Faculty Profiles - NAKAMURA, Masanao

Papers - NAKAMURA, Masanao

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Diagnosis and treatment of obscure GI bleeding at double balloon endoscopy Reviewed

Naoki Ohmiya,Tomonori Yano,Hironori Yamamoto,Daigo Arakawa, Masanao Nakamura,Wataru Honda,Akihiro Itoh,Yoshiki Hirooka,Yasumasa Niwa,Osamu Maeda,Takafumi Ando,Tsuneyoshi Matsui,Mitsuo Iida,Shinji Tanaka,Tsutomu Chiba,Choitsu Sakamoto,Kantaro Sugano,Hidemi Goto.

Gastrointestinal Endoscopy Vol. 66 ( 3 ) page： S72-S77 2007.3

Ilealcancer and erosions in small intestine revealed by capsule endoscopy. Reviewed

Niwa Y, Nakamura M, Omiya N, Itoh A, Hirooka Y, Goto H

Endoscopy Vol. 38 page： E91-92 2006

* Preliminary comparison of Capsule Endoscopy and Double-Balloon Enteroscopy in Patients with suspected Small-Bowel Bleeding Reviewed

Nakamura, M., Niwa, Y., Ohmiya, N., Miyahara, R., Ohashi, A., Itoh, A., Hirooka, Y., Goto, H.

Endoscopy Vol. 38 ( 1 ) page： 59-66 2006.1

Endscopic resection of Peutz-Jeghers polips throughout the small intestine at double-balloon enteroscopy without laparotomy Reviewed

Ohmiya,N., Taguchi, A., Shirai, K., Mabuchi, N., Arakawa, D., Kanazawa, H., Ozeki, M., Yamada, M.,Nakamura, M., Itoh, A., Hirooka, Y., Niwa, Y., (Nagasaka, T., Ito, M., Ohashi, S., Okamura, S.,Goto, H.,

Gastrointestinal Endoscopy Vol. 61 ( 1 ) page： 140-148 2005.1

Usefulness of endoscopic ultrasonography for differentiating between non-functional pancreatic neuroendocrine neoplasm and intrapancreatic accessory spleen.

Kano Y, Ishikawa T, Yamao K, Mizutani Y, Iida T, Uetsuki K, Yamamura T, Furukawa K, Nakamura M, Kawashima H

Scientific reports Vol. 15 ( 1 ) page： 6385 2025.2

Prognostic Role of Enhancing Mural Nodules in Intraductal Papillary Mucinous Neoplasms with High-Risk Stigmata.

Kumano R, Ohno E, Ishikawa T, Yamao K, Mizutani Y, Iida T, Uetsuki K, Yamamura T, Furukawa K, Nakamura M, Honda T, Kawashima H

Annals of surgery 2025.2

New drug-delivery balloon catheter for easy and fast injection of triamcinolone after esophageal endoscopic submucosal dissection.

Hirose T, Shibata H, Furukawa K, Yamamura T, Ishikawa T, Nakamura M, Kawashima H

Endoscopy Vol. 56 ( S 01 ) page： E634 - E635 2024.12

Nationwide multicenter prospective study on the usefulness, safety, and acceptability of colon capsule endoscopy in Japan.

Hotta N, Ohmiya N, Hiraga H, Nakaji K, Osawa S, Omori T, Mitsufuji S, Hosoe N, Nouda S, Kobayashi T, Nakamura M, Oka S, Nonogaki K, Baba Y, Mukai R, Matsumoto H, Ikebuchi Y, Shimada M, Togashi K, Katsuki S, Sasaki Y, Sawada R, Kawano S, Furuta T, Tajiri H, Tanaka S, ColoCam-J Study Group

Gastrointestinal endoscopy 2024.11

Clinical factors influencing patency capsule excretion and confirmation in patients with intestinal patency.

Ikegami S, Yamamura T, Nakamura M, Maeda K, Sawada T, Ishikawa E, Ishikawa T, Furukawa K, Hirose T, Kawashima H

Revista espanola de enfermedades digestivas 2024.11

特集炎症性腸疾患update [Chapter 2]　IBD治療のupdate CD内科治療 ②(腸管狭窄に対する内視鏡治療)

中村正直, 山村健史, 澤田つな騎, 石川恵里, 川嶋啓揮

内科 Vol. 134 ( 5 ) page： 1065 - 1067 2024.11

特集炎症性腸疾患update [Chapter 2]　IBD治療のupdate UC内科治療 ③(ステロイド後)

澤田つな騎, 中村正直, 山村健史, 川嶋啓揮

内科 Vol. 134 ( 5 ) page： 1042 - 1049 2024.11

Chronic obstructive pulmonary disease, asthma, and mechanical ventilation are risk factors for dyspnea in patients with long COVID: A Japanese nationwide cohort study.

Matsuyama E, Miyata J, Terai H, Miyazaki N, Iwasaki T, Nagashima K, Watase M, Sunata K, Namkoong H, Asakura T, Masaki K, Chubachi S, Ohgino K, Kawada I, Minami K, Hagiwara R, Ueda S, Yoshiyama T, Kokuto H, Kusumoto T, Oashi A, Miyawaki M, Saito F, Tani T, Ishioka K, Takahashi S, Nakamura M, Ishii M, Sato Y, Fukunaga K

Respiratory investigation Vol. 62 ( 6 ) page： 1094 - 1101 2024.11

Predicting early rebleeding and mortality after endoscopic hemostasis of esophagogastric varices: Diagnostic performance of aspartate aminotransferase-to-platelet ratio index and model for end-stage liver disease-Na score.

