Faculty Profiles - NAKAMURA, Masanao

Papers - NAKAMURA, Masanao

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Prevalence and distribution of serrated polyps in the colon

Pu L. Zorron Cheng Tao, Singh G, Krishnamurthi S, Ovenden A, Nakamura M, Yamamura T, Rana K, Lu K, Edwards S, Ruszkiewicz A, Hoong C. K, Hirooka Y, Burt A. D, Singh R

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Vol. 33 page： 185 - 186 2018.9

Effect of training and time of the day on polyp detection rates

Pu L. Zorron Cheng Tao, Lu K, Ovenden A, Rana K, Singh G, Krishnamurthi S, Edwards S, Wilson B, Nakamura M, Yamamura T, Ruszkiewicz A, Hoong C. K, Hirooka Y, Burt A. D, Singh R

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Vol. 33 page： 184 - 185 2018.9

Prospective study predicting histology in colorectal lesions using wNICE, wJNET, and MS classifications

Pu L. Zorron Cheng Tao, Yamamura T, Nakamura M, Koay D. S. C, Ovenden A, Edwards S, Hoong C. K, Burt A. D, Hirooka Y, Singh R

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Vol. 33 page： 14 - 14 2018.9

Effect of training and time of the day on polyp detection rates

Pu L. Zorron Cheng Tao, Lu K, Ovenden A, Rana K, Singh G, Krishnamurthi S, Edwards S, Wilson B, Nakamura M, Yamamura T, Ruszkiewicz A, Hoong C. K, Hirooka Y, Burt A. D, Singh R

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Vol. 33 page： 184 - 185 2018.9

Prevalence and distribution of serrated polyps in the colon

Pu L. Zorron Cheng Tao, Singh G, Krishnamurthi S, Ovenden A, Nakamura M, Yamamura T, Rana K, Lu K, Edwards S, Ruszkiewicz A, Hoong C. K, Hirooka Y, Burt A. D, Singh R

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Vol. 33 page： 185 - 186 2018.9

Effect of training and time of the day on polyp detection rates

Pu L. Zorron Cheng Tao, Lu K, Ovenden A, Rana K, Singh G, Krishnamurthi S, Edwards S, Wilson B, Nakamura M, Yamamura T, Ruszkiewicz A, Hoong C. K, Hirooka Y, Burt A. D, Singh R

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Vol. 33 page： 184 - 185 2018.9

Prevalence and distribution of serrated polyps in the colon

Pu L. Zorron Cheng Tao, Singh G, Krishnamurthi S, Ovenden A, Nakamura M, Yamamura T, Rana K, Lu K, Edwards S, Ruszkiewicz A, Hoong C. K, Hirooka Y, Burt A. D, Singh R

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Vol. 33 page： 185 - 186 2018.9

Prospective study predicting histology in colorectal lesions using wNICE, wJNET, and MS classifications

Pu L. Zorron Cheng Tao, Yamamura T, Nakamura M, Koay D. S. C, Ovenden A, Edwards S, Hoong C. K, Burt A. D, Hirooka Y, Singh R

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Vol. 33 page： 14 - 14 2018.9

Objective evaluation of blood flow in the small-intestinal villous: quantification of findings from dynamic endoscopy with concomitant narrow-band imaging. Reviewed International journal

Takeyama T, Hirooka Y, Kawashima H, Ohno E, Ishikawa T, Yamamura T, Furukawa K, Funasaka K, Nakamura M, Miyahara R, Ishigami M, Goto H

Endoscopy international open Vol. 6 ( 8 ) page： E941 - E949 2018.8

Language：Japanese Publishing type：Research paper (scientific journal)

