研究者詳細 - 中村　正直

論文 - 中村　正直

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Novel EMR Technique for Preoperative Diagnosis and Treatment of Submucosal Tumor in the Small Bowel at Double-Balloon Endoscopy

Nakamura Masanao, Watanabe Osamu, Yamamura Takeshi, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Saito Masashi, Matsuura Rinzaburo, Mizutani Yasuyuki, Sawada Tsunaki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Kawashima Hiroki, Miyahara Ryoji, Goto Hidemi, Hirooka Yoshiki

GASTROINTESTINAL ENDOSCOPY 85 巻 ( 5 ) 頁： AB300 - AB300 2017年5月

Objective Assessment of Jejunal Villous Blood Flow for Evaluating Pancreas-Jejunum Functional Correlation Using a Novel Image Analyzing System

Takeyama Tomoaki, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Kawai Manabu, Suhara Hiroki, Hashizume Kiyotaka, Koya Toshinari, Tanaka Hiroyuki, Sakai Daisuke, Matsushita Masanobu, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Goto Hidemi

GASTROINTESTINAL ENDOSCOPY 85 巻 ( 5 ) 頁： AB319 - AB320 2017年5月

Clinical Factors Related to False Positive Rates of Patency Capsule Examination

Sawada Tsunaki, Nakamura Masanao, Watanabe Osamu, Yamamura Takeshi, Matsushita Masanobu, Oshima Hiroshi, Sato Junichi, Saito Masashi, Matsuura Rinzaburo, Mizutani Yasuyuki, Niwa Yoshiki, Ishikawa Eri, Uchida Genta, Otsuka Hiroyuki, Suzuki Hiroto, Nishikawa Takahiro, Ishida Tetsuya, Ishikawa Takuya, Furukawa Kazuhiro, Funasaka Kohei, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Goto Hidemi, Hirooka Yoshiki

GASTROINTESTINAL ENDOSCOPY 85 巻 ( 5 ) 頁： AB305 - AB305 2017年5月

Prospective, Multicenter Study for Evaluation of the Clinical Efficacy and Safety of Pillcam Patency Capsule in 1,096 Cases With Suspected Small Bowel Stenosis

Nakamura Masanao, Watanabe Kenji, Ohmiya Naoki, Hirai Fumihito, Omori Teppei, Tokuhara Daisuke, Nakaji Konosuke, Nouda Sadaharu, Washio Ema, Sameshima Yukinori, Mannami Tomohiko, Maeda Kohei, Ninomiya Kazeo, Wakamatsu Takahiro, Araki Akihiro, Ishii Manabu, Higaki Shingo, Abe Takashi, Handa Osamu, Kawano Seiji, Iwamoto Maho, Kato Shingo, Kagaya Takashi, Goto Hidemi, Matsui Toshiyuki

GASTROINTESTINAL ENDOSCOPY 85 巻 ( 5 ) 頁： AB53 - AB53 2017年5月

A Nationwide Multicenter Study on Adverse Events Associated With a Patency Capsule: Additional Survey for the Japanese Association for Capsule Endoscopy-Oriented Appropriate Use Survey for Patency Capsule (J-Pop) Study

Omori Teppei, Watanabe Kenji, Ohmiya Naoki, Hirai Fumihito, Nakamura Masanao, Kagaya Takashi, Oka Shiro, Ozeki Keiji, Kawano Seiji, Ninomiya Kazeo, Nakaji Konosuke, Iimuro Masaki, Handa Osamu, Tokuhara Daisuke, Sagawa Tamotsu, Wakamatsu Takahiro, Kato Shingo, Araki Akihiro, Koike Yuji, Hashimoto Shinichi, Mannami Tomohiko, Higaki Shingo, Hayashida Mari, Sameshima Yukinori, Hasegawa Daisuke, Tokushige Katsutoshi, Matsui Toshiyuki

