movements are sensorimotor functions of the brain, and aging and sex would affect their characteristics. A precise understanding of normal eye movements is required to distinguish disease-related abnormalities from natural differences associated with aging or sex. To date, there is no multicohort study examining age-related dependency and sex effects of eye movements in healthy, normal individuals using large samples to ensure the robustness and reproducibility of the results. In this study, we aimed to provide findings showing the impact of age and sex on eye movement measures. The present study used eye movement measures of more than seven hundred healthy individuals from three large independent cohorts. We herein evaluated eye movement measures quantified by using a set of standard eye movement tests that have been utilized for the examination of patients with schizophrenia. We assessed the statistical significance of the effects of age and sex and its reproducibility across cohorts. We found that 4-18 out of 35 eye movement measures were significantly correlated with age, depending on the cohort, and that 10 of those, which are related to the fixation and motor control of smooth pursuit and saccades, showed high reproducibility. On the other hand, the effects of sex, if any, were less reproducible. The present results suggest that we should take age into account when we evaluate abnormalities in eye movements.

DOI： 10.1002/npr2.12163

Sleep fragmentation and working memory in healthy adults. Open Access

Okuda M, Noda A, Mabuchi S, Iwamoto K, Banno M, Miyata S, Yasuma F, Ozaki N

Sleep science (Sao Paulo, Brazil) 14 巻 ( Spec 2 ) 頁： 111 - 117 2021年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Sleep Science

Introduction: Sleep is essential for performing cognitive function in humans. We have hypothesized that sleep fragmentation compared to sleep efficiency may have a negative impact on the working memory. Material and Methods: Twenty-eight healthy adults (18 males and 10 females; mean age 27.8±15.5 years) were enrolled in this study. We measured the total sleep time (TST), sleep efficiency, %stage wakefulness (W), %stage rapid eye movement (REM), %stage N1, %stage N2, %stage N3, wake after sleep onset (WASO), and arousal index using polysomnography. Working memory, executive function, and sustained attention of three domains of cognitive function were evaluated with the number of back task (N-back task), Wisconsin card sorting test (WCST), and continuous performance test-identical pairs (CPT-IP), respectively. Results: The percentage of correct answers on the 2-back task was significantly correlated with %stage REM, %stage N1, and %stage N2 (%stage REM: r=0.505, p=0.006; %stage N1: r=-0.637, p<0.001; %stage N2: r=0.670, p<0.001), and multiple regression analysis including the stepwise forward selection method revealed that %stage N2 was the most significant factor (%stage N2: β=0.670, p<0.001). The percentage of correct answers on the 2-back task was also significantly correlated with TST, sleep efficiency, WASO, and arousal index (TST: r=0.492, p=0.008; sleep efficiency: r=0.622, p<0.001; WASO: r=-0.721, p<0.001; arousal index: r=-0.656, p<0.001), and WASO was the significant factor (β=-2.086, p=0.007). The WCST category achievement and CPT-IP d-prime score were correlated with none of the sleep variables. Conclusion: Increased WASO and a decrease in %stage N2 were associated with worse working memory.

DOI： 10.5935/1984-0063.20200088

Effects of long sleep time and irregular sleep-wake rhythm on cognitive function in older people. Open Access

Okuda M, Noda A, Iwamoto K, Nakashima H, Takeda K, Miyata S, Yasuma F, Ozaki N, Shimouchi A

Scientific reports 11 巻 ( 1 ) 頁： 7039 2021年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Scientific Reports

Sleep disturbances and cognitive decline are common in older adults. We aimed to investigate the effects of the total sleep time (TST) and sleep–wake rhythm on executive function and working memory in older adults. In 63 older participants, we measured the TST, wake after sleep onset (WASO), and sleep timing (midpoint between bedtime and wake-up time) using actigraphy. Executive function was evaluated with the trail making test B (TMT-B) and Wisconsin card sorting test (WCST). The number of back task (N-back task) was used to measure working memory. Participants with a TST ≥ 8 h had a significantly lower percentage of correct answers (% correct) on the 1-back task than those with a TST < 8 h. The % correct on the 1-back task was significantly correlated with the TST, WASO, and sleep timing. Multiple regression analyses revealed that the TST and sleep timing were significant factors of the % correct on the 1-back task. The TMT-B score was significantly correlated with the sleep timing. Category achievement on the WCST was significantly correlated with the standard deviation of the sleep timing. Therefore, a long sleep time and an irregular sleep–wake rhythm could have adverse effects on executive function and working memory in older people.

DOI： 10.1038/s41598-021-85817-y

健康で快適な生活を送るための日常的予防策への一考

横江彩, 野田明子, 宮田聖子, 山羽基

空気調和・衛生工学会　中部支部学術研究発表会論文集 22 巻 ( 0 ) 頁： 77 - 80 2021年

Patient characteristics affecting accurate detection of sleep apnea using a bed sheet-type portable monitor.