Background and aims: We have previously shown that the increase in blood flow volume in jejunum villi after spraying of 10 % dextrose solution correlates with pancreatic exocrine function (PEF). The aim of this study was to establish an objective method to evaluate the amount of jejunum villous blood flow using a novel image analysis system. Patients and methods: The subjects were 26 patients who underwent upper gastrointestinal endoscopy with a newly developed small intestine endoscope (SIF-Y0007, Olympus, Tokyo, Japan). By defining the ratio of capillary occupancy in each villus at levels from 1 to 5, villous blood flow was evaluated subjectively on the villous blood flow scale (VBFS). Objective evaluation was performed based on luminance analysis. The morphological opening process was used to make images with leveled brightness. A histogram was prepared from the luminance information and the standard deviation was determined and defined as SDOV (Standard Deviation calculated from a histogram made by luminance analysis Of Villi). PEF was evaluated by measuring the BT-PABA (N-benzoyl-L-tyrosyl-p-aminobenzoic acid) excretion rate. Results: There was a significant positive correlation between VBFS and SDOV ( P < 0.0001, ρ = 0.5882). SDOV was also positively correlated with PEF ( P = 0.0004, ρ = 0.6421). Conclusions: SDOV is a new objective index for evaluation of blood flow volume in jejunum villi. SDOV may be useful in clinical practice to estimate PEF and for clarification of the mechanisms underlying the functional correlation between the pancreas and small intestine.

DOI： 10.1055/a-0619-4965

Web of Science

PubMed

groove膵癌の1症例

橋詰清孝, 廣岡芳樹, 川嶋啓揮, 大野栄三郎, 石川卓哉, 桑原崇通, 河合学, 須原寛樹, 竹山友章, 小屋敏也, 松下正伸, 山村健史, 古川和宏, 舩坂好平, 中村正直, 宮原良二, 渡辺修, 後藤秀実

肝胆膵治療研究会誌 Vol. 15 ( 1 ) page： 39 - 46 2018.8

Language：Japanese Publisher：肝胆膵治療研究会

症例は60歳代男性。膵頭部腫大と肝胆道系酵素高値にて当院紹介受診となった。造影CT検査ではgroove領域に正常膵実質と比較し、早期動脈相・後期動脈相では低吸収、門脈相でほぼ等吸収、平衡相でやや高吸収な腫瘤様所見を認めた。肝内・肝外胆管は拡張しており、膵内胆管に狭窄を認めたが、主膵管拡張は認めなかった。ERCP施行時、副乳頭周囲の十二指腸粘膜に発赤・襞のひきつれ所見を認めた。膵管像は膵頭部の主膵管に不整所見を認め、副膵管は造影されなかった。胆管像では膵内胆管の狭窄は平滑であった。EUSでは膵頭部に径約30mmの輪郭不明瞭な低エコー腫瘤を認めた。Sonazoidを用いた造影では全体が均一に染影されたが、内部に造影効果が著明に減弱する部位を認めた。診断目的にEUS-FNAを施行したが悪性所見は認めず、ERCP施行時の副乳頭周囲と胆管狭窄部からの生検でも悪性所見は認めなかった。画像診断(特に膵管造影所見)より悪性疾患の可能性が否定できず、十分な説明のもと膵頭十二指腸切除術を施行した。病理結果はgroove膵癌であった。(著者抄録)

groove膵癌の一例

橋詰清孝, 廣岡芳樹, 川嶋啓揮, 大野栄三郎, 桑原崇通, 森島大雅, 河合学, 須原寛樹, 竹山友章, 小屋敏也, 山村健史, 舩坂好平, 中村正直, 宮原良二, 渡辺修, 後藤秀実

肝胆膵治療研究会誌 Vol. 15 ( 1 ) page： 101 - 101 2018.8

主膵管と交通した膵漿液性嚢胞腺腫の1症例

酒井大輔, 廣岡芳樹, 川嶋啓揮, 大野栄三郎, 石川卓哉, 須原寛樹, 竹山友章, 小屋敏也, 田中浩敬, 飯田忠, 西尾亮, 鈴木博貴, 植月康太, 松下正伸, 山村健史, 古川和宏, 舩坂好平, 中村正直, 宮原良二, 渡辺修, 石上雅敏, 後藤秀実