GASTROINTESTINAL ENDOSCOPY 85 巻 ( 5 ) 頁： AB294 - AB294 2017年5月

今月の主題消化管結核の診断と治療─最近の進歩主題症例抗結核薬による診断的治療が奏効した小腸多発潰瘍の1例

齋藤雅之, 中村正直, 渡辺修, 山村健史, 松下正伸, 中野有泰, 大島啓嗣, 佐藤淳一, 松浦倫三郎, 舩坂好平, 大野栄三郎, 川嶋啓揮, 宮原良二, 廣岡芳樹, 後藤秀実

胃と腸 52 巻 ( 2 ) 頁： 233 - 238 2017年2月

Risk factors

Uchida G., Nakamura M., Watanabe O., Yamamura T., Matsushita M., Ishikawa T., Furukawa K., Funasaka K., Ohno K., Kawashima H., Miyahara R., Goto H., Hirooka Y.

Journal of Japanese Society of Gastroenterology 114 巻 ( 10 ) 頁： 1819 - 1828 2017年

出版者・発行元：Journal of Japanese Society of Gastroenterology

Capsule endoscopy (CE) and double-balloon endoscopy (DBE) have revolutionized the diagnosis and treatment of obscure gastrointestinal bleeding (OGIB). Although CE and DBE provide access to the small bowel and OGIB can be effectively treated by the identification of specific bleeding lesions, some patients experience rebleeding after small bowel investigation. There are no definite algorithms to determine the best follow-up period for patients with OGIB. The purpose of this study was to investigate the long-term outcomes and risk factors for rebleeding and to develop a follow-up strategy for patients with overt OGIB. Among 386 patients who underwent CE for OGIB at Nagoya University Hospital between June 2004 and December 2015, 318 patients with overt OGIB were enrolled in this retrospective study. The clinical characteristics and risk factors for rebleeding were analyzed, and a predictive model for the same was developed. Rebleeding occurred in 45 patients (14.2%) during a median follow-up period of 16.8 months. Multivariable regression analysis identified the following factors as significant independent predictors of rebleeding : vascular lesions seen during CE, transfusion requirement, and patients aged ≥60 years. The predictive model for rebleeding was developed using these factors to identify patients who had a high risk of rebleeding and to provide useful information to physicians in clinical practice. The C-statistic of the predictive model was 0.698. A risk-based approach to follow-up patients with OGIB can help clinicians determine a follow-up period for patients after small bowel investigation.

Scopus

Endoscopic ultrasound-guided drainage using a forward-viewing echoendoscope for peripancreatic fluid collection after Child resection. 国際誌

Ishikawa T, Yamao K, Mizutani Y, Iida T, Uetsuki K, Nakamura M, Kawashima H

Endoscopy 56 巻 ( S 01 ) 頁： E83 - E84 2024年12月

Endoscopic Papillectomy for Ampullary Gangliocytic Paraganglioma: A Case Series and Literature Review.

Takada Y, Ishikawa T, Yamao K, Mizutani Y, Iida T, Uetsuki K, Nakamura M, Furukawa K, Yamamura T, Kawashima H

Internal medicine (Tokyo, Japan) advpub 巻 ( 0 ) 2024年9月

A prospective study on the histological evaluation of type 1 autoimmune pancreatitis using endoscopic ultrasound-guided fine needle biopsy with a 19-gauge Franseen needle.

Ishikawa T, Yamao K, Mizutani Y, Iida T, Uetsuki K, Shimoyama Y, Nakamura M, Furukawa K, Yamamura T, Kawashima H

Journal of hepato-biliary-pancreatic sciences 31 巻 ( 8 ) 頁： 581 - 590 2024年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Hepato-Biliary-Pancreatic Sciences

