Faculty Profiles - NAKAMURA, Masanao

Papers - NAKAMURA, Masanao

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A preliminary result of three-dimensional microarray technology to gene analysis with endoscopic ultrasound-guided fine-needle aspiration specimens and pancreatic juices. Reviewed

Nonogaki K, Itoh A, Kawashima H, Ohno E, Ishikawa T, Matsubara H, Itoh Y, Nakamura Y, Nakamura M, Miyahara R, Ohmiya N, Ishigami M, Katano Y, Goto H, Hirooka Y.

J Exp Clin Cancer Res. Vol. 25 page： 29-36 2010

Usefulness of EUS combined with contrast-enhancement in the differential diagnosis of malignant versus benign and preoperative localization of pancreatic endocrine tumors. Reviewed

Ishikawa T, Itoh A, Kawashima H, Ohno E, Matsubara H, Itoh Y, Nakamura Y, Nakamura M, Miyahara R, Hayashi K, Ishigami M, Katano Y, Ohmiya N, Goto H, Hirooka Y.

Gastrointest Endosc. Vol. 75 page： 951-959 2010

Confocal endomicroscopy for phenotypic diagnosis of gastric cancer. Reviewed

Banno K, Niwa Y, Miyahara R, Nakamura M, Nagaya T, Nagasaka T, Watanabe O, Ando T, Kawashima H, Ohmiya N, Itoh A, Hirooka Y, Goto H.

J Gastroenterol Hepatol. Vol. 25 page： 712-718 2010

Restriction-modification systems may be associated with Helicobacter pylori virulence. Reviewed

Ando T, Ishiguro K, Watanabe O, Miyake N, Kato T, Hibi S, Mimura S, Nakamura M, Miyahara R, Ohmiya N, Niwa Y, Goto H.

J Gastroenterol Hepatol. Vol. 25 page： S95-98 2010

Route selection for double-balloon endoscopy, based on capsule transit time, in obscure gastrointestinal bleeding. Reviewed

Nakamura M, Ohmiya N, Shirai O, Takenaka H, Morishima K, Miyahara R, Ando T, Watanabe O, Kawashima H, Itoh A, Hirooka Y, Goto H.

J Gastroenterol. Vol. 45 page： 592-599 2010

Establishment of an interpretation system for video capsule endoscopy for obscure gastrointestinal bleeding. Reviewed

Goto H, Nakamura M, Ohmiya N, Hirooka Y, Itoh A.

J Gastroenterol. Vol. 45 page： 468-469 2010

Advance of Video Capsule Endoscopy and the Detection of Anatomic Landmarks. Reviewed

Nakamura M, Ohmiya N, Shirai O, Takenaka H, Kenji, Morishima, Miyahara R, Ando T,Watanabe O, Kawashima H, Itoh A, Hirooka Y, Niwa Y, Goto H.

Hepatogastroenterology. Vol. 56 page： 1600-1605 2009

Pilot study on confocal endomicroscopy for determination of the depth of squamous cell esophageal cancer on vivo. Reviewed

Iguchi Y, Niwa Y, Miyahara R, Nakamura M, Banno K, Nagaya T, Nagasaka T, Watanabe O, Ando T, Kawashima H, Ohmiya N, Itoh A, Hirooka Y, Goto H.

J Gastroenterol and Hepatol. Vol. 24 page： 1733-1739 2009

Role of endoscopic ultrasonography in predicting the response to cyclosporin A in ulcerative colitis refractory to steroids. Reviewed

Watanabe O, Ando T, El-Omar EM, Shimada M, Ina K, Ishiguro K, Hasegawa M, Miyake N, Nakamura M, Miyahara R, Ohmiya N, Niwa Y, Goto H.

Dig Liver Dis. Vol. 41 page： 735-739 2009

Diagnosis of Pancreatic Discorders Using Contrast-Enhanced Endoscopic Ultrasonography and Endoscopic Elastography. Reviewed

Hirooka Y, Itoh A, Kawashima H, Ohno E, Ishikawa T, Matsubara H, Itoh Y, Nakamura M, Miyahara R, Ohmiya N, Niwa Y, Ishigami M, Katano Y, Goto H.