肝胆膵治療研究会誌 Vol. 15 ( 1 ) page： 71 - 78 2018.8

Language：Japanese Publisher：肝胆膵治療研究会

症例は70歳代男性。近医にて膵頭部に多房性嚢胞性病変、主膵管拡張を指摘。2年の経過で嚢胞性病変の増大を認め当科紹介となった。腹部造影CT検査では、膵頭部に70mm大で中心部が早期動脈相から平衡相まで均一に淡く造影される多房性嚢胞性病変を認め、主膵管は径15mmと拡張を認めた。EUSでは膵頭部病変はhoneycomb appearanceを認める多房性嚢胞性病変として描出された。また主膵管は嚢胞との交通が疑われ最大径17mmと著明に拡張していた。ERPでは膵頭部主膵管の腫瘍による圧排性狭窄と同部位で嚢胞との交通を認めた。画像診断上は膵漿液性腫瘍が第一に考えられたが70mm大の巨大な腫瘤で増大傾向があり、主膵管との交通を認めることから膵管内乳頭粘液性腫瘍を完全には否定できず亜全胃温存膵頭十二指腸切除術を施行した。手術標本の病理組織学的診断は漿液性嚢胞腺腫で、悪性所見は認めなかった。(著者抄録)

【知っておこう!遺伝性消化器疾患】Peutz-Jeghers症候群

中村正直, 大宮直木, 廣岡芳樹, 後藤秀実

消化器内視鏡 Vol. 30 ( 8 ) page： 1031 - 1034 2018.8

Language：Japanese Publisher：(株)東京医学社

Peutz-Jeghers症候群(PJS)は、食道を除く全消化管の過誤腫性ポリポーシスと、口唇、口腔、指趾の色素沈着を特徴とする常染色体優性遺伝性疾患である。消化管ポリポーシスでは小腸で最もポリープ数が多く、サイズも大きくなる。ポリープは有茎性であり頭部は分葉傾向を有する。組織学的には過誤腫であるが、上皮の過形成と粘膜筋板のポリープ内への樹枝状増生が他のポリポーシスと異なる。PJSの臨床経過中、腸重積の合併と、諸臓器における悪性疾患の合併に注意が必要である。他消化管と比較し小腸は管腔が狭く、ポリープの発育が速いため腸重積を起こしやすい。腸重積の好発年齢は若年であり、約30%は10歳までに起こるといわれる。一方、悪性腫瘍の合併は30歳以降で多く、消化管以外にも乳腺、子宮、卵巣、膵臓、肺などで発生する。消化管の状態の把握、腹部超音波、胸腹部CTや婦人科受診を行い、経年的な経過観察が重要である。(著者抄録)

主膵管と交通した膵漿液性嚢胞腫瘍の一例

酒井大輔, 廣岡芳樹, 川嶋啓揮, 大野栄三郎, 石川卓哉, 須原寛樹, 竹山友章, 橋詰清孝, 小屋敏也, 田中浩敬, 飯田忠, 西尾亮, 鈴木博貴, 松下正伸, 山村健史, 古川和宏, 舩坂好平, 中村正直, 宮原良二, 渡辺修, 後藤秀実

肝胆膵治療研究会誌 Vol. 15 ( 1 ) page： 116 - 116 2018.8

Increase in breath hydrogen concentration was correlated with the main pancreatic duct stenosis

Sakai Daisuke, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Suhara Hiroki, Takeyama Tomoaki, Koya Toshinari, Tanaka Hiroyuki, Iida Tadashi, Nishio Ryo, Suzuki Hirotaka, Uetsuki Kota, Matsushita Masanobu, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Ishigami Masatoshi, Tsuruta Akihiro, Shin Woosuck, Goto Hidemi

JOURNAL OF BREATH RESEARCH Vol. 12 ( 3 ) page： 036004 2018.7

A prognostic model, including the EBV status of tumor cells, for primary gastric diffuse large B-cell lymphoma in the rituximab era. Reviewed International journal

Eri Ishikawa, Tsutomu Tanaka, Kazuyuki Shimada, Kei Kohno, Akira Satou, Ahmed E Eladl, Ayako Sakakibara, Kazuhiro Furukawa, Kohei Funasaka, Ryoji Miyahara, Masanao Nakamura, Hidemi Goto, Shigeo Nakamura, Seiichi Kato, Yoshiki Hirooka

Cancer medicine Vol. 7 ( 7 ) page： 3510 - 3520 2018.7

Language：English Publishing type：Research paper (scientific journal)