Background/Purpose: To assess the diagnostic efficacy and safety of endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) using a 19-gauge Franseen needle for autoimmune pancreatitis (AIP). Methods: Twenty patients suspected of having type 1 AIP were prospectively enrolled and underwent EUS-FNB with a 19-gauge Franseen needle. Their data were compared with those of historical controls: a total of 29 type 1 AIP patients had EUS-FNB with a 22-gauge Franseen needle. Results: Specimens suitable for histological evaluation were obtained from 19 of the 20 patients (95%), and the median total tissue area was 11.9 mm2. The histological diagnosis rate of AIP was 65% (95% CI: 43.2%–82%). Adverse events were observed in three patients (15%), and a switch to 22-gauge needles occurred during transduodenal puncture in two patients. Compared to those punctured with 22-gauge needles, patients punctured with 19-gauge needles had greater prevalence of each characteristic feature of lymphoplasmacytic sclerosing pancreatitis, but the difference was not statistically significant. Conclusions: EUS-FNB using a 19-gauge Franseen needle demonstrated favorable performance for the histological diagnosis of AIP and allowed for large tissue samples, potentially facilitating pathological diagnosis. However, during transduodenal puncture, maneuverability is reduced; therefore, the needle may need to be selected according to the puncture site.

DOI： 10.1002/jhbp.1438

Scopus

PubMed

Predictors of the efficacy of vedolizumab in patients with ulcerative colitis.

Kajikawa G, Sawada T, Nakamura M, Yamamura T, Maeda K, Ishikawa E, Uetsuki K, Hirose T, Iida T, Mizutani Y, Yamao K, Ishikawa T, Furukawa K, Kawashima H

Nagoya journal of medical science 86 巻 ( 3 ) 頁： 407 - 421 2024年8月

What is the appropriate method of pathological specimen collection for cholangiocarcinoma detection in primary sclerosing cholangitis?

Kano Y, Ishikawa T, Yamao K, Mizutani Y, Iida T, Uetsuki K, Yamamura T, Furukawa K, Nakamura M, Kawashima H

Journal of gastroenterology 59 巻 ( 7 ) 頁： 621 - 628 2024年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Gastroenterology

Background: In primary sclerosing cholangitis (PSC), it is important to understand the cholangiographic findings suggestive of malignancy, but it is difficult to determine whether cholangiocarcinoma is present due to modifications caused by inflammation. This study aimed to clarify the appropriate method of pathological specimen collection during endoscopic retrograde cholangiopancreatography for surveillance of PSC. Methods: A retrospective observational study was performed on 59 patients with PSC. The endpoints were diagnostic performance for benign or malignant on bile cytology and transpapillary bile duct biopsy, cholangiographic findings of biopsied bile ducts, diameters of the strictures and upstream bile ducts, and their differences. Results: The sensitivity (77.8% vs. 14.3%, P = 0.04), specificity (97.8% vs. 83.0%, P = 0.04), and accuracy (94.5% vs. 74.1%, P = 0.007) were all significantly greater for bile duct biopsy than for bile cytology. All patients with cholangiocarcinoma with bile duct stricture presented with dominant stricture (DS). The diameter of the upstream bile ducts (7.1 (4.2–7.2) mm vs. 2.1 (1.2–4.1) mm, P < 0.001) and the diameter differences (6.6 (3.1–7) mm vs. 1.5 (0.2–3.6) mm, P < 0.001) were significantly greater in the cholangiocarcinoma group than in the noncholangiocarcinoma group with DS. For diameter differences, the optimal cutoff value for the diagnosis of benign or malignant was 5.1 mm (area under the curve = 0.972). Conclusion: Transpapillary bile duct biopsy should be performed via localized DS with upstream dilation for the detection of cholangiocarcinoma in patients with PSC. Especially when the diameter differences are greater than 5 mm, the development of cholangiocarcinoma should be strongly suspected.