Clin Gastroenterol and Hepatol. Vol. 7 page： S63-67 2009

原因不明の消化管出血例におけるカプセル内視鏡の診断的意義 Reviewed

中村正直、大宮直木、宮原良二、安藤貴文、渡辺修、川嶋啓揮、伊藤彰浩、廣岡芳樹、丹羽康正、後藤秀実

日本消化器内視鏡学会雑誌 Vol. 51 ( 11 ) page： 2866-2875 2009.11

Geranylgeranylacetone Protects against Diclofenac-Induced Gastric and Small Intestinal Mucosal Injuries in Healthy Subjects: A Prospective Randomized Placebo-Controlled Double-Blind Cross-Over Study. Reviewed

Niwa, Y., Nakamura, M., Miyahara, R., Ohmiya, N., Watanabe, O., Ando, T., Kawashima, H., Itoh, A., Hirooka, Y., Goto, H..

Digestion Vol. 80 ( 4 ) page： 260-266 2009.10

Outcome after enteroscopy for patients with obscure GI bleeding: diagnostic comparison between double-balloon endoscopy and videocapsule endoscopy. Reviewed

Gastrointestinal Endoscopy Vol. 69 ( 4 ) page： 875-876 2009.4

Small-bowel obstruction: diagnostic comparison between double-balloon endoscopy and fluoroscopic enteroclysis, and the outcome of enteroscopic treatment. Reviewed

Ohmiya, N., Arakawa, D., Nakamura, M., Honda, W.,Shirai, O., Taguchi, A., Itoh, A., Hirooka, Y., Niwa, Y., Maeda, O., Ando, T., Goto, H.,

Gastrointestinal Endoscopy Vol. 69 ( 1 ) page： 84-93 2009.1

"NEW INSTRUMENTS AND TECHNIQUESNEW OBJECTIVE EVALUATION METHOD FOR FUNCTIONAL BOWEL DISORDER USING VIDEO CAPSULE ENDSCOPY" Reviewed

Nakamura, M., Niwa, Y., Yagihara, M., Ohmiya, N.,Miyahara, R., Ando, T., Watanabe, O., Kawashima, H., Itoh, A., Hirooka, Y., Fujimoto. H., Goto, H.,

Digestive Endoscopy Vol. 21 ( 1 ) page： 29-33 2009.1

Observation of Deworming Process in Intestinal Diphyllobothrium latum Parasitism by Gastrografin Injection Into Jejunum Through Double-Balloon Enteroscope Reviewed

Ko S, Ohmiya N, Nakamura M, Honda W, Shirai O, Takenaka H, Niwa Y, Goto H.

Am J Gastroenterol Vol. 103 page： 2149-2150 2008

Efficacy of rebamipide for diclofenac-induced small-intestinal mucosal injuries in healthy subjects: a prospective,rando mized,double-blinded,placebo-controlled,cross-over study Reviewed

Niwa, Y., Nakamura, M., Ohmiya, N., Maeda, O., Ando, T., Itoh, A., Hirooka, Y., Goto, H.,

J Gastroenterol Vol. 43 ( 4 ) page： 270-276 2008.4

Which route should we select when performing double-ballon enteroscopy? Reviewed

Nakamura, M., Niwa, Y., Ohmiya, N., Goto, H.

Gastrointestinal Endoscopy Vol. 3 ( 67 ) page： 577-578 2008.3

Analysis of Large Bowel Peristalsis with Video Capsule Endoscopy. Reviewed

Yagihashi M, Niwa Y, Nakamura M, Goto H, Fujimoto H.

Complex Medical Engineering page： 766–769 2007

Small bowel tuberculosis diagnosed by the combination of video capsule endoscopy and double balloon enteroscopy Reviewed

Nakamura, M., Niwa, Y., Ohmiya, N., Arakawa, D., Honda, W., Miyahara, R., Matsuura, T., Ando, T., Maeda, O., Itoh, A., Hirooka, Y., Goto, H.