Yokoyama S, Honda T, Ishizu Y, Imai N, Ito T, Yamamoto K, Mizuno K, Nakamura M, Kawashima H

Journal of hepato-biliary-pancreatic sciences Vol. 31 ( 11 ) page： 830 - 839 2024.11

特集小腸疾患に対する最新の内視鏡臨床 10.腫瘍性疾患に対する最新の診断治療戦略

中村正直, 山村健史, 前田啓子, 澤田つな騎, 石川恵里, 川嶋啓揮

臨床消化器内科 Vol. 39 ( 12 ) page： 1545 - 1552 2024.10

New Role of the Serotonin as a Biomarker of Gut-Brain Interaction.

Liu HN, Nakamura M, Kawashima H

Life (Basel, Switzerland) Vol. 14 ( 10 ) 2024.10

Monoclonal Antibodies Against Mature Interleukin-18 Ameliorate Colitis and Repair Goblet Cell Function.

Mu J, Maeda K, Ohashi A, Urano T, Nariai Y, Kamino H, Nakamura M, Yamamura T, Sawada T, Ishikawa E, Murate K, Yamamoto K, Hirose T, Furukawa K, Fujishiro M, Kawashima H

Digestive diseases and sciences Vol. 69 ( 7 ) page： 2573 - 2585 2024.7

Language：English Publisher：Digestive Diseases and Sciences

Background: Numerous biological interventions and small molecules are used to treat Crohn’s disease; however, the effectiveness of these treatments varies largely. Non-responsiveness to biological therapies is associated with interleukin (IL)-18 gene polymorphisms and high IL-18 expression has been implicated in the pathogenesis of Crohn’s disease. Aims: The aim of this study was to elucidate the expression of precursor and mature IL-18 in patients with Crohn’s disease who exhibited varied responses to cytokine-targeted treatments and determine whether selective inhibition of mature IL-18 offers a novel therapeutic avenue. Methods: We generated a monoclonal antibody that specifically recognizes the neoepitope of caspase-cleaved mature IL-18. Expression of precursor and mature IL-18 was analyzed in patients with Crohn’s disease. Anti-mature IL-18 monoclonal antibodies were intraperitoneally administered in an acute colitis mouse model, and the disease activity index, body weight loss, tissue pathology, proinflammatory cytokine expression, goblet cell function, and microbiota composition were assessed. Results: Precursor and mature IL-18 expression was upregulated and goblet cell function was impaired in patients with Crohn’s disease who were unresponsive to biological therapies. Administration of anti-mature IL-18 antibodies ameliorated induced colitis by repairing goblet cell function and restoring the mucus layer. Conclusions: The newly developed monoclonal antibody holds promise as a therapeutic alternative for Crohn’s disease.

DOI： 10.1007/s10620-024-08453-2

Scopus

PubMed

Reply - Letter to the editor.

Yokoyama S, Honda T, Ishizu Y, Imai N, Ito T, Yamamoto K, Mizuno K, Kojima T, Kariya N, Nakamura M, Kawashima H

Clinical nutrition (Edinburgh, Scotland) Vol. 43 ( 8 ) page： 1855 - 1856 2024.6

Outcomes of surgical treatment for enterovesical fistula in Crohn's disease.

Hattori N, Nakayama G, Umeda S, Nakamura M, Yamamura T, Sawada T, Nakanishi K, Shimizu D, Kanda M, Hayashi M, Tanaka C, Kodera Y

Nagoya journal of medical science Vol. 86 ( 2 ) page： 280 - 291 2024.5

Language：English Publisher：Nagoya Journal of Medical Science

Enterovesical fistula (EVF) in Crohn’s disease (CD) often does not improve with medical treatment and requires surgical treatment. The surgical treatment strategy for EVF in CD is definitive resection of the intestinal tract side, and performing a leak test using dye injection into the bladder after EVF dissection to determine the appropriate surgical procedure for the bladder side. This study aimed to evaluate the outcomes of surgical treatment for EVF in CD. Twenty-one patients who underwent surgery for EVF between 2006 and 2021 were included and retrospectively evaluated for clinical background, surgical procedures, and postoperative complications. The most common origin of EVF was the ileum (17 cases; 81%), and the most common site of EVF formation was the apex (12; 57%). Surgical approaches were laparotomy in 11 (52%) cases and laparoscopy in 10 (48%). Surgical procedures on the bladder side were fistula dissection in 13 (62%) cases and sutured closure of fistula in 8 (38%). A comparison of approaches revealed no significant difference in operative time, but the amount of blood loss was significantly less in the laparoscopy (p < 0.01). There was no significant difference in the occurrence of postoperative complications between approaches. Postoperative anti-TNF-a antibody agents were used in 17 (81%) cases, and there were no cases of recurrent EVF. In conclusion, definitive resection of the intestinal tract and minimal treatment on the bladder side were sufficient to achieve satisfactory outcomes for EVF in CD.

DOI： 10.18999/nagjms.86.2.280

Scopus

PubMed

特集外科医必携　患者さんとのトラブルを防ぐためのハンドブック各論上部消化管内視鏡検査における鎮静と患者説明

柴田寛幸, 古川和宏, 古根聡, 廣瀨崇, 中村正直, 川嶋啓揮

臨床外科 Vol. 79 ( 3 ) page： 308 - 312 2024.3

特集 IBD診療-ますます増えた薬剤の選択とさらなる進化の展望 1.治療薬の使い分けの総論と各論(4)中等症UCにおけるバイオ製剤/JAK阻害薬の使い分け-抗IL-23抗体も含めて

中村正直, 山村健史, 前田啓子, 澤田つな騎, 石川恵里, 川嶋啓揮

臨床消化器内科 Vol. 39 ( 2 ) page： 140 - 146 2024.1

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Papers - NAKAMURA, Masanao