研究者詳細 - 宮田　聖子

Association of sleep-wake state discrepancy and depressive symptoms with restorative sleep in patients with depression. Open Access

Kawai K, Iwamoto K, Miyata S, Okada I, Ando M, Fujishiro H, Noda A, Ozaki N, Ikeda M

Sleep medicine 127 巻頁： 166 - 169 2025年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Sleep Medicine

Objective: One of the common symptoms of mood disorders is insomnia, and the recovery processes can be negatively impacted by a lack of restorative sleep. Although factors related to restorative sleep in healthy subjects have been investigated, evaluations of these factors in patients with depression have been rarely done. Patients with depression are known to have sleep-wake state discrepancy, which can further influence their restorative sleep beyond that associated with depressive symptoms. Thus, we investigated restorative sleep in depressed patients in our current study, and attempted to identify associated factors, with a particular focus on sleep-wake state discrepancy. Methods: In the 91 participants evaluated in this cross-sectional study, all subjects filled out questionnaires on their symptoms prior to undergoing polysomnography (PSG). Sleep duration and restorative sleep were evaluated on the morning after the PSG. The association between restorative sleep and various factors was then examined using multiple regression analysis. Results: A negative association with restorative sleep was found through multiple regression analysis for depressive symptoms (β = −0.055, p = 0.007), daytime sleepiness (β = −0.106, p = 0.020), and overestimation of wake after sleep onset (β = −0.006, p = 0.030). Conclusions: By subjectively and objectively assessing sleep, addressing depressive symptoms, and implementing appropriate sleep hygiene, clinicians could be able to improve restorative sleep in depressed patients.

DOI： 10.1016/j.sleep.2025.01.021

Sleep Deprivation Elevates Resting and Exercise Blood Pressures and Augments Pressor Response at Exercise Onset.

MR Imaging Indices for Brain Interstitial Fluid Dynamics and the Effects of Orexin Antagonists on Sleep.

Taoka T, Iwamoto K, Miyata S, Ito R, Nakamichi R, Nakane T, Okada I, Ichikawa K, Kan H, Kamagata K, Kikuta J, Aoki S, Fujimoto A, Kogo Y, Ichinose N, Naganawa S, Ozaki N

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine advpub 巻 ( 0 ) 2025年2月

Hori A, Su X, Sagasaki S, Saito R, Suijo K, Miyata S, Hasegawa D, Mizuno M, Hotta N

Medicine and science in sports and exercise 2024年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Medicine and Science in Sports and Exercise

Purpose: Sleep deprivation and elevated blood pressure (BP) increase the risk of cardiovascular diseases. However, the effects of sleep deprivation on BP response, especially at exercise onset remain unclear. We aimed to elucidate the effects of experimental sleep deprivation (ESD) on resting and exercise BPs, including that at exercise onset, and investigate whether a night-time nap during ESD changes the ESD-altered BP. Methods: Twelve healthy young men underwent 2-min submaximal isometric elbow flexion (IEF) exercise to measure BP after 7 days of normal sleep (control trial), 24-h ESD (ESD trial), and ESD with a 2-h night-time nap (ESD+NAP trial), which were randomly performed. Results: ESD significantly elevated the mean arterial pressure (MAP) at rest (85.8 ± 8.0 to 93.3 ± 5.1 mmHg, P = 0.003) and at the last minute of IEF (116.9 ± 13.0 to 126.2 ± 11.8 mmHg, P = 0.003) compared with that observed in the control trial. At IEF onset (the initial 15 s), ESD significantly elevated the MAP (88.7 ± 12.6 to 103.1 ± 8.8 mmHg, P < 0.001) and augmented the MAP responsiveness from baseline, compared with that observed in the control trial (Δ2.9 ± 11.4 to Δ9.8 ± 6.6 mmHg, P = 0.017). The MAP responsiveness in the ESD+NAP trial (Δ7.3 ± 5.2 mmHg) was not significantly different from that in the control trial (P = 0.165) and the ESD trial (P = 0.129). Conclusions: ESD significantly elevated both resting BP and the BP during submaximal isometric exercise and significantly augmented the initial pressor response to the exercise. A 2-h night-time nap during ESD appears to be insufficient to completely attenuate ESD-induced augmented pressor responses.

DOI： 10.1249/MSS.0000000000003640

Phenotypes for general behavior, activity, and body temperature in 3q29 deletion model mice. Open Access

Mori D, Ikeda R, Sawahata M, Yamaguchi S, Kodama A, Hirao T, Arioka Y, Okumura H, Inami C, Suzuki T, Hayashi Y, Kato H, Nawa Y, Miyata S, Kimura H, Kushima I, Aleksic B, Mizoguchi H, Nagai T, Nakazawa T, Hashimoto R, Kaibuchi K, Kume K, Yamada K, Ozaki N

Translational psychiatry 14 巻 ( 1 ) 頁： 138 2024年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Translational Psychiatry

Whole genome analysis has identified rare copy number variations (CNV) that are strongly involved in the pathogenesis of psychiatric disorders, and 3q29 deletion has been found to have the largest effect size. The 3q29 deletion mice model (3q29-del mice) has been established as a good pathological model for schizophrenia based on phenotypic analysis; however, circadian rhythm and sleep, which are also closely related to neuropsychiatric disorders, have not been investigated. In this study, our aims were to reevaluate the pathogenesis of 3q29-del by recreating model mice and analyzing their behavior and to identify novel new insights into the temporal activity and temperature fluctuations of the mouse model using a recently developed small implantable accelerometer chip, Nano-tag. We generated 3q29-del mice using genome editing technology and reevaluated common behavioral phenotypes. We next implanted Nano-tag in the abdominal cavity of mice for continuous measurements of long-time activity and body temperature. Our model mice exhibited weight loss similar to that of other mice reported previously. A general behavioral battery test in the model mice revealed phenotypes similar to those observed in mouse models of schizophrenia, including increased rearing frequency. Intraperitoneal implantation of Nano-tag, a miniature acceleration sensor, resulted in hypersensitive and rapid increases in the activity and body temperature of 3q29-del mice upon switching to lights-off condition. Similar to the 3q29-del mice reported previously, these mice are a promising model animals for schizophrenia. Successive quantitative analysis may provide results that could help in treating sleep disorders closely associated with neuropsychiatric disorders.

DOI： 10.1038/s41398-023-02679-w

Assessment of cognitive function and sleep-wake rhythms in community-dwelling older adults. Open Access

Okuda M, Noda A, Iwamoto K, Hishikawa N, Miyata S, Yasuma F, Taoka T, Ozaki N, Suhr JA, Miyazaki S

Sleep and biological rhythms 22 巻 ( 1 ) 頁： 137 - 145 2024年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Sleep and Biological Rhythms

Disruption of the circadian rhythm and sleep–wake cycles is a consequence of aging and is associated with the cognitive decline and many neurodegenerative conditions. We investigated the bedtime, wake-up time, sleep timing (midpoint between bedtime and wake-up time), and sleep timing standard deviation (SD) using the actigraphy among 80 consecutive volunteers aged ≥ 60 years. Global cognitive function and executive function of detailed cognitive domains were evaluated using the mini-mental state examination (MMSE) and Wisconsin card sorting test (WCST) and subjective daytime sleepiness was assessed using the Epworth Sleepiness Scale (ESS). The category achievement (CA), total errors (TE), perseverative errors of Nelson (PEN), non-perseverative errors (NPE), and difficulties in maintaining set (DMS) on the WCST were significantly correlated with sleep timing SD (CA: r = − 0.276, p = 0.013, TE: r = 0.311, p = 0.005, PEN: r = 0.241, p = 0.032, NPE: r = 0.250, p = 0.025, DMS: r = 0.235, p = 0.036), but not with the MMSE score. Multiple regression analyses with the stepwise forward selection method including age, ESS score, bedtime, sleep timing, and sleep timing SD, revealed that the ESS score, and sleep timing SD were significant factors related to CA on the WCST (ESS score: β = − 0.322, p = 0.004; sleep timing SD: β = − 0.250, p = 0.022). Assessment of sleep–wake rhythms, daytime sleepiness, and cognitive function using the MMSE and WCST is valuable for the prediction of cognitive decline in the geriatric population.