DOI： 10.1007/s00535-024-02105-y

Scopus

PubMed

Characteristics of microbiomes of the saliva, duodenal bulb, and descending portion of superficial nonampullary duodenal epithelial tumors. 国際誌

Shibata H, Yamamoto K, Hirose T, Furune S, Kakushima N, Furukawa K, Nakamura M, Honda T, Fujishiro M, Kawashima H

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 56 巻 ( 6 ) 頁： 941 - 950 2024年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Digestive and Liver Disease

Introduction: Nonampullary duodenal epithelial tumors are rare, but their prevalence is increasing. Various gastrointestinal cancers have been associated with microbiomes. We evaluated the characteristics of the salivary and duodenal microbiomes of patients with nonampullary duodenal epithelial tumors. Methods: Saliva and biopsy samples from the duodenal bulb and descending portion were obtained from 15 patients with nonampullary duodenal epithelial tumors and 10 controls. Next-generation sequencing was performed to identify bacteria for comparison. Results: Saliva samples had higher Amplicon Sequence Variants (ASVs) and more observed species than duodenal samples. Saliva samples from patients with nonampullary duodenal epithelial tumor were dominated by Bacteroidetes and Prevotella, whereas Proteobacteria and Neisseria were dominant in the control samples. The relative abundance of bacteria was higher in patients with nonampullary duodenal epithelial tumors. Most bacteria were classified as bacteria of oral origin. Oribacterium and Stomatobaculum were significantly higher in the saliva, duodenal bulb, and descending portion of patients with nonampullary duodenal epithelial tumors. Conclusion: Patients with nonampullary duodenal epithelial tumors had different salivary and duodenal microbiomes than controls. Bacteria types differed between groups at each site, and most bacteria of oral origin were more abundant in patients with nonampullary duodenal epithelial tumors.

DOI： 10.1016/j.dld.2024.01.212

Scopus

PubMed

Risk factors for decreased bone mineral density in patients with metabolic dysfunction-associated steatotic liver disease: A cross-sectional study at a health examination center. 国際誌

Yokoyama S, Honda T, Ishizu Y, Imai N, Ito T, Yamamoto K, Mizuno K, Kojima T, Kariya N, Nakamura M, Kawashima H

Clinical nutrition (Edinburgh, Scotland) 43 巻 ( 6 ) 頁： 1425 - 1432 2024年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Clinical Nutrition

Background & aims: Steatotic liver disease (SLD) is often detected in health examinations. However, although individuals with metabolic dysfunction-associated SLD (MASLD) may have decreased bone mineral density (BMD), the specific risk factors remain unclarified. The objective of this study was to identify the factors associated with decreased BMD in patients with MASLD. Methods: Individuals who underwent abdominal ultrasonography and BMD measurements at our healthcare center were included. The BMD of the calcaneus was assessed using an AOS-10SA bone densitometer. Decreased BMD was defined as a T-score below −1.0 SD or the administration of osteoporosis treatment. SLD was diagnosed based on specific ultrasonographic criteria. Results: A total of 1410 patients were diagnosed with MASLD. The median age was 52 years. Multivariate analysis using a logistic regression model revealed that the independent predictors of decreased BMD were a low body mass index (BMI) or a small waist circumference (odds ratio (OR): 0.48, 95% confidence interval (CI): 0.34–0.67), hypertriglyceridemia (OR: 1.29, 95% CI: 1.00–1.65), and a weak grip strength (OR: 0.98, 95% CI: 0.97–1.00). Subgroup analyses of individuals aged 50 years or older, men, and individuals with a FIB-4 index of 1.3 or greater revealed that the absence of a high BMI or a large waist circumference was associated with decreased BMD. The subgroup analysis of men revealed that a weaker grip strength was associated with decreased BMD. Conclusion: The present study suggested several potential risk factors for decreased BMD in patients with MASLD. Individuals with the abovementioned risk factors should be encouraged to undergo BMD measurement from the perspective of preventive medicine.