European Journal of Gastroenterology & Hepatology Vol. 19 ( 7 ) page： 595-598 2007.7

Diagnosis and treatment of obscure GI bleeding at double balloon endoscopy Reviewed

Naoki Ohmiya,Tomonori Yano,Hironori Yamamoto,Daigo Arakawa, Masanao Nakamura,Wataru Honda,Akihiro Itoh,Yoshiki Hirooka,Yasumasa Niwa,Osamu Maeda,Takafumi Ando,Tsuneyoshi Matsui,Mitsuo Iida,Shinji Tanaka,Tsutomu Chiba,Choitsu Sakamoto,Kantaro Sugano,Hidemi Goto.

Gastrointestinal Endoscopy Vol. 66 ( 3 ) page： S72-S77 2007.3

Ilealcancer and erosions in small intestine revealed by capsule endoscopy. Reviewed

Niwa Y, Nakamura M, Omiya N, Itoh A, Hirooka Y, Goto H

Endoscopy Vol. 38 page： E91-92 2006

* Preliminary comparison of Capsule Endoscopy and Double-Balloon Enteroscopy in Patients with suspected Small-Bowel Bleeding Reviewed

Nakamura, M., Niwa, Y., Ohmiya, N., Miyahara, R., Ohashi, A., Itoh, A., Hirooka, Y., Goto, H.

Endoscopy Vol. 38 ( 1 ) page： 59-66 2006.1

Endscopic resection of Peutz-Jeghers polips throughout the small intestine at double-balloon enteroscopy without laparotomy Reviewed

Ohmiya,N., Taguchi, A., Shirai, K., Mabuchi, N., Arakawa, D., Kanazawa, H., Ozeki, M., Yamada, M.,Nakamura, M., Itoh, A., Hirooka, Y., Niwa, Y., (Nagasaka, T., Ito, M., Ohashi, S., Okamura, S.,Goto, H.,

Gastrointestinal Endoscopy Vol. 61 ( 1 ) page： 140-148 2005.1

Usefulness of endoscopic ultrasonography for differentiating between non-functional pancreatic neuroendocrine neoplasm and intrapancreatic accessory spleen.

Kano Y, Ishikawa T, Yamao K, Mizutani Y, Iida T, Uetsuki K, Yamamura T, Furukawa K, Nakamura M, Kawashima H

Scientific reports Vol. 15 ( 1 ) page： 6385 2025.2

Prognostic Role of Enhancing Mural Nodules in Intraductal Papillary Mucinous Neoplasms with High-Risk Stigmata.

Kumano R, Ohno E, Ishikawa T, Yamao K, Mizutani Y, Iida T, Uetsuki K, Yamamura T, Furukawa K, Nakamura M, Honda T, Kawashima H

Annals of surgery 2025.2

New drug-delivery balloon catheter for easy and fast injection of triamcinolone after esophageal endoscopic submucosal dissection.

Hirose T, Shibata H, Furukawa K, Yamamura T, Ishikawa T, Nakamura M, Kawashima H

Endoscopy Vol. 56 ( S 01 ) page： E634 - E635 2024.12

Nationwide multicenter prospective study on the usefulness, safety, and acceptability of colon capsule endoscopy in Japan.

Hotta N, Ohmiya N, Hiraga H, Nakaji K, Osawa S, Omori T, Mitsufuji S, Hosoe N, Nouda S, Kobayashi T, Nakamura M, Oka S, Nonogaki K, Baba Y, Mukai R, Matsumoto H, Ikebuchi Y, Shimada M, Togashi K, Katsuki S, Sasaki Y, Sawada R, Kawano S, Furuta T, Tajiri H, Tanaka S, ColoCam-J Study Group

Gastrointestinal endoscopy 2024.11

Clinical factors influencing patency capsule excretion and confirmation in patients with intestinal patency.