Miyata S, Otake H, Ando M, Okuda M, Fujishiro H, Iwamoto K, Noda A, Sone M, Ozaki N

Sleep & breathing = Schlaf & Atmung 24 巻 ( 2 ) 頁： 783 - 790 2020年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Sleep and Breathing

Purpose: Although performed inside a laboratory, attended polysomnography (PSG) has long been the gold standard for the diagnosis of sleep apnea. However, high costs and long wait times have led to the development of home-based portable monitoring devices. A bed sheet-shaped device called SD102 (Suzuken Co., Nagoya, Japan) has been developed, and its accuracy in evaluating sleep apnea is becoming evident. The purpose of this study was to confirm the accuracy of SD102 in evaluating sleep apnea and to investigate patient characteristics that may contribute to inaccurate test results in patients with suspected obstructive sleep apnea (OSA). Methods: One hundred and eighty-nine patients simultaneously underwent PSG and portable monitoring by using a home sleep apnea testing (HSAT) device. A blinded, experienced technologist using the American Academy of Sleep Medicine criteria versions 2.1 and 2.3 scored the PSG data and HSAT device data, respectively. Results: The respiratory event index (REI) by HSAT significantly correlated with the apnea–hypopnea index (AHI) by PSG (r = 0.974, p < 0.001). HSAT sensitivity, specificity, and positive and negative predictive values of 0.99, 0.83, 0.95, and 0.97, respectively. Body mass index and arousal index were significantly associated with the difference between REI from SD102 HSAT and AHI from PSG. Conclusions: This study demonstrates the good agreement between REI and AHI in patients with suspected OSA and suggests that understanding the limitations of different testing methods may help in the accurate detection of OSA.

DOI： 10.1007/s11325-019-01963-8

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Scopus

PubMed

SLEEP MONITORING WITH A SINGLE CHANNEL EEG RECORDER IN PATIENTS WITH PSYCHIATRIC DISORDERS

Miyata S., Iwamoto K., Banno M., Ito Y., Noda A., Ozaki N.

SLEEP 43 巻頁： A220 - A221 2020年4月

Effects of sleep-disordered breathing and hypertension on cognitive function in elderly adults.

Kato K, Noda A, Yasuma F, Matsubara Y, Miyata S, Iwamoto K, Miyazaki S, Ozaki N

Clinical and experimental hypertension (New York, N.Y. : 1993) 42 巻 ( 3 ) 頁： 250 - 256 2020年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Clinical and Experimental Hypertension

Purpose: The prevalence of sleep-disordered breathing (SDB) increases with aging. SDB is a risk of hypertension, and both might lead to cognitive decline. However, the role of SDB and hypertension on the pathogenesis of age-related cognitive decline remains unclear. We examined the effects of these two diseases on cognitive function in elderly adults. Methods: Fifty-two elderly individuals (mean age, 69.6 ± 4.0 years) free from impairment in daily living activities participated in this study. Apnea/hypopnea index (AHI) and minimum oxygen saturation (SpO2) were assessed using a portable home monitoring device. We evaluated excessive daytime sleepiness with the Epworth sleepiness scale (ESS). Cognitive performance was assessed using the Wisconsin card sorting test (WCST), continuous performance test-Identical pairs (CPT-IP), and N-back task. Hypertension and diabetes mellitus were evaluated via questionnaire and blood pressure value. Results: The WCST category achievement was significantly lower in participants with minimum SpO2 <90% than those with minimum SpO2 ≥90%. The percentage of correct answer on the 0- and 1-back tasks was significantly lower in the hypertensives than normotensives. Minimum SpO2 was correlated with category achievement on the WCST. Multiple regression analysis including age, sex, body mass index, AHI, minimum SpO2, ESS, hypertension, and diabetes mellitus revealed that hypertension was the most significant factor for percentage correct answers on the 0- and 1-back tasks. There were no significant correlations between body mass index, ESS or diabetes mellitus and the parameters of WCST, CPT-IP, or N-back tasks. Conclusion: In elderly adults, nocturnal hypoxia and hypertension had a negative effect on cognitive function.

DOI： 10.1080/10641963.2019.1632338

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PubMed

認知症と睡眠障害

宮田聖子

日本臨牀 78 巻頁： 567 - 571 2020年

高齢者の不眠、過眠、薬物療法が運転に及ぼす影響と指導法を教えてください

宮田聖子

老年医学 58 巻頁： 433 - 436 2020年

Clinical profiles of late-onset psychiatric patients exhibiting incidental REM sleep without atonia.