DOI： 10.1007/s41105-023-00491-z

Assessing the Real-World, Long-Term Impact of Lemborexant on Sleep Quality in a Home-Based Clinical Study. Open Access

Miyata S, Iwamoto K, Okada I, Fujimoto A, Kogo Y, Mori D, Amano M, Matsuyama N, Nishida K, Ando M, Taoka T, Naganawa S, Ozaki N

Nature and science of sleep 16 巻頁： 291 - 303 2024年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nature and Science of Sleep

Purpose: Both subjective and objective evaluations are essential for the treatment of insomnia. Lemborexant has been shown to be effective in the long-term based solely on a subjective basis, and no long-term objective measures have been evaluated under natural sleep conditions. Small, lightweight sleep electroencephalogram (EEG) monitor was used, instead of polysomnography, to objectively evaluate sleep at home 4 and 12 weeks after lemborexant treatment. Patients and Methods: Adults and elderly subjects with insomnia disorder, per the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, were enrolled in this open-label, single-arm, single-center trial. Objective and subjective measures of sleep were prospectively assessed. Sleep disturbance, excessive sleepiness, and depressive symptoms were assessed using questionnaires. Results: A total of 45 subjects were screened, of which 33 were enrolled. Paired t-tests were conducted to evaluate changes in sleep variables and compared with the baseline; subjects showed significant improvements in objective sleep efficiency (SE) and subjective sleep parameters at weeks 4 and 12 following treatment with lemborexant. When baseline values were taken into account, a repeated-multivariate analysis of variance (MANOVA) revealed statistically significant changes in the objective measures. Sleep disturbance, excessive sleepiness, and depressive symptoms improved after three months of lemborexant treatment. Conclusion: Furthermore, lemborexant therapy improved nocturnal sleep, when measured objectively using sleep EEG monitoring at home, and improved daytime sleepiness and depressive symptoms in older adults with insomnia disorder.

DOI： 10.2147/NSS.S448871

LPS and its relationship with subjective-objective discrepancies of sleep onset latency in patients with psychiatric disorders.

Kawai K, Iwamoto K, Miyata S, Okada I, Ando M, Fujishiro H, Ando M, Noda A, Ozaki N

Scientific reports 13 巻 ( 1 ) 頁： 22637 2023年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Scientific Reports

Subjective–objective discrepancies in sleep onset latency (SOL), which is often observed among psychiatric patients, is attributed partly to the definition of sleep onset. Recently, instead of SOL, latency to persistent sleep (LPS), which is defined as the duration from turning out the light to the first consecutive minutes of non-wakefulness, has been utilized in pharmacological studies. This study aimed to determine the non-awake time in LPS that is most consistent with subjective sleep onset among patients with psychiatric disorders. We calculated the length of non-awake time in 30-s segments from lights-out to 0.5–60 min. The root mean square error was then calculated to determine the most appropriate length. The analysis of 149 patients with psychiatric disorders showed that the optimal non-awake time in LPS was 12 min. On the other hands, when comorbid with moderate or severe obstructive sleep apnea (OSA), the optimal length was 19.5 min. This study indicates that 12 min should be the best fit for the LPS non-awake time in patients with psychiatric disorders. When there is comorbidity with OSA, however, a longer duration should be considered. Measuring LPS minimizes discrepancies in SOL and provides important clinical information.

DOI： 10.1038/s41598-023-49261-4

Comparison of Polysomnography, Single-Channel Electroencephalogram, Fitbit, and Sleep Logs in Patients With Psychiatric Disorders: Cross-Sectional Study. Open Access

Kawai K, Iwamoto K, Miyata S, Okada I, Fujishiro H, Noda A, Nakagome K, Ozaki N, Ikeda M

Journal of medical Internet research 25 巻 ( 1 ) 頁： e51336 2023年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Medical Internet Research

Background: Sleep disturbances are core symptoms of psychiatric disorders. Although various sleep measures have been developed to assess sleep patterns and quality of sleep, the concordance of these measures in patients with psychiatric disorders remains relatively elusive. Objective: This study aims to examine the degree of agreement among 3 sleep recording methods and the consistency between subjective and objective sleep measures, with a specific focus on recently developed devices in a population of individuals with psychiatric disorders. Methods: We analyzed 62 participants for this cross-sectional study, all having data for polysomnography (PSG), Zmachine, Fitbit, and sleep logs. Participants completed questionnaires on their symptoms and estimated sleep duration the morning after the overnight sleep assessment. The interclass correlation coefficients (ICCs) were calculated to evaluate the consistency between sleep parameters obtained from each instrument. Additionally, Bland-Altman plots were used to visually show differences and limits of agreement for sleep parameters measured by PSG, Zmachine, Fitbit, and sleep logs. Results: The findings indicated a moderate agreement between PSG and Zmachine data for total sleep time (ICC=0.46; P<.001), wake after sleep onset (ICC=0.39; P=.002), and sleep efficiency (ICC=0.40; P=.006). In contrast, Fitbit demonstrated notable disagreement with PSG (total sleep time: ICC=0.08; wake after sleep onset: ICC=0.18; sleep efficiency: ICC=0.10) and exhibited particularly large discrepancies from the sleep logs (total sleep time: ICC=–0.01; wake after sleep onset: ICC=0.05; sleep efficiency: ICC=–0.02). Furthermore, subjective and objective concordance among PSG, Zmachine, and sleep logs appeared to be influenced by the severity of the depressive symptoms and obstructive sleep apnea, while these associations were not observed between the Fitbit and other sleep instruments. Conclusions: Our study results suggest that Fitbit accuracy is reduced in the presence of comorbid clinical symptoms. Although user-friendly, Fitbit has limitations that should be considered when assessing sleep in patients with psychiatric disorders.

DOI： 10.2196/51336

Assessment of cognitive function and sleep-wake rhythms in community-dwelling older adults

Okuda Masato, Noda Akiko, Iwamoto Kunihiro, Hishikawa Nozomi, Miyata Seiko, Yasuma Fumihiko, Taoka Toshiaki, Ozaki Norio, Suhr Julie A., Miyazaki Soichiro

SLEEP AND BIOLOGICAL RHYTHMS 2023年9月

高齢発症うつ病とPsychiatric-onset DLB

藤城弘樹, 鳥居洋太, 宮田聖子, 岩本邦弘

自殺予防と危機介入 43 巻 ( 2 ) 頁： 81 - 89 2023年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本自殺予防学会

高齢発症うつ病では、若年発症と比較して、焦燥、心気症、身体症状、認知機能障害などを伴うことが多く、加齢による脳器質的変化の影響が一要因と推測されるが、その背景病理は不明である。加齢に伴い、レビー病理は高齢者剖検脳に認められ、パーキンソン病やレビー小体型認知症（DLB）を含むレビー小体病の背景病理であり、その前駆（初期）症状として、しばしば抑うつ状態が出現する。症候学的にうつ病と重複することから、両者の鑑別診断に注意が必要であり、レム睡眠行動障害、嗅覚障害、視覚認知障害、自律神経障害に着目することが重要である。Prodromal DLBの研究目的の臨床診断基準が公表され、Psychiatric-onset DLBとして前駆・病初期の抑うつ状態に関心が向けられているが、65歳未満における認知症告知後の自殺リスクに留意しつつ、治療方法の確立が課題となっている。

DOI： 10.51098/spcijasp.43.2_81

Evaluating sleep-wake rhythm using a wearable device in patients with mental disorders.

Miyata S, Iwamoto K, Ozaki N

Psychiatry and clinical neurosciences 77 巻 ( 8 ) 頁： 419 - 419 2023年8月

LONG-TERM EFFICACY OF LEMBOREXANT ON OBJECTIVE SLEEP MEASURES IN CLINICAL PRACTICE

Miyata Seiko, Iwamoto Kunihiro, Okada Ippei, Fujimoto Akihiro, Kogo Yuki, Amano Manabu, Matsuyama Nao, Ozaki Norio

SLEEP 46 巻 2023年5月

Temporal trajectories of proposed biomarkers in psychiatric-onset prodromal dementia with Lewy bodies: a case report.

Fujishiro H, Arafuka S, Ogasawara K, Iwamoto K, Miyata S, Torii Y, Iritani S, Ozaki N

Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society 23 巻 ( 1 ) 頁： 196 - 200 2023年1月

Feasibility of a wrist-worn wearable device for estimating mental health status in patients with mental illness. Open Access

Nakagome K, Makinodan M, Uratani M, Kato M, Ozaki N, Miyata S, Iwamoto K, Hashimoto N, Toyomaki A, Mishima K, Ogasawara M, Takeshima M, Minato K, Fukami T, Oba M, Takeda K, Oi H

Frontiers in psychiatry 14 巻頁： 1189765 2023年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Frontiers in Psychiatry

Object: Real-world data from wearable devices has the potential to understand mental health status in everyday life. We aimed to investigate the feasibility of estimating mental health status using a wrist-worn wearable device (Fitbit Sense) that measures movement using a 3D accelerometer and optical pulse photoplethysmography (PPG). Methods: Participants were 110 patients with mental illnesses from different diagnostic groups. The study was undertaken between 1 October 2020 and 31 March 2021. Participants wore a Fitbit Sense on their wrist and also completed the State–Trait Anxiety Inventory (STAI), Positive and Negative Affect Schedule (PANAS), and EuroQol 5 dimensions 5-level (EQ-5D-5L) during the study period. To determine heart rate (HR) variability (HRV), we calculated the sdnn (standard deviation of the normal-to-normal interval), coefficient of variation of R-R intervals, and mean HR separately for each sleep stage and the daytime. The association between mental health status and HR and HRV was analyzed. Results: The following significant correlations were found in the wake after sleep onset stage within 3 days of mental health status assessment: sdnn, HR and STAI scores, HR and PANAS scores, HR and EQ-5D-5L scores. The association between mental health status and HR and HRV was stronger the closer the temporal distance between mental health status assessment and HR measurement. Conclusion: A wrist-worn wearable device that measures PPG signals was feasible for use with patients with mental illness. Resting state HR and HRV could be used as an objective assessment of mental health status within a few days of measurement.