Ikegami S, Yamamura T, Nakamura M, Maeda K, Sawada T, Ishikawa E, Ishikawa T, Furukawa K, Hirose T, Kawashima H

Revista espanola de enfermedades digestivas 2024.11

特集炎症性腸疾患update [Chapter 2]　IBD治療のupdate CD内科治療 ②(腸管狭窄に対する内視鏡治療)

中村正直, 山村健史, 澤田つな騎, 石川恵里, 川嶋啓揮

内科 Vol. 134 ( 5 ) page： 1065 - 1067 2024.11

特集炎症性腸疾患update [Chapter 2]　IBD治療のupdate UC内科治療 ③(ステロイド後)

澤田つな騎, 中村正直, 山村健史, 川嶋啓揮

内科 Vol. 134 ( 5 ) page： 1042 - 1049 2024.11

Chronic obstructive pulmonary disease, asthma, and mechanical ventilation are risk factors for dyspnea in patients with long COVID: A Japanese nationwide cohort study.

Matsuyama E, Miyata J, Terai H, Miyazaki N, Iwasaki T, Nagashima K, Watase M, Sunata K, Namkoong H, Asakura T, Masaki K, Chubachi S, Ohgino K, Kawada I, Minami K, Hagiwara R, Ueda S, Yoshiyama T, Kokuto H, Kusumoto T, Oashi A, Miyawaki M, Saito F, Tani T, Ishioka K, Takahashi S, Nakamura M, Ishii M, Sato Y, Fukunaga K

Respiratory investigation Vol. 62 ( 6 ) page： 1094 - 1101 2024.11

Predicting early rebleeding and mortality after endoscopic hemostasis of esophagogastric varices: Diagnostic performance of aspartate aminotransferase-to-platelet ratio index and model for end-stage liver disease-Na score.

Yokoyama S, Honda T, Ishizu Y, Imai N, Ito T, Yamamoto K, Mizuno K, Nakamura M, Kawashima H

Journal of hepato-biliary-pancreatic sciences Vol. 31 ( 11 ) page： 830 - 839 2024.11

特集小腸疾患に対する最新の内視鏡臨床 10.腫瘍性疾患に対する最新の診断治療戦略

中村正直, 山村健史, 前田啓子, 澤田つな騎, 石川恵里, 川嶋啓揮

臨床消化器内科 Vol. 39 ( 12 ) page： 1545 - 1552 2024.10

New Role of the Serotonin as a Biomarker of Gut-Brain Interaction.

Liu HN, Nakamura M, Kawashima H

Life (Basel, Switzerland) Vol. 14 ( 10 ) 2024.10

Monoclonal Antibodies Against Mature Interleukin-18 Ameliorate Colitis and Repair Goblet Cell Function.

Mu J, Maeda K, Ohashi A, Urano T, Nariai Y, Kamino H, Nakamura M, Yamamura T, Sawada T, Ishikawa E, Murate K, Yamamoto K, Hirose T, Furukawa K, Fujishiro M, Kawashima H

Digestive diseases and sciences Vol. 69 ( 7 ) page： 2573 - 2585 2024.7

Language：English Publisher：Digestive Diseases and Sciences

Background: Numerous biological interventions and small molecules are used to treat Crohn’s disease; however, the effectiveness of these treatments varies largely. Non-responsiveness to biological therapies is associated with interleukin (IL)-18 gene polymorphisms and high IL-18 expression has been implicated in the pathogenesis of Crohn’s disease. Aims: The aim of this study was to elucidate the expression of precursor and mature IL-18 in patients with Crohn’s disease who exhibited varied responses to cytokine-targeted treatments and determine whether selective inhibition of mature IL-18 offers a novel therapeutic avenue. Methods: We generated a monoclonal antibody that specifically recognizes the neoepitope of caspase-cleaved mature IL-18. Expression of precursor and mature IL-18 was analyzed in patients with Crohn’s disease. Anti-mature IL-18 monoclonal antibodies were intraperitoneally administered in an acute colitis mouse model, and the disease activity index, body weight loss, tissue pathology, proinflammatory cytokine expression, goblet cell function, and microbiota composition were assessed. Results: Precursor and mature IL-18 expression was upregulated and goblet cell function was impaired in patients with Crohn’s disease who were unresponsive to biological therapies. Administration of anti-mature IL-18 antibodies ameliorated induced colitis by repairing goblet cell function and restoring the mucus layer. Conclusions: The newly developed monoclonal antibody holds promise as a therapeutic alternative for Crohn’s disease.

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Papers - NAKAMURA, Masanao