Fujishiro H, Okuda M, Iwamoto K, Miyata S, Torii Y, Iritani S, Ozaki N

Journal of neural transmission (Vienna, Austria : 1996) 126 巻 ( 8 ) 頁： 1095 - 1104 2019年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Neural Transmission

Rapid eye movement (REM) sleep without atonia (RWA), which is a hallmark of REM sleep behavior disorder (RBD) on polysomnography (PSG), may represent specific characteristics of prodromal Parkinson’s disease (PD)/dementia with Lewy bodies (DLB), even when dream-enactment behavior is absent. We investigated the clinical profiles associated with PD/DLB in late-onset psychiatric patients exhibiting incidental RWA. Among patients who underwent PSG in our psychiatric ward, eight with incidental RWA, nine with idiopathic RBD, and seven with PD or DLB who had preceding RBD were included. Clinical variables, including the percentage of RWA in the total REM sleep (%RWA), were compared among the three groups. The frequency of depressive disorders as a primary psychiatric diagnosis and antidepressant usage were significantly higher in the incidental RWA group than in the other groups. There were no differences in the prevalence of supportive features of DLB among the three groups. The median %RWA was significantly lower in the incidental RWA group than in the other groups. Although the cardiac 123I-metaiodobenzylguanidine uptake was significantly higher in the incidental RWA group compared with the other groups, the groups showed overlap in the specific binding ratios on dopamine transporter imaging. All patients in the three groups exhibited cingulate island sign ratios on brain perfusion single-photon emission computed tomography within a threshold of 0.281, which is the optimal cut-off value for a diagnosis of DLB. In this series, late-onset psychiatric patients with incidental RWA partially shared common clinical profiles with idiopathic RBD and PD/DLB.

DOI： 10.1007/s00702-019-02035-7

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Scopus

PubMed

CUFF-LESS BLOOD PRESSURE MONITORING DURING SLEEP

Noda A., Mita Y., Miyata S., Ando M., Okumura T.

JOURNAL OF HYPERTENSION 37 巻頁： E254 - E254 2019年7月

Effect of Valvular Regurgitation on Left Ventricular Function in Middle-aged and Elderly

MIYATA Seiko, NODA Akiko

Journal of Clinical Physiology 49 巻 ( 2 ) 頁： 89 - 96 2019年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Japanese Society of Clinical Physiology

Background: Valvular regurgitation, a degenerative condition, increases in prevalence with age. Its impact on left ventricular (LV) function in the elderly remains unclear, however.Objective: The purpose of this study was to characterize the relationship between LV function and valvular regurgitation in middle-aged and elderly.Methods: Echocardiography was performed to assess LV systolic and diastolic function in 98 community-dwelling middle-aged and older adults. Mitral regurgitation (MR) and aortic regurgitation (AR) were qualitatively graded from absent or trivial to severe.Results: The LV ejection fraction was significantly higher and the deceleration time at the mitral level during rapid filling significantly longer in the MR group than in the non-MR group. The ratio of early diastolic wave peak velocity to mitral annular early diastolic peak velocity was significantly greater in the AR group than in the non-AR group.Conclusions: Both MR and AR may play an important role in change in LV systolic and diastolic function, even in cases of mild regurgitation, in middle-aged and elderly.

DOI： 10.34363/jocp.49.2_89

CiNii Research

EFFECTS OF AROMATHERAPY ON SLEEP AND COGNITIVE FUNCTION IN THE ELDERLY

Noda Akiko, Funaki Narumi, Hirashita Rie, Nakashima Honoka, Mita Yasuaki, Masato Okuda, Miyata Seiko, Iwamoto Kunihiro, Ozaki Norio, Urakami Katsuya

SLEEP 42 巻頁： . 2019年4月

DIFFERENCES IN SLEEP DURATION AND QUALITY BETWEEN WEEKDAYS AND WEEKENDS IN JAPANESE ADULTS

Miyata Seiko, Iwamoto Kunihiro, Ando Motoo, Ito Yuki, Noda Aiko, Ozaki Norio

SLEEP 42 巻頁： . 2019年4月

Delayed sleep/wake rhythm and excessive daytime sleepiness correlate with decreased daytime brain activity during cognitive task in university students

Miyata S., Noda A., Kawai S., Honda K., Iwamoto K., Ozaki N., Miyazaki S., Kondo T.