DOI： 10.3389/fpsyt.2023.1189765

Prevalence of obstructive sleep apnea as assessed by polysomnography in psychiatric patients with sleep-related problems.

Okada I, Miyata S, Iwamoto K, Fujishiro H, Noda A, Ozaki N

Sleep & breathing = Schlaf & Atmung 26 巻 ( 4 ) 頁： 1983 - 1991 2022年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Sleep and Breathing

Purpose: Patients with psychiatric disorders often complain of sleep disturbances and are frequently suspected of obstructive sleep apnea (OSA). However, data regarding sleep problems evaluated by attended polysomnography (PSG) remain limited in this population. We analyzed the results of attended PSG from psychiatric patients with sleep-related problems to determine the prevalence and features of sleep disorders among this population. Methods: We retrospectively investigated the attended PSG results of patients with psychiatric disorders: major depressive disorder, bipolar disorder, neurodevelopmental disorder, schizophrenia, neurocognitive disorder, anxiety disorder, somatic symptom disorder. Results: Of 264 patients, 158 men (60%), mean age was 47 ± 19.9 years. More than half of the patients with major depressive disorder (62%), bipolar disorder (70%), schizophrenia (58%), neurocognitive disorders (55%), and somatic symptom disorder (56%) had OSA. Among the psychiatric patients with OSA, 62% of these patients had moderate to severe OSA. The risk factors for OSA were snoring, male, age, and body mass index. The presence of OSA was not associated with the Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale score, or benzodiazepine, antipsychotic, or antidepressant use. Other sleep disorders were insomnia (19%), central disorders of hypersomnia (8%), restless legs syndrome/periodic limb movement of sleep (8%), rapid eye movement sleep behavior disorder (7%), and central sleep apnea syndrome (3%). Conclusions: PSG revealed that moderate to severe OSA was common in psychiatric patients with or without snoring. Subjective symptoms and psychotropics did not predict OSA. Therefore, PSG is needed to reveal sleep conditions in patients with psychiatric disorders.

DOI： 10.1007/s11325-022-02566-6

FLUID study: study protocol for an open-label, single-centre pilot study to investigate the efFect of Lemborexant on sleep management in Japanese sUbjects aged 50 years and older with Insomnia Disorder. Open Access

Polysomnographic characteristics and predictors of positional obstructive sleep apnea in Japanese elderly. Open Access

Miyata S, Otake H, Fujishiro H, Iwamoto K, Noda A, Sone M, Ozaki N

Sleep and biological rhythms 20 巻 ( 3 ) 頁： 403 - 411 2022年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Sleep and Biological Rhythms

Sleep problems and obstructive sleep apnea (OSA) increase with age and disturb life in old age. Positional therapy is one option to treat OSA, but the differences in clinical pathophysiology between elderly and other age groups have not been fully investigated. We explored the pathophysiological features of sleep apnea, factors that are independently associated with positional OSA and the prevalence in elderly patients. We studied demographic and polysomnographic data of 85 elderly individuals with OSA (age ≥ 65 years) and 124 non-elderly patients with OSA (age, 20–64 years). The Amsterdam Positional OSA Classification (APOC) was used to evaluate positional OSA. Body mass index (BMI) and Epworth sleepiness scale were both significantly lower in the elderly group than in the non-elderly group, although apnea/hypopnea index (AHI) did not differ between groups. OSA severity affected total sleep time, sleep efficiency, and waking after sleep onset more in the elderly than in the non-elderly. AHI in the lateral position was significantly lower in elderly than in non-elderly, although AHI in the supine position was almost the same between two groups. The distribution of APOC 1 and 2 (lateral sleep effective) was significantly higher in the elderly than in the non-elderly. Relative factors such as BMI, rate of hypopnea, and lowest SpO2 associated with positional OSA in non-elderly groups did not differ significantly among APOC subgroups in elderly patients. Our findings are suggesting that characteristics of the positional OSA is different between elderly and younger-age OSA patients.

DOI： 10.1007/s41105-022-00385-6

A Study of Factors Causing Sleep State Misperception in Patients with Depression. Open Access

Kawai K, Iwamoto K, Miyata S, Okada I, Ando M, Fujishiro H, Noda A, Ozaki N

Nature and science of sleep 14 巻頁： 1273 - 1283 2022年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nature and Science of Sleep

Purpose: Sleep state misperception, which is the discrepancy between subjective and objective sleep, is often observed in patients with depression. This phenomenon may delay the remission of depression. Previous studies have focused on the total sleep time (TST) misperception, with many of these studies using actigraphy. Thus, our study investigated depressed patients with the exploratory aim of clarifying factors associated with the sleep state misperception including the wake after sleep onset (WASO) misperception, with their objective sleep additionally evaluated by polysomnography (PSG). Patients and Methods: We conducted a cross-sectional study. Before undergoing overnight PSG monitoring, 40 patients with depression completed questionnaires that included the Beck Depression Inventory (BDI), Epworth sleepiness scale, Temperament and Character Inventory, and the Pittsburgh sleep quality index. Patients were also asked to estimate their subjective sleep duration after they woke up in the morning. Based on this data, we calculated the misperception using the following formula: subjective sleep duration minus objective sleep duration. We compared each factor between negative and positive misperception groups and the multiple regression analysis was performed for TST and WASO misperception, respectively. Results: Although sleep architectures, age, severity of depression and obstructive sleep apnea (OSA) exhibited differences in underestimating or overestimating the WASO, only sex differences were associated with underestimating or overestimating their total sleep time (TST). Moreover, BDI, the severity of OSA, sleep architectures (N1% and N2%), and benzodiazepine (BZD) use were significantly correlated with WASO misperception, whereas only OSA severity was significantly correlated with TST misperception. A subsequent multiple regression analysis demonstrated the BDI was independently correlated with the WASO misperception (β=0.341, p=0.049). Conclusion: In clinical practice, interventions especially for OSA, and the reduction of depressive symptoms are an important method for improving patient sleep perception. Moreover, current results suggest that BZD prescriptions should be avoided as well.

DOI： 10.2147/NSS.S366774

Okada I, Iwamoto K, Miyata S, Fujimoto A, Tanaka M, Amano M, Matsuyama N, Taoka T, Naganawa S, Ozaki N

BMJ open 11 巻 ( 11 ) 頁： e054885 2021年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BMJ Open

Introduction Bidirectional associations have been reported between sleep disturbance and both cognitive impairment, including Alzheimer’s disease and amyloid beta-peptide (Aβ) accumulation. These relationships can be explained by the glymphatic system, which acts as a garbage drainage system in the brain. As interstitial fluid dynamics are suggested to increase during sleep, clearance of Aβ can be influenced by sleep disturbance or deprivation. We hypothesised that using lemborexant, an orexin receptor antagonist, to improve sleep quality would also improve the function of the glymphatic system. We plan to examine the effect of lemborexant on sleep quality and the glymphatic system among patients with insomnia disorder. Methods and analysis This pilot study is designed as an open-label, single-arm, single-centre trial. Thirty patients aged 50 years and over with insomnia will be recruited. The participants will take lemborexant (5 mg) at bedtime for 12 weeks and undergo a home-based sleep study at baseline and weeks 4 and 12, as well as MRI examinations to evaluate the glymphatic system at baseline and week 12. The primary outcome will be changes in objective sleep parameters as evaluated using a sleep monitoring system. The secondary outcomes will be changes in subjective sleep parameters. The relationships between changes in sleep parameters and the glymphatic system will be evaluated using diffusion tensor image analysis along the perivascular space, which is called the ALPS-index. Sleep parameters and the ALPS-index will be analysed using a paired t-test or Pearson’s correlation coefficient. Ethics and dissemination The study protocol was approved by Nagoya University Certified Review Board. The findings from this research will be published in peer-reviewed journals and be presented at local, national and international conferences.

DOI： 10.1136/bmjopen-2021-054885

Performance of an ambulatory electroencephalogram sleep monitor in patients with psychiatric disorders.