DOI： 10.1016/j.clnu.2024.04.034

Scopus

PubMed

大腸ポリープに対するコールドスネアポリペクトミーで腹腔内出血をきたした1例

池上脩二, 山村健史, 中村正直, 前田啓子, 澤田つな騎, 石川恵里, 山下彩子, 河村達哉, 横井太紀雄, 川嶋啓揮

Gastroenterological Endoscopy 66 巻 ( 5 ) 頁： 1236 - 1241 2024年5月

記述言語：日本語出版者・発行元：(一社)日本消化器内視鏡学会

症例は51歳男性.CT colonographyで指摘された大腸ポリープの切除目的に施行された大腸内視鏡検査において,脾彎曲部に腺腫性ポリープを認め,Cold Snare Polypectomy(CSP)が施行された.治療2時間後に急激な心窩部痛が出現し,腹部造影CTでは脾彎曲部の結腸壁が腫瘤状に肥厚し,壁内の血管から造影剤の漏出ならびに腹腔内に血性腹水を認めた.CSP手技に伴う腹腔内出血と診断し,同日,横行結腸部分切除術ならびに人工肛門造設術が施行された.手術標本ではCSP施行部位の直下において,筋層内に著明な血腫を認めたが,穿孔所見はなく,CSPの偶発症としての腹腔内出血と診断した.(著者抄録)

Intestinal Microbiome Associated with Efficacy of Atezolizumab and Bevacizumab Therapy for Hepatocellular Carcinoma. 国際誌

Inukai Y, Yamamoto K, Honda T, Yokoyama S, Ito T, Imai N, Ishizu Y, Nakamura M, Ishigami M, Kawashima H

Cancers 16 巻 ( 9 ) 2024年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Cancers

The combination of atezolizumab and bevacizumab has become the first-line treatment for patients with unresectable hepatocellular carcinoma (HCC). However, no studies have reported on specific intestinal microbiota associated with the efficacy of atezolizumab and bevacizumab. In this study, we analyzed fecal samples collected before treatment to investigate the relationship between the intestinal microbiome and the efficacy of atezolizumab and bevacizumab. A total of 37 patients with advanced HCC who were treated with atezolizumab and bevacizumab were enrolled. Fecal samples were collected from the patients, and they were divided into responder (n = 28) and non-responder (n = 9) groups. We compared the intestinal microbiota of the two groups and analyzed the intestinal bacteria associated with prognosis using QIIME2. The alpha and beta diversities were not significantly different between both groups, and the proportion of microbiota was similar. The relative abundance of Bacteroides stercoris and Parabacteroides merdae was higher in the responder group than in the non-responder group. When the prognosis was analyzed by the presence or absence of those bacteria, patients without both had a significantly poorer prognosis. Differences in intestinal microbiome are involved in the therapeutic effect of atezolizumab and bevacizumab.

DOI： 10.3390/cancers16091675

Scopus

PubMed

【十二指腸・小腸疾患アトラス】その他血管性病変小腸多発血管腫

河村達哉, 山村健史, 中村正直, 前田啓子, 澤田つな騎, 石川恵里, 横井太紀雄, 川嶋啓揮

消化器内視鏡 36 巻 ( 4 ) 頁： 652 - 653 2024年4月

【十二指腸・小腸疾患アトラス】腫瘍,腫瘍様病変リンパ増殖性病変 MALT lymphoma

中村正直, 山村健史, 前田啓子, 澤田つな騎, 石川恵里, 村手健太郎, 古川和宏, 廣瀬崇, 川嶋啓揮

消化器内視鏡 36 巻 ( 4 ) 頁： 480 - 481 2024年4月

【十二指腸・小腸疾患アトラス】炎症性疾患自己免疫疾患・膠原病・血管炎など腸リンパ管拡張症

山下彩子, 中村正直, 山村健史, 前田啓子, 澤田つな騎, 石川恵里, 村手健太郎, 加留部謙之輔, 川嶋啓揮

消化器内視鏡 36 巻 ( 4 ) 頁： 622 - 623 2024年4月

Artificial intelligence-based diagnostic imaging system with virtual enteroscopy and virtual unfolded views to evaluate small bowel lesions in Crohn's disease. 国際誌

Furukawa K, Oda M, Watanabe O, Nakamura M, Yamamura T, Maeda K, Mori K, Kawashima H

Revista espanola de enfermedades digestivas 2024年3月

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