Biological Rhythm Research 50 巻 ( 2 ) 頁： 171 - 179 2019年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Biological Rhythm Research

Insufficient sleep and irregular sleep/wake rhythm are common problems among university students. We investigated the effect of sleep/wake rhythm and excessive daytime sleepiness (EDS) on the cortical oxygenation as measured by near-infrared spectroscopy (NIRS) and cognitive performance in university students. Peak- and integral values by a word fluency task were measured with NIRS. EDS was evaluated by the Epworth sleepiness scale (ESS), and performance function was evaluated using N-back task. Peak cerebral oxygenation was significantly correlated with ESS, bedtime, wake-up time, and median time of sleep. Accuracy on 2-back task was significantly correlated with integral value. Peak- and integral values were significantly lower, and bedtime and median time of sleep were significantly delayed in the EDS group than in the non-EDS group. EDS accompanied by delayed sleep/wake rhythm and short sleep duration may play an important role in decreasing daytime brain activity and cognitive performance.

DOI： 10.1080/09291016.2018.1433467

Web of Science

Scopus

Application of eye trackers for understanding mental disorders: Cases for schizophrenia and autism spectrum disorder.

Shishido E, Ogawa S, Miyata S, Yamamoto M, Inada T, Ozaki N

Neuropsychopharmacology reports 2019年2月

今月の特集1 発症を予測する臨床検査-先制医療で5疾病に立ち向かう! 精神疾患の先制医療

宮田聖子, 尾崎紀夫

臨床検査 63 巻 ( 1 ) 頁： 37 - 41 2019年1月

Very low frequency component of heart rate variability as a marker for therapeutic efficacy in patients with obstructive sleep apnea: Preliminary study. Open Access

Noda A, Hayano J, Ito N, Miyata S, Yasuma F, Yasuda Y

Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 24 巻 ( 1 ) 頁： 84 2019年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Research in Medical Sciences

Background: Although positive airway pressure (PAP) therapy is effective for treating obstructive sleep apnea (OSA), some patients with severe OSA are intolerable to this treatment, which may lead to an increase in the mortality and morbidity of cardiovascular diseases. We investigated the relationship between heart rate variability (HRV) and sleep parameters during natural sleep and treatment of patients with OSA. Materials and Methods: This was the cross-sectional observation study. Patients were 17 males with severe OSA who were unable to accept continuous PAP. Standard polysomnography was performed for two consecutive nights, i.e., during natural sleep and following night with bilevel PAP (BiPAP) treatment. Time-dependent responses of the amplitudes of low frequency (LF), very low frequency (VLF), and high frequency components of HRV were assessed with the technique of complex demodulation. Results: Apnea-hypopnea index, oxygen desaturation time, and percentage of stage 1 sleep were significantly reduced, whereas the percentages of rapid eye movement and stages 3 + 4 sleep were increased, by BiPAP treatment. Therapy also reduced the amplitudes of VLF and LF components of HRV. Difference in amplitudes of VLF during natural sleep and treatment with BiPAP was significantly correlated with difference in percentages of stage 1 and stages 3 + 4 sleep. Conclusion: Therapy-induced amelioration of OSA and sleep quality was accompanied by decrease in the amplitudes of VLF components of HRV. The VLF component may thus reflect physiological changes in both autonomic activity and sleep structure and serve as an objective marker for therapeutic efficacy in patients with severe OSA.

DOI： 10.4103/jrms.JRMS_62_18

宮田聖子, 野田明子, 岩本邦弘, 尾崎紀夫

オレオサイエンス 19 巻 ( 7 ) 頁： 285 - 290 2019年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：公益社団法人日本油化学会

睡眠は，代謝調節に重要な役割を果たし，睡眠障害は脂質代謝異常を来す。中でも睡眠呼吸障害は，脂質代謝異常，高血圧や糖尿病と密接に関わっており，心血管病の発症リスクを高めるとの証左が多い。近年，質量分析計を用い睡眠障害による脂質代謝異常の分子的なメカニズムを解明しようという試みがなされている。閉塞性睡眠時無呼吸患者において重症度と脂質分子種プロファイルが関連すること，睡眠時間制限によりいくつかの脂質分子種が変動することが報告されている。質量分析計を用いた脂質代謝産物の包括的解析は，睡眠 / 覚醒調節および関連する代謝プロセスの理解をさらに深め，代謝プロファイリングを利用することで病態および治療効果評価においてバイオマーカー探索に不可欠となると考えられている。本稿では，睡眠と脂質代謝異常との関連について疫学研究および質量分析による研究を紹介する。

DOI： 10.5650/oleoscience.19.285

CiNii Research

Effects of hypnotics on prefrontal cortex activity during a verbal fluency task in healthy male subjects: A near-infrared spectroscopy study

Tsuruta Yoshiyuki, Iwamoto Kunihiro, Banno Masahiro, Kawano Naoko, Kohmura Kunihiro, Miyata Seiko, Fujishiro Hiroshige, Noda Yukihiro, Noda Akiko, Iritani Shuji, Ozaki Norio

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL 33 巻 ( 6 ) 頁： e2678 2018年11月

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