Miyata S, Iwamoto K, Banno M, Eguchi J, Kaneko S, Noda A, Ozaki N

Journal of sleep research 30 巻 ( 4 ) 頁： e13273 2021年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Sleep Research

Key clinical symptoms observed among individuals with psychiatric disorders include difficulty falling asleep or maintaining sleep, poor sleep quality and nightmares. Those suffering from sleep disorders often present with symptoms of discontent with regard to sleep quality, timing and quantity, and these symptoms have an adverse impact on function and quality of life. A minimally invasive technique would be preferable in patients with psychiatric disorders, who tend to be sensitive to environmental change. Accordingly, we evaluated the performance of Zmachine Insight Plus, an ambulatory electroencephalography sleep monitor, in patients with psychiatric disorders. One hundred and three patients undergoing polysomnography were enrolled in this study. Zmachine Insight Plus was performed simultaneously with polysomnography. Total sleep time, sleep efficiency, wake after sleep onset, rapid eye movement (REM) sleep, light sleep (stages N1 and N2) and deep sleep (stage N3) were assessed. Total sleep time, sleep efficiency, wake after sleep onset, REM sleep duration and non-REM sleep duration of Zmachine Insight Plus showed a significant correlation with those of polysomnography. Lower sleep efficiency and increased frequency of waking after sleep onset, the arousal index and the apnea–hypopnea index on polysomnography were significantly associated with the difference in sleep parameters between the two methods. Among patients with psychiatric disorders who are sensitive to environmental change, Zmachine Insight Plus would be a useful technique to objectively evaluate sleep quality.

DOI： 10.1111/jsr.13273

Patient characteristics affecting accurate detection of sleep apnea using a bed sheet-type portable monitor.

Effects of age and sex on eye movement characteristics. Open Access

Takahashi J, Miura K, Morita K, Fujimoto M, Miyata S, Okazaki K, Matsumoto J, Hasegawa N, Hirano Y, Yamamori H, Yasuda Y, Makinodan M, Kasai K, Ozaki N, Onitsuka T, Hashimoto R

Neuropsychopharmacology reports 41 巻 ( 2 ) 頁： 152 - 158 2021年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Neuropsychopharmacology Reports

Abnormal eye movements are often associated with psychiatric disorders. Eye movements are sensorimotor functions of the brain, and aging and sex would affect their characteristics. A precise understanding of normal eye movements is required to distinguish disease-related abnormalities from natural differences associated with aging or sex. To date, there is no multicohort study examining age-related dependency and sex effects of eye movements in healthy, normal individuals using large samples to ensure the robustness and reproducibility of the results. In this study, we aimed to provide findings showing the impact of age and sex on eye movement measures. The present study used eye movement measures of more than seven hundred healthy individuals from three large independent cohorts. We herein evaluated eye movement measures quantified by using a set of standard eye movement tests that have been utilized for the examination of patients with schizophrenia. We assessed the statistical significance of the effects of age and sex and its reproducibility across cohorts. We found that 4-18 out of 35 eye movement measures were significantly correlated with age, depending on the cohort, and that 10 of those, which are related to the fixation and motor control of smooth pursuit and saccades, showed high reproducibility. On the other hand, the effects of sex, if any, were less reproducible. The present results suggest that we should take age into account when we evaluate abnormalities in eye movements.

DOI： 10.1002/npr2.12163

Sleep fragmentation and working memory in healthy adults. Open Access

Okuda M, Noda A, Mabuchi S, Iwamoto K, Banno M, Miyata S, Yasuma F, Ozaki N

Sleep science (Sao Paulo, Brazil) 14 巻 ( Spec 2 ) 頁： 111 - 117 2021年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Sleep Science

Introduction: Sleep is essential for performing cognitive function in humans. We have hypothesized that sleep fragmentation compared to sleep efficiency may have a negative impact on the working memory. Material and Methods: Twenty-eight healthy adults (18 males and 10 females; mean age 27.8±15.5 years) were enrolled in this study. We measured the total sleep time (TST), sleep efficiency, %stage wakefulness (W), %stage rapid eye movement (REM), %stage N1, %stage N2, %stage N3, wake after sleep onset (WASO), and arousal index using polysomnography. Working memory, executive function, and sustained attention of three domains of cognitive function were evaluated with the number of back task (N-back task), Wisconsin card sorting test (WCST), and continuous performance test-identical pairs (CPT-IP), respectively. Results: The percentage of correct answers on the 2-back task was significantly correlated with %stage REM, %stage N1, and %stage N2 (%stage REM: r=0.505, p=0.006; %stage N1: r=-0.637, p<0.001; %stage N2: r=0.670, p<0.001), and multiple regression analysis including the stepwise forward selection method revealed that %stage N2 was the most significant factor (%stage N2: β=0.670, p<0.001). The percentage of correct answers on the 2-back task was also significantly correlated with TST, sleep efficiency, WASO, and arousal index (TST: r=0.492, p=0.008; sleep efficiency: r=0.622, p<0.001; WASO: r=-0.721, p<0.001; arousal index: r=-0.656, p<0.001), and WASO was the significant factor (β=-2.086, p=0.007). The WCST category achievement and CPT-IP d-prime score were correlated with none of the sleep variables. Conclusion: Increased WASO and a decrease in %stage N2 were associated with worse working memory.

DOI： 10.5935/1984-0063.20200088

Effects of long sleep time and irregular sleep-wake rhythm on cognitive function in older people. Open Access

Okuda M, Noda A, Iwamoto K, Nakashima H, Takeda K, Miyata S, Yasuma F, Ozaki N, Shimouchi A

Scientific reports 11 巻 ( 1 ) 頁： 7039 2021年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Scientific Reports

Sleep disturbances and cognitive decline are common in older adults. We aimed to investigate the effects of the total sleep time (TST) and sleep–wake rhythm on executive function and working memory in older adults. In 63 older participants, we measured the TST, wake after sleep onset (WASO), and sleep timing (midpoint between bedtime and wake-up time) using actigraphy. Executive function was evaluated with the trail making test B (TMT-B) and Wisconsin card sorting test (WCST). The number of back task (N-back task) was used to measure working memory. Participants with a TST ≥ 8 h had a significantly lower percentage of correct answers (% correct) on the 1-back task than those with a TST < 8 h. The % correct on the 1-back task was significantly correlated with the TST, WASO, and sleep timing. Multiple regression analyses revealed that the TST and sleep timing were significant factors of the % correct on the 1-back task. The TMT-B score was significantly correlated with the sleep timing. Category achievement on the WCST was significantly correlated with the standard deviation of the sleep timing. Therefore, a long sleep time and an irregular sleep–wake rhythm could have adverse effects on executive function and working memory in older people.

DOI： 10.1038/s41598-021-85817-y

健康で快適な生活を送るための日常的予防策への一考

横江彩, 野田明子, 宮田聖子, 山羽基

空気調和・衛生工学会　中部支部学術研究発表会論文集 22 巻 ( 0 ) 頁： 77 - 80 2021年

Miyata S, Otake H, Ando M, Okuda M, Fujishiro H, Iwamoto K, Noda A, Sone M, Ozaki N

Sleep & breathing = Schlaf & Atmung 24 巻 ( 2 ) 頁： 783 - 790 2020年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Sleep and Breathing

Purpose: Although performed inside a laboratory, attended polysomnography (PSG) has long been the gold standard for the diagnosis of sleep apnea. However, high costs and long wait times have led to the development of home-based portable monitoring devices. A bed sheet-shaped device called SD102 (Suzuken Co., Nagoya, Japan) has been developed, and its accuracy in evaluating sleep apnea is becoming evident. The purpose of this study was to confirm the accuracy of SD102 in evaluating sleep apnea and to investigate patient characteristics that may contribute to inaccurate test results in patients with suspected obstructive sleep apnea (OSA). Methods: One hundred and eighty-nine patients simultaneously underwent PSG and portable monitoring by using a home sleep apnea testing (HSAT) device. A blinded, experienced technologist using the American Academy of Sleep Medicine criteria versions 2.1 and 2.3 scored the PSG data and HSAT device data, respectively. Results: The respiratory event index (REI) by HSAT significantly correlated with the apnea–hypopnea index (AHI) by PSG (r = 0.974, p < 0.001). HSAT sensitivity, specificity, and positive and negative predictive values of 0.99, 0.83, 0.95, and 0.97, respectively. Body mass index and arousal index were significantly associated with the difference between REI from SD102 HSAT and AHI from PSG. Conclusions: This study demonstrates the good agreement between REI and AHI in patients with suspected OSA and suggests that understanding the limitations of different testing methods may help in the accurate detection of OSA.

DOI： 10.1007/s11325-019-01963-8

Effects of sleep-disordered breathing and hypertension on cognitive function in elderly adults.

SLEEP MONITORING WITH A SINGLE CHANNEL EEG RECORDER IN PATIENTS WITH PSYCHIATRIC DISORDERS

Miyata S., Iwamoto K., Banno M., Ito Y., Noda A., Ozaki N.

SLEEP 43 巻頁： A220 - A221 2020年4月

Kato K, Noda A, Yasuma F, Matsubara Y, Miyata S, Iwamoto K, Miyazaki S, Ozaki N

Clinical and experimental hypertension (New York, N.Y. : 1993) 42 巻 ( 3 ) 頁： 250 - 256 2020年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Clinical and Experimental Hypertension

Purpose: The prevalence of sleep-disordered breathing (SDB) increases with aging. SDB is a risk of hypertension, and both might lead to cognitive decline. However, the role of SDB and hypertension on the pathogenesis of age-related cognitive decline remains unclear. We examined the effects of these two diseases on cognitive function in elderly adults. Methods: Fifty-two elderly individuals (mean age, 69.6 ± 4.0 years) free from impairment in daily living activities participated in this study. Apnea/hypopnea index (AHI) and minimum oxygen saturation (SpO2) were assessed using a portable home monitoring device. We evaluated excessive daytime sleepiness with the Epworth sleepiness scale (ESS). Cognitive performance was assessed using the Wisconsin card sorting test (WCST), continuous performance test-Identical pairs (CPT-IP), and N-back task. Hypertension and diabetes mellitus were evaluated via questionnaire and blood pressure value. Results: The WCST category achievement was significantly lower in participants with minimum SpO2 <90% than those with minimum SpO2 ≥90%. The percentage of correct answer on the 0- and 1-back tasks was significantly lower in the hypertensives than normotensives. Minimum SpO2 was correlated with category achievement on the WCST. Multiple regression analysis including age, sex, body mass index, AHI, minimum SpO2, ESS, hypertension, and diabetes mellitus revealed that hypertension was the most significant factor for percentage correct answers on the 0- and 1-back tasks. There were no significant correlations between body mass index, ESS or diabetes mellitus and the parameters of WCST, CPT-IP, or N-back tasks. Conclusion: In elderly adults, nocturnal hypoxia and hypertension had a negative effect on cognitive function.

DOI： 10.1080/10641963.2019.1632338

Clinical profiles of late-onset psychiatric patients exhibiting incidental REM sleep without atonia.

認知症と睡眠障害

宮田聖子

日本臨牀 78 巻頁： 567 - 571 2020年

高齢者の不眠、過眠、薬物療法が運転に及ぼす影響と指導法を教えてください

宮田聖子

老年医学 58 巻頁： 433 - 436 2020年

Fujishiro H, Okuda M, Iwamoto K, Miyata S, Torii Y, Iritani S, Ozaki N

Journal of neural transmission (Vienna, Austria : 1996) 126 巻 ( 8 ) 頁： 1095 - 1104 2019年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Neural Transmission

Rapid eye movement (REM) sleep without atonia (RWA), which is a hallmark of REM sleep behavior disorder (RBD) on polysomnography (PSG), may represent specific characteristics of prodromal Parkinson’s disease (PD)/dementia with Lewy bodies (DLB), even when dream-enactment behavior is absent. We investigated the clinical profiles associated with PD/DLB in late-onset psychiatric patients exhibiting incidental RWA. Among patients who underwent PSG in our psychiatric ward, eight with incidental RWA, nine with idiopathic RBD, and seven with PD or DLB who had preceding RBD were included. Clinical variables, including the percentage of RWA in the total REM sleep (%RWA), were compared among the three groups. The frequency of depressive disorders as a primary psychiatric diagnosis and antidepressant usage were significantly higher in the incidental RWA group than in the other groups. There were no differences in the prevalence of supportive features of DLB among the three groups. The median %RWA was significantly lower in the incidental RWA group than in the other groups. Although the cardiac 123I-metaiodobenzylguanidine uptake was significantly higher in the incidental RWA group compared with the other groups, the groups showed overlap in the specific binding ratios on dopamine transporter imaging. All patients in the three groups exhibited cingulate island sign ratios on brain perfusion single-photon emission computed tomography within a threshold of 0.281, which is the optimal cut-off value for a diagnosis of DLB. In this series, late-onset psychiatric patients with incidental RWA partially shared common clinical profiles with idiopathic RBD and PD/DLB.

DOI： 10.1007/s00702-019-02035-7

Effect of Valvular Regurgitation on Left Ventricular Function in Middle-aged and Elderly

CUFF-LESS BLOOD PRESSURE MONITORING DURING SLEEP

Noda A., Mita Y., Miyata S., Ando M., Okumura T.

JOURNAL OF HYPERTENSION 37 巻頁： E254 - E254 2019年7月

MIYATA Seiko, NODA Akiko

Journal of Clinical Physiology 49 巻 ( 2 ) 頁： 89 - 96 2019年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Japanese Society of Clinical Physiology

Background: Valvular regurgitation, a degenerative condition, increases in prevalence with age. Its impact on left ventricular (LV) function in the elderly remains unclear, however.Objective: The purpose of this study was to characterize the relationship between LV function and valvular regurgitation in middle-aged and elderly.Methods: Echocardiography was performed to assess LV systolic and diastolic function in 98 community-dwelling middle-aged and older adults. Mitral regurgitation (MR) and aortic regurgitation (AR) were qualitatively graded from absent or trivial to severe.Results: The LV ejection fraction was significantly higher and the deceleration time at the mitral level during rapid filling significantly longer in the MR group than in the non-MR group. The ratio of early diastolic wave peak velocity to mitral annular early diastolic peak velocity was significantly greater in the AR group than in the non-AR group.Conclusions: Both MR and AR may play an important role in change in LV systolic and diastolic function, even in cases of mild regurgitation, in middle-aged and elderly.

DOI： 10.34363/jocp.49.2_89

Delayed sleep/wake rhythm and excessive daytime sleepiness correlate with decreased daytime brain activity during cognitive task in university students

EFFECTS OF AROMATHERAPY ON SLEEP AND COGNITIVE FUNCTION IN THE ELDERLY

Noda Akiko, Funaki Narumi, Hirashita Rie, Nakashima Honoka, Mita Yasuaki, Masato Okuda, Miyata Seiko, Iwamoto Kunihiro, Ozaki Norio, Urakami Katsuya

SLEEP 42 巻頁： . 2019年4月

DIFFERENCES IN SLEEP DURATION AND QUALITY BETWEEN WEEKDAYS AND WEEKENDS IN JAPANESE ADULTS

Miyata Seiko, Iwamoto Kunihiro, Ando Motoo, Ito Yuki, Noda Aiko, Ozaki Norio

SLEEP 42 巻頁： . 2019年4月

Miyata S., Noda A., Kawai S., Honda K., Iwamoto K., Ozaki N., Miyazaki S., Kondo T.

Biological Rhythm Research 50 巻 ( 2 ) 頁： 171 - 179 2019年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Biological Rhythm Research

Insufficient sleep and irregular sleep/wake rhythm are common problems among university students. We investigated the effect of sleep/wake rhythm and excessive daytime sleepiness (EDS) on the cortical oxygenation as measured by near-infrared spectroscopy (NIRS) and cognitive performance in university students. Peak- and integral values by a word fluency task were measured with NIRS. EDS was evaluated by the Epworth sleepiness scale (ESS), and performance function was evaluated using N-back task. Peak cerebral oxygenation was significantly correlated with ESS, bedtime, wake-up time, and median time of sleep. Accuracy on 2-back task was significantly correlated with integral value. Peak- and integral values were significantly lower, and bedtime and median time of sleep were significantly delayed in the EDS group than in the non-EDS group. EDS accompanied by delayed sleep/wake rhythm and short sleep duration may play an important role in decreasing daytime brain activity and cognitive performance.

DOI： 10.1080/09291016.2018.1433467

Very low frequency component of heart rate variability as a marker for therapeutic efficacy in patients with obstructive sleep apnea: Preliminary study. Open Access

Application of eye trackers for understanding mental disorders: Cases for schizophrenia and autism spectrum disorder.

Shishido E, Ogawa S, Miyata S, Yamamoto M, Inada T, Ozaki N

Neuropsychopharmacology reports 2019年2月

今月の特集1 発症を予測する臨床検査-先制医療で5疾病に立ち向かう! 精神疾患の先制医療

宮田聖子, 尾崎紀夫

臨床検査 63 巻 ( 1 ) 頁： 37 - 41 2019年1月

Noda A, Hayano J, Ito N, Miyata S, Yasuma F, Yasuda Y

Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 24 巻 ( 1 ) 頁： 84 2019年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Research in Medical Sciences

Background: Although positive airway pressure (PAP) therapy is effective for treating obstructive sleep apnea (OSA), some patients with severe OSA are intolerable to this treatment, which may lead to an increase in the mortality and morbidity of cardiovascular diseases. We investigated the relationship between heart rate variability (HRV) and sleep parameters during natural sleep and treatment of patients with OSA. Materials and Methods: This was the cross-sectional observation study. Patients were 17 males with severe OSA who were unable to accept continuous PAP. Standard polysomnography was performed for two consecutive nights, i.e., during natural sleep and following night with bilevel PAP (BiPAP) treatment. Time-dependent responses of the amplitudes of low frequency (LF), very low frequency (VLF), and high frequency components of HRV were assessed with the technique of complex demodulation. Results: Apnea-hypopnea index, oxygen desaturation time, and percentage of stage 1 sleep were significantly reduced, whereas the percentages of rapid eye movement and stages 3 + 4 sleep were increased, by BiPAP treatment. Therapy also reduced the amplitudes of VLF and LF components of HRV. Difference in amplitudes of VLF during natural sleep and treatment with BiPAP was significantly correlated with difference in percentages of stage 1 and stages 3 + 4 sleep. Conclusion: Therapy-induced amelioration of OSA and sleep quality was accompanied by decrease in the amplitudes of VLF components of HRV. The VLF component may thus reflect physiological changes in both autonomic activity and sleep structure and serve as an objective marker for therapeutic efficacy in patients with severe OSA.

DOI： 10.4103/jrms.JRMS_62_18

宮田聖子, 野田明子, 岩本邦弘, 尾崎紀夫

オレオサイエンス 19 巻 ( 7 ) 頁： 285 - 290 2019年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：公益社団法人日本油化学会

睡眠は，代謝調節に重要な役割を果たし，睡眠障害は脂質代謝異常を来す。中でも睡眠呼吸障害は，脂質代謝異常，高血圧や糖尿病と密接に関わっており，心血管病の発症リスクを高めるとの証左が多い。近年，質量分析計を用い睡眠障害による脂質代謝異常の分子的なメカニズムを解明しようという試みがなされている。閉塞性睡眠時無呼吸患者において重症度と脂質分子種プロファイルが関連すること，睡眠時間制限によりいくつかの脂質分子種が変動することが報告されている。質量分析計を用いた脂質代謝産物の包括的解析は，睡眠 / 覚醒調節および関連する代謝プロセスの理解をさらに深め，代謝プロファイリングを利用することで病態および治療効果評価においてバイオマーカー探索に不可欠となると考えられている。本稿では，睡眠と脂質代謝異常との関連について疫学研究および質量分析による研究を紹介する。

DOI： 10.5650/oleoscience.19.285

Effects of hypnotics on prefrontal cortex activity during a verbal fluency task in healthy male subjects: A near-infrared spectroscopy study

Tsuruta Yoshiyuki, Iwamoto Kunihiro, Banno Masahiro, Kawano Naoko, Kohmura Kunihiro, Miyata Seiko, Fujishiro Hiroshige, Noda Yukihiro, Noda Akiko, Iritani Shuji, Ozaki Norio

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL 33 巻 ( 6 ) 頁： e2678 2018年11月

The effect of short sleep on lipid metabolism in Japanese university students

Miyata S., Noda A., Iwamoto K., Fujishiro H., Taguchi R., Ozaki N.

JOURNAL OF SLEEP RESEARCH 27 巻頁： . 2018年9月

Hydrogen gas improves left ventricular hypertrophy in Dahl rat of salt-sensitive hypertension.

Matsuoka H, Miyata S, Okumura N, Watanabe T, Hashimoto K, Nagahara M, Kato K, Sobue S, Takeda K, Ichihara M, Iwamoto T, Noda A

Clinical and experimental hypertension (New York, N.Y. : 1993) 頁： 1-5 2018年6月

Early diagnosis of Lewy body disease in patients with late-onset psychiatric disorders using clinical history of rapid eye movement sleep behavior disorder and [I-123]-metaiodobenzylguanidine cardiac scintigraphy

Fujishiro Hiroshige, Okuda Masato, Iwamoto Kunihiro, Miyata Seiko, Torii Youta, Iritani Shuji, Ozaki Norio

PSYCHIATRY AND CLINICAL NEUROSCIENCES 72 巻 ( 6 ) 頁： 423-434 2018年6月

BENEFICIAL EFFECTS OF POSITIONAL THERAPY ON COGNITIVE FUNCTION IN ELDERLY PATIENTS WITH OBSTRUCTIVE SLEEP APNEA

Noda A., Miyata S., Iwamoto K., Ozaki N.

SLEEP 41 巻頁： A209 - A209 2018年4月

睡眠覚醒制御系を用いた精神障害の分類システム構築

宮田聖子

精神医学 60 巻頁： 33 - 41 2018年

Effects of lower limb vibrations in the supine position on autonomic activity in healthy adults 査読有り

Noda A, Tsukano S, Miyata S, Inoue S, Honda K, Yasuma F

Br J Res 4 巻頁： 34 2017年12月

POLYSOMNOGRAPHIC AND MORPHOLOGICAL CHARACTERISTICS IN ELDERLY PATIENTS WITH OBSTRUCTIVE SLEEP APNEA

Miyata S., Otake H., Noda A., Okuda M., Ando M., Fujishiro H., Iwamoto K., Ozaki N.

SLEEP MEDICINE 40 巻頁： E228-E229 2017年12月

Influence of sleep duration on cortical oxygenation in elderly individuals 査読有り

Kato K, Miyata S, Ando M, Matsuoka H, Yasuma F, Iwamoto K, Kawano N, Banno M, Ozaki N, Noda A

Psychiatry Clin Neurosci 71 巻頁： 44-51 2017年11月

Nitric Oxide Plasma Level as a Barometer of Endothelial Dysfunction in Factory Workers

Miyata Seiko, Noda Akiko, Hara Yuki, Ueyama Jun, Kitaichi Kiyoyuki, Kondo Takaaki, Koike Yasuo

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES 125 巻 ( 10 ) 頁： 684-689 2017年11月

Beneficial effects of CPAP treatment on endothelial function in patients with mild to moderate obstructive sleep apnea. 査読有り

4. Miyata S, Noda A, Yasuda Y, Kojima MS, Tsukano S, Sugiura T, Koike Y, Otake H

Cardiovasc Disord Med 2 巻頁： 1-4 2017年5月

REM sleep without atonia in middle-aged and older psychiatric patients and Lewy body disease: a case series. 査読有り

5. Fujishiro H, Okuda M, Iwamoto K, Miyata S, Otake H, Noda A, Iritani S, Ozaki N

Int J Geriatr Psychiatry 32 巻頁： 397-406 2017年4月

REM sleep without atonia in middle-aged and older psychiatric patients and Lewy body disease: a case series

Fujishiro Hiroshige, Okuda Masato, Iwamoto Kunihiro, Miyata Seiko, Otake Hironao, Noda Akiko, Iritani Shuji, Ozaki Norio

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY 32 巻 ( 4 ) 頁： 397-406 2017年4月

EFFECTS OF SLEEP DISORDER AND PHYSICAL ACTIVITY ON COGNITIVE FUNCTION IN OLDER ADULTS

Noda A., Miyata S., Iwamoto K., Ozaki N.

SLEEP 40 巻頁： A314 - A314 2017年4月

Influence of sleep duration on cortical oxygenation in elderly individuals

Kato Kazuko, Miyata Seiko, Ando Motoo, Matsuoka Hiroki, Yasuma Fumihiko, Iwamoto Kunihiro, Kawano Naoko, Banno Masahiro, Ozaki Norio, Noda Akiko

PSYCHIATRY AND CLINICAL NEUROSCIENCES 71 巻 ( 1 ) 頁： 44-51 2017年1月

第3章　睡眠検査

野田明子, 宮田聖子

医学検査 66 巻 ( J-STAGE-2 ) 頁： 95 - 105 2017年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本臨床衛生検査技師会

睡眠障害・睡眠不足は認知症のリスクファクターであり，認知症の発症・重症化の予防において睡眠検査は有用である。睡眠の客観評価法として，終夜における睡眠深度・睡眠中の呼吸循環の生理現象を総合的に評価する睡眠ポリグラフ検査，睡眠覚醒リズムを評価するアクチグラフィ，過眠症の診断や治療効果の判定として実施される反復睡眠潜時検査および在宅で行うことができる簡易睡眠呼吸障害検査がある。主観的睡眠検査として，ピッツバーグ睡眠質問票およびエプワース眠気尺度は睡眠障害のスクリーニングとして日常臨床で汎用されている。また，睡眠日誌はアクチグラフィとともに概日リズム睡眠障害の診断に必須の検査である。これらの睡眠検査の臨床的意義，検査方法および評価を十分理解し，実施することが重要である。

DOI： 10.14932/jamt.17j2-13

Smoking acutely impaired endothelial function in healthy college students

第3章睡眠検査.認知症予防のための検査特集第6部その他の検査査読有り

野田明子, 宮田聖子

医学検査 66 巻頁： 95 - 105 2017年

睡眠検査査読有り

宮田聖子

医学検査 66 巻頁： 95 - 105 2017年

Endomyocardial radial strain rate imaging during dobutamine stress echocardiography for the evaluation of contractile reserve in patients with dilated cardiomyopathy 査読有り

Minoshima M, Noda A, Kobayashi M, Miyata S, Hirashiki A, Okumura T, Izawa H, Ishii H, Kondo T, Murohara T

J Clin Ultrasound ( 44 ) 頁： 555-560 2016年11月

Masked hypertension and morning blood pressure surge in patients with obstructive sleep apnea syndrome 査読有り

Miyata S, Noda A, Otake H, Yasuda Y.

J Sleep Disor: Treat Care 5 巻頁： 1 2016年2月

The effect of habitual physical training on left ventricular function during exercise by three-dimensional echocardiography 査読有り

Kojima MS, Noda A, Miyata S, Kojima J, Hara Y, Minoshima M, Matsushita T, Murohara T

Echocardiography 32 巻頁： 1670-1675 2015年11月

Impaired cortical oxygenation is related to mood disturbance resulting from three nights of sleep restriction. 査読有り

Miyata S, Noda A, Iwamoto K, Kawano N, Banno M, Tsuruta Y, Noda Y, Ozaki N.

Sleep Biol Rhythms 2015年7月

The effect of habitual physical training on left ventricular function during exercise by three-dimensional echocardiography 査読有り

Kojima MS, Noda A, Miyata S, Kojima J, Hara Y, Minoshima M, Matsushita T, Murohara T

Echocardiography 2015年3月

Miyata S., Noda A., Ito Y., Iizuka R., Shimokata K.

Acta Cardiologica 70 巻 ( 3 ) 頁： 282 - 285 2015年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Acta Cardiologica

Objective Cigarette smoking has been clearly pointed out as a risk factor for cardiovascular disease. Endothelial dysfunction contributes to the development of cardiovascular disease. Flow-mediated dilation (FMD) has been known as one of the endothelial function markers. We investigated the acute and chronic effects of smoking on endothelial function in college-aged smokers. Methods Eighteen smokers (mean age: 21 ± 1 y) and 14 non-smokers (mean age: 20 ± 1 y) were enrolled in this study. Brachial-ankle pulsed wave velocity (baPWV), systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) were measured using a plethysmograph. Endotheliumdependent FMD was induced by reactive hyperaemia. High-resolution ultrasound with a 7.5-MHz linear array transducer was used to measure the diameter of the right brachial artery. Measurement of baPWV, SBP, DBP, HR, artery diameter, and %FMD was performed in smokers and non-smokers after 10 min bed rest, and after smoking one cigarette in the smokers. The interval between the two measurements was more than 15 minutes. Results There were no significant differences on baPWV, SBP, DBP, HR, baseline brachial artery diameter between smokers and non-smokers. Percent FMD after smoking was significantly lower than that at rest values in smokers (8.7 ± 4.0 vs 5.3 ± 2.4, P < 0.005), although %FMD at rest was not significantly different between smokers and non-smokers. No other markers showed any significant differences between smokers at rest and after smoking. Conclusion Even the smoking of one cigarette dramatically impaired endothelial function, although habitual cigarette smoking did not decrease FMD in young healthy smokers.

DOI： 10.2143/AC.70.3.3080632

The effects of acute treatment with paroxetine, amitriptyline, and placebo on equilibrium function in healthy subjects: A double-blind crossover trial. 査読有り

Miyata S, Noda A, Iwamoto K, Takahashi M, Hara Y, Kojima J, Iidaka T, Ozaki N.

Int J Psy Clin Pract. 18 巻 ( 1 ) 頁： 32-36 2014年

Effects of a custom-made pillow on sleep and blood pressure circadian rhythm 査読有り

MiyataS, Noda A

J Hypertens 3 巻頁： 183 2014年

睡眠ポリグラフ検査における心電図モニターの役割

宮田聖子, 野田明子

睡眠医療 7 巻頁： 406 - 410 2014年

Effects of Aged Garlic Extract on Left Ventricular Diastolic Function and Fibrosis in a Rat Hypertension Model

Hara Yuki, Noda Akiko, Miyata Seiko, Minoshima Makoto, Sugiurai Mari, Kojima Jun, Takeo Masafumi, Furukawa Mayuko, Cheng Xian Wu, Nagata Kohzo, Murohara Toyoaki

EXPERIMENTAL ANIMALS 62 巻 ( 4 ) 頁： 305-310 2013年10月

Disproportionate change of blood flow between the upper limbs and the lower limbs in healthy young adults during recovery from exercise. 査読有り

Miyata S, Noda A, Nishikimi N, Yamada A, Murohara T, Komori K.

Gazzetta Medica Italiana. 172 巻 ( 3 ) 頁： 131-136 2013年

Comparison of oxygen desaturation patterns in children and adults with sleep-disordered breathing. 査読有り

Hara Y, Noda A, Miyata S, Otake H, Yasuda Y, Okuda M, Koike Y, Nakata S, Nakashima T.

Am J Otolaryngol. 34 巻 ( 5 ) 頁： 537-540 2013年

Poor sleep quality impaired cognitive performance in older adults. 査読有り

Miyata S, Noda A, Iwamoto K, Kawano N, Okuda M, Ozaki N.

J Sleep Res 22 巻 ( 5 ) 頁： 535-541 2013年

Effect of Aged Garlic Extract on Left Ventricular Diastolic Function and Fibrosis in Rats Model of Hypertension. 査読有り

Hara Y, Noda A, Miyata S, Minoshima M, Sugiura M, Kojima J, Otake M, Furukawa M, Cheng XW, Nagata K, Murohara T.

Exp Animal. 62 巻頁： 305-310 2013年

Therapeutic strategies for sleep apnea in patients with hypertension and heart failure 査読有り

Noda A, Miyata S, Yasuda Y

Pulmonary Medicine 2013 巻頁： 814169 2013年

Therapeutic strategies for sleep apnea in hypertension and heart failure. Open Access

Noda A, Miyata S, Yasuda Y

Pulmonary medicine 2013 巻頁： 814169 2013年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Pulmonary Medicine

Sleep-disordered breathing (SDB) causes hypoxemia, negative intrathoracic pressure, and frequent arousal, contributing to increased cardiovascular disease mortality and morbidity. Obstructive sleep apnea syndrome (OSAS) is linked to hypertension, ischemic heart disease, and cardiac arrhythmias. Successful continuous positive airway pressure (CPAP) treatment has a beneficial effect on hypertension and improves the survival rate of patients with cardiovascular disease. Thus, long-term compliance with CPAP treatment may result in substantial blood pressure reduction in patients with resistant hypertension suffering from OSAS. Central sleep apnea and Cheyne-Stokes respiration occur in 30-50% of patients with heart failure (HF). Intermittent hypoxemia, nocturnal surges in sympathetic activity, and increased left ventricular preload and afterload due to negative intrathoracic pressure all lead to impaired cardiac function and poor life prognosis. SDB-related HF has been considered the potential therapeutic target. CPAP, nocturnal O2 therapy, and adaptive servoventilation minimize the effects of sleep apnea, thereby improving cardiac function, prognosis, and quality of life. Early diagnosis and treatment of SDB will yield better therapeutic outcomes for hypertension and HF. © 2013 Akiko Noda et al.

DOI： 10.1155/2013/814169

Rapid eye movement (REM) sleep: New research

心房細動と睡眠呼吸障害

宮田聖子, 野田明子

睡眠医療 7 巻頁： 272 - 275 2013年

Noda A.

Rapid Eye Movement Sleep: New Research 頁： 73-83 2012年3月

The effects of the prone position on the physiological function in healthy students. 査読有り

Miyata S, Noda A, Fujii Y, Maekawa A, Okuda M, Nakazaki C, Otake H, Nakata S, Yasuma F, Koike Y, Shimokata K, Nakashima T, Hinohara S.

Open Gen Intern Med J. 5 巻頁： 9-12 2012年

The effects of the prone position on the physiological function in healthy students. 査読有り

Miyata S, Noda A, Fujii Y, Maekawa A, Okuda M, Nakazaki C, Otake H, Nakata S, Yasuma F, Koike Y, Shimokata K, Nakashima T, Hinohara S

Open Gen Intern Med J 5 巻頁： 9-12 2012年

RELATIONSHIP BETWEEN SLEEP DURATION AND CARDIO-ANKLE VASCULAR INDEX IN HEALTHY YOUNG ADULTS

Noda A., Miyata S.

SLEEP 35 巻頁： A317 - A317 2012年

The ratio of adiponectin to homeostasis model assessment of insulin resistance is a powerful index of each component of metabolic syndrome in an aged Japanese population: results from the KING Study.

Nakatochi M, Miyata S, Tanimura D, Izawa H, Asano H, Murase Y, Kato R, Ichihara S, Naruse K, Matsubara T, Honda H, Yokota M

Diabetes research and clinical practice 92 巻 ( 3 ) 頁： e61 - 5 2011年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Diabetes Research and Clinical Practice

We evaluated the ratio of adiponectin level to homeostasis model assessment of insulin resistance (A/H ratio) as a risk marker for metabolic syndrome (MetS) and each of its components. The A/H ratio may prove to be a powerful index for evaluation of risk for MetS and each of its components. © 2011 Elsevier Ireland Ltd.