EBV-positive diffuse large B-cell lymphoma (DLBCL), not otherwise specified (NOS), often affects the gastrointestinal tract. However, the prognostic significance of EBV associated with primary gastric DLBCL (gDLBCL) has not been established. This retrospective study included 240 patients with primary gDLBCL, diagnosed between 1995 and 2015. Tumor specimens were analyzed with EBER in situ hybridization. In 25 (10%) cases, tumor cells harbored EBV. The EBV+ group more frequently exhibited programmed death-ligand 1 (PD-L1) expression in microenvironment immune cells, but not tumor cells, compared to the EBV- group (86% vs 43%, P = .006). Among 156 patients that received rituximab-containing chemotherapy, the EBV+ group had a significantly worse overall survival (OS) than the EBV- group (P = .0029). Multivariate analyses identified 3 independent adverse prognostic factors of OS: multiple gastric lesions (P = .002), EBER positivity (P = .003), and B symptoms (P = .018). These factors were combined to develop a gDLBCL prognostic (gDLP) model that significantly stratified the patients into 3 distinct risk groups (Scores: good = 0, intermediate = 1, and poor = 2/3, P < .0001) with 5-year OS rates of 100%, 81%, and 39%, respectively. Patients with EBV+ gDLBCL commonly exhibited microenvironmental PD-L1 expression and showed a significantly worse prognosis than subjects with EBV- gDLBCL. Our gDLP model, which included EBV+ tumor cells, provided good predictions of clinical outcome and may be useful for selecting patients in trials in the immune-oncology era.

DOI： 10.1002/cam4.1595

ENDOSCOPIC TREATMENT FOR SUPERFICIAL NON-AMPULLARY DUODENAL TUMORS

Furukawa Kazuhiro, Miyahara Ryoji, Funasaka Kohei, Suhara Hiroki, Matsushita Masanobu, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Watanabe Osamu, Hirooka Yoshiki, Goto Hidemi

GASTROINTESTINAL ENDOSCOPY Vol. 87 ( 6 ) page： AB315-AB316 2018.6

EVALUATION OF LOCAL RECURRENCE AFTER COLD POLYPECTOMY COMPARED WITH CONVENTIONAL HOT POLYPECTOMY IN A PROSPECTIVE RANDOMIZED CONTROLLED TRIAL

Yamamura Takeshi, Saito Masashi, Watanabe Osamu, Nakamura Masanao, Matsushita Masanobu, Sawada Tsunaki, Mizutani Yasuyuki, Niwa Yoshiki, Ishikawa Eri, Suzuki Hiroto, Otsuka Hiroyuki, Uchida Genta, Nishikawa Takahiro, Ishida Tetsuya, Kuno Takeshi, Yamada Keisaku, Hattori Shun, Hashiguchi Hiroki, Suhara Hiroki, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Hirooka Yoshiki, Goto Hidemi

GASTROINTESTINAL ENDOSCOPY Vol. 87 ( 6 ) page： AB478-AB478 2018.6

USEFULNESS OF HISTOLOGICAL ASSESSMENT WITH EUS-GUIDED FINE NEEDLE BIOPSY USING A NEW CORE NEEDLE IN PANCREATIC DISEASES

Ishikawa Takuya, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Suhara Hiroki, Takeyama Tomoaki, Koya Toshinari, Tanaka Hiroyuki, Sakai Daisuke, Nishio Ryo, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Matsushita Masanobu, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Goto Hidemi

GASTROINTESTINAL ENDOSCOPY Vol. 87 ( 6 ) page： AB432 - AB433 2018.6

USEFULLNESS OF CONTRAST-ENHANCED HARMONIC EUS(CH-EUS) FOR THE PREOPERATIVE ASSESSMENT OF MPD INVOLVEMENT IN IPMN; A RETROSPECTIVE COMPARISON STUDY OF CH-EUS AND IDUS

Ohno Eizaburo, Hirooka Yoshiki, Kawashima Hiroki, Ishikawa Takuya, Suhara Hiroki, Takeyama Tomoaki, Koya Toshinari, Tanaka Hiroyuki, Sakai Daisuke, Nishio Ryo, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Matsushita Masanobu, Furukawa Kazuhiro, Yamamura Takeshi, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Goto Hidemi

GASTROINTESTINAL ENDOSCOPY Vol. 87 ( 6 ) page： AB426 - AB427 2018.6

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Papers - NAKAMURA, Masanao