DOI： 10.1016/j.diabres.2011.02.029

Relation of a common variant of the adiponectin gene to serum adiponectin concentration and metabolic traits in an aged Japanese population. Open Access

Tanimura D, Shibata R, Izawa H, Hirashiki A, Asano H, Murase Y, Miyata S, Nakatochi M, Ouchi N, Ichihara S, Yasui K, Yoshida T, Naruse K, Matsubara T, Yokota M

European journal of human genetics : EJHG 19 巻 ( 3 ) 頁： 262 - 9 2011年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：European Journal of Human Genetics

Adiponectin is an adipocyte-derived protein that is down-regulated in obesity-linked disorders. Variants of the adiponectin gene (ADIPOQ) have been shown to affect adiponectin level. We have now examined the relation of polymorphisms of ADIPOQ to adiponectin concentration and to metabolic disorders in the Kita-Nagoya Genomic Epidemiology study, a population-based study of elderly Japanese. The genomic region including ADIPOQ was genotyped for 30 single nucleotide polymorphisms in 500 subjects of a screening population with the use of a fluorescence- or colorimetry-based allele-specific DNA primer-probe assay system. Four polymorphisms were then selected for genotyping in an additional 2797 subjects. Serum adiponectin level was negatively associated with metabolic abnormalities after adjustment for age and sex. The minor alleles of the rs1656930, Ile164Thr, and rs9882205 polymorphisms were associated with a low serum adiponectin level. Whereas the minor alleles of rs1656930 and rs9882205 were common (minor allele frequency of 6.2 and 38.5%, respectively), that of Ile164Thr was rare (0.9%). The minor allele of rs1656930 was positively associated with systolic blood pressure and the prevalence of hypertension. The association of rs1656930 with adiponectin level was replicated in an independent population. A subject with the 164Thr/Thr genotype had an extremely low serum adiponectin level (0.6 g/ml) and the phenotype of metabolic syndrome. Our results suggest that a common variant of ADIPOQ, the minor allele of rs1656930, is associated with hypoadiponectinemia and hypertension. Screening for a common genetic background underlying low adiponectin levels might provide important information for assessment and management of metabolic disorders. © 2011 Macmillan Publishers Limited All rights reserved.

DOI： 10.1038/ejhg.2010.201

Monitoring sleep-wake rhythm with actigraphy in patients on CPAP therapy. 査読有り

Otake M, Miyata S, Noda A, Koike Y, Hara Y, Sugiura M, Minoshima M, Kojima J, Nakata S, Nakashima T.

Respiration 82 巻頁： 136-141 2011年

Monitoring sleep-wake rhythm with actigraphy in patients on continuous positive airway pressure therapy. Open Access

Otake M, Miyata S, Noda A, Koike Y, Hara Y, Sugiura M, Minoshima M, Kojima J, Nakata S, Nakashima T

Respiration; international review of thoracic diseases 82 巻 ( 2 ) 頁： 136 - 41 2011年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Respiration

Background:Continuous positive airway pressure (CPAP) therapy has been shown to be effective in alleviating the underlying obstruction as well as reducing patients' excessive sleepiness and improving their functioning and health-related quality of life. However, residual excessive sleepiness is observed in some patients even though CPAP therapy eliminates sleep apnea and desaturation. Objectives:The aim of this study was to determine the prognostic effect of actigraphic sleep-wake rhythm evaluation in the management of patients with obstructive sleep apnea syndrome (OSAS) treated with CPAP. Methods: Eighteen patients with OSAS diagnosed by standard polysomnography (PSG; 48.1 ± 12.5 years) were enrolled in this study. The sleep-wake parameters were determined by actigraphy before and after 1 month of CPAP treatment, and results were compared with PSG data. In addition, data obtained before CPAP were compared with those measured after 1 month of CPAP treatment. Results:The total sleep time (TST) and sleep efficiency using PSG were significantly correlated with those using actigraphy. Bland-Altman plots of TST and sleep efficiency confirmed good agreement between PSG and actigraphy data. Sleep efficiency significantly improved following CPAP compared to baseline, and sleep fragmentation and sleep fragmentation >5 min determined by actigraphy were significantly lower during CPAP therapy than at baseline. Movement was significantly lower on CPAP therapy than at baseline. Conclusions:Actigraphy provides a valuable sleep-wake rhythm assessment in outpatients with OSAS where PSG is difficult to perform. © 2011 S. Karger AG, Basel.

DOI： 10.1159/000321238

健常成人における熟成にんにくの血管内皮機能へ及ぼす影響

ONE NIGHT SLEEP RESTRICTION IMPAIRS THE CORTICAL OXYGENATION RESPONSES

Miyata S., Noda A., Ito M., Iwamoto K., Ozaki N.

EUROPEAN PSYCHIATRY 26 巻頁： . 2011年

Relation of polymorphisms of the adiponectin gene to components of metabolic syndrome in a population-based study in Japan

Tanimura D., Shibata R., Izawa H., Asano H., Hirashiki A., Miyata S., Nakatochi M., Naruse K., Matsubara T., Yokota M.

EUROPEAN HEART JOURNAL 31 巻頁： 1006-1006 2010年9月

宮田聖子, 野田明子, 永井万由佳, 大嶽正文, 上山純, 古池保雄

日本臨床生理学会雑誌 = Japanese journal of applied physiology 40 巻 ( 2 ) 頁： 103 - 108 2010年4月

Insufficient sleep impairs driving performance and cognitive function. 査読有り

Miyata S, Noda A, Ozaki N, Hara Y, Minoshima M, Iwamoto K, Takahashi M, Iidaka T, Koike Y

Neurosci Lett 469 巻頁： 229-233 2010年

EFFECT OF SLEEP DISORDER ON CARDIOVASCULAR FUNCTION IN THE ELDERLY

Nakazaki C., Noda A., Yamada S., Miyata S., Koike Y.

SLEEP 33 巻頁： A353 - A354 2010年

SLEEP FRAGMENTATION AND HYPOXIA IMPAIR ENDOTHELIAL FUNCTION IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA SYNDROME

Noda A., Miyata S., Nakazaki C., Nakata S., Koike Y.

SLEEP 33 巻頁： A118 - A118 2010年

Sleep and lifestyle habits in morning and evening types of human circadian rhythm. 査読有り

Sukegawa M, Noda A, Morishita Y, Ohi H, Miyata S, Honda K, Maeno N, Ozaki N, Koike Y

Biological Rhythm Research 40 巻頁： 121-127 2009年

Impact of microarousal associated with increased negative esophageal pressure in sleep-disordered breathing. 査読有り

Sukegawa M, Noda A, Yasuda Y, Nakata S, Sugiura T, Miyata S, Honda K, Hasegawa Y, Nakashima T, Koike Y

Sleep Breath 13 巻頁： 369-373 2009年

Aortic Pressure Augmentation as a Marker of Cardiovascular Risk in Obstructive Sleep Apnea Syndrome

NODA Akiko, NAKATA Seiichi, FUKATSU Hiroshi, YASUDA Yoshinari, MIYAO Etsuko, MIYATA Seiko, YASUMA Fumihiko, MUROHARA Toyoaki, YOKOTA Mitsuhiro, KOIKE Yasuo

Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension 31 巻 ( 6 ) 頁： 1109 - 1114 2008年6月

Evaluation of left ventricular function in healthy subjects during exercise using three-dimensional echocardiography

Sugiura M., Noda A., Gotoh Y., Minoshima M., Hara Y., Miyata S., Itoh R., Iino S., Nagata K., Koike Y.

Choonpa Igaku 35 巻 ( 4 ) 頁： 409 - 414 2008年2月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Choonpa Igaku

Purpose : Three-dimensional (3D) echocardiography is useful for the accurate evaluation of left ventricular (LV) function, but its reliability during exercise remains unclear. We conducted an investigation to determine whether 3D echocardiography was practicable for evaluating LV function during exercise. Subjects and Methods : We studied 18 healthy subjects (12 males, 6 females: 22. 7 ±1. 8 years). All subjects underwent supine bicycle ergometer exercise tests. We compared stroke volume index (SVI, stroke volume / body surface area), cardiac index (CI, cardiac output / body surface area), and LV ejection fraction (LVEF) during exercise using pulsed wave Doppler (PWD) and two-dimensional (2D) and 3D echocardiography. The interobserver and intraobserver variations were measured repeatedly during exercise. Results : The SVI and CI measured by 3D echocardiography continued to increase during exercise, and these were accompanied by heart rate elevation. The interobserver and intraobserver variations in LV volume measured by 3D echocardiography were better than those for PWD and 2D echocardiography. We could evaluate the dyssynchrony at maximum exercise using 3D echocardiography. Conclusion : 3D echocardiography is a reproducible tool that could feasibly be used for the evaluation of LV function during exercise. © 2008, The Japan Society of Ultrasonics in Medicine. All rights reserved.

DOI： 10.3179/jjmu